{"id":"https://openalex.org/W3132997051","doi":null,"title":"Determination and evaluation of endocrine disrupting chemicals in urine samples of pregnant women by liquid chromatography-tandem mass spectrometry","display_name":"Determination and evaluation of endocrine disrupting chemicals in urine samples of pregnant women by liquid chromatography-tandem mass spectrometry","publication_year":2020,"publication_date":"2020-02-26","ids":{"openalex":"https://openalex.org/W3132997051","mag":"3132997051"},"language":"en","primary_location":{"id":"pmh:oai:repository.hkbu.edu.hk:etd_oa-1760","doi":null,"is_oa":false,"landing_page_url":"https://repository.hkbu.edu.hk/etd_oa/757","pdf_url":null,"source":{"id":"https://openalex.org/S4377196872","display_name":"HKBU Institutional Repository (Hong Kong Baptist University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I141568987","host_organization_name":"Hong Kong Baptist University","host_organization_lineage":["https://openalex.org/I141568987"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067154889","display_name":"Jiufeng Li","orcid":"https://orcid.org/0000-0001-9039-5082","observed_orcids":["https://orcid.org/0000-0001-9039-5082"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Li, Jiufeng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5067154889"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16516992,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endocrine-disruptors","display_name":"endocrine disruptors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/urinary-biomonitoring","display_name":"urinary biomonitoring","score":0.7839999794960022},{"id":"https://openalex.org/keywords/pregnant-women","display_name":"pregnant women","score":0.9789999723434448},{"id":"https://openalex.org/keywords/phthalate-metabolites","display_name":"phthalate metabolites","score":0.8109999895095825},{"id":"https://openalex.org/keywords/bisphenols","display_name":"bisphenols","score":0.9819999933242798},{"id":"https://openalex.org/keywords/parabens","display_name":"parabens","score":0.9850000143051147},{"id":"https://openalex.org/keywords/benzophenone","display_name":"benzophenone","score":0.9929999709129333},{"id":"https://openalex.org/keywords/triclosan","display_name":"triclosan","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bisphenol-a","display_name":"bisphenol A","score":0.7459999918937683},{"id":"https://openalex.org/keywords/monobenzyl-phthalate","display_name":"monobenzyl phthalate","score":0.7979999780654907},{"id":"https://openalex.org/keywords/exposure-patterns","display_name":"exposure patterns","score":0.36000001430511475},{"id":"https://openalex.org/keywords/trimester-specific-exposure","display_name":"trimester-specific exposure","score":0.7300000190734863},{"id":"https://openalex.org/keywords/health-risk-assessment","display_name":"health risk assessment","score":0.7229999899864197},{"id":"https://openalex.org/keywords/prenatal-exposure","display_name":"prenatal exposure","score":0.5170000195503235},{"id":"https://openalex.org/keywords/wuhan","display_name":"Wuhan","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7554758787155151},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.6556127071380615},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6322639584541321},{"id":"https://openalex.org/C64489805","wikidata":"https://www.wikidata.org/wiki/Q873864","display_name":"Liquid chromatography\u2013mass spectrometry","level":3,"score":0.5595118999481201},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.558214545249939},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5432291626930237},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.417178750038147},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.3465667963027954},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.14604094624519348},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06308141350746155}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:repository.hkbu.edu.hk:etd_oa-1760","doi":null,"is_oa":false,"landing_page_url":"https://repository.hkbu.edu.hk/etd_oa/757","pdf_url":null,"source":{"id":"https://openalex.org/S4377196872","display_name":"HKBU Institutional Repository (Hong Kong Baptist University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I141568987","host_organization_name":"Hong Kong Baptist University","host_organization_lineage":["https://openalex.org/I141568987"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Theses and Dissertations","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7202175026","https://openalex.org/W4408858005","https://openalex.org/W2395861701","https://openalex.org/W4406715922","https://openalex.org/W2357560817","https://openalex.org/W2911550749","https://openalex.org/W4390875686","https://openalex.org/W7015358041","https://openalex.org/W4323767247","https://openalex.org/W3123123587"],"abstract_inverted_index":{"Endocrine":[0],"disrupting":[1],"chemicals":[2],"(EDCs)":[3],"are":[4,1191],"emerging":[5],"contaminants":[6],"that":[7,41,295,335,390,418,522,580,644,678,710,748,950,1059,1145,1163],"can":[8],"interfere":[9],"with":[10,104,218,512,532,555,620,652,813,829,839,914,1076,1128],"the":[11,34,150,231,236,261,308,318,323,379,437,445,487,492,516,559,567,581,593,604,621,645,671,695,714,724,792,865,869,885,906,909,921,926,932,953,1034,1077,1091,1102,1109,1122,1164],"hormone":[12],"system":[13,22],"and":[14,20,28,53,60,92,132,146,155,165,228,249,279,385,388,425,429,449,459,477,508,528,549,569,614,628,670,717,726,737,743,785,819,843,851,916,925,946,962,984,986,1023,1031,1041,1045,1054,1082,1095,1116,1130,1133,1140,1154,1186],"may":[15,681,1089],"cause":[16],"cancers,":[17],"birth":[18,735,783,786,797,814,831,890],"defects":[19],"reproductive":[21],"disorders.":[23],"Prevalence":[24],"of":[25,48,81,120,158,239,242,263,298,325,337,352,365,383,393,421,440,447,465,472,572,606,617,623,647,667,673,729,872,911,923,936,956,960,964,981,1012,1048,1084,1104,1112,1166,1181,1189],"endocrine-related":[26],"dysfunction":[27],"disease":[29],"has":[30],"increased":[31,696,830,893,987,1078,1155],"steadily":[32],"over":[33,245,255,292,479,535],"past":[35],"decades.":[36],"Although":[37],"accumulating":[38],"data":[39,1057],"suggest":[40,1162],"these":[42,171,1049],"diseases":[43],"have":[44,62],"fetal":[45,733,758,781,887,1105],"origins,":[46],"associations":[47,446,540,663,910],"EDC":[49,314],"exposure":[50,153,297,315,345,608,619,680,731,874,913,1035,1037,1067,1073,1088,1147],"during":[51],"pregnancy":[52],"adverse":[54],"health":[55,156,310,341,381,403,595,1043,1046,1063],"effects":[56,439,571,605,728,1047],"on":[57,149,161,322,574,611,635,732,1051,1114],"both":[58,612],"mothers":[59,511,531,554,613],"fetuses":[61,514,534,557],"not":[63,588],"been":[64],"thoroughly":[65],"evaluated,":[66],"particularly":[67,1170],"at":[68,129,136,289,329,396,462,740,817,841,855],"multiple":[69,284],"points":[70],"in":[71,94,117,141,167,223,356,427,515,558,650,897,938,966,992,1009,1158,1172,1178],"time.":[72],"We":[73,234,258,305,376,467,601,746,948,1143],"firstly":[74],"developed":[75],"an":[76],"analytical":[77],"method":[78,110],"for":[79,686,875,1136,1193],"quantification":[80,151],"28":[82,159,1007],"EDCs":[83,160,285,1008],"(9":[84],"phthalates,":[85,1171],"8":[86],"bisphenols,":[87],"5":[88,90],"parabens,":[89],"benzophenones":[91,248],"triclosan)":[93],"urine":[95,122,1014],"samples":[96,123,1015],"using":[97,277,944],"ultra":[98],"high":[99,363],"performance":[100],"liquid":[101],"chromatography":[102],"coupled":[103],"triple":[105],"quadrupole":[106],"mass":[107,772],"spectrometer.":[108],"The":[109,349,562],"was":[111,333,642,754,777,804,827,836,858,952,1074],"applied":[112,1131],"to":[113,346,361,474,544,591,609,694,757,769,780,791,798,884,999,1068],"measure":[114],"targeted":[115,264],"compounds":[116,265,1050],"a":[118,252,362,636,683,1010],"total":[119,1011],"5220":[121,1013],"collected":[124],"from":[125,796],"951":[126,1018],"pregnant":[127,134,1019,1025,1052,1173],"women":[128,135,357,651,1020,1026,1053,1174],"three":[130,256,330,450,463,536],"trimesters":[131,140,464,480],"1501":[133,1024],"one":[137,366,409],"or":[138,372,413,1028,1070],"two":[139,1029],"Wuhan,":[142],"China":[143],"between":[144,506,526,547,664,849],"2014":[145],"2015.":[147],"Based":[148],"results,":[152],"patterns":[154,1038],"risks":[157,342,354,382,397,596,622,672,1044,1064,1083],"participants":[162,338,394,1060],"were":[163,216,230,286,300,359,395,405,485,551,632,654,675,692,882,969,990,997],"evaluated":[164,307,378,633,1033],"discussed":[166],"detail":[168],"below.":[169],"Among":[170],"samples,":[172],"bisphenol":[173,176,179,400,411],"A":[174,846],"(BPA),":[175],"S":[177],"(BPS),":[178],"F":[180],"(BPF),":[181],"methylparaben":[182],"(MeP),":[183],"ethylparaben":[184],"(EtP),":[185],"propylparaben":[186],"(PrP),":[187],"4-hydroxybenzophenone":[188],"(4-OH-BP),":[189],"2,4-dihydroxybenzophenone":[190],"(BP-1),":[191],"2-hydroxy-4-methoxybenzophenone":[192],"(BP-3),":[193],"triclosan,":[194],"mono(2-ethylhexyl)":[195,204],"phthalate":[196,199,202,205,208,211,214,243,347,370,374,618,648,668,679,690],"(MEHP),":[197],"mono(2-ethyl-5-carboxypentyl)":[198],"(MECPP),":[200],"mono(2-ethyl-5-oxohexyl)":[201],"(MEOHP),":[203],"(MEHHP),":[206],"monobenzyl":[207],"(MBzP),":[209],"mono-n-butyl":[210],"(MnBP),":[212],"monoisobutyl":[213],"(MiBP)":[215],"determined":[217,288],"detection":[219],"rates":[220,795,854,896],"exceeding":[221],"50%,":[222],"which":[224,996,1100],"BPA,":[225,441],"BP-3,":[226],"MeP":[227],"MnBP":[229],"predominant":[232],"compounds.":[233],"found":[235,260,334,389,496,521,643,747,949,1144],"U-shaped":[237],"trends":[238],"urinary":[240,327,665],"concentrations":[241,328,484,666],"metabolites":[244,649,669],"trimesters.":[246,331,537],"Parabens,":[247],"triclosan":[250],"displayed":[251],"downward":[253],"trend":[254],"visits.":[257],"also":[259,377,578],"levels":[262,631,646,691,699,881,1081],"varied":[266],"by":[267,302,313,344,399,408,598,930,1017,1066],"exposure-related":[268],"factors,":[269],"such":[270],"as":[271],"sampling":[272],"seasons,":[273],"physical":[274],"activities,":[275],"computer":[276],"time":[278],"decoration":[280],"information.":[281],"In":[282,491,688,1002],"addition,":[283,689],"mostly":[287],"low":[290],"doses":[291],"trimesters,":[293],"indicating":[294,677],"real-world":[296],"pollutants":[299],"dominated":[301],"low-dose":[303,438],"mixtures.":[304,348],"then":[306,1032],"combined":[309],"hazards":[311,404],"induced":[312,398,597,929,1065],"via":[316],"calculating":[317],"estimated":[319],"daily":[320,584],"intakes":[321],"basis":[324],"average":[326],"It":[332,641],"24.9%":[336],"had":[339,1061],"potential":[340,594,1062,1138],"caused":[343,1151],"most":[350],"frequency":[351],"cumulative":[353,380],"occurred":[355],"who":[358],"exposed":[360,1121],"dose":[364],"specific":[367,410],"phthalate,":[368],"di-n-butyl":[369],"(DnBP)":[371],"di(2-ethylhexyl)":[373],"(DEHP).":[375],"BPA":[384,424,448,473,483,507,527,548,573,599,1190],"its":[386],"alternatives":[387],"about":[391],"1.6%":[392],"exposure.":[401,600,973],"Combined":[402],"mainly":[406],"driven":[407],"(BPS":[412],"BPA).":[414],"Our":[415,576,707,862,1056],"findings":[416,565,577,708,863,1161],"suggested":[417,566,709,1058],"regional":[419],"interventions":[420],"DnBP,":[422],"DEHP,":[423,937],"BPS":[426,1182],"application":[428],"production":[430],"should":[431,1175,1183],"be":[432,682,1176,1184],"tighten":[433],"and/or":[434],"taken.":[435],"Considering":[436],"we":[442,495,520,722,919,1005,1120],"further":[443],"investigated":[444,603,920],"major":[451,954],"natural":[452],"estrogens,":[453],"including":[454],"estrone":[455],"(E1),":[456],"estradiol":[457],"(E2)":[458],"estriol":[460],"(E3),":[461],"pregnancy.":[466],"observed":[468,552],"non-monotonic":[469,539],"dose-response":[470],"relationships":[471,499],"E1,":[475],"E2":[476,509,529],"E3":[478,550],"even":[481],"when":[482],"below":[486],"current":[488,582],"safety":[489],"thresholds.":[490],"gender-stratified":[493],"models,":[494],"significant":[497,524,542],"negative":[498,543,847],"(\u03b2":[500,760,806],"<":[501,504,761,764,810],"0,":[502,762,808],"p":[503,763,809],"0.05)":[505,811],"among":[510,530,553,749,823,860,901,1098],"male":[513,750,902],"first":[517],"trimester.":[518,561],"However,":[519,822],"no":[523],"relationship":[525],"female":[533,556],"Significant":[538],"(from":[541],"positive":[545,662],"associations)":[546],"second":[560,866],"above":[563],"mentioned":[564],"gender-specific":[568,727],"trimester-specific":[570,725],"estrogens.":[575],"indicated":[579,864],"tolerance":[583,705],"intake":[585],"value":[586],"maybe":[587,868],"safe":[589],"enough":[590],"evaluate":[592],"next":[602],"maternal":[607],"phthalates":[610,711,1069],"fetuses.":[615,1055],"Associations":[616],"gestational":[624],"diabetes":[625],"mellitus":[626],"(GDM)":[627],"plasma":[629,697,1079],"glucose":[630,698,704,715,915,961,965,1080,1115,1149],"based":[634],"nested":[637],"case-control":[638],"study":[639],"design.":[640],"GDM":[653,674,719],"significantly":[655],"higher":[656],"than":[657],"those":[658],"without":[659],"GDM.":[660,687,1085],"Meanwhile,":[661],"obvious,":[676],"risk":[684],"factor":[685],"related":[693,756,768,779,790,883,998,1075],"after":[700,971],"75":[701],"g":[702],"oral":[703],"test.":[706],"might":[712],"disturb":[713],"homeostasis":[716],"increase":[718],"risks.":[720],"Furthermore,":[721],"assessed":[723],"DEHP":[730,753,776,803,826,835,850,873,880,912,924,1087],"growth,":[734,782,888],"size":[736],"postnatal":[738],"growth":[739,759,877,1093,1097],"6,":[741],"12":[742,799,820,844],"24":[744],"months.":[745,821,845],"offspring,":[751],"1st-trimester":[752,825],"negatively":[755,778,837],"0.05),":[765],"but":[766,788,892],"positively":[767,789,805],"24-month":[770],"body":[771],"index":[773],"(BMI).":[774],"2nd-trimester":[775,834,879],"weight":[784,793,852,894],"length,":[787,832],"gain":[794,853,895],"months":[800,857],"old.":[801],"3rd-trimester":[802],">":[807],"associated":[812,828,838],"weight,":[815],"BMI":[816,840],"6":[818,842,856],"females,":[824],"while":[833],"association":[848],"noted":[859,991],"females.":[861],"trimester":[867],"sensitive":[870],"window":[871],"offspring":[876],"since":[878],"decreased":[886,889],"size,":[891],"early":[898],"childhood":[899],"age":[900],"offspring.":[903],"To":[904,1107],"investigate":[905],"mechanism":[907],"underlying":[908,1110],"lipid":[917,1117],"metabolism,":[918],"biotransformation":[922],"disturbed":[927,1141],"metabolisms":[928],"MEHP,":[931,1129],"putative":[933],"toxic":[934],"metabolite":[935,955],"human":[939,1123],"normal":[940,1124],"liver":[941,967],"cell":[942],"L02":[943,994,1126],"metabolomics":[945],"lipidomics.":[947],"MEHP":[951,972,1113,1146],"DEHP.":[957],"Decreased":[958],"uptake":[959],"accumulation":[963],"cells":[968,1127],"obvious":[970],"Phospholipid":[974],"remodeling,":[975],"incomplete":[976],"fatty":[977],"acid":[978],"\u03b2-oxidation,":[979],"inhibition":[980],"purine":[982],"metabolism":[983],"glycolysis,":[985],"oxidative":[988,1156],"stress":[989,1157],"MEHP-exposed":[993],"cells,":[995],"insulin":[1000],"resistance.":[1001],"this":[1003],"work,":[1004],"measured":[1006],"provided":[1016],"(three":[1021],"trimesters)":[1022,1030],"(one":[1027],"levels,":[1036],"(variations,":[1039],"variability":[1040],"correlations),":[1042],"bisphenols.":[1071],"Phthalate":[1072],"Prenatal":[1086],"induce":[1090],"intrauterine":[1092],"restriction":[1094],"catch-up":[1096],"males,":[1099],"supported":[1101],"evidence":[1103],"origin.":[1106],"explore":[1108],"mechanisms":[1111],"metabolic":[1118],"disorders,":[1119],"hepatic":[1125],"metabolomic":[1132],"lipidomic":[1134],"approaches":[1135],"finding":[1137],"biomarkers":[1139],"pathways.":[1142],"inhibited":[1148],"uptake,":[1150],"phospholipid":[1152],"remodeling":[1153],"L02.":[1159],"These":[1160],"usage":[1165],"products":[1167],"containing":[1168],"EDCs,":[1169],"limited":[1177],"China,":[1179],"intervention":[1180],"considered,":[1185],"threshold":[1187],"values":[1188],"called":[1192],"reevaluation.":[1194]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-10-10T00:00:00"}