{"id":"https://openalex.org/W3133314164","doi":"https://doi.org/10.1016/j.synbio.2021.01.001","title":"Chemical modifications of proteins and their applications in metalloenzyme studies","display_name":"Chemical modifications of proteins and their applications in metalloenzyme studies","publication_year":2021,"publication_date":"2021-02-16","ids":{"openalex":"https://openalex.org/W3133314164","doi":"https://doi.org/10.1016/j.synbio.2021.01.001","mag":"3133314164","pmid":"https://pubmed.ncbi.nlm.nih.gov/33665390","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7897936"},"language":"en","primary_location":{"id":"doi:10.1016/j.synbio.2021.01.001","doi":"https://doi.org/10.1016/j.synbio.2021.01.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.synbio.2021.01.001","pdf_url":null,"source":{"id":"https://openalex.org/S2898462621","display_name":"Synthetic and Systems Biotechnology","issn_l":"2097-1206","issn":["2097-1206","2405-805X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synthetic and Systems Biotechnology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.synbio.2021.01.001","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023097625","display_name":"Nathchar Naowarojna","orcid":"https://orcid.org/0000-0002-7952-3458","observed_orcids":["https://orcid.org/0000-0002-7952-3458"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathchar Naowarojna","raw_affiliation_strings":["Department of Chemistry, Boston University, Boston, MA, 02215, United States"],"raw_orcid":"https://orcid.org/0000-0002-7952-3458","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Boston University, Boston, MA, 02215, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075499318","display_name":"Ronghai Cheng","orcid":"https://orcid.org/0000-0003-4763-8047","observed_orcids":["https://orcid.org/0000-0003-4763-8047"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronghai Cheng","raw_affiliation_strings":["Department of Chemistry, Boston University, Boston, MA, 02215, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Boston University, Boston, MA, 02215, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085498546","display_name":"Juan Lopez","orcid":"https://orcid.org/0000-0002-9828-0818","observed_orcids":["https://orcid.org/0000-0002-9828-0818"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Lopez","raw_affiliation_strings":["Department of Chemistry, Boston University, Boston, MA, 02215, United States"],"raw_orcid":"https://orcid.org/0000-0002-9828-0818","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Boston University, Boston, MA, 02215, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015882911","display_name":"Christina Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Wong","raw_affiliation_strings":["Department of Chemistry, Boston University, Boston, MA, 02215, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Boston University, Boston, MA, 02215, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018467175","display_name":"Lu Qiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu Qiao","raw_affiliation_strings":["Department of Chemistry, Boston University, Boston, MA, 02215, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Boston University, Boston, MA, 02215, United States","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057359919","display_name":"Pinghua Liu","orcid":"https://orcid.org/0000-0002-9768-559X","observed_orcids":["https://orcid.org/0000-0002-9768-559X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pinghua Liu","raw_affiliation_strings":["Department of Chemistry, Boston University, Boston, MA, 02215, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Boston University, Boston, MA, 02215, United States","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5057359919"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":{"value":1500,"currency":"USD","value_usd":1500},"fwci":0.9177,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.68753333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"6","issue":"1","first_page":"32","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.47510001063346863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.47510001063346863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.12430000305175781,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.08020000159740448,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemical-modification-of-proteins","display_name":"protein chemical modification","score":0.9520000219345093},{"id":"https://openalex.org/keywords/metalloenzymes","display_name":"metalloenzymes","score":0.9950000047683716},{"id":"https://openalex.org/keywords/unnatural-amino-acid-incorporation","display_name":"unnatural amino acid incorporation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/genetic-code-expansion","display_name":"genetic code expansion","score":0.9959999918937683},{"id":"https://openalex.org/keywords/enzyme-mechanism","display_name":"enzyme mechanism","score":0.7590000033378601},{"id":"https://openalex.org/keywords/enzyme-activity-enhancement","display_name":"enzyme activity enhancement","score":0.6579999923706055},{"id":"https://openalex.org/keywords/enzyme-mimics","display_name":"enzyme mimics","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5565295219421387},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5377521514892578},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.5111320614814758},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5077527761459351},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47415488958358765},{"id":"https://openalex.org/C2994376932","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Amino acid residue","level":4,"score":0.44794559478759766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2411613166332245},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1679738163948059},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.16265961527824402},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06817582249641418}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.synbio.2021.01.001","doi":"https://doi.org/10.1016/j.synbio.2021.01.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.synbio.2021.01.001","pdf_url":null,"source":{"id":"https://openalex.org/S2898462621","display_name":"Synthetic and Systems Biotechnology","issn_l":"2097-1206","issn":["2097-1206","2405-805X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synthetic and Systems Biotechnology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7897936","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7897936","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synth Syst Biotechnol","raw_type":"Text"},{"id":"pmid:33665390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33665390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synthetic and systems biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:null:2144/44497","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.synbio.2021.01.001","pdf_url":null,"source":{"id":"https://openalex.org/S4306402384","display_name":"OpenBU (Boston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I111088046","host_organization_name":"Boston University","host_organization_lineage":["https://openalex.org/I111088046"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:f3a2d1a7115a4c44978f7da4a362a766","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f3a2d1a7115a4c44978f7da4a362a766","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Synthetic and Systems Biotechnology, Vol 6, Iss 1, Pp 32-49 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.synbio.2021.01.001","doi":"https://doi.org/10.1016/j.synbio.2021.01.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.synbio.2021.01.001","pdf_url":null,"source":{"id":"https://openalex.org/S2898462621","display_name":"Synthetic and Systems Biotechnology","issn_l":"2097-1206","issn":["2097-1206","2405-805X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synthetic and Systems Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7908804388","display_name":"Mechanistic Studies of C-X Bond Formation Chemistries","funder_award_id":"2004109","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":161,"referenced_works":["https://openalex.org/W138094741","https://openalex.org/W1260748775","https://openalex.org/W1550493224","https://openalex.org/W1555210661","https://openalex.org/W1765180661","https://openalex.org/W1922028241","https://openalex.org/W1925430051","https://openalex.org/W1963724731","https://openalex.org/W1966819685","https://openalex.org/W1968222033","https://openalex.org/W1968652549","https://openalex.org/W1970821340","https://openalex.org/W1972000827","https://openalex.org/W1978513278","https://openalex.org/W1982703486","https://openalex.org/W1985592905","https://openalex.org/W1988901523","https://openalex.org/W1990095828","https://openalex.org/W1991028037","https://openalex.org/W1993849862","https://openalex.org/W1997854913","https://openalex.org/W1998798346","https://openalex.org/W2001716931","https://openalex.org/W2002336386","https://openalex.org/W2004315839","https://openalex.org/W2006824068","https://openalex.org/W2008439251","https://openalex.org/W2010363872","https://openalex.org/W2011407829","https://openalex.org/W2014479174","https://openalex.org/W2015027122","https://openalex.org/W2016206195","https://openalex.org/W2017486986","https://openalex.org/W2023225498","https://openalex.org/W2024544120","https://openalex.org/W2028094900","https://openalex.org/W2029802561","https://openalex.org/W2035856006","https://openalex.org/W2036767876","https://openalex.org/W2037796752","https://openalex.org/W2038096044","https://openalex.org/W2041806467","https://openalex.org/W2042469001","https://openalex.org/W2044647456","https://openalex.org/W2050188620","https://openalex.org/W2054513658","https://openalex.org/W2055204581","https://openalex.org/W2058461010","https://openalex.org/W2060746246","https://openalex.org/W2062692447","https://openalex.org/W2067154055","https://openalex.org/W2069269641","https://openalex.org/W2071291971","https://openalex.org/W2075365129","https://openalex.org/W2075734597","https://openalex.org/W2076047438","https://openalex.org/W2076992251","https://openalex.org/W2077605453","https://openalex.org/W2077790287","https://openalex.org/W2080662803","https://openalex.org/W2083350289","https://openalex.org/W2085560162","https://openalex.org/W2088868630","https://openalex.org/W2090655331","https://openalex.org/W2094850431","https://openalex.org/W2101867399","https://openalex.org/W2107167859","https://openalex.org/W2110069436","https://openalex.org/W2116574883","https://openalex.org/W2130876515","https://openalex.org/W2137250659","https://openalex.org/W2143036076","https://openalex.org/W2145662716","https://openalex.org/W2148313902","https://openalex.org/W2148405034","https://openalex.org/W2149431869","https://openalex.org/W2153089815","https://openalex.org/W2157162286","https://openalex.org/W2159468231","https://openalex.org/W2163266294","https://openalex.org/W2165788095","https://openalex.org/W2166945596","https://openalex.org/W2168912171","https://openalex.org/W2169025823","https://openalex.org/W2169164852","https://openalex.org/W2270583408","https://openalex.org/W2301941353","https://openalex.org/W2312455466","https://openalex.org/W2317873538","https://openalex.org/W2322836921","https://openalex.org/W2324621510","https://openalex.org/W2329318318","https://openalex.org/W2331937820","https://openalex.org/W2332024781","https://openalex.org/W2465674018","https://openalex.org/W2507410184","https://openalex.org/W2517960934","https://openalex.org/W2537629632","https://openalex.org/W2544629499","https://openalex.org/W2548801425","https://openalex.org/W2569641753","https://openalex.org/W2573219864","https://openalex.org/W2587649655","https://openalex.org/W2588345894","https://openalex.org/W2592791925","https://openalex.org/W2623166754","https://openalex.org/W2729329687","https://openalex.org/W2735208100","https://openalex.org/W2735839143","https://openalex.org/W2753393433","https://openalex.org/W2762743006","https://openalex.org/W2763278454","https://openalex.org/W2765304871","https://openalex.org/W2766423195","https://openalex.org/W2775291626","https://openalex.org/W2777700910","https://openalex.org/W2790553494","https://openalex.org/W2790864644","https://openalex.org/W2791928416","https://openalex.org/W2795122379","https://openalex.org/W2803954658","https://openalex.org/W2806557186","https://openalex.org/W2809075674","https://openalex.org/W2809736008","https://openalex.org/W2885710132","https://openalex.org/W2896511056","https://openalex.org/W2896749190","https://openalex.org/W2897392685","https://openalex.org/W2901036462","https://openalex.org/W2902321532","https://openalex.org/W2904011061","https://openalex.org/W2908038781","https://openalex.org/W2912459103","https://openalex.org/W2913116772","https://openalex.org/W2917912064","https://openalex.org/W2921255450","https://openalex.org/W2923401475","https://openalex.org/W2930951846","https://openalex.org/W2936213937","https://openalex.org/W2947372745","https://openalex.org/W2956107682","https://openalex.org/W2961566029","https://openalex.org/W2968825107","https://openalex.org/W2969793649","https://openalex.org/W2975526777","https://openalex.org/W2997333704","https://openalex.org/W2998934264","https://openalex.org/W3002324109","https://openalex.org/W3014321121","https://openalex.org/W3016753178","https://openalex.org/W3023641764","https://openalex.org/W3023678398","https://openalex.org/W3033651710","https://openalex.org/W3040574802","https://openalex.org/W3044254600","https://openalex.org/W3092443431","https://openalex.org/W4206625644","https://openalex.org/W4213262935","https://openalex.org/W4230127325","https://openalex.org/W4234076445","https://openalex.org/W4249806989"],"related_works":["https://openalex.org/W1966935274","https://openalex.org/W2294942216","https://openalex.org/W2296423762","https://openalex.org/W2358211912","https://openalex.org/W2804313806","https://openalex.org/W2032549657","https://openalex.org/W1590895837","https://openalex.org/W2031019580","https://openalex.org/W3216702743","https://openalex.org/W2124544537"],"abstract_inverted_index":{"Protein":[0],"chemical":[1,8],"modifications":[2],"are":[3],"important":[4],"tools":[5],"for":[6],"elucidating":[7],"and":[9,36,56],"biological":[10],"functions":[11],"of":[12,67],"proteins.":[13],"Several":[14],"strategies":[15],"have":[16,41],"been":[17,42],"developed":[18],"to":[19],"implement":[20],"these":[21,72],"modifications,":[22],"including":[23],"enzymatic":[24,54],"tailoring":[25],"reactions,":[26],"unnatural":[27],"amino":[28],"acid":[29],"incorporation":[30],"using":[31],"the":[32,68],"expanded":[33],"genetic":[34],"codes,":[35],"recognition-driven":[37],"transformations.":[38],"These":[39],"technologies":[40],"applied":[43],"in":[44,48,71],"metalloenzyme":[45,80],"studies,":[46],"specifically":[47],"dissecting":[49],"their":[50,53],"mechanisms,":[51],"improving":[52],"activities,":[55],"creating":[57],"artificial":[58],"enzymes":[59],"with":[60,74],"non-natural":[61],"activities.":[62],"Herein,":[63],"we":[64],"summarize":[65],"some":[66],"recent":[69],"efforts":[70],"areas":[73],"an":[75],"emphasis":[76],"on":[77],"a":[78],"few":[79],"case":[81],"studies.":[82]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2021-03-01T00:00:00"}