{"id":"https://openalex.org/W3133461664","doi":"https://doi.org/10.1038/s41436-021-01098-w","title":"The effect of early hormonal treatment (EHT) on expressive and receptive language capabilities in boys with 47,XXY (Klinefelter syndrome) during infancy and early childhood","display_name":"The effect of early hormonal treatment (EHT) on expressive and receptive language capabilities in boys with 47,XXY (Klinefelter syndrome) during infancy and early childhood","publication_year":2021,"publication_date":"2021-02-24","ids":{"openalex":"https://openalex.org/W3133461664","doi":"https://doi.org/10.1038/s41436-021-01098-w","mag":"3133461664","pmid":"https://pubmed.ncbi.nlm.nih.gov/33627828"},"language":"en","primary_location":{"id":"doi:10.1038/s41436-021-01098-w","doi":"https://doi.org/10.1038/s41436-021-01098-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41436-021-01098-w","pdf_url":"https://www.gimjournal.org/article/S1098-3600(21)05212-6/pdf","source":{"id":"https://openalex.org/S187186932","display_name":"Genetics in Medicine","issn_l":"1098-3600","issn":["1098-3600","1530-0366"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.gimjournal.org/article/S1098-3600(21)05212-6/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063619464","display_name":"Carole A. Samango\u2010Sprouse","orcid":"https://orcid.org/0000-0001-9941-0568","observed_orcids":["https://orcid.org/0000-0001-9941-0568"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]},{"id":"https://openalex.org/I19700959","display_name":"Florida International University","ror":"https://ror.org/02gz6gg07","country_code":"US","type":"education","lineage":["https://openalex.org/I19700959"]},{"id":"https://openalex.org/I4405269860","display_name":"Fundaci\u00f3n Focus","ror":"https://ror.org/05fdner10","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4405269860"]}],"countries":["ES","US"],"is_corresponding":true,"raw_author_name":"Carole Samango-Sprouse","raw_affiliation_strings":["Department of Human and Molecular Genetics, Florida International University, Miami, FL, USA. cssprouse@email.gwu.edu","Department of Pediatrics, George Washington University, Washington, DC, USA. cssprouse@email.gwu.edu","Department of Research, The Focus Foundation, Davidsonville, MD, USA. cssprouse@email.gwu.edu","Department of Human and Molecular Genetics, Florida International University, Miami, FL, USA","Department of Pediatrics, George Washington University, Washington, DC, USA","Department of Research, The Focus Foundation, Davidsonville, MD, USA"],"raw_orcid":"https://orcid.org/0000-0001-9941-0568","affiliations":[{"raw_affiliation_string":"Department of Human and Molecular Genetics, Florida International University, Miami, FL, USA. cssprouse@email.gwu.edu","institution_ids":["https://openalex.org/I19700959"]},{"raw_affiliation_string":"Department of Pediatrics, George Washington University, Washington, DC, USA. cssprouse@email.gwu.edu","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"Department of Research, The Focus Foundation, Davidsonville, MD, USA. cssprouse@email.gwu.edu","institution_ids":["https://openalex.org/I4405269860"]},{"raw_affiliation_string":"Department of Human and Molecular Genetics, Florida International University, Miami, FL, USA","institution_ids":["https://openalex.org/I19700959"]},{"raw_affiliation_string":"Department of Pediatrics, George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"Department of Research, The Focus Foundation, Davidsonville, MD, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083424409","display_name":"Michaela Reiko Brooks","orcid":"https://orcid.org/0000-0003-2808-9142","observed_orcids":["https://orcid.org/0000-0003-2808-9142"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michaela Reiko Brooks","raw_affiliation_strings":["Department of Research, The Focus Foundation, Davidsonville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, The Focus Foundation, Davidsonville, MD, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065968641","display_name":"Patricia C. Lasutschinkow","orcid":"https://orcid.org/0000-0003-0258-1534","observed_orcids":["https://orcid.org/0000-0003-0258-1534"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia Lasutchinkow","raw_affiliation_strings":["Department of Research, The Focus Foundation, Davidsonville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, The Focus Foundation, Davidsonville, MD, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042800393","display_name":"Teresa Sadeghin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teresa Sadeghin","raw_affiliation_strings":["Department of Research, The Focus Foundation, Davidsonville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, The Focus Foundation, Davidsonville, MD, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024665450","display_name":"Sherida Powell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherida Powell","raw_affiliation_strings":["Department of Economics, George Washington University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Economics, George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017393457","display_name":"Mary Pat Hamzik","orcid":"https://orcid.org/0000-0002-8165-4430","observed_orcids":["https://orcid.org/0000-0002-8165-4430"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary Pat Hamzik","raw_affiliation_strings":["Department of Research, The Focus Foundation, Davidsonville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, The Focus Foundation, Davidsonville, MD, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054881561","display_name":"Sophia Song","orcid":"https://orcid.org/0000-0003-4979-4799","observed_orcids":["https://orcid.org/0000-0003-4979-4799"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sophia Song","raw_affiliation_strings":["Department of Research, The Focus Foundation, Davidsonville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, The Focus Foundation, Davidsonville, MD, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063382637","display_name":"Andrea Lynne Gropman","orcid":"https://orcid.org/0000-0002-2106-6776","observed_orcids":["https://orcid.org/0000-0002-2106-6776"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea L. Gropman","raw_affiliation_strings":["Department of Neurology, George Washington University, Washington, DC, USA","Division of Neurogenetics and Developmental Pediatrics, Children's National Health System, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"Division of Neurogenetics and Developmental Pediatrics, Children's National Health System, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5063619464"],"corresponding_institution_ids":["https://openalex.org/I193531525","https://openalex.org/I19700959","https://openalex.org/I4405269860"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":1.2017,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.7659314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"23","issue":"6","first_page":"1017","last_page":"1022"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.05050000175833702,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10730","display_name":"Language Development and Disorders","score":0.04560000076889992,"subfield":{"id":"https://openalex.org/subfields/3204","display_name":"Developmental and Educational Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/klinefelter-syndrome","display_name":"Klinefelter syndrome","score":0.972000002861023},{"id":"https://openalex.org/keywords/testosterone-replacement-therapy","display_name":"testosterone replacement therapy","score":0.6420000195503235},{"id":"https://openalex.org/keywords/expressive-language-development","display_name":"expressive language development","score":0.8690000176429749},{"id":"https://openalex.org/keywords/receptive-language-development","display_name":"receptive language development","score":0.9980000257492065},{"id":"https://openalex.org/keywords/language-comprehension","display_name":"language comprehension","score":0.46399998664855957},{"id":"https://openalex.org/keywords/neurodevelopmental-outcomes","display_name":"neurodevelopmental outcomes","score":0.8420000076293945},{"id":"https://openalex.org/keywords/boys","display_name":"boys","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C2776314099","wikidata":"https://www.wikidata.org/wiki/Q207133","display_name":"Klinefelter syndrome","level":2,"score":0.5911943912506104},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5639368891716003},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.49965524673461914},{"id":"https://openalex.org/C2993924013","wikidata":"https://www.wikidata.org/wiki/Q6486792","display_name":"Receptive language","level":3,"score":0.48247507214546204},{"id":"https://openalex.org/C3019804573","wikidata":"https://www.wikidata.org/wiki/Q1322198","display_name":"Expressive language","level":2,"score":0.4786413908004761},{"id":"https://openalex.org/C2777082460","wikidata":"https://www.wikidata.org/wiki/Q3377398","display_name":"Early childhood","level":2,"score":0.4127635955810547},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3637813329696655},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.3462185263633728},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3388693630695343},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.32185685634613037},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C2777601683","wikidata":"https://www.wikidata.org/wiki/Q6499736","display_name":"Vocabulary","level":2,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007713","descriptor_name":"Klinefelter Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007713","descriptor_name":"Klinefelter Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007804","descriptor_name":"Language Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032882","descriptor_name":"Comprehension","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/s41436-021-01098-w","doi":"https://doi.org/10.1038/s41436-021-01098-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41436-021-01098-w","pdf_url":"https://www.gimjournal.org/article/S1098-3600(21)05212-6/pdf","source":{"id":"https://openalex.org/S187186932","display_name":"Genetics in Medicine","issn_l":"1098-3600","issn":["1098-3600","1530-0366"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics in Medicine","raw_type":"journal-article"},{"id":"pmid:33627828","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33627828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics in medicine : official journal of the American College of Medical Genetics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41436-021-01098-w","doi":"https://doi.org/10.1038/s41436-021-01098-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41436-021-01098-w","pdf_url":"https://www.gimjournal.org/article/S1098-3600(21)05212-6/pdf","source":{"id":"https://openalex.org/S187186932","display_name":"Genetics in Medicine","issn_l":"1098-3600","issn":["1098-3600","1530-0366"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133461664.pdf","grobid_xml":"https://content.openalex.org/works/W3133461664.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W35702902","https://openalex.org/W114554603","https://openalex.org/W139011375","https://openalex.org/W1571066306","https://openalex.org/W1577637340","https://openalex.org/W1906504840","https://openalex.org/W1968097359","https://openalex.org/W1978542969","https://openalex.org/W1985398262","https://openalex.org/W1987795888","https://openalex.org/W2007002547","https://openalex.org/W2016854111","https://openalex.org/W2023561307","https://openalex.org/W2027981626","https://openalex.org/W2031724889","https://openalex.org/W2038640136","https://openalex.org/W2046195580","https://openalex.org/W2055824296","https://openalex.org/W2060761342","https://openalex.org/W2071059208","https://openalex.org/W2077449530","https://openalex.org/W2077833546","https://openalex.org/W2078494206","https://openalex.org/W2079465697","https://openalex.org/W2088910861","https://openalex.org/W2102356712","https://openalex.org/W2108449190","https://openalex.org/W2112366626","https://openalex.org/W2113346685","https://openalex.org/W2122617439","https://openalex.org/W2140442910","https://openalex.org/W2157043810","https://openalex.org/W2165766103","https://openalex.org/W2333848437","https://openalex.org/W2791044095","https://openalex.org/W2911995209","https://openalex.org/W3004831049","https://openalex.org/W4206441646"],"related_works":["https://openalex.org/W3013827443","https://openalex.org/W4392291511","https://openalex.org/W4220751719","https://openalex.org/W3153152345","https://openalex.org/W4293229568","https://openalex.org/W3045589541","https://openalex.org/W2981422404","https://openalex.org/W2103941891","https://openalex.org/W4383345600","https://openalex.org/W4293229733"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-01T00:00:00"}