{"id":"https://openalex.org/W3133367969","doi":"https://doi.org/10.1152/ajpregu.00205.2020","title":"Hydroxyurea improves nitric oxide bioavailability in humanized sickle cell mice","display_name":"Hydroxyurea improves nitric oxide bioavailability in humanized sickle cell mice","publication_year":2021,"publication_date":"2021-02-24","ids":{"openalex":"https://openalex.org/W3133367969","doi":"https://doi.org/10.1152/ajpregu.00205.2020","mag":"3133367969","pmid":"https://pubmed.ncbi.nlm.nih.gov/33624556","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8163606"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.00205.2020","doi":"https://doi.org/10.1152/ajpregu.00205.2020","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00205.2020","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8163606","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102348549","display_name":"Crystal M. Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crystal M. Taylor","raw_affiliation_strings":["Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048039890","display_name":"Ma\u0142gorzata Kasztan","orcid":"https://orcid.org/0000-0003-3345-1580","observed_orcids":["https://orcid.org/0000-0003-3345-1580"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malgorzata Kasztan","raw_affiliation_strings":["Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013169687","display_name":"Randee S. Sedaka","orcid":"https://orcid.org/0000-0001-7014-0832","observed_orcids":["https://orcid.org/0000-0001-7014-0832"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randee Sedaka","raw_affiliation_strings":["Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047551105","display_name":"Patrick Axel Molina","orcid":"https://orcid.org/0000-0001-8855-0880","observed_orcids":["https://orcid.org/0000-0001-8855-0880"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick A. Molina","raw_affiliation_strings":["Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090374298","display_name":"Luke S. Dunaway","orcid":"https://orcid.org/0000-0002-7458-9669","observed_orcids":["https://orcid.org/0000-0002-7458-9669"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke S. Dunaway","raw_affiliation_strings":["Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003642259","display_name":"Jennifer S. Pollock","orcid":"https://orcid.org/0000-0003-1956-0449","observed_orcids":["https://orcid.org/0000-0003-1956-0449"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer S. Pollock","raw_affiliation_strings":["Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066047278","display_name":"David M. Pollock","orcid":"https://orcid.org/0000-0002-0233-2362","observed_orcids":["https://orcid.org/0000-0002-0233-2362","https://orcid.org/0000-0002-7546-6003"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David M. Pollock","raw_affiliation_strings":["Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5066047278"],"corresponding_institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"],"apc_list":null,"apc_paid":null,"fwci":2.1053,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.87016037,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"320","issue":"5","first_page":"R630","last_page":"R640"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.9909999966621399},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9340000152587891},{"id":"https://openalex.org/keywords/sickle-cell-nephropathy","display_name":"sickle cell nephropathy","score":0.9679999947547913},{"id":"https://openalex.org/keywords/nitric-oxide-bioavailability","display_name":"nitric oxide bioavailability","score":0.9980000257492065},{"id":"https://openalex.org/keywords/arginase-2","display_name":"arginase II","score":0.8270000219345093},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.8679999709129333},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.753000020980835},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-3","display_name":"nitric oxide synthase 3","score":0.8809999823570251},{"id":"https://openalex.org/keywords/kidney-injury","display_name":"kidney injury","score":0.8159999847412109},{"id":"https://openalex.org/keywords/plasma-nitrite","display_name":"plasma nitrite","score":0.625},{"id":"https://openalex.org/keywords/urinary-concentrating-ability","display_name":"urine concentrating ability","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C164007495","wikidata":"https://www.wikidata.org/wiki/Q24721374","display_name":"Arginase","level":4,"score":0.841333270072937},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7071458101272583},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.6263335347175598},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5540383458137512},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.5179620981216431},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.46079498529434204},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45774099230766296},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.42882055044174194},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41736167669296265},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3872593641281128},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.16566872596740723},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13183951377868652},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05818936228752136},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.052348792552948},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000986","descriptor_name":"Antisickling Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001119","descriptor_name":"Arginase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006441","descriptor_name":"Hemoglobin A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006441","descriptor_name":"Hemoglobin A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006451","descriptor_name":"Hemoglobin, Sickle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006451","descriptor_name":"Hemoglobin, Sickle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpregu.00205.2020","doi":"https://doi.org/10.1152/ajpregu.00205.2020","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00205.2020","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8163606","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8163606","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Regul Integr Comp Physiol","raw_type":"Text"},{"id":"pmid:33624556","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33624556","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Regulatory, integrative and comparative physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8163606","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8163606","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Regul Integr Comp Physiol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1122485289","display_name":"The Role of Endothelin-1 in Sickle Cell Disease","funder_award_id":"U01HL117684","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1409832062","display_name":"Novel Mechanisms of Nitric Oxide Activation in the Kidney","funder_award_id":"F31DK111067","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2544214759","display_name":"The Role of Endothelin-1 in Tubular Injury in Sickle Cell Disease","funder_award_id":"R00HL144817","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G477637483","display_name":"HDAC1 Regulation of Endothelial NO","funder_award_id":"F31HL149235","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4778867451","display_name":null,"funder_award_id":"DK111067","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5351974881","display_name":null,"funder_award_id":"HL144817","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5644356042","display_name":"The role of endothelin-1 in tubular injury in sickle cell disease","funder_award_id":"K99HL144817","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5669464837","display_name":null,"funder_award_id":"GM109780","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6650670331","display_name":null,"funder_award_id":"HL117684","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6738802141","display_name":"UAB Predoctoral Training Grant in Translational and Molecular Sciences","funder_award_id":"T32GM109780","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7697823738","display_name":null,"funder_award_id":"HL151264","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7901811566","display_name":"Novel Endothelial and Immunologic Mechanisms of Pathophysiology in Sickle Cell Disease","funder_award_id":"F31HL151264","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320308436","display_name":"American Physiological Society","ror":"https://ror.org/01y68k842"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W36330543","https://openalex.org/W70346993","https://openalex.org/W117828388","https://openalex.org/W1843161625","https://openalex.org/W1973484838","https://openalex.org/W1974649841","https://openalex.org/W1978444866","https://openalex.org/W1978485157","https://openalex.org/W1983297963","https://openalex.org/W1990599619","https://openalex.org/W2002456771","https://openalex.org/W2012026140","https://openalex.org/W2013392029","https://openalex.org/W2015155237","https://openalex.org/W2016339719","https://openalex.org/W2017943437","https://openalex.org/W2018783141","https://openalex.org/W2021850499","https://openalex.org/W2027837178","https://openalex.org/W2032102036","https://openalex.org/W2033040678","https://openalex.org/W2034399408","https://openalex.org/W2035494124","https://openalex.org/W2039423483","https://openalex.org/W2043340279","https://openalex.org/W2049129790","https://openalex.org/W2049292864","https://openalex.org/W2053495832","https://openalex.org/W2056584805","https://openalex.org/W2058552460","https://openalex.org/W2059295932","https://openalex.org/W2063416975","https://openalex.org/W2065773232","https://openalex.org/W2069570335","https://openalex.org/W2069895986","https://openalex.org/W2079276179","https://openalex.org/W2080613214","https://openalex.org/W2084518939","https://openalex.org/W2084540644","https://openalex.org/W2086832534","https://openalex.org/W2088373599","https://openalex.org/W2092169332","https://openalex.org/W2093580567","https://openalex.org/W2101043007","https://openalex.org/W2111059895","https://openalex.org/W2111983416","https://openalex.org/W2127265286","https://openalex.org/W2132971040","https://openalex.org/W2136427930","https://openalex.org/W2137247821","https://openalex.org/W2137629026","https://openalex.org/W2150027863","https://openalex.org/W2153336025","https://openalex.org/W2155803841","https://openalex.org/W2157574389","https://openalex.org/W2163204987","https://openalex.org/W2195280390","https://openalex.org/W2245930599","https://openalex.org/W2313541759","https://openalex.org/W2326476344","https://openalex.org/W2334263927","https://openalex.org/W2412053231","https://openalex.org/W2417063740","https://openalex.org/W2419604885","https://openalex.org/W2460895384","https://openalex.org/W2508194225","https://openalex.org/W2560693613","https://openalex.org/W2592339311","https://openalex.org/W2597810023","https://openalex.org/W2888014035","https://openalex.org/W2945652183","https://openalex.org/W2947309701","https://openalex.org/W2987121884","https://openalex.org/W3017359776","https://openalex.org/W4249969224"],"related_works":["https://openalex.org/W3173996799","https://openalex.org/W1973484838","https://openalex.org/W2016339719","https://openalex.org/W4220854150","https://openalex.org/W2084540644","https://openalex.org/W1978444866","https://openalex.org/W2508194225","https://openalex.org/W2013392029","https://openalex.org/W2460895384","https://openalex.org/W4389023332"],"abstract_inverted_index":{"Despite":[0],"advancements":[1],"in":[2,15,38,64,130,158,230],"disease":[3,32],"management,":[4],"sickle":[5,30,67,73],"cell":[6,31,68],"nephropathy,":[7],"a":[8,25,220],"major":[9],"contributor":[10],"to":[11],"mortality":[12],"and":[13,75,93,114,126,140,154,175,211],"morbidity":[14],"patients,":[16],"has":[17],"limited":[18],"therapeutic":[19],"options.":[20],"Previous":[21],"studies":[22],"indicate":[23],"hydroxyurea,":[24],"commonly":[26],"prescribed":[27],"therapy":[28],"for":[29,88,223],"(SCD),":[33],"can":[34],"reduce":[35],"renal":[36,92,100,189,193,210,227],"injury":[37,101,228],"SCD":[39,46,231],"but":[40],"the":[41,65,204,224],"mechanisms":[42],"are":[43],"uncertain.":[44],"Because":[45],"is":[47],"associated":[48],"with":[49,82,120,146,180],"reduced":[50,115,124,137],"nitric":[51,170],"oxide":[52,171],"(NO)":[53],"bioavailability,":[54],"we":[55],"hypothesized":[56],"that":[57,206],"hydroxyurea":[58,83,207],"treatment":[59,150,185,208],"would":[60],"improve":[61],"NO":[62,95,213],"bioavailability":[63,96,214],"humanized":[66],"mouse.":[69],"Humanized":[70],"male":[71],"12-wk-old":[72],"(HbSS)":[74],"genetic":[76],"control":[77],"(HbAA)":[78],"mice":[79,106,135,166],"were":[80,102],"treated":[81],"or":[84],"regular":[85],"tap":[86],"water":[87],"2":[89,177,196],"wk":[90],"before":[91],"systemic":[94,212],"as":[97,99,219],"well":[98],"assessed.":[103],"Untreated":[104,133],"HbSS":[105,131,134,159,165],"exhibited":[107],"increased":[108],"proteinuria,":[109],"elevated":[110,141,169],"plasma":[111,127,138,142,152,156],"endothelin-1":[112],"(ET-1),":[113],"urine":[116],"concentrating":[117],"ability":[118],"compared":[119,145,179],"HbAA":[121,147,182],"mice.":[122,132,148,160,183,232],"Hydroxyurea":[123,149,184],"proteinuria":[125],"ET-1":[128],"levels":[129],"had":[136,168],"nitrite":[139,153],"arginase":[143,157,176,195,217],"concentrations":[144],"augmented":[151],"attenuated":[155],"Renal":[161],"vessels":[162],"isolated":[163],"from":[164],"also":[167],"synthase":[172],"3":[173],"(NOS3)":[174],"expression":[178,197],"untreated":[181],"did":[186],"not":[187],"alter":[188],"vascular":[190,194],"NOS3,":[191],"however,":[192],"was":[198],"significantly":[199],"reduced.":[200],"These":[201],"data":[202],"support":[203],"hypothesis":[205],"augments":[209],"by":[215],"reducing":[216],"activity":[218],"potential":[221],"mechanism":[222],"improvement":[225],"on":[226],"seen":[229]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-01T00:00:00"}
