{"id":"https://openalex.org/W3133055995","doi":"https://doi.org/10.1021/acs.molpharmaceut.0c00694","title":"Nanomedicine for Drug Delivery throughout the Alimentary Canal","display_name":"Nanomedicine for Drug Delivery throughout the Alimentary Canal","publication_year":2021,"publication_date":"2021-02-19","ids":{"openalex":"https://openalex.org/W3133055995","doi":"https://doi.org/10.1021/acs.molpharmaceut.0c00694","mag":"3133055995","pmid":"https://pubmed.ncbi.nlm.nih.gov/33605146"},"language":"en","primary_location":{"id":"doi:10.1021/acs.molpharmaceut.0c00694","doi":"https://doi.org/10.1021/acs.molpharmaceut.0c00694","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.molpharmaceut.0c00694","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047067802","display_name":"Brianna Cote","orcid":"https://orcid.org/0000-0001-5434-4288","observed_orcids":["https://orcid.org/0000-0001-5434-4288"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brianna Cote","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 S. Moody Avenue, RLSB, Portland, Oregon 97201, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 S. Moody Avenue, RLSB, Portland, Oregon 97201, United States","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008709380","display_name":"Deepa A. Rao","orcid":"https://orcid.org/0000-0001-9951-9221","observed_orcids":["https://orcid.org/0000-0001-9951-9221"]},"institutions":[{"id":"https://openalex.org/I108541056","display_name":"Pacific University Oregon","ror":"https://ror.org/03g873n36","country_code":"US","type":"education","lineage":["https://openalex.org/I108541056"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepa Rao","raw_affiliation_strings":["School of Pharmacy, Pacific University, 222 SE 8th Avenue, Suite 451, Hillsboro, Oregon 97123, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Pacific University, 222 SE 8th Avenue, Suite 451, Hillsboro, Oregon 97123, United States","institution_ids":["https://openalex.org/I108541056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073688663","display_name":"Adam W. G. Alani","orcid":"https://orcid.org/0000-0002-9214-9317","observed_orcids":["https://orcid.org/0000-0002-9214-9317"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4390039369","display_name":"OHSU Knight Cancer Institute","ror":"https://ror.org/002shna07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adam W. G. Alani","raw_affiliation_strings":["Biomedical Engineering Department, Oregon Health & Science University, 2730 S. Moody Avenue, RLSB, Portland, Oregon 97201, United States","Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 S. Moody Avenue, RLSB, Portland, Oregon 97201, United States","Knight Cancer Institute, Oregon Health & Science University, 2730 S. Moody Avenue, RLSB, Portland, Oregon 97201, United States"],"raw_orcid":"https://orcid.org/0000-0002-9214-9317","affiliations":[{"raw_affiliation_string":"Biomedical Engineering Department, Oregon Health & Science University, 2730 S. Moody Avenue, RLSB, Portland, Oregon 97201, United States","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 2730 S. Moody Avenue, RLSB, Portland, Oregon 97201, United States","institution_ids":["https://openalex.org/I131249849"]},{"raw_affiliation_string":"Knight Cancer Institute, Oregon Health & Science University, 2730 S. Moody Avenue, RLSB, Portland, Oregon 97201, United States","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5073688663"],"corresponding_institution_ids":["https://openalex.org/I131249849","https://openalex.org/I165690674","https://openalex.org/I4390039369"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.4416,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.34795322,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"19","issue":"8","first_page":"2690","last_page":"2711"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.4912000000476837,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.4912000000476837,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.25850000977516174,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.2159000039100647,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.984000027179718},{"id":"https://openalex.org/keywords/oral-drug-delivery","display_name":"oral drug delivery","score":0.7860000133514404},{"id":"https://openalex.org/keywords/gastrointestinal-tract","display_name":"gastrointestinal tract","score":0.6380000114440918},{"id":"https://openalex.org/keywords/enteric-drug-delivery","display_name":"enteric drug delivery","score":0.6510000228881836},{"id":"https://openalex.org/keywords/buccal-drug-delivery","display_name":"buccal drug delivery","score":0.9110000133514404},{"id":"https://openalex.org/keywords/sublingual-drug-delivery","display_name":"sublingual drug delivery","score":0.9929999709129333},{"id":"https://openalex.org/keywords/gastric-drug-delivery","display_name":"gastric drug delivery","score":0.7590000033378601},{"id":"https://openalex.org/keywords/nanotherapeutics","display_name":"nanotherapeutics","score":0.7059999704360962},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.8180645704269409},{"id":"https://openalex.org/C2993106767","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Alimentary tract","level":2,"score":0.7612992525100708},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6797801852226257},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.659212589263916},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.45560091733932495},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39735913276672363},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21526017785072327},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.21453773975372314},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050997","descriptor_name":"Nanomedicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.molpharmaceut.0c00694","doi":"https://doi.org/10.1021/acs.molpharmaceut.0c00694","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.molpharmaceut.0c00694","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:33605146","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33605146","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmaceutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308528","display_name":"American Foundation for Pharmaceutical Education","ror":"https://ror.org/006dn3r34"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":103,"referenced_works":["https://openalex.org/W1966631624","https://openalex.org/W2013703844","https://openalex.org/W2035297692","https://openalex.org/W2057107904","https://openalex.org/W2062977057","https://openalex.org/W2086806820","https://openalex.org/W2104882286","https://openalex.org/W2114949163","https://openalex.org/W2211540712","https://openalex.org/W2271588916","https://openalex.org/W2408580586","https://openalex.org/W2518431240","https://openalex.org/W2531834066","https://openalex.org/W2545238138","https://openalex.org/W2560698385","https://openalex.org/W2567873580","https://openalex.org/W2581002215","https://openalex.org/W2589033390","https://openalex.org/W2590678484","https://openalex.org/W2593814487","https://openalex.org/W2593897649","https://openalex.org/W2597832334","https://openalex.org/W2606132289","https://openalex.org/W2607888492","https://openalex.org/W2608226129","https://openalex.org/W2608319900","https://openalex.org/W2611567783","https://openalex.org/W2623488283","https://openalex.org/W2668780319","https://openalex.org/W2735795365","https://openalex.org/W2738224943","https://openalex.org/W2744576413","https://openalex.org/W2744972203","https://openalex.org/W2750604688","https://openalex.org/W2751824458","https://openalex.org/W2753926918","https://openalex.org/W2755247557","https://openalex.org/W2762901260","https://openalex.org/W2766245658","https://openalex.org/W2768226653","https://openalex.org/W2769924941","https://openalex.org/W2770670771","https://openalex.org/W2772974777","https://openalex.org/W2774003697","https://openalex.org/W2774817394","https://openalex.org/W2783353562","https://openalex.org/W2783711237","https://openalex.org/W2789525274","https://openalex.org/W2789799389","https://openalex.org/W2790702868","https://openalex.org/W2791027356","https://openalex.org/W2791916147","https://openalex.org/W2791979595","https://openalex.org/W2793650926","https://openalex.org/W2794238998","https://openalex.org/W2794335390","https://openalex.org/W2794907478","https://openalex.org/W2796352776","https://openalex.org/W2800003355","https://openalex.org/W2801182520","https://openalex.org/W2801616937","https://openalex.org/W2803343415","https://openalex.org/W2803835693","https://openalex.org/W2809867968","https://openalex.org/W2810237334","https://openalex.org/W2879220906","https://openalex.org/W2883362043","https://openalex.org/W2885749073","https://openalex.org/W2887016530","https://openalex.org/W2887366202","https://openalex.org/W2887855309","https://openalex.org/W2888188773","https://openalex.org/W2888210862","https://openalex.org/W2890545592","https://openalex.org/W2892320819","https://openalex.org/W2892330315","https://openalex.org/W2893042312","https://openalex.org/W2896282353","https://openalex.org/W2898657245","https://openalex.org/W2900147759","https://openalex.org/W2900487804","https://openalex.org/W2904572694","https://openalex.org/W2904932300","https://openalex.org/W2907152970","https://openalex.org/W2911762231","https://openalex.org/W2912211938","https://openalex.org/W2913420245","https://openalex.org/W2915022716","https://openalex.org/W2915122805","https://openalex.org/W2916790242","https://openalex.org/W2923626186","https://openalex.org/W2932670353","https://openalex.org/W2942762534","https://openalex.org/W2943672989","https://openalex.org/W2943738752","https://openalex.org/W2944558394","https://openalex.org/W2945605919","https://openalex.org/W2946636651","https://openalex.org/W2947453152","https://openalex.org/W2950603814","https://openalex.org/W2961377254","https://openalex.org/W2980281329","https://openalex.org/W3145762328"],"related_works":["https://openalex.org/W7000396434","https://openalex.org/W3000654597","https://openalex.org/W2601743358","https://openalex.org/W3022444210","https://openalex.org/W7165468058","https://openalex.org/W2765222644","https://openalex.org/W3042183592","https://openalex.org/W7118639387","https://openalex.org/W4220738944","https://openalex.org/W2982433888"],"abstract_inverted_index":{"The":[0,124],"field":[1],"of":[2,24,29,73,91,101,105,120,126],"nanomedicine":[3,50,82],"continues":[4],"to":[5],"grow":[6],"with":[7],"new":[8,79],"technologies":[9],"and":[10,77,116,135],"formulations":[11,35],"in":[12,36,81,83,140],"development":[13,37,139],"for":[14,27,46,55,137],"several":[15,34],"disease":[16,85],"states.":[17],"Much":[18],"research":[19,80,95],"focuses":[20],"on":[21,98],"the":[22,64,74,99,102,110,121,141],"use":[23,39],"injectable":[25],"nanomedicines":[26],"treatment":[28],"neoplasms;":[30],"however,":[31],"there":[32],"are":[33,129],"that":[38,41],"nanotechnology":[40],"can":[42],"be":[43],"administered":[44],"enterally":[45],"noncancer":[47,84],"indications.":[48],"These":[49],"treatments":[51],"have":[52],"been":[53],"developed":[54],"systemic":[56],"drug":[57,61],"delivery":[58,62,128],"or":[59,107],"local":[60],"along":[63],"gastrointestinal":[65],"tract.":[66],"This":[67],"Review":[68],"gives":[69],"a":[70],"brief":[71],"overview":[72],"alimentary":[75,122],"canal":[76],"highlights":[78],"states":[86],"delivered":[87],"via":[88],"enteral":[89],"routes":[90],"administration.":[92],"Relevant":[93],"recent":[94],"is":[96],"summarized":[97],"basis":[100],"targeted":[103],"site":[104],"action":[106],"absorption,":[108],"including":[109],"buccal,":[111],"sublingual,":[112],"stomach,":[113],"small":[114],"intestine,":[115],"large":[117],"intestine":[118],"areas":[119],"canal.":[123],"benefits":[125],"nanodrug":[127],"discussed":[130],"as":[131,133],"well":[132],"barriers":[134],"challenges":[136],"future":[138],"field.":[142]},"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-03-01T00:00:00"}