{"id":"https://openalex.org/W3133526409","doi":null,"title":"Cell Cycle Progression Effects of Albumin","display_name":"Cell Cycle Progression Effects of Albumin","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3133526409","mag":"3133526409"},"language":"en","primary_location":{"id":"pmh:oai:academicworks.cuny.edu:gc_etds-5182","doi":null,"is_oa":true,"landing_page_url":"https://academicworks.cuny.edu/gc_etds/4126","pdf_url":"https://academicworks.cuny.edu/gc_etds/4126","source":{"id":"https://openalex.org/S4377196304","display_name":"CUNY Academic Works (City University of New York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I174216632","host_organization_name":"City University of New York","host_organization_lineage":["https://openalex.org/I174216632"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations, Theses, and Capstone Projects","raw_type":"doctoral_dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://academicworks.cuny.edu/gc_etds/4126","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104256893","display_name":"Sharmeen Uddin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sharmeen Uddin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5104256893"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-serum-albumin","display_name":"bovine serum albumin","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cell-cycle-progression","display_name":"cell cycle progression","score":0.8560000061988831},{"id":"https://openalex.org/keywords/g1-s-transition","display_name":"G1/S transition","score":0.796999990940094},{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.8339999914169312},{"id":"https://openalex.org/keywords/restriction-point","display_name":"restriction point","score":0.7229999899864197},{"id":"https://openalex.org/keywords/lipids","display_name":"lipids","score":0.6169999837875366},{"id":"https://openalex.org/keywords/amino-acid-availability","display_name":"amino acid availability","score":0.6690000295639038},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.8379999995231628},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.7490000128746033},{"id":"https://openalex.org/keywords/quiescent-fibroblasts","display_name":"quiescent fibroblasts","score":0.7720000147819519},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.4434671998023987},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34889402985572815},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3342973589897156},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20196795463562012}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:academicworks.cuny.edu:gc_etds-5182","doi":null,"is_oa":true,"landing_page_url":"https://academicworks.cuny.edu/gc_etds/4126","pdf_url":"https://academicworks.cuny.edu/gc_etds/4126","source":{"id":"https://openalex.org/S4377196304","display_name":"CUNY Academic Works (City University of New York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I174216632","host_organization_name":"City University of New York","host_organization_lineage":["https://openalex.org/I174216632"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations, Theses, and Capstone Projects","raw_type":"doctoral_dissertation"},{"id":"mag:3133526409","doi":null,"is_oa":false,"landing_page_url":"https://academicworks.cuny.edu/cgi/viewcontent.cgi?article=5182&context=gc_etds","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:academicworks.cuny.edu:gc_etds-5182","doi":null,"is_oa":true,"landing_page_url":"https://academicworks.cuny.edu/gc_etds/4126","pdf_url":"https://academicworks.cuny.edu/gc_etds/4126","source":{"id":"https://openalex.org/S4377196304","display_name":"CUNY Academic Works (City University of New York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I174216632","host_organization_name":"City University of New York","host_organization_lineage":["https://openalex.org/I174216632"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations, Theses, and Capstone Projects","raw_type":"doctoral_dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133526409.pdf","grobid_xml":"https://content.openalex.org/works/W3133526409.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1829589101","https://openalex.org/W1968113908","https://openalex.org/W1969170451","https://openalex.org/W1981206208","https://openalex.org/W1984736455","https://openalex.org/W1992538884","https://openalex.org/W2037555314","https://openalex.org/W2039442380","https://openalex.org/W2041855679","https://openalex.org/W2045795713","https://openalex.org/W2051014867","https://openalex.org/W2059716825","https://openalex.org/W2077029264","https://openalex.org/W2079172266","https://openalex.org/W2080810925","https://openalex.org/W2086528604","https://openalex.org/W2101579411","https://openalex.org/W2110443482","https://openalex.org/W2111341684","https://openalex.org/W2117692326","https://openalex.org/W2129917557","https://openalex.org/W2147044753","https://openalex.org/W2153497031","https://openalex.org/W2153607816","https://openalex.org/W2361838659","https://openalex.org/W2415141352","https://openalex.org/W2565251648","https://openalex.org/W2581841075","https://openalex.org/W2589276620","https://openalex.org/W2739510344","https://openalex.org/W2766921609","https://openalex.org/W2767250022","https://openalex.org/W2809455364","https://openalex.org/W2883860383","https://openalex.org/W2954781190","https://openalex.org/W2973278134","https://openalex.org/W2989728700"],"related_works":["https://openalex.org/W3045964744","https://openalex.org/W2502569920","https://openalex.org/W7095784372","https://openalex.org/W2001660301","https://openalex.org/W2041855679","https://openalex.org/W2110443482","https://openalex.org/W2042873125","https://openalex.org/W2164612331","https://openalex.org/W1988643126","https://openalex.org/W1995548246"],"abstract_inverted_index":{"Progression":[0],"through":[1,72,180],"G1":[2,16,22,35,74,84],"phase":[3],"of":[4,46,93,154,207,225,239,258],"the":[5,60,126,218,237,242,251],"cell":[6,28,36,173,252],"cycle":[7,37],"is":[8],"controlled":[9],"largely":[10],"by":[11,18,113],"growth":[12],"factors":[13],"in":[14,20,70,120,172,211,217,246],"early":[15],"and":[17,52,95,221,256],"nutrients":[19],"late":[21,34,73],"indicating":[23],"sufficient":[24,193],"raw":[25],"material":[26],"for":[27,39,68],"division.":[29],"We":[30,63,145,234],"previously":[31],"mapped":[32],"a":[33,43,55,66,91,181,205,253],"checkpoint":[38,51,57],"lipids":[40,69,94,127],"upstream":[41],"from":[42,54,169],"mammalian":[44],"target":[45],"rapamycin":[47,157],"complex":[48],"1":[49],"(mTORC1)-mediated":[50],"downstream":[53],"mid-G1":[56],"known":[58],"as":[59,204],"Restriction":[61],"point.":[62],"therefore":[64],"investigated":[65],"role":[67],"progression":[71,108,122,161,179,196],"into":[75,83,109,197],"S-phase.":[76,110,163,198],"Quiescent":[77],"BJ-hTERT":[78],"human":[79],"fibroblasts":[80],"primed":[81],"back":[82],"with":[85,90,102,189],"FBS":[86,119],"treatment,":[87,176],"were":[88,215],"treated":[89],"mixture":[92],"carrier":[96],"bovine":[97],"serum":[98,247],"albumin":[99,191,240],"(BSA)":[100],"along":[101],"[3H]-thymidine":[103],"deoxyribose":[104],"([3H]-TdR)":[105],"to":[106,123,162,194,250],"monitor":[107],"Surprisingly,":[111],"BSA":[112,149,164,200],"itself,":[114],"was":[115,192],"more":[116],"effective":[117],"than":[118],"promoting":[121],"S-phase":[124],"\u2013":[125,241,248],"had":[128],"no":[129],"impact":[130,142],"on":[131],"progression.":[132],"While":[133],"insulin":[134],"strongly":[135,158],"stimulated":[136],"mTORC1":[137,155],"activity,":[138,156],"it":[139],"did":[140,201,229],"not":[141,178,202,230],"[3H]-TdR":[143],"incorporation.":[144],"show":[146],"that":[147,212,236],"though":[148],"only":[150],"sustained":[151],"low":[152],"levels":[153],"inhibited":[159],"BSA-induced":[160],"treatment":[165],"promoted":[166],"mitosis":[167],"evident":[168],"an":[170],"increase":[171],"number":[174],"after":[175,185],"but":[177],"second":[182],"G1.":[183],"Thus,":[184],"priming":[186],"quiescent":[187],"cells":[188],"FBS,":[190],"promote":[195],"The":[199],"compensate":[203],"source":[206],"free":[208],"amino":[209,213,227,259],"acids":[210,214,228,260],"present":[216],"culture":[219],"media":[220],"additional":[222],"increasing":[223],"doses":[224],"exogenous":[226],"affect":[231],"DNA":[232],"synthesis.":[233],"propose":[235],"presence":[238],"most":[243],"abundant":[244],"protein":[245],"signals":[249],"broader":[254],"availability":[255],"variety":[257],"over":[261],"abundance.":[262]},"counts_by_year":[],"updated_date":"2026-09-01T08:31:24.195828","created_date":"2021-03-15T00:00:00"}
