{"id":"https://openalex.org/W3133515584","doi":"https://doi.org/10.1007/s10557-021-07169-z","title":"Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines","display_name":"Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines","publication_year":2021,"publication_date":"2021-03-10","ids":{"openalex":"https://openalex.org/W3133515584","doi":"https://doi.org/10.1007/s10557-021-07169-z","mag":"3133515584","pmid":"https://pubmed.ncbi.nlm.nih.gov/33689087","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9270274"},"language":"en","primary_location":{"id":"doi:10.1007/s10557-021-07169-z","doi":"https://doi.org/10.1007/s10557-021-07169-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10557-021-07169-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10557-021-07169-z.pdf","source":{"id":"https://openalex.org/S131791641","display_name":"Cardiovascular Drugs and Therapy","issn_l":"0920-3206","issn":["0920-3206","1573-7241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Drugs and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10557-021-07169-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056302432","display_name":"Jae-Sung Yi","orcid":"https://orcid.org/0000-0003-3479-5895","observed_orcids":["https://orcid.org/0000-0003-3479-5895"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jae-Sung Yi","raw_affiliation_strings":["Department of Pharmacology, Yale University School of Medicine, New Haven, CT, 06520, USA. jae-sung.yi@yale.edu","Department of Pharmacology, Yale University School of Medicine, New Haven, CT, 06520, USA"],"raw_orcid":"https://orcid.org/0000-0003-3479-5895","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Yale University School of Medicine, New Haven, CT, 06520, USA. jae-sung.yi@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pharmacology, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071680132","display_name":"Sravan Perla","orcid":"https://orcid.org/0000-0003-4925-6720","observed_orcids":["https://orcid.org/0000-0003-4925-6720"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sravan Perla","raw_affiliation_strings":["Department of Pharmacology, Yale University School of Medicine, New Haven, CT, 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102746225","display_name":"Yan Huang","orcid":"https://orcid.org/0000-0003-1722-4468","observed_orcids":["https://orcid.org/0000-0003-1722-4468"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Huang","raw_affiliation_strings":["Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016188071","display_name":"Kana Mizuno","orcid":"https://orcid.org/0000-0002-3154-7477","observed_orcids":["https://orcid.org/0000-0002-3154-7477"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kana Mizuno","raw_affiliation_strings":["Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000662762","display_name":"Frank J. Giordano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank J. Giordano","raw_affiliation_strings":["Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040060343","display_name":"Alexander A. T. M. M. Vinks","orcid":"https://orcid.org/0000-0003-4224-2967","observed_orcids":["https://orcid.org/0000-0003-4224-2967"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander A. Vinks","raw_affiliation_strings":["Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH, USA","Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072505832","display_name":"Anton M. Bennett","orcid":"https://orcid.org/0000-0001-5187-7599","observed_orcids":["https://orcid.org/0000-0001-5187-7599"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anton M. Bennett","raw_affiliation_strings":["Department of Pharmacology, Yale University School of Medicine, New Haven, CT, 06520, USA","Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, CT, 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, CT, 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5056302432"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":{"value":3860,"currency":"USD","value_usd":3860},"fwci":1.0983,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.74929004,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"36","issue":"4","first_page":"589","last_page":"604"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/noonan-syndrome-with-multiple-lentigines","display_name":"Noonan syndrome with multiple lentigines","score":0.9610000252723694},{"id":"https://openalex.org/keywords/hypertrophic-cardiomyopathy","display_name":"hypertrophic cardiomyopathy","score":0.9769999980926514},{"id":"https://openalex.org/keywords/dasatinib","display_name":"dasatinib","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ptpn11-mutation","display_name":"PTPN11 mutation","score":0.859000027179718},{"id":"https://openalex.org/keywords/shp2","display_name":"SHP2","score":0.8949999809265137},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7429999709129333},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9890000224113464},{"id":"https://openalex.org/keywords/c-src-phosphorylation","display_name":"c-Src phosphorylation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cardiac-transcriptome","display_name":"cardiac transcriptome","score":0.8149999976158142},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.6399999856948853},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitor-therapy","display_name":"tyrosine kinase inhibitor therapy","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.984056830406189},{"id":"https://openalex.org/C2776149932","wikidata":"https://www.wikidata.org/wiki/Q1543446","display_name":"Noonan syndrome","level":2,"score":0.9089813828468323},{"id":"https://openalex.org/C2780185194","wikidata":"https://www.wikidata.org/wiki/Q1364270","display_name":"Hypertrophic cardiomyopathy","level":2,"score":0.7384445667266846},{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.7244590520858765},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5969811677932739},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5888228416442871},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.5758694410324097},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.17501336336135864},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.06875410676002502},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069439","descriptor_name":"Dasatinib","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000069439","descriptor_name":"Dasatinib","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002312","descriptor_name":"Cardiomyopathy, Hypertrophic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002312","descriptor_name":"Cardiomyopathy, Hypertrophic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044542","descriptor_name":"LEOPARD Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D044542","descriptor_name":"LEOPARD Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044542","descriptor_name":"LEOPARD Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10557-021-07169-z","doi":"https://doi.org/10.1007/s10557-021-07169-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10557-021-07169-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10557-021-07169-z.pdf","source":{"id":"https://openalex.org/S131791641","display_name":"Cardiovascular Drugs and Therapy","issn_l":"0920-3206","issn":["0920-3206","1573-7241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Drugs and Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9270274","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9270274","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovasc Drugs Ther","raw_type":"Text"},{"id":"pmid:33689087","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33689087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular drugs and therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s10557-021-07169-z","doi":"https://doi.org/10.1007/s10557-021-07169-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10557-021-07169-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10557-021-07169-z.pdf","source":{"id":"https://openalex.org/S131791641","display_name":"Cardiovascular Drugs and Therapy","issn_l":"0920-3206","issn":["0920-3206","1573-7241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Drugs and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1649259414","display_name":"Signaling by Shp2 mutants in RASopathies","funder_award_id":"R01HL134166","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133515584.pdf","grobid_xml":"https://content.openalex.org/works/W3133515584.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W43806604","https://openalex.org/W1488372279","https://openalex.org/W1584815339","https://openalex.org/W1597890814","https://openalex.org/W1674292201","https://openalex.org/W1819317942","https://openalex.org/W1965681094","https://openalex.org/W1979753188","https://openalex.org/W1980407442","https://openalex.org/W1989950796","https://openalex.org/W1994817846","https://openalex.org/W1995612782","https://openalex.org/W2005508652","https://openalex.org/W2006147172","https://openalex.org/W2012789489","https://openalex.org/W2020117837","https://openalex.org/W2024021544","https://openalex.org/W2025217136","https://openalex.org/W2029254213","https://openalex.org/W2037995730","https://openalex.org/W2041318682","https://openalex.org/W2044935257","https://openalex.org/W2050203819","https://openalex.org/W2053156270","https://openalex.org/W2058829665","https://openalex.org/W2063870723","https://openalex.org/W2064997769","https://openalex.org/W2069068447","https://openalex.org/W2073586734","https://openalex.org/W2077636676","https://openalex.org/W2081439838","https://openalex.org/W2081688751","https://openalex.org/W2084199623","https://openalex.org/W2089428199","https://openalex.org/W2092606584","https://openalex.org/W2094548766","https://openalex.org/W2098174002","https://openalex.org/W2101498722","https://openalex.org/W2106136075","https://openalex.org/W2107359871","https://openalex.org/W2118719488","https://openalex.org/W2124171936","https://openalex.org/W2126015832","https://openalex.org/W2139089901","https://openalex.org/W2142609785","https://openalex.org/W2146816193","https://openalex.org/W2154438447","https://openalex.org/W2160789215","https://openalex.org/W2161444026","https://openalex.org/W2166748152","https://openalex.org/W2169365832","https://openalex.org/W2196561742","https://openalex.org/W2466008579","https://openalex.org/W2474906951","https://openalex.org/W2530595333","https://openalex.org/W2560676950","https://openalex.org/W2589353468","https://openalex.org/W2622765713","https://openalex.org/W2738367101","https://openalex.org/W2750808153","https://openalex.org/W2756123472","https://openalex.org/W2799513706","https://openalex.org/W2897410651","https://openalex.org/W2900434387","https://openalex.org/W2901596703","https://openalex.org/W2914900408","https://openalex.org/W3013646404","https://openalex.org/W3020887261","https://openalex.org/W3035498184","https://openalex.org/W3037727557"],"related_works":["https://openalex.org/W2560676950","https://openalex.org/W2622765713","https://openalex.org/W3037727557","https://openalex.org/W2762265944","https://openalex.org/W2238895810","https://openalex.org/W2756123472","https://openalex.org/W2101498722","https://openalex.org/W7203643850","https://openalex.org/W1967671316","https://openalex.org/W4381848276"],"abstract_inverted_index":{"Abstract":[0],"Purpose":[1],"Noonan":[2],"syndrome":[3],"with":[4,14,110],"multiple":[5],"lentigines":[6],"(NSML)":[7],"is":[8,72,258],"an":[9,192,280],"autosomal":[10],"dominant":[11],"disorder":[12],"presenting":[13],"hypertrophic":[15],"cardiomyopathy":[16],"(HCM).":[17],"Up":[18],"to":[19,74,92,115,144,237,264],"85%":[20],"of":[21,56,63,83,86,100,120,148,150,162,182,195,214,231],"NSML":[22,64,89,108,123,138,178,189,219,232,269,286],"cases":[23],"are":[24],"caused":[25],"by":[26,152,241],"mutations":[27],"in":[28,59,88,96,122,177,188,218,228,268,285],"the":[29,35,54,76,98,159,229],"PTPN11":[30],"gene":[31],"that":[32,49,172,207,234,249,257,274],"encodes":[33],"for":[34,131,260],"Src":[36],"homology":[37],"2":[38,44],"(SH2)":[39],"domain-containing":[40],"protein":[41],"tyrosine":[42],"phosphatase":[43],"(SHP2).":[45],"We":[46,205],"previously":[47],"showed":[48],"low-dose":[50,85,163,242,250,275],"dasatinib":[51,87,121,168,215,243,251,276],"protects":[52],"from":[53,113,134,158],"development":[55,99],"cardiac":[57],"fibrosis":[58],"a":[60,66,84],"mouse":[61],"model":[62],"harboring":[65],"Ptpn11":[67],"Y279C":[68],"mutation.":[69],"This":[70],"study":[71],"performed":[73,157],"determine":[75,93],"pharmacokinetic":[77],"(PK)":[78],"and":[79,91,146,185,197,201],"pharmacodynamic":[80],"(PD)":[81],"properties":[82,171,256],"mice":[90,109,124,139,190,233],"its":[94],"effectiveness":[95],"ameliorating":[97],"HCM.":[101],"Methods":[102],"Dasatinib":[103,180],"was":[104,156],"administered":[105],"intraperitoneally":[106],"into":[107],"doses":[111,176,208],"ranging":[112],"0.05":[114,184],"0.5":[116,186],"mg/kg.":[117],"PK":[118,170,255],"parameters":[119,128],"were":[125,129,142,173,235],"determined.":[126],"PD":[127],"obtained":[130],"biochemical":[132],"analyses":[133],"heart":[135,160,230],"tissue.":[136],"Dasatinib-treated":[137],"(0.1":[140],"mg/kg)":[141],"subjected":[143],"echocardiography":[145],"assessment":[147],"markers":[149],"HCM":[151,217,266,284],"qRT-PCR.":[153],"Transcriptome":[154,221],"analysis":[155,222],"tissue":[161],"dasatinib-treated":[164],"mice.":[165,179,220,270],"Results":[166],"Low-dose":[167],"exhibited":[169],"linear":[174],"across":[175],"treatment":[181,277],"between":[183],"mg/kg":[187,213],"yielded":[191],"exposure-dependent":[193],"inhibition":[194],"c-Src":[196],"PZR":[198],"tyrosyl":[199],"phosphorylation":[200],"inhibited":[202],"AKT":[203],"phosphorylation.":[204],"found":[206],"as":[209,211],"low":[210],"0.1":[212],"prevented":[216],"identified":[223],"differentially":[224],"expressed":[225],"HCM-associated":[226],"genes":[227],"reverted":[236],"wild":[238],"type":[239],"levels":[240],"administration.":[244],"Conclusion":[245],"These":[246,271],"data":[247,272],"demonstrate":[248,273],"exhibits":[252],"desirable":[253],"therapeutic":[254],"sufficient":[259],"effective":[261,281],"target":[262],"engagement":[263],"ameliorate":[265],"progression":[267],"may":[278],"be":[279],"therapy":[282],"against":[283],"patients.":[287]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-15T00:00:00"}