{"id":"https://openalex.org/W3133527263","doi":"https://doi.org/10.1186/s12934-021-01549-8","title":"Strategy for mass production of lytic Staphylococcus aureus bacteriophage pSa-3: contribution of multiplicity of infection and response surface methodology","display_name":"Strategy for mass production of lytic Staphylococcus aureus bacteriophage pSa-3: contribution of multiplicity of infection and response surface methodology","publication_year":2021,"publication_date":"2021-03-02","ids":{"openalex":"https://openalex.org/W3133527263","doi":"https://doi.org/10.1186/s12934-021-01549-8","mag":"3133527263","pmid":"https://pubmed.ncbi.nlm.nih.gov/33653327","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7923500"},"language":"en","primary_location":{"id":"doi:10.1186/s12934-021-01549-8","doi":"https://doi.org/10.1186/s12934-021-01549-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12934-021-01549-8","pdf_url":"https://microbialcellfactories.biomedcentral.com/track/pdf/10.1186/s12934-021-01549-8","source":{"id":"https://openalex.org/S171368329","display_name":"Microbial Cell Factories","issn_l":"1475-2859","issn":["1475-2859"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Cell Factories","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://microbialcellfactories.biomedcentral.com/track/pdf/10.1186/s12934-021-01549-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006474488","display_name":"Sang Guen Kim","orcid":"https://orcid.org/0000-0001-5352-4914","observed_orcids":["https://orcid.org/0000-0001-5352-4914"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang Guen Kim","raw_affiliation_strings":["Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023348613","display_name":"Jun Kwon","orcid":"https://orcid.org/0000-0003-4965-6409","observed_orcids":["https://orcid.org/0000-0003-4965-6409"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jun Kwon","raw_affiliation_strings":["Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000864455","display_name":"Sib Sankar Giri","orcid":"https://orcid.org/0000-0002-2383-1937","observed_orcids":["https://orcid.org/0000-0002-2383-1937"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sib Sankar Giri","raw_affiliation_strings":["Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101929938","display_name":"Saekil Yun","orcid":"https://orcid.org/0000-0002-4529-8934","observed_orcids":["https://orcid.org/0000-0002-4529-8934"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Saekil Yun","raw_affiliation_strings":["Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012249352","display_name":"Hyoun Joong Kim","orcid":"https://orcid.org/0000-0001-7847-6015","observed_orcids":["https://orcid.org/0000-0001-7847-6015"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyoun Joong Kim","raw_affiliation_strings":["Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102918972","display_name":"Sang Wha Kim","orcid":"https://orcid.org/0000-0001-7205-7741","observed_orcids":["https://orcid.org/0000-0001-7205-7741"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang Wha Kim","raw_affiliation_strings":["Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110643951","display_name":"Jung Woo Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung Woo Kang","raw_affiliation_strings":["Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062121581","display_name":"Sung Bin Lee","orcid":"https://orcid.org/0000-0001-8913-0087","observed_orcids":["https://orcid.org/0000-0001-8913-0087"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung Bin Lee","raw_affiliation_strings":["Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049886131","display_name":"Won Joon Jung","orcid":"https://orcid.org/0000-0003-2810-5528","observed_orcids":["https://orcid.org/0000-0003-2810-5528"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Won Joon Jung","raw_affiliation_strings":["Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100643659","display_name":"Se Chang Park","orcid":"https://orcid.org/0000-0001-9821-387X","observed_orcids":["https://orcid.org/0000-0001-9821-387X"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Se Chang Park","raw_affiliation_strings":["Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea. parksec@snu.ac.kr","Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-9821-387X","affiliations":[{"raw_affiliation_string":"Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea. parksec@snu.ac.kr","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]},{"raw_affiliation_string":"Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100643659"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":2.7965,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.91852746,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"20","issue":"1","first_page":"56","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13220","display_name":"Plant and Fungal Interactions Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9110000133514404},{"id":"https://openalex.org/keywords/lytic-phages","display_name":"lytic phages","score":0.8460000157356262},{"id":"https://openalex.org/keywords/multiplicity-of-infection","display_name":"multiplicity of infection","score":0.9959999918937683},{"id":"https://openalex.org/keywords/response-surface-methodology","display_name":"response surface methodology","score":0.8389999866485596},{"id":"https://openalex.org/keywords/glycerol","display_name":"glycerol","score":0.6830000281333923},{"id":"https://openalex.org/keywords/glycine","display_name":"glycine","score":0.972000002861023},{"id":"https://openalex.org/keywords/calcium","display_name":"calcium","score":0.9409999847412109},{"id":"https://openalex.org/keywords/antibiotic-alternatives","display_name":"antibiotic alternatives","score":0.6909999847412109},{"id":"https://openalex.org/keywords/phage-therapy","display_name":"phage therapy","score":0.7620000243186951},{"id":"https://openalex.org/keywords/lag-phase","display_name":"lag phase","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.9606465697288513},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.8187638521194458},{"id":"https://openalex.org/C203233990","wikidata":"https://www.wikidata.org/wiki/Q1511135","display_name":"Multiplicity of infection","level":3,"score":0.8134742975234985},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7034744620323181},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.6930050849914551},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.649357795715332},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.6487802267074585},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5425179600715637},{"id":"https://openalex.org/C136199206","wikidata":"https://www.wikidata.org/wiki/Q1148110","display_name":"Lysogenic cycle","level":5,"score":0.4161113202571869},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3566818833351135},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3136739134788513},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.27496981620788574},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.07682457566261292},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.057952046394348145},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013204","descriptor_name":"Staphylococcus Phages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12934-021-01549-8","doi":"https://doi.org/10.1186/s12934-021-01549-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12934-021-01549-8","pdf_url":"https://microbialcellfactories.biomedcentral.com/track/pdf/10.1186/s12934-021-01549-8","source":{"id":"https://openalex.org/S171368329","display_name":"Microbial Cell Factories","issn_l":"1475-2859","issn":["1475-2859"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Cell Factories","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-122062/v1","doi":"https://doi.org/10.21203/rs.3.rs-122062/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-122062/v1","pdf_url":"https://www.researchsquare.com/article/rs-122062/v1.pdf?c=1631880647000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:33653327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33653327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial cell factories","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7923500","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7923500/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microb Cell Fact","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:47244b95acca40e2a341d64a33ebdda1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/47244b95acca40e2a341d64a33ebdda1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbial Cell Factories, Vol 20, Iss 1, Pp 1-12 (2021)","raw_type":"article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/173905","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/173905","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/180090","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/180090","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/s12934-021-01549-8","doi":"https://doi.org/10.1186/s12934-021-01549-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12934-021-01549-8","pdf_url":"https://microbialcellfactories.biomedcentral.com/track/pdf/10.1186/s12934-021-01549-8","source":{"id":"https://openalex.org/S171368329","display_name":"Microbial Cell Factories","issn_l":"1475-2859","issn":["1475-2859"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Cell Factories","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1071877572","display_name":null,"funder_award_id":"KRF: 2016H1D3A1909005","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G5625633043","display_name":null,"funder_award_id":"2016H1D3A1909005","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G6166032212","display_name":null,"funder_award_id":"PJ04965022020","funder_id":"https://openalex.org/F4320322035","funder_display_name":"Rural Development Administration"},{"id":"https://openalex.org/G6909675927","display_name":null,"funder_award_id":"2016H1D3A1909005","funder_id":"https://openalex.org/F4320322035","funder_display_name":"Rural Development Administration"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322035","display_name":"Rural Development Administration","ror":"https://ror.org/03xs9yg50"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133527263.pdf","grobid_xml":"https://content.openalex.org/works/W3133527263.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W141927696","https://openalex.org/W1446707807","https://openalex.org/W1531553111","https://openalex.org/W1568648551","https://openalex.org/W1800190270","https://openalex.org/W1878073525","https://openalex.org/W1878225840","https://openalex.org/W1968034367","https://openalex.org/W1976487277","https://openalex.org/W1985515739","https://openalex.org/W1987793423","https://openalex.org/W1991772704","https://openalex.org/W1994631264","https://openalex.org/W2006065303","https://openalex.org/W2044401265","https://openalex.org/W2056277537","https://openalex.org/W2064821779","https://openalex.org/W2093732539","https://openalex.org/W2097999790","https://openalex.org/W2099798492","https://openalex.org/W2103527334","https://openalex.org/W2113689947","https://openalex.org/W2117085296","https://openalex.org/W2125381415","https://openalex.org/W2128453909","https://openalex.org/W2129074322","https://openalex.org/W2132103751","https://openalex.org/W2143226881","https://openalex.org/W2144328457","https://openalex.org/W2150403913","https://openalex.org/W2157083090","https://openalex.org/W2162693588","https://openalex.org/W2188014327","https://openalex.org/W2224055327","https://openalex.org/W2285637698","https://openalex.org/W2313149310","https://openalex.org/W2317769113","https://openalex.org/W2534756159","https://openalex.org/W2601396538","https://openalex.org/W2619699249","https://openalex.org/W2644133316","https://openalex.org/W2753663123","https://openalex.org/W2772066286","https://openalex.org/W2790747958","https://openalex.org/W2793615182","https://openalex.org/W2795015626","https://openalex.org/W2795402554","https://openalex.org/W2799598773","https://openalex.org/W2802411339","https://openalex.org/W2889989499","https://openalex.org/W2892211216","https://openalex.org/W2900690521","https://openalex.org/W2903295354","https://openalex.org/W2910284051","https://openalex.org/W2987786698","https://openalex.org/W2990389524","https://openalex.org/W3003397957","https://openalex.org/W3004227146","https://openalex.org/W3007565704","https://openalex.org/W3008127222","https://openalex.org/W3008818488","https://openalex.org/W3017912446","https://openalex.org/W3021538678","https://openalex.org/W3024722812","https://openalex.org/W3114089396","https://openalex.org/W3115464959","https://openalex.org/W3117379532"],"related_works":["https://openalex.org/W2795015626","https://openalex.org/W4296803708","https://openalex.org/W1491847993","https://openalex.org/W4404327840","https://openalex.org/W4415525684","https://openalex.org/W7110600088","https://openalex.org/W2531068040","https://openalex.org/W4280572138","https://openalex.org/W2338950690","https://openalex.org/W3193692902"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Antibiotic-resistant":[2],"bacteria":[3,91],"have":[4,27],"emerged":[5],"as":[6,15,24,215],"a":[7,16,157],"serious":[8],"problem;":[9],"bacteriophages":[10,33,41,58,67],"have,":[11],"therefore,":[12],"been":[13],"proposed":[14],"therapeutic":[17],"alternative":[18],"to":[19,44,56,76,121,143,149,166,168],"antibiotics.":[20],"Several":[21],"authorities,":[22],"such":[23],"pharmacopeia,":[25],"FDA,":[26],"confirmed":[28],"their":[29,118],"safety,":[30],"and":[31,110,117,183,213,218,267,273],"some":[32],"are":[34,68,95],"commercially":[35],"available":[36],"worldwide.":[37],"The":[38],"demand":[39],"for":[40,223,293],"is":[42,52],"expected":[43],"increase":[45],"exponentially":[46],"in":[47,92,154],"the":[48,61,77,87,99,104,123,151,170,173,189,232,236,264,269,279,291,295],"future;":[49],"hence,":[50,82],"there":[51],"an":[53,132],"urgent":[54],"need":[55],"mass-produce":[57],"economically.":[59],"Unlike":[60],"replication":[62],"of":[63,79,89,107,114,135,160,172,177,186,206,235,298],"non-lytic":[64],"bacteriophages,":[65],"lytic":[66,237,299],"replicated":[69],"by":[70,262],"lysing":[71],"host":[72,90],"bacteria,":[73],"which":[74],"leads":[75],"termination":[78],"phage":[80,111,128,161,184,192,224,239,256,271,280],"production;":[81],"strategies":[83],"that":[84,286],"can":[85,259],"prolong":[86],"lysis":[88,171],"bacteria\u2013bacteriophage":[93],"co-cultures,":[94],"required.":[96],"Results":[97],"In":[98],"current":[100],"study,":[101],"we":[102,209,284],"manipulated":[103],"inoculum":[105,137,162,266],"concentrations":[106],"Staphylococcus":[108,238,255],"aureus":[109],"pSa-3":[112,257],"(multiplicity":[113],"infection,":[115],"MOI),":[116],"energy":[119],"sources":[120],"delay":[122,169],"bactericidal":[124],"effect":[125],"while":[126],"optimizing":[127,294],"production.":[129,225],"We":[130],"examined":[131],"increasing":[133,263],"range":[134,159],"bacterial":[136,265],"concentration":[138,176,234],"(2":[139],"\u00d7":[140,145,179,196,242,247],"10":[141,146,180,197,198,243,244,248],"8":[142,181],"2":[144,178],"9":[147,249],"CFU/mL)":[148],"decrease":[150,278],"lag":[152],"phase,":[153],"combination":[155,205],"with":[156],"decreasing":[158],"(from":[163],"MOI":[164,185],"0.01":[165],"0.00000001)":[167],"host.":[174],"Bacterial":[175],"CFU/mL":[182],"0.0001":[187],"showed":[188],"maximum":[190],"final":[191,233],"production":[193,258,281,297],"rate":[194],"(1.68":[195],"plaque":[199],"forming":[200],"unit":[201],"(PFU)/mL).":[202],"With":[203],"this":[204,274],"phage\u2013bacteria":[207],"inoculum,":[208],"selected":[210],"glycerol,":[211],"glycine,":[212],"calcium":[214],"carbon,":[216],"nitrogen,":[217],"divalent":[219],"ion":[220],"sources,":[221],"respectively,":[222],"After":[226],"optimization":[227],"using":[228],"response":[229,287],"surface":[230,288],"methodology,":[231],"was":[240],"8.63":[241],"\u00b1":[245],"9.71":[246],"PFU/mL":[250],"(5.13-fold":[251],"increase).":[252],"Conclusions":[253],"Therefore,":[254],"be":[260],"maximized":[261],"reducing":[268],"seeding":[270],"MOI,":[272],"combinatorial":[275],"strategy":[276],"could":[277],"time.":[282],"Further,":[283],"suggest":[285],"methodology":[289],"has":[290],"potential":[292],"mass":[296],"bacteriophages.":[300]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-15T00:00:00"}
