{"id":"https://openalex.org/W313334097","doi":null,"title":"Glass fibers and vapor phase components of cigarette smoke as cofactors in experimental respiratory tract carcinogenesis.","display_name":"Glass fibers and vapor phase components of cigarette smoke as cofactors in experimental respiratory tract carcinogenesis.","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W313334097","mag":"313334097","pmid":"https://pubmed.ncbi.nlm.nih.gov/3986837"},"language":"en","primary_location":{"id":"pmid:3986837","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3986837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis; a comprehensive survey","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006184743","display_name":"V.J. Feron","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V J Feron","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081174471","display_name":"C. Frieke Kuper","orcid":"https://orcid.org/0000-0001-8273-2915","observed_orcids":["https://orcid.org/0000-0001-8273-2915"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C F Kuper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110942452","display_name":"Ben J. Spit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B J Spit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076978230","display_name":"Paul G. J. Reuzel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P G Reuzel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110012087","display_name":"Ruud A. Woutersen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R A Woutersen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.01205053,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"8","issue":null,"first_page":"93","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.03759999945759773,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cigarette-smoke","display_name":"cigarette smoke","score":0.9129999876022339},{"id":"https://openalex.org/keywords/acetaldehyde","display_name":"acetaldehyde","score":0.8130000233650208},{"id":"https://openalex.org/keywords/glass-fiber-reinforced-polymer","display_name":"glass fiber","score":0.593999981880188},{"id":"https://openalex.org/keywords/benzopyrene","display_name":"benzopyrene","score":0.6579999923706055},{"id":"https://openalex.org/keywords/norharmane","display_name":"norharman","score":0.8500000238418579},{"id":"https://openalex.org/keywords/laryngeal-tumors","display_name":"laryngeal tumors","score":0.7950000166893005},{"id":"https://openalex.org/keywords/nasal-cancer","display_name":"nasal cancer","score":0.7540000081062317},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.7889999747276306},{"id":"https://openalex.org/keywords/isoprene","display_name":"isoprene","score":0.8629999756813049},{"id":"https://openalex.org/keywords/chloromethane","display_name":"methyl chloride","score":0.9959999918937683},{"id":"https://openalex.org/keywords/methyl-nitrite","display_name":"methyl nitrite","score":0.9980000257492065},{"id":"https://openalex.org/keywords/respiratory-tract-carcinogenesis","display_name":"respiratory tract carcinogenesis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/synergistic-carcinogenesis","display_name":"synergistic carcinogenesis","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C2779644171","wikidata":"https://www.wikidata.org/wiki/Q13400765","display_name":"Respiratory tract","level":3,"score":0.843325138092041},{"id":"https://openalex.org/C2777595113","wikidata":"https://www.wikidata.org/wiki/Q61457","display_name":"Acetaldehyde","level":3,"score":0.8136119842529297},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5484382510185242},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.5435712933540344},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.5379325747489929},{"id":"https://openalex.org/C2780474809","wikidata":"https://www.wikidata.org/wiki/Q9637","display_name":"Larynx","level":2,"score":0.48549965023994446},{"id":"https://openalex.org/C2779078736","wikidata":"https://www.wikidata.org/wiki/Q23542019","display_name":"Intratracheal instillation","level":4,"score":0.47658440470695496},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4674915373325348},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.46358299255371094},{"id":"https://openalex.org/C87568996","wikidata":"https://www.wikidata.org/wiki/Q1428754","display_name":"Respiratory epithelium","level":3,"score":0.44199591875076294},{"id":"https://openalex.org/C2778355491","wikidata":"https://www.wikidata.org/wiki/Q2386268","display_name":"Tobacco smoke","level":2,"score":0.4408157467842102},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4095134139060974},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.35094648599624634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3283384442329407},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3047427833080292},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.28922152519226074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27457183599472046},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.20050859451293945},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.19628101587295532},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.19364067912101746},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.15321269631385803},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13495180010795593},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07295551896095276}],"mesh":[{"descriptor_ui":"D000079","descriptor_name":"Acetaldehyde","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003043","descriptor_name":"Cocarcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005898","descriptor_name":"Glass","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010947","descriptor_name":"Plants, Toxic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012142","descriptor_name":"Respiratory Tract Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012142","descriptor_name":"Respiratory Tract Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012906","descriptor_name":"Smoke","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D012906","descriptor_name":"Smoke","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014835","descriptor_name":"Volatilization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:3986837","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3986837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis; a comprehensive survey","raw_type":"Journal Article"},{"id":"pmh:oai:oai-pmh.tno.nl:73522","doi":null,"is_oa":false,"landing_page_url":"https://resolver.tno.nl/uuid:cf94ec16-b7aa-4f70-a98e-56949d1d6a4d","pdf_url":null,"source":{"id":"https://openalex.org/S7407055233","display_name":"TNO Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/bookPart"},{"id":"mag:313334097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3986837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1971662543","https://openalex.org/W7097066425","https://openalex.org/W2026864913","https://openalex.org/W2295670289","https://openalex.org/W2073886155","https://openalex.org/W2305986730","https://openalex.org/W1963650064","https://openalex.org/W326157390","https://openalex.org/W4297966611","https://openalex.org/W1930359595"],"abstract_inverted_index":{"Syrian":[0,65],"golden":[1,66],"hamsters":[2,39,67,136],"were":[3,36,68,114,128],"given":[4,116],"intratracheal":[5,118],"instillations":[6,119],"of":[7,32,55,77,83,105,111,120,153,166,180,190,202,208,221,228,234,249,264,274],"glass":[8,42,50],"fibers":[9,43,51],"with":[10,41,170],"or":[11,73,122,172,213,268],"without":[12],"BP":[13,121,173],"suspended":[14],"in":[15,38,124,130,148,186,217,255,271],"saline,":[16],"once":[17],"a":[18,75,103,218,262],"fortnight":[19],"for":[20,102,261],"52":[21],"weeks;":[22],"the":[23,33,53,112,140,154,164,177,181,187,229,235,247,272],"experiment":[24],"was":[25,46,239,259],"terminated":[26],"at":[27,106,193,206],"week":[28],"85.":[29],"No":[30,257],"tumors":[31,58,127,146],"respiratory":[34,56,230],"tract":[35,57],"observed":[37],"treated":[40],"alone.":[44],"There":[45],"no":[47,144],"indication":[48],"that":[49,241],"enhanced":[52],"development":[54],"induced":[59],"by":[60,252,277],"BP.":[61],"In":[62],"another":[63],"study":[64],"exposed":[69,137],"to":[70,74,139,159,163,196,204,246],"fresh":[71],"air":[72],"mixture":[76],"4":[78],"major":[79],"vapor":[80,141,188],"phase":[81,189],"components":[82],"cigarette":[84,191,253,278],"smoke,":[85],"viz.":[86],"isoprene":[87],"(800----700":[88],"ppm),":[89,93],"methyl":[90,94,266,269],"chloride":[91,267],"(1000----900":[92],"nitrite":[95,270],"(200----190":[96],"ppm)":[97,101],"and":[98,133,232],"acetaldehyde":[99,205,242],"(1400----1200":[100],"period":[104],"most":[107,156],"23":[108],"months.":[109],"Some":[110],"animals":[113],"also":[115],"repeated":[117],"norharman":[123,171],"saline.":[125],"Laryngeal":[126],"found":[129],"7/31":[131],"male":[132],"6/32":[134],"female":[135],"only":[138],"mixture,":[142],"whereas":[143],"laryngeal":[145],"occurred":[147],"controls.":[149],"The":[150],"tumor":[151,178],"response":[152,179],"larynx":[155],"probably":[157],"has":[158],"be":[160],"ascribed":[161],"entirely":[162],"action":[165],"acetaldehyde.":[167],"Simultaneous":[168],"treatment":[169],"did":[174],"not":[175],"affect":[176],"larynx.":[182],"Acetaldehyde":[183],"may":[184,243],"occur":[185],"smoke":[192,254],"levels":[194,207],"up":[195],"2000":[197],"ppm.":[198],"Chronic":[199],"inhalation":[200],"exposure":[201],"rats":[203],"0":[209],"(controls),":[210],"750,":[211],"1500":[212],"3000----1000":[214],"ppm":[215],"resulted":[216],"high":[219],"incidence":[220],"nasal":[222],"carcinomas,":[223],"both":[224],"squamous":[225],"cell":[226],"carcinomas":[227],"epithelium":[231],"adenocarcinomas":[233],"olfactory":[236],"epithelium.":[237],"It":[238],"discussed":[240],"significantly":[244],"contribute":[245],"induction":[248,273],"bronchogenic":[250],"cancer":[251,276],"man.":[256],"evidence":[258],"obtained":[260],"role":[263],"isoprene,":[265],"lung":[275],"smoke.":[279]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
