{"id":"https://openalex.org/W3133064086","doi":null,"title":"Novel Rapid Noncompetitive Immunodiagnostics for Mycotoxins - HT-2 toxin as a Forerunner","display_name":"Novel Rapid Noncompetitive Immunodiagnostics for Mycotoxins - HT-2 toxin as a Forerunner","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3133064086","mag":"3133064086"},"language":"en","primary_location":{"id":"mag:3133064086","doi":null,"is_oa":false,"landing_page_url":"https://aaltodoc.aalto.fi:443/handle/123456789/101760","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057230840","display_name":"Henri O. Arola","orcid":"https://orcid.org/0000-0002-4931-2529","observed_orcids":["https://orcid.org/0000-0002-4931-2529"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Henri Arola","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4931-2529","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057230840"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ht-2-toxin","display_name":"HT-2 toxin","score":0.9559999704360962},{"id":"https://openalex.org/keywords/mycotoxins","display_name":"mycotoxins","score":0.9599999785423279},{"id":"https://openalex.org/keywords/recombinant-antibodies","display_name":"recombinant antibodies","score":0.8610000014305115},{"id":"https://openalex.org/keywords/noncompetitive-immunoassay","display_name":"noncompetitive immunoassay","score":0.8370000123977661},{"id":"https://openalex.org/keywords/immune-complex-assay","display_name":"immune complex assay","score":0.871999979019165},{"id":"https://openalex.org/keywords/homogeneous-immunoassay","display_name":"homogeneous immunoassay","score":0.8299999833106995},{"id":"https://openalex.org/keywords/wheat","display_name":"wheat","score":0.6869999766349792},{"id":"https://openalex.org/keywords/barley","display_name":"barley","score":0.9620000123977661},{"id":"https://openalex.org/keywords/oat","display_name":"oat","score":0.9980000257492065},{"id":"https://openalex.org/keywords/label-free-detection","display_name":"label-free detection","score":0.847000002861023},{"id":"https://openalex.org/keywords/food-safety","display_name":"food safety","score":0.6150000095367432},{"id":"https://openalex.org/keywords/biosensing","display_name":"biosensing","score":0.703000009059906},{"id":"https://openalex.org/keywords/fungal-secondary-metabolites","display_name":"fungal secondary metabolites","score":0.7239999771118164},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.49799999594688416},{"id":"https://openalex.org/keywords/cross-reactivity","display_name":"cross-reactivity","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C84699730","wikidata":"https://www.wikidata.org/wiki/Q422449","display_name":"Mycotoxin","level":2,"score":0.897732138633728},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.8733459115028381},{"id":"https://openalex.org/C2776889654","wikidata":"https://www.wikidata.org/wiki/Q257954","display_name":"Trichothecene","level":3,"score":0.5602213740348816},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5123053789138794},{"id":"https://openalex.org/C104488531","wikidata":"https://www.wikidata.org/wiki/Q864212","display_name":"Bioassay","level":2,"score":0.504895031452179},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4942781925201416},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.48594868183135986},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.4794846475124359},{"id":"https://openalex.org/C112570922","wikidata":"https://www.wikidata.org/wiki/Q60528603","display_name":"Contamination","level":2,"score":0.46607017517089844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42353254556655884},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3812773823738098},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3282562494277954},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3047080338001251},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3046116530895233},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12451040744781494},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3133064086","doi":null,"is_oa":false,"landing_page_url":"https://aaltodoc.aalto.fi:443/handle/123456789/101760","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Zero hunger","score":0.40450000762939453,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2345362743","https://openalex.org/W2065537198","https://openalex.org/W4205679756","https://openalex.org/W6981037204","https://openalex.org/W2164211753","https://openalex.org/W2003927476","https://openalex.org/W2334366487","https://openalex.org/W1944138148","https://openalex.org/W2119174227","https://openalex.org/W2605691080"],"abstract_inverted_index":{"Mycotoxins":[0,33],"are":[1,34,53],"among":[2],"the":[3,39,49,91,110,113,134,139,145,150,154,173,189,193,238,292],"most":[4,299],"important":[5,208],"contaminants":[6],"of":[7,41,64,90,101,109,115,172,192,221,237,247,273,283,288,302,307],"agricultural":[8],"products.":[9],"These":[10,157,215],"fungal":[11],"secondary":[12],"metabolites":[13],"cause":[14],"significant":[15],"annual":[16],"crop":[17],"losses":[18],"and":[19,25,38,44,88,153,175,213,355],"different":[20,336],"adverse":[21],"effects":[22],"for":[23,60,67,120,127,181,202,244,278,294,312,339,352,356],"humans":[24],"animals":[26],"consuming":[27],"mycotoxin":[28,68,92,104],"contaminated":[29,227],"food":[30,65],"or":[31],"feed.":[32],"a":[35,102,116,122,195,230,241,284,308],"global":[36],"problem":[37],"significance":[40],"their":[42],"measurement":[43,246,287],"control":[45],"is":[46,270,305],"increasing":[47],"all":[48],"time.":[50],"\nNovel":[51],"solutions":[52],"needed":[54],"to":[55,77,144,347],"improve":[56,85],"rapid":[57,79],"high-throughput":[58],"methods":[59,81],"screening":[61],"large":[62],"batches":[63],"materials":[66],"contamination.":[69],"In":[70],"this":[71,303],"work,":[72,194],"recombinant":[73,117,330],"antibodies":[74,159],"were":[75,160,219],"applied":[76],"develop":[78,348],"noncompetitive":[80,197],"that":[82],"hypothetically":[83],"would":[84],"both":[86,216],"sensitivity":[87],"specificity":[89],"assay.":[93],"HT-2":[94,128,135,182,203,223,248,289,313,340],"toxin":[95,136,183,204,224,249,290,314],"was":[96,179,200,266,332],"selected":[97],"as":[98],"an":[99,251],"example":[100,282],"specific":[103,123,310,349],"target.":[105],"\nThe":[106,234,298],"first":[107,131,151,309],"part":[108,191,236],"work":[111,239,304],"describes":[112,240],"development":[114,306],"antibody":[118,132,141,152],"pair":[119],"realizing":[121],"immune":[124,146,166,324],"complex":[125,147,167,325],"assay":[126,168,178,199,311,326,337],"toxin.":[129,156,341],"The":[130,177,260,281],"recognizes":[133],"molecule,":[137],"while":[138],"second":[140,190],"binds":[142],"only":[143,170],"formed":[148],"by":[149],"target":[155],"two":[158,329,335],"then":[161],"implemented":[162],"in":[163,185,206,229,264,360],"one-step":[164],"homogeneous":[165],"requiring":[169],"addition":[171],"sample":[174],"measuring.":[176],"demonstrated":[180,333],"determination":[184],"wheat":[186],"samples.":[187],"\nIn":[188],"simple":[196],"ELISA":[198],"realized":[201],"detection":[205,262],"three":[207],"grain":[209],"matrices":[210],"wheat,":[211],"barley":[212],"oats.":[214],"developed":[217],"assays":[218,350],"capable":[220],"measuring":[222],"from":[225],"naturally":[226],"samples":[228],"relevant":[231],"concentration":[232],"range.":[233],"last":[235],"proof-of-concept":[242],"study":[243],"direct":[245,285],"employing":[250],"ultra-sensitive":[252],"graphene":[253],"protected":[254],"copper":[255],"surface":[256],"plasmon":[257],"resonance":[258],"method.":[259],"obtained":[261],"limit":[263],"buffer":[265],"~0.5":[267],"fg/mL,":[268],"which":[269],"several":[271],"orders":[272],"magnitude":[274],"better":[275],"than":[276],"reported":[277],"conventional":[279],"methods.":[280],"label-free":[286],"paves":[291],"way":[293],"future":[295],"biosensing":[296],"applications.":[297],"evident":[300],"contribution":[301],"without":[315],"any":[316],"cross-reactivity":[317],"with":[318,334],"other":[319,353,357],"structurally":[320],"related":[321],"mycotoxins.":[322],"This":[323],"based":[327],"on":[328,398],"antibodies,":[331],"platforms":[338],"Similar":[342],"technology":[343],"can":[344],"be":[345],"adapted":[346],"also":[351],"mycotoxins":[354],"small":[358],"molecules,":[359],"general.;":[361],"Homesienten":[362],"tuottamat":[363],"homemyrkyt,":[364],"mykotoksiinit,":[365],"ovat":[366,390],"tarkeimpia":[367],"maataloustuotteiden":[368],"pilaajia.":[369],"Mykotoksiinit":[370,389],"aiheuttavat":[371],"vuosittain":[372],"merkittavia":[373],"sadon":[374],"menetyksia":[375],"maailmanlaajuisesti,":[376],"seka":[377],"erilaisia":[378],"haitallisia":[379],"terveysvaikutuksia":[380],"saastunutta":[381],"ruokaa":[382],"tai":[383],"rehua":[384],"syoville":[385],"ihmisille":[386],"ja":[387,393,396],"elaimille.":[388],"maailmanlaajuinen":[391],"ongelma":[392],"niiden":[394],"maarittaminen":[395],"kontrollointi":[397],"yha":[399],"tarkeampaa.":[400],"\nMykotoksiinien":[401],"maarittamiseen":[402],"kehitettyjen":[403],"pikamenetelmien":[404],"parantamiseksi":[405],"tarvitaan":[406],"uusia":[407],"ratkaisuja,":[408],"jotta":[409],"suuret":[410],"maarat":[411],"ruoan":[412],"tuotantoon":[413],"kaytettavasta":[414],"materiaalista":[415],"voidaan":[416],"analysoida":[417],"tehokkaasti":[418],"ja\u2026":[419]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2021-03-01T00:00:00"}