{"id":"https://openalex.org/W3133489768","doi":"https://doi.org/10.1038/s41598-021-85319-x","title":"Profiling of three H3F3A-mutated and denosumab-treated giant cell tumors of bone points to diverging pathways during progression and malignant transformation","display_name":"Profiling of three H3F3A-mutated and denosumab-treated giant cell tumors of bone points to diverging pathways during progression and malignant transformation","publication_year":2021,"publication_date":"2021-03-11","ids":{"openalex":"https://openalex.org/W3133489768","doi":"https://doi.org/10.1038/s41598-021-85319-x","mag":"3133489768","pmid":"https://pubmed.ncbi.nlm.nih.gov/33707617","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7952552"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-021-85319-x","doi":"https://doi.org/10.1038/s41598-021-85319-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-85319-x","pdf_url":"https://www.nature.com/articles/s41598-021-85319-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-021-85319-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088444747","display_name":"Marc Hasenfratz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marc Hasenfratz","raw_affiliation_strings":["Institute of Pathology, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078541338","display_name":"Kevin Mellert","orcid":"https://orcid.org/0000-0001-6338-1857","observed_orcids":["https://orcid.org/0000-0001-6338-1857"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kevin Mellert","raw_affiliation_strings":["Institute of Pathology, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004620989","display_name":"Ralf B. Marienfeld","orcid":"https://orcid.org/0000-0002-1309-1429","observed_orcids":["https://orcid.org/0000-0002-1309-1429"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf Marienfeld","raw_affiliation_strings":["Institute of Pathology, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082890747","display_name":"Alexandra von Baer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexandra von Baer","raw_affiliation_strings":["Department of Trauma and Orthopaedic Surgery, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Trauma and Orthopaedic Surgery, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081614505","display_name":"Markus Schulthei\u00df","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Schultheiss","raw_affiliation_strings":["Department of Trauma and Orthopaedic Surgery, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Trauma and Orthopaedic Surgery, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080601469","display_name":"Pablo Daniel Roitman","orcid":"https://orcid.org/0000-0002-9363-1463","observed_orcids":["https://orcid.org/0000-0002-9363-1463"]},"institutions":[{"id":"https://openalex.org/I2802359038","display_name":"Hospital Italiano de Buenos Aires","ror":"https://ror.org/00bq4rw46","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I2802359038"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"P. D. Roitman","raw_affiliation_strings":["Pathology Department, Italian Hospital of Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Department, Italian Hospital of Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I2802359038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025501900","display_name":"Luis Alberto Aponte-Tinao","orcid":"https://orcid.org/0000-0002-2096-7206","observed_orcids":["https://orcid.org/0000-0002-2096-7206"]},"institutions":[{"id":"https://openalex.org/I2802359038","display_name":"Hospital Italiano de Buenos Aires","ror":"https://ror.org/00bq4rw46","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I2802359038"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"L. A. Aponte-Tinao","raw_affiliation_strings":["Institute of Orthopaedics ''Carlos E. Ottolenghi'', Italian Hospital of Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Orthopaedics ''Carlos E. Ottolenghi'', Italian Hospital of Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I2802359038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102845236","display_name":"Burkhard Lehner","orcid":"https://orcid.org/0000-0002-6776-4801","observed_orcids":["https://orcid.org/0000-0002-6776-4801"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Burkhard Lehner","raw_affiliation_strings":["Department of Orthopaedics and Trauma, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics and Trauma, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107831312","display_name":"Peter M\u04e7ller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter M\u00f6ller","raw_affiliation_strings":["Institute of Pathology, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030930203","display_name":"Gunhild Mechtersheimer","orcid":"https://orcid.org/0000-0002-9442-3930","observed_orcids":["https://orcid.org/0000-0002-9442-3930"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gunhild Mechtersheimer","raw_affiliation_strings":["Institute of Pathology, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101807408","display_name":"Thomas F.E. Barth","orcid":"https://orcid.org/0000-0002-3379-6311","observed_orcids":["https://orcid.org/0000-0002-3379-6311"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thomas F. E. Barth","raw_affiliation_strings":["Institute of Pathology, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany. thomas.barth@uniklinik-ulm.de","Institute of Pathology, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany. thomas.barth@uniklinik-ulm.de","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"Institute of Pathology, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101807408"],"corresponding_institution_ids":["https://openalex.org/I196349391"],"apc_list":{"value":1990,"currency":"USD","value_usd":1990},"apc_paid":{"value":1837,"currency":"EUR","value_usd":1981},"fwci":2.8153,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.89656845,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"1","first_page":"5709","last_page":"5709"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11787","display_name":"Oral and Maxillofacial Pathology","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/giant-cell-tumor-of-bone","display_name":"giant cell tumor of bone","score":1.0},{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":0.8429999947547913},{"id":"https://openalex.org/keywords/h3f3a-mutation","display_name":"H3F3A mutation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.925000011920929},{"id":"https://openalex.org/keywords/pleomorphic-sarcoma","display_name":"pleomorphic sarcoma","score":0.8579999804496765},{"id":"https://openalex.org/keywords/osteoblastic-osteosarcoma","display_name":"osteoblastic osteosarcoma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/fgfr1-mutation","display_name":"FGFR1 mutation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nras-mutation","display_name":"NRAS mutation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rankl-inhibition","display_name":"RANKL inhibition","score":0.7879999876022339},{"id":"https://openalex.org/keywords/tumor-progression-pathways","display_name":"tumor progression pathways","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C2776286101","wikidata":"https://www.wikidata.org/wiki/Q408283","display_name":"Denosumab","level":3,"score":0.9218586683273315},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6289846897125244},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.5538892149925232},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5401502847671509},{"id":"https://openalex.org/C2777190185","wikidata":"https://www.wikidata.org/wiki/Q1785791","display_name":"Giant-cell tumor of bone","level":3,"score":0.49874138832092285},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.47377943992614746},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4695133864879608},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.42823922634124756},{"id":"https://openalex.org/C77076574","wikidata":"https://www.wikidata.org/wiki/Q2152526","display_name":"Giant cell","level":2,"score":0.40276896953582764},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.09232223033905029}],"mesh":[{"descriptor_ui":"D000069448","descriptor_name":"Denosumab","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000069448","descriptor_name":"Denosumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017809","descriptor_name":"Fatal Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018212","descriptor_name":"Giant Cell Tumor of Bone","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018212","descriptor_name":"Giant Cell Tumor of Bone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018212","descriptor_name":"Giant Cell Tumor of Bone","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41598-021-85319-x","doi":"https://doi.org/10.1038/s41598-021-85319-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-85319-x","pdf_url":"https://www.nature.com/articles/s41598-021-85319-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7952552","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7952552","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:33707617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33707617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Case Reports"},{"id":"pmh:oai:doaj.org/article:7e362e1fc5aa4bdcbb09fa7a3c4adf92","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7e362e1fc5aa4bdcbb09fa7a3c4adf92","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)","raw_type":"article"},{"id":"pmh:oai:oparu.uni-ulm.de:123456789/49756","doi":null,"is_oa":true,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-49756-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400353","display_name":"OPen Access Repositorium der Universit\u00e4t Ulm (OPARU) (Ulm University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I196349391","host_organization_name":"Universit\u00e4t Ulm","host_organization_lineage":["https://openalex.org/I196349391"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doc-type:article"},{"id":"doi:10.18725/oparu-49680","doi":"https://doi.org/10.18725/oparu-49680","is_oa":true,"landing_page_url":"https://doi.org/10.18725/oparu-49680","pdf_url":null,"source":{"id":"https://openalex.org/S7407052964","display_name":"Universit\u00e4t Ulm, Kommunikations- und Informationszentrum (kiz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"}],"best_oa_location":{"id":"doi:10.1038/s41598-021-85319-x","doi":"https://doi.org/10.1038/s41598-021-85319-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-85319-x","pdf_url":"https://www.nature.com/articles/s41598-021-85319-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320325530","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133489768.pdf","grobid_xml":"https://content.openalex.org/works/W3133489768.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W176742834","https://openalex.org/W1507649428","https://openalex.org/W1559130591","https://openalex.org/W2004061849","https://openalex.org/W2017953817","https://openalex.org/W2028541032","https://openalex.org/W2034585055","https://openalex.org/W2034733905","https://openalex.org/W2075069343","https://openalex.org/W2076395246","https://openalex.org/W2088131077","https://openalex.org/W2090082358","https://openalex.org/W2090344207","https://openalex.org/W2097529940","https://openalex.org/W2102275777","https://openalex.org/W2109757701","https://openalex.org/W2128785809","https://openalex.org/W2149821313","https://openalex.org/W2152591136","https://openalex.org/W2159152276","https://openalex.org/W2171595133","https://openalex.org/W2212487443","https://openalex.org/W2255556454","https://openalex.org/W2524753794","https://openalex.org/W2588291630","https://openalex.org/W2610474435","https://openalex.org/W2745156788","https://openalex.org/W2761400643","https://openalex.org/W2774415611","https://openalex.org/W2929748814","https://openalex.org/W2940919179","https://openalex.org/W2983489711","https://openalex.org/W3006492364","https://openalex.org/W3034079650","https://openalex.org/W4292542148"],"related_works":["https://openalex.org/W2775769320","https://openalex.org/W2745156788","https://openalex.org/W2324825062","https://openalex.org/W4200044630","https://openalex.org/W4386168721","https://openalex.org/W2990013463","https://openalex.org/W2097529940","https://openalex.org/W3216302302","https://openalex.org/W3097847115","https://openalex.org/W2907223527"],"abstract_inverted_index":{"Giant":[0],"cell":[1],"tumor":[2,189],"of":[3,11,16,31,40,51,57,87,98,103,178,181,188,191],"bone":[4],"(GCTB)":[5],"is":[6,18],"a":[7,19,96,113,125,141,163],"locally":[8],"aggressive":[9],"lesion":[10],"intermediate":[12],"malignancy.":[13],"Malignant":[14],"transformation":[15,56],"GCTB":[17,105,182,192],"rare":[20],"event.":[21],"In":[22,154],"2013,":[23],"the":[24,49,101,104,130,133,137,146,150,156,171,176],"humanized":[25],"monoclonal":[26],"antibody":[27],"against":[28],"receptor":[29],"activator":[30],"nuclear":[32],"factor-\u03bab-Ligand":[33],"(RANKL)":[34],"denosumab":[35,52,173],"was":[36],"approved":[37],"for":[38],"treatment":[39,107],"advanced":[41],"GCTB.":[42,58],"Since":[43],"then,":[44],"several":[45],"reports":[46],"have":[47],"questioned":[48],"role":[50,172],"during":[53,121],"occasional":[54],"malignant":[55,179],"We":[59],"report":[60],"on":[61],"three":[62],"patients":[63],"with":[64,68,108,194],"H3F3A-mutated":[65],"GCTBs,":[66],"treated":[67],"denosumab.":[69,109],"The":[70],"tissue":[71],"samples":[72,88],"were":[73],"analysed":[74],"by":[75,82],"histomorphology,":[76],"immunohistochemistry,":[77],"and":[78,90,116,148,162,183],"in":[79,100,129,145,149,175],"two":[80],"instances":[81],"next":[83],"generation":[84],"panel":[85],"sequencing":[86],"before":[89],"after":[91],"treatment.":[92,122,196],"One":[93,110],"patient":[94,111],"had":[95],"mutation":[97,128],"ARID2":[99],"recurrence":[102,147],"under":[106],"developed":[112],"pleomorphic":[114,134,151,157],"sarcoma":[115,135,152,158],"one":[117],"an":[118,160],"osteoblastic":[119],"osteosarcoma":[120,131],"Sequencing":[123],"revealed":[124],"persisting":[126],"H3F3A":[127,138],"while":[132],"lost":[136],"mutation;":[139],"however,":[140],"FGFR1":[142],"mutation,":[143],"both":[144],"persisted.":[153],"addition,":[155],"showed":[159],"AKT2":[161],"NRAS":[164],"mutation.":[165],"These":[166],"data":[167],"are":[168],"inconclusive":[169],"concerning":[170],"plays":[174],"event":[177],"progression/transformation":[180],"point":[184],"to":[185],"diverging":[186],"pathways":[187],"progression":[190],"associated":[193],"this":[195]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-03-15T00:00:00"}