{"id":"https://openalex.org/W3133365109","doi":"https://doi.org/10.7326/m20-6315","title":"Comparative Effectiveness and Harms of Antibiotics for Outpatient Diverticulitis","display_name":"Comparative Effectiveness and Harms of Antibiotics for Outpatient Diverticulitis","publication_year":2021,"publication_date":"2021-02-22","ids":{"openalex":"https://openalex.org/W3133365109","doi":"https://doi.org/10.7326/m20-6315","mag":"3133365109","pmid":"https://pubmed.ncbi.nlm.nih.gov/33617725","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9035276"},"language":"en","primary_location":{"id":"doi:10.7326/m20-6315","doi":"https://doi.org/10.7326/m20-6315","is_oa":false,"landing_page_url":"https://doi.org/10.7326/m20-6315","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9035276","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012012526","display_name":"Charles E. Gaber","orcid":"https://orcid.org/0000-0002-6752-2968","observed_orcids":["https://orcid.org/0000-0002-6752-2968"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles E. Gaber","raw_affiliation_strings":["Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, and School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (C.E.G.)"],"raw_orcid":"https://orcid.org/0000-0002-6752-2968","affiliations":[{"raw_affiliation_string":"Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, and School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (C.E.G.)","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086239617","display_name":"Alan C. Kinlaw","orcid":"https://orcid.org/0000-0002-4279-8685","observed_orcids":["https://orcid.org/0000-0002-4279-8685"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan C. Kinlaw","raw_affiliation_strings":["University of North Carolina School of Pharmacy and Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (A.C.K.)"],"raw_orcid":"https://orcid.org/0000-0002-4279-8685","affiliations":[{"raw_affiliation_string":"University of North Carolina School of Pharmacy and Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (A.C.K.)","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054161918","display_name":"Jessie K. Edwards","orcid":"https://orcid.org/0000-0002-1741-335X","observed_orcids":["https://orcid.org/0000-0002-1741-335X","https://orcid.org/0000-0003-0770-1179"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessie K. Edwards","raw_affiliation_strings":["School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.K.E., J.L.L., S.P.H., V.P.)"],"raw_orcid":"https://orcid.org/0000-0002-1741-335X","affiliations":[{"raw_affiliation_string":"School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.K.E., J.L.L., S.P.H., V.P.)","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030530617","display_name":"Jennifer Leigh Lund","orcid":"https://orcid.org/0000-0002-1108-0689","observed_orcids":["https://orcid.org/0000-0002-1108-0689"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L. Lund","raw_affiliation_strings":["School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.K.E., J.L.L., S.P.H., V.P.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.K.E., J.L.L., S.P.H., V.P.)","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043069598","display_name":"Til St\u00fcrmer\u200e","orcid":"https://orcid.org/0000-0002-9204-7177","observed_orcids":["https://orcid.org/0000-0002-9204-7177"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Til St\u00fcrmer","raw_affiliation_strings":["School of Public Health and the Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (T.S.)"],"raw_orcid":"https://orcid.org/0000-0002-9204-7177","affiliations":[{"raw_affiliation_string":"School of Public Health and the Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (T.S.)","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037665786","display_name":"Sharon Peacock Hinton","orcid":"https://orcid.org/0000-0001-6045-5283","observed_orcids":["https://orcid.org/0000-0001-6045-5283"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon Peacock Hinton","raw_affiliation_strings":["School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.K.E., J.L.L., S.P.H., V.P.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.K.E., J.L.L., S.P.H., V.P.)","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036291591","display_name":"Virginia Pate","orcid":"https://orcid.org/0000-0002-2141-8882","observed_orcids":["https://orcid.org/0000-0002-2141-8882"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia Pate","raw_affiliation_strings":["School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.K.E., J.L.L., S.P.H., V.P.)"],"raw_orcid":"https://orcid.org/0000-0002-2141-8882","affiliations":[{"raw_affiliation_string":"School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.K.E., J.L.L., S.P.H., V.P.)","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072028054","display_name":"Luther A. Bartelt","orcid":"https://orcid.org/0000-0002-7596-4272","observed_orcids":["https://orcid.org/0000-0002-7596-4272"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luther A. Bartelt","raw_affiliation_strings":["Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill, North Carolina (L.A.B., R.S.S., A.F.P.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill, North Carolina (L.A.B., R.S.S., A.F.P.)","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014526300","display_name":"Robert S. Sandler","orcid":"https://orcid.org/0000-0002-1323-6245","observed_orcids":["https://orcid.org/0000-0002-1323-6245"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert S. Sandler","raw_affiliation_strings":["Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill, North Carolina (L.A.B., R.S.S., A.F.P.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill, North Carolina (L.A.B., R.S.S., A.F.P.)","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010139385","display_name":"Anne F. Peery","orcid":"https://orcid.org/0000-0002-2005-0780","observed_orcids":["https://orcid.org/0000-0002-2005-0780"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne F. Peery","raw_affiliation_strings":["Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill, North Carolina (L.A.B., R.S.S., A.F.P.)"],"raw_orcid":"https://orcid.org/0000-0002-2005-0780","affiliations":[{"raw_affiliation_string":"Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill, North Carolina (L.A.B., R.S.S., A.F.P.)","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":3.2362,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.92476332,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"174","issue":"6","first_page":"737","last_page":"746"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12518","display_name":"Diverticular Disease and Complications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12518","display_name":"Diverticular Disease and Complications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11473","display_name":"Appendicitis Diagnosis and Management","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metronidazole","display_name":"metronidazole","score":0.8769999742507935},{"id":"https://openalex.org/keywords/fluoroquinolones","display_name":"fluoroquinolones","score":0.9890000224113464},{"id":"https://openalex.org/keywords/amoxicillin-clavulanic-acid","display_name":"amoxicillin-clavulanic acid","score":0.9869999885559082},{"id":"https://openalex.org/keywords/comparative-effectiveness","display_name":"comparative effectiveness","score":0.7390000224113464},{"id":"https://openalex.org/keywords/clostridium-difficile-infection","display_name":"Clostridium difficile infection","score":0.9259999990463257},{"id":"https://openalex.org/keywords/urgent-surgery","display_name":"urgent surgery","score":0.6460000276565552},{"id":"https://openalex.org/keywords/elective-surgery","display_name":"elective surgery","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.7229999899864197},{"id":"https://openalex.org/keywords/antibiotic-stewardship","display_name":"antibiotic stewardship","score":0.6349999904632568},{"id":"https://openalex.org/keywords/medicare","display_name":"Medicare","score":0.4090000092983246},{"id":"https://openalex.org/keywords/employer-sponsored-health-insurance","display_name":"employer-sponsored health insurance","score":0.800000011920929},{"id":"https://openalex.org/keywords/new-users","display_name":"new users","score":0.31700000166893005},{"id":"https://openalex.org/keywords/claims-data","display_name":"claims data","score":0.35600000619888306},{"id":"https://openalex.org/keywords/marketscan","display_name":"MarketScan","score":0.3409999907016754}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9435039758682251},{"id":"https://openalex.org/C2777396551","wikidata":"https://www.wikidata.org/wiki/Q169569","display_name":"Metronidazole","level":3,"score":0.8214835524559021},{"id":"https://openalex.org/C2779708577","wikidata":"https://www.wikidata.org/wiki/Q201928","display_name":"Amoxicillin","level":3,"score":0.7056021690368652},{"id":"https://openalex.org/C2777929615","wikidata":"https://www.wikidata.org/wiki/Q1066061","display_name":"Diverticulitis","level":2,"score":0.607623815536499},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5391511917114258},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49461814761161804},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3577563762664795},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.26847708225250244},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.09383407235145569},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000553","descriptor_name":"Ambulatory Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003015","descriptor_name":"Clostridium Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D004238","descriptor_name":"Diverticulitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004238","descriptor_name":"Diverticulitis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008795","descriptor_name":"Metronidazole","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008795","descriptor_name":"Metronidazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017281","descriptor_name":"Cost of Illness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019980","descriptor_name":"Amoxicillin-Potassium Clavulanate Combination","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019980","descriptor_name":"Amoxicillin-Potassium Clavulanate Combination","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D024841","descriptor_name":"Fluoroquinolones","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D024841","descriptor_name":"Fluoroquinolones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057186","descriptor_name":"Comparative Effectiveness Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.7326/m20-6315","doi":"https://doi.org/10.7326/m20-6315","is_oa":false,"landing_page_url":"https://doi.org/10.7326/m20-6315","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:33617725","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33617725","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of internal medicine","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:9035276","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9035276","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ann Intern Med","raw_type":"Text"},{"id":"pmh:cdr.lib.unc.edu:5x21ts60q","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/2cxj-0096","pdf_url":"https://doi.org/10.17615/2cxj-0096","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annals of Internal Medicine, 174(6)","raw_type":"Article"},{"id":"doi:10.17615/2cxj-0096","doi":"https://doi.org/10.17615/2cxj-0096","is_oa":true,"landing_page_url":"https://doi.org/10.17615/2cxj-0096","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9035276","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9035276","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ann Intern Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1706846686","display_name":"Risk factors for asymptomatic diverticulosis","funder_award_id":"R01DK094738","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6628848920","display_name":"North Carolina Translational and Clinical Science Institute (NC TraCS)","funder_award_id":"UL1TR002489","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G671671361","display_name":"Comparative Effectiveness Research and Patient Reported Outcomes in Diverticulitis","funder_award_id":"K23DK113225","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000861374","display_name":"Digestive Disease Epidemiology Training Program","funder_award_id":"T32DK007634","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000868127","display_name":"Center for Gastrointestinal Biology and Disease","funder_award_id":"P30DK034987","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3133365109.pdf","grobid_xml":"https://content.openalex.org/works/W3133365109.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W168822424","https://openalex.org/W1522902637","https://openalex.org/W1849521086","https://openalex.org/W1901037770","https://openalex.org/W1978351154","https://openalex.org/W2011207177","https://openalex.org/W2016582138","https://openalex.org/W2023326451","https://openalex.org/W2026967554","https://openalex.org/W2036193982","https://openalex.org/W2060603296","https://openalex.org/W2072047757","https://openalex.org/W2075352120","https://openalex.org/W2082693656","https://openalex.org/W2110349466","https://openalex.org/W2116787565","https://openalex.org/W2144113585","https://openalex.org/W2146815722","https://openalex.org/W2150285448","https://openalex.org/W2154746519","https://openalex.org/W2164595809","https://openalex.org/W2168458505","https://openalex.org/W2193782113","https://openalex.org/W2265914419","https://openalex.org/W2331527667","https://openalex.org/W2337544276","https://openalex.org/W2519686753","https://openalex.org/W2525803483","https://openalex.org/W2593473543","https://openalex.org/W2767837858","https://openalex.org/W2799907419","https://openalex.org/W2853861388","https://openalex.org/W2897031692","https://openalex.org/W2908839642","https://openalex.org/W2943496789","https://openalex.org/W2953763924","https://openalex.org/W2956098521","https://openalex.org/W3003519966","https://openalex.org/W3021557093","https://openalex.org/W3022871146","https://openalex.org/W3108725181","https://openalex.org/W4253751822"],"related_works":["https://openalex.org/W4386112793","https://openalex.org/W2979143126","https://openalex.org/W2901730286","https://openalex.org/W3168345691","https://openalex.org/W3197912537","https://openalex.org/W3133886325","https://openalex.org/W4281641736","https://openalex.org/W2071565416","https://openalex.org/W4406956572","https://openalex.org/W3024414950"],"abstract_inverted_index":{"Background:":[0],"Outpatient":[1],"diverticulitis":[2,45,104,319],"is":[3,46,299],"commonly":[4],"treated":[5],"with":[6,32,81,95,103,306,324],"either":[7],"a":[8,13],"combination":[9],"of":[10,40,55,140,217,343],"metronidazole":[11],"and":[12,22,53,121,126,146,223,301],"fluoroquinolone":[14],"(metronidazole-with-fluoroquinolone)":[15],"or":[16,88,93,111,198,260],"amoxicillin\u2013clavulanate":[17,43,58,147,224,286,325],"alone.":[18],"The":[19,37,276],"U.S.":[20,74],"Food":[21],"Drug":[23],"Administration":[24],"advised":[25],"that":[26],"fluoroquinolones":[27],"be":[28,315],"reserved":[29],"for":[30,44,59,116,129,282,285,330],"conditions":[31],"no":[33,156,232],"alternative":[34],"treatment":[35],"options.":[36],"comparative":[38],"effectiveness":[39,52],"metronidazole-with-fluoroquinolone":[41,56,141,218,283],"versus":[42,57],"uncertain.":[47],"Objective:":[48],"To":[49],"determine":[50],"the":[51,106,321,328],"harms":[54,304,332],"outpatient":[60,107,322],"diverticulitis.":[61],"Design:":[62],"Active-comparator,":[63],"new-user,":[64],"retrospective":[65],"cohort":[66],"studies.":[67],"Setting:":[68],"Nationwide":[69],"population-based":[70],"claims":[71],"data":[72],"on":[73],"residents":[75],"aged":[76,90],"18":[77],"to":[78,86,98,170,183,196,209,245,258,272,294],"64":[79],"years":[80,92],"private":[82],"employer-sponsored":[83],"insurance":[84],"(2000":[85],"2018)":[87],"those":[89],"65":[91],"older":[94],"Medicare":[96],"(2006":[97],"2015).":[99],"Participants:":[100],"Immunocompetent":[101],"adults":[102],"in":[105,158,234,320],"setting.":[108],"Intervention:":[109],"Metronidazole-with-fluoroquinolone":[110],"amoxicillin\u2013clavulanate.":[112],"Measurements:":[113],"1-year":[114,159,172,199,235,247,277],"risks":[115],"inpatient":[117],"admission,":[118],"urgent":[119,173,248],"surgery,":[120],"Clostridioides":[122],"difficile":[123],"infection":[124],"(CDI)":[125],"3-year":[127,185,261],"risk":[128,161,175,188,201,237,250,264,279,329],"elective":[130,186,262],"surgery.":[131],"Results:":[132],"In":[133,213],"MarketScan":[134],"(IBM":[135],"Watson":[136],"Health),":[137],"new":[138,215],"users":[139,216],"(n":[142,148,219,225],"=":[143,149,220,226],"106":[144],"361)":[145],"13":[150],"160)":[151],"were":[152,155,228,231],"identified.":[153,229],"There":[154,230],"differences":[157,233],"admission":[160,236],"(risk":[162,176,189,202,238,251,265,287],"difference,":[163,177,190,203,239,252,266,288],"0.1":[164,240],"percentage":[165,179,192,205,241,254,268,290],"points":[166,180,193,206,242,255,269,291],"[95%":[167],"CI,":[168],"\u22120.3":[169,195,267],"0.6]),":[171],"surgery":[174,187,249,263],"0.0":[178,204],"[CI,":[181,194,207,243,256,270,292],"\u22120.1":[182,208],"0.1]),":[184,259],"0.2":[191,293],"0.7]),":[197],"CDI":[200,278],"0.1])":[210],"between":[211,274],"groups.":[212,275],"Medicare,":[214],"17":[221],"639)":[222],"2709)":[227],"\u22120.7":[244],"0.9]),":[246],"\u22120.2":[253],"\u22120.6":[257],"\u22121.1":[271],"0.4])":[273],"was":[280],"higher":[281],"than":[284],"0.6":[289],"1.0]).":[295],"Limitation:":[296],"Residual":[297],"confounding":[298],"possible,":[300],"not":[302],"all":[303],"associated":[305],"these":[307],"antibiotics,":[308],"most":[309],"notably":[310],"drug-induced":[311],"liver":[312],"injury,":[313],"could":[314],"assessed.":[316],"Conclusion:":[317],"Treating":[318],"setting":[323],"may":[326],"reduce":[327],"fluoroquinolone-related":[331],"without":[333],"adversely":[334],"affecting":[335],"diverticulitis-specific":[336],"outcomes.":[337],"Primary":[338],"Funding":[339],"Source:":[340],"National":[341],"Institutes":[342],"Health.":[344]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-01T00:00:00"}