{"id":"https://openalex.org/W313341022","doi":null,"title":"Differentiation and breast cancer.","display_name":"Differentiation and breast cancer.","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W313341022","mag":"313341022","pmid":"https://pubmed.ncbi.nlm.nih.gov/9567346"},"language":"en","primary_location":{"id":"pmid:9567346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9567346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108321824","display_name":"J. Russo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Russo","raw_affiliation_strings":["Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111869300","display_name":"I H Russo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I H Russo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7704,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.72055576,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"57 Suppl 2","issue":null,"first_page":"81","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.10409999638795853,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mammary-gland-differentiation","display_name":"mammary gland differentiation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8889999985694885},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.7369999885559082},{"id":"https://openalex.org/keywords/parity","display_name":"parity","score":0.6399999856948853},{"id":"https://openalex.org/keywords/nulliparity","display_name":"nulliparity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/mammary-carcinogenesis","display_name":"mammary carcinogenesis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/hormone-regulation","display_name":"hormonal regulation","score":0.33799999952316284},{"id":"https://openalex.org/keywords/puberty","display_name":"puberty","score":0.48899999260902405},{"id":"https://openalex.org/keywords/lactation","display_name":"lactation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.8970000147819519},{"id":"https://openalex.org/keywords/mammary-epithelium","display_name":"mammary epithelium","score":0.7110000252723694},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/chemical-carcinogens","display_name":"chemical carcinogens","score":0.5870000123977661},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7601664066314697},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.7271063923835754},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.7086285948753357},{"id":"https://openalex.org/C2776659692","wikidata":"https://www.wikidata.org/wiki/Q719426","display_name":"Lactation","level":3,"score":0.6705514192581177},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5967296957969666},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5485095977783203},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5449910759925842},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.5166783332824707},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5126609206199646},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.5017313957214355},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.50166916847229},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47012293338775635},{"id":"https://openalex.org/C2993273003","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Neoplastic transformation","level":4,"score":0.4429534375667572},{"id":"https://openalex.org/C2776880931","wikidata":"https://www.wikidata.org/wiki/Q6745783","display_name":"Breast development","level":3,"score":0.4287514090538025},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.418410062789917},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3484860062599182},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3160395622253418},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2670651078224182},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010298","descriptor_name":"Parity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9567346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9567346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"Journal Article"},{"id":"mag:313341022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9567346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4872575454","display_name":"MOLECULAR BASIS OF BREAST CELL TRANSFORMATION","funder_award_id":"R01CA067238","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4981724456","display_name":"CHORIONIC GONADOTROPIN AND MAMMARY CARCINOGENESIS","funder_award_id":"R01CA064896","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6053277485","display_name":"SUSCEPTIBILITY OF THE BREAST TO ENVIRONMENTAL CARCINOGEN","funder_award_id":"R01ES007280","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2022508086","https://openalex.org/W2015938432","https://openalex.org/W1502632513","https://openalex.org/W2112574617","https://openalex.org/W1965070738","https://openalex.org/W2072581315","https://openalex.org/W2240494930","https://openalex.org/W4242856030","https://openalex.org/W60702075","https://openalex.org/W26721703"],"abstract_inverted_index":{"The":[0,185,214,247,277],"mammary":[1,27,118,143,207,224],"gland":[2,28],"is":[3,164,226],"an":[4],"organ":[5,158,262],"whose":[6],"size,":[7],"shape":[8],"and":[9,43,57,283],"function":[10],"undergo":[11,264],"fundamental":[12],"changes":[13,35],"during":[14,30,54],"the":[15,23,26,32,38,46,50,72,85,92,99,105,128,131,135,142,154,157,167,174,198,202,221,229,258,261],"various":[16],"phases":[17],"of":[18,25,40,49,74,87,95,117,130,137,141,156,177,188,201,217,231,238,249,260,279],"a":[19,79,138,178,235],"woman's":[20,179],"growth.":[21],"Although":[22,98],"development":[24,48],"begins":[29],"infancy,":[31],"most":[33],"dramatic":[34],"occur":[36],"with":[37,197,234,286],"initiation":[39,129],"puberty.":[41],"Pregnancy":[42],"lactation":[44],"complete":[45,139],"functional":[47],"organ,":[51],"which":[52,102,150,256,267],"regresses":[53],"menopause.":[55],"Epidemiological":[56],"experimental":[58,115,284,292],"studies":[59],"have":[60,120],"demonstrated":[61],"that":[62,125,166],"certain":[63],"hormonal":[64,161],"influences,":[65],"especially":[66],"those":[67,253,287],"related":[68],"to":[69,123,159,205,211,228,263,296],"reproduction,":[70],"modify":[71,153],"risk":[73],"developing":[75],"breast":[76,96,106,108,189,248],"cancer.":[77,97],"Thus,":[78],"full":[80,182],"term":[81,183],"pregnancy":[82,103,126],"completed":[83],"before":[84],"age":[86],"24":[88],"years":[89,273],"significantly":[90],"reduces":[91],"lifetime":[93],"incidence":[94,187],"mechanism":[100,169],"through":[101,134],"protects":[104],"from":[107],"cancer":[109,190],"has":[110],"not":[111],"been":[112],"clearly":[113],"established,":[114],"models":[116,293],"carcinogenesis":[119],"allowed":[121],"researchers":[122],"determine":[124],"inhibits":[127],"neoplastic":[132],"process":[133,146],"induction":[136,216],"differentiation":[140],"gland.":[144],"This":[145],"activates":[147],"specific":[148],"genes,":[149],"in":[151,192,220,290],"turn":[152],"response":[155],"ulterior":[160],"changes.":[162],"It":[163],"postulated":[165],"same":[168],"might":[170],"be":[171],"responsible":[172],"for":[173],"protective":[175],"effect":[176],"early":[180],"first":[181],"pregnancy.":[184,246],"greater":[186,199],"observed":[191],"nulliparous":[193,250],"women":[194,251],"correlates":[195],"well":[196],"susceptibility":[200],"virgin":[203,222],"rat":[204],"develop":[206],"carcinomas":[208],"when":[209],"exposed":[210],"chemical":[212],"carcinogens.":[213],"successful":[215],"malignant":[218,265],"transformation":[219],"animal":[223],"epithelium":[225],"due":[227],"presence":[230],"undifferentiated":[232,254],"structures":[233,242],"high":[236],"rate":[237],"cell":[239],"proliferation.":[240],"These":[241],"are":[243],"eliminated":[244],"by":[245],"retains":[252],"structures,":[255],"increase":[257],"predisposition":[259],"transformation,":[266],"will":[268],"manifest":[269],"itself":[270],"clinically":[271],"several":[272],"after":[274],"its":[275],"initiation.":[276],"correlation":[278],"human":[280],"epidemiological,":[281],"clinical":[282],"data":[285,288],"obtained":[289],"rodent":[291],"lends":[294],"support":[295],"this":[297],"hypothesis.":[298]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}