{"id":"https://openalex.org/W3133376848","doi":"https://doi.org/10.1186/s13045-021-01039-9","title":"Preclinical evaluation of the Hsp90 inhibitor SNX-5422 in ibrutinib resistant CLL","display_name":"Preclinical evaluation of the Hsp90 inhibitor SNX-5422 in ibrutinib resistant CLL","publication_year":2021,"publication_date":"2021-02-24","ids":{"openalex":"https://openalex.org/W3133376848","doi":"https://doi.org/10.1186/s13045-021-01039-9","mag":"3133376848","pmid":"https://pubmed.ncbi.nlm.nih.gov/33627156","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7905592"},"language":"en","primary_location":{"id":"doi:10.1186/s13045-021-01039-9","doi":"https://doi.org/10.1186/s13045-021-01039-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13045-021-01039-9","pdf_url":"https://jhoonline.biomedcentral.com/track/pdf/10.1186/s13045-021-01039-9","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology & Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jhoonline.biomedcentral.com/track/pdf/10.1186/s13045-021-01039-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052244476","display_name":"Timothy L. Chen","orcid":"https://orcid.org/0009-0007-0932-5492","observed_orcids":["https://orcid.org/0009-0007-0932-5492","https://orcid.org/0000-0002-2704-4105"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy L. Chen","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050861419","display_name":"Bonnie K. Harrington","orcid":"https://orcid.org/0000-0003-2658-6188","observed_orcids":["https://orcid.org/0000-0003-2658-6188"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bonnie Harrington","raw_affiliation_strings":["Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA","Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008780196","display_name":"Jean Truxall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean Truxall","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110583610","display_name":"Ronni Wasmuth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronni Wasmuth","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032248460","display_name":"Alexander Prouty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Prouty","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073002557","display_name":"Shelby L. Sloan","orcid":"https://orcid.org/0000-0001-7366-9184","observed_orcids":["https://orcid.org/0000-0001-7366-9184"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelby Sloan","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110955412","display_name":"Amy M. Lehman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy M. Lehman","raw_affiliation_strings":["Center for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046657449","display_name":"Deepa Sampath","orcid":"https://orcid.org/0000-0002-4366-8436","observed_orcids":["https://orcid.org/0000-0002-4366-8436"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepa Sampath","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014798421","display_name":"Eric O. M. Orlemans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Orlemans","raw_affiliation_strings":["Esanex Inc., Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Esanex Inc., Indianapolis, IN, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012846289","display_name":"Robert A. Baiocchi","orcid":"https://orcid.org/0000-0002-1619-4853","observed_orcids":["https://orcid.org/0000-0002-1619-4853","https://orcid.org/0000-0002-6518-8169"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Baiocchi","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054730003","display_name":"Lapo Alinari","orcid":"https://orcid.org/0000-0002-8870-4162","observed_orcids":["https://orcid.org/0000-0002-8870-4162"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lapo Alinari","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000921376","display_name":"John C. Byrd","orcid":"https://orcid.org/0000-0001-9830-0711","observed_orcids":["https://orcid.org/0000-0001-9830-0711"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Byrd","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA","Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014241029","display_name":"Jennifer Ann Woyach","orcid":"https://orcid.org/0000-0002-3403-9144","observed_orcids":["https://orcid.org/0000-0002-3403-9144"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer A. Woyach","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026993490","display_name":"Erin K. Hertlein","orcid":"https://orcid.org/0000-0001-8493-5679","observed_orcids":["https://orcid.org/0000-0001-8493-5679"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Erin Hertlein","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA. erin.hertlein@osumc.edu","Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA"],"raw_orcid":"https://orcid.org/0000-0001-8493-5679","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA. erin.hertlein@osumc.edu","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, The Ohio State University, 462 OSUCCC, 410 W 12th Avenue, Columbus, OH, 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026993490"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":{"value":3990,"currency":"USD","value_usd":3990},"fwci":2.5016,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.89808524,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"14","issue":"1","first_page":"36","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp90-inhibitors","display_name":"Hsp90 inhibitors","score":0.9300000071525574},{"id":"https://openalex.org/keywords/ibrutinib-resistance","display_name":"ibrutinib resistance","score":0.953000009059906},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bruton-tyrosine-kinase","display_name":"Bruton's tyrosine kinase","score":0.9330000281333923},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9470000267028809},{"id":"https://openalex.org/keywords/emu-tcl1-mouse-model","display_name":"E\u03bc-TCL1 mouse model","score":0.9610000252723694},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2779878957","wikidata":"https://www.wikidata.org/wiki/Q5984881","display_name":"Ibrutinib","level":4,"score":0.9961138963699341},{"id":"https://openalex.org/C90059517","wikidata":"https://www.wikidata.org/wiki/Q423572","display_name":"Bruton's tyrosine kinase","level":4,"score":0.7182847261428833},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.6971733570098877},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5476353764533997},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43376830220222473},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41116422414779663},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3844868540763855},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38111069798469543},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3670411705970764},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.35335564613342285},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17580050230026245},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.07945993542671204}],"mesh":[{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007191","descriptor_name":"Indazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007191","descriptor_name":"Indazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13045-021-01039-9","doi":"https://doi.org/10.1186/s13045-021-01039-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13045-021-01039-9","pdf_url":"https://jhoonline.biomedcentral.com/track/pdf/10.1186/s13045-021-01039-9","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology & Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7905592","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7905592","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Hematol Oncol","raw_type":"Text"},{"id":"pmid:33627156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33627156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hematology & oncology","raw_type":"Letter"},{"id":"pmh:oai:doaj.org/article:4c01d238e7a84a94ba1ec2e43998f4b6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4c01d238e7a84a94ba1ec2e43998f4b6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-5 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13045-021-01039-9","doi":"https://doi.org/10.1186/s13045-021-01039-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13045-021-01039-9","pdf_url":"https://jhoonline.biomedcentral.com/track/pdf/10.1186/s13045-021-01039-9","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology & Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1395449595","display_name":null,"funder_award_id":"CA81534","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2560578072","display_name":"Targeted Therapy for Leukemia","funder_award_id":"R35CA197734","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3007936770","display_name":null,"funder_award_id":"P01 CA81534","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G36614667","display_name":null,"funder_award_id":"CA016058","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6534654515","display_name":null,"funder_award_id":"CA197734","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6787435234","display_name":null,"funder_award_id":"3077-12","funder_id":"https://openalex.org/F4320308295","funder_display_name":"Leukemia and Lymphoma Society"},{"id":"https://openalex.org/G8225889400","display_name":"Chronic Lymphocytic Leukemia Research Consortium","funder_award_id":"4p01ca081534-16","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000887552","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016058","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000891558","display_name":"OSU K12 Training Grant in Oncology","funder_award_id":"K12CA133250","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G944802235","display_name":null,"funder_award_id":"P01-CA-081534","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F1575272430","display_name":"William Matheus Sullivan Musical Foundation","ror":null},{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"},{"id":"https://openalex.org/F4320310322","display_name":"D. Warren Brown Family Foundation","ror":"https://ror.org/00t0rzx51"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133376848.pdf","grobid_xml":"https://content.openalex.org/works/W3133376848.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1999128869","https://openalex.org/W2010140241","https://openalex.org/W2018466312","https://openalex.org/W2046853799","https://openalex.org/W2055393972","https://openalex.org/W2067064694","https://openalex.org/W2085961273","https://openalex.org/W2109784904","https://openalex.org/W2206193651","https://openalex.org/W2884660389","https://openalex.org/W2885382985","https://openalex.org/W2973195462"],"related_works":["https://openalex.org/W2887075199","https://openalex.org/W6958144986","https://openalex.org/W3210574806","https://openalex.org/W2530938430","https://openalex.org/W2035536649","https://openalex.org/W1505640975","https://openalex.org/W2141973433","https://openalex.org/W2990290302","https://openalex.org/W3031304050","https://openalex.org/W2741362518"],"abstract_inverted_index":{"B-cell":[0,118],"receptor":[1],"(BCR)":[2],"antagonists":[3],"such":[4],"as":[5,115,117,133],"the":[6,37,61,68,86,96,99,134,144,158,166,177,188,197],"BTK":[7,75,87,122],"inhibitor":[8,108,199],"ibrutinib":[9,58,78,139,149,180,220],"have":[10],"proven":[11],"to":[12,22,52,83,138,165],"effectively":[13],"target":[14],"chronic":[15],"lymphocytic":[16],"leukemia":[17],"(CLL)":[18],"tumor":[19,211],"cells,":[20,114],"leading":[21],"impressive":[23],"response":[24],"rates":[25],"in":[26,103,111,140,153,157,176,187,205,208],"these":[27],"patients.":[28,142],"However":[29],"patients":[30,54],"do":[31],"still":[32],"relapse":[33,56,66],"on":[34,57],"ibrutinib,":[35],"and":[36,148,179,212],"progressive":[38],"disease":[39],"is":[40,67,215],"often":[41],"quite":[42],"aggressive":[43],"requiring":[44],"immediate":[45],"treatment.":[46],"Several":[47],"strategies":[48],"are":[49,89],"being":[50],"pursued":[51,204],"treat":[53],"who":[55],"therapy.":[59],"As":[60],"most":[62],"common":[63],"form":[64,73],"of":[65,70,74,85,98,146,162],"development":[69],"a":[71,90,151,216],"mutant":[72,127],"which":[76,81,129,201],"limits":[77],"binding,":[79],"agents":[80],"lead":[82],"degradation":[84],"protein":[88],"promising":[91],"strategy.":[92],"Our":[93],"study":[94],"explores":[95],"efficacy":[97],"Hsp90":[100,107,198],"inhibitor,":[101],"SNX-5422,":[102,200],"CLL.":[104,222],"The":[105],"SNX":[106],"was":[109],"effective":[110],"primary":[112,135],"CLL":[113,141,163],"well":[116],"lines":[119],"expressing":[120],"either":[121],"wild":[123],"type":[124],"or":[125,168],"C481":[126],"BTK,":[128],"has":[130,202],"been":[131,203],"identified":[132],"resistance":[136],"mechanism":[137],"Furthermore":[143],"combination":[145],"SNX-5422":[147],"provided":[150],"remarkable":[152],"vivo":[154],"survival":[155,175,186],"benefit":[156],"E\u03bc-TCL1":[159],"mouse":[160],"model":[161],"compared":[164],"vehicle":[167,178],"single":[169],"agent":[170],"groups":[171,181],"(51":[172],"day":[173,184],"median":[174,185],"versus":[182],"100":[183],"combination).":[189],"We":[190],"report":[191],"here":[192],"preclinical":[193],"data":[194],"suggesting":[195],"that":[196],"clinical":[206],"trials":[207],"both":[209],"solid":[210],"hematological":[213],"malignancies,":[214],"potential":[217],"therapy":[218],"for":[219],"resistant":[221]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-01T00:00:00"}