{"id":"https://openalex.org/W3132941844","doi":"https://doi.org/10.30970/vlubs.2020.83.01","title":"Von Willebrand factor: structure, properties and role in the process of hemostasis","display_name":"Von Willebrand factor: structure, properties and role in the process of hemostasis","publication_year":2020,"publication_date":"2020-12-25","ids":{"openalex":"https://openalex.org/W3132941844","doi":"https://doi.org/10.30970/vlubs.2020.83.01","mag":"3132941844"},"language":"en","primary_location":{"id":"doi:10.30970/vlubs.2020.83.01","doi":"https://doi.org/10.30970/vlubs.2020.83.01","is_oa":true,"landing_page_url":"https://doi.org/10.30970/vlubs.2020.83.01","pdf_url":"http://publications.lnu.edu.ua/bulletins/index.php/biology/article/download/11078/11368","source":{"id":"https://openalex.org/S4210229824","display_name":"Visnyk of Lviv University Biological series","issn_l":"0206-5657","issn":["0206-5657","2075-5236"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320811","host_organization_name":"\u0412\u0438\u0434\u0430\u0432\u043d\u0438\u0447\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u041b\u044c\u0432\u0456\u0432\u0441\u044c\u043a\u043e\u0433\u043e \u043d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0443 \u0456\u043c\u0435\u043d\u0456 \u0406\u0432\u0430\u043d\u0430 \u0424\u0440\u0430\u043d\u043a\u0430","host_organization_lineage":["https://openalex.org/P4310320811","https://openalex.org/P4383735918"],"host_organization_lineage_names":["\u0412\u0438\u0434\u0430\u0432\u043d\u0438\u0447\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u041b\u044c\u0432\u0456\u0432\u0441\u044c\u043a\u043e\u0433\u043e \u043d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0443 \u0456\u043c\u0435\u043d\u0456 \u0406\u0432\u0430\u043d\u0430 \u0424\u0440\u0430\u043d\u043a\u0430","Lviv University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Visnyk of Lviv University. Biological series","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://publications.lnu.edu.ua/bulletins/index.php/biology/article/download/11078/11368","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002061197","display_name":"N. Shurko","orcid":"https://orcid.org/0000-0003-3224-8679","observed_orcids":["https://orcid.org/0000-0003-3224-8679"]},"institutions":[{"id":"https://openalex.org/I4210109983","display_name":"Institute of Blood Pathology and Transfusion Medicine of the National Academy of Medical Sciences of Ukraine","ror":"https://ror.org/017wx6w12","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210109983","https://openalex.org/I4210144782"]}],"countries":["UA"],"is_corresponding":true,"raw_author_name":"N Shurko","raw_affiliation_strings":["\u0414\u0423 \u00ab\u0406\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0456\u0457 \u043a\u0440\u043e\u0432\u0456 \u0442\u0430 \u0442\u0440\u0430\u043d\u0441\u0444\u0443\u0437\u0456\u0439\u043d\u043e\u0457 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0438 \u041d\u0410\u041c\u041d \u0423\u043a\u0440\u0430\u0457\u043d\u0438\u00bb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0414\u0423 \u00ab\u0406\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0456\u0457 \u043a\u0440\u043e\u0432\u0456 \u0442\u0430 \u0442\u0440\u0430\u043d\u0441\u0444\u0443\u0437\u0456\u0439\u043d\u043e\u0457 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0438 \u041d\u0410\u041c\u041d \u0423\u043a\u0440\u0430\u0457\u043d\u0438\u00bb","institution_ids":["https://openalex.org/I4210109983"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002061197"],"corresponding_institution_ids":["https://openalex.org/I4210109983"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"83","first_page":"3","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/von-willebrand-disease","display_name":"von Willebrand disease","score":0.9319999814033508},{"id":"https://openalex.org/keywords/factor-viii","display_name":"factor VIII","score":0.5770000219345093},{"id":"https://openalex.org/keywords/platelet-adhesion","display_name":"platelet adhesion","score":0.9649999737739563},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.6029999852180481},{"id":"https://openalex.org/keywords/vwf-gene","display_name":"VWF gene","score":0.5709999799728394},{"id":"https://openalex.org/keywords/weibel-palade-bodies","display_name":"Weibel-Palade bodies","score":0.8009999990463257},{"id":"https://openalex.org/keywords/alpha-granules","display_name":"alpha-granules","score":0.7609999775886536},{"id":"https://openalex.org/keywords/bleeding-disorders","display_name":"bleeding disorders","score":0.5040000081062317},{"id":"https://openalex.org/keywords/von-willebrand-factor-inhibitor","display_name":"von Willebrand factor inhibitor","score":0.609000027179718},{"id":"https://openalex.org/keywords/von-willebrand-factor-receptor","display_name":"von Willebrand factor receptor","score":0.5509999990463257},{"id":"https://openalex.org/keywords/von-willebrand-factor-cleavage","display_name":"von Willebrand factor cleavage","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.9350156784057617},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.7454097867012024},{"id":"https://openalex.org/C2778780528","wikidata":"https://www.wikidata.org/wiki/Q709360","display_name":"Von Willebrand disease","level":4,"score":0.7303685545921326},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7017408013343811},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.6127060055732727},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5347456336021423},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5292669534683228},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.4449559450149536},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43996939063072205},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28400129079818726},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2517096698284149},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24987441301345825},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24387696385383606},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16956210136413574}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.30970/vlubs.2020.83.01","doi":"https://doi.org/10.30970/vlubs.2020.83.01","is_oa":true,"landing_page_url":"https://doi.org/10.30970/vlubs.2020.83.01","pdf_url":"http://publications.lnu.edu.ua/bulletins/index.php/biology/article/download/11078/11368","source":{"id":"https://openalex.org/S4210229824","display_name":"Visnyk of Lviv University Biological series","issn_l":"0206-5657","issn":["0206-5657","2075-5236"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320811","host_organization_name":"\u0412\u0438\u0434\u0430\u0432\u043d\u0438\u0447\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u041b\u044c\u0432\u0456\u0432\u0441\u044c\u043a\u043e\u0433\u043e \u043d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0443 \u0456\u043c\u0435\u043d\u0456 \u0406\u0432\u0430\u043d\u0430 \u0424\u0440\u0430\u043d\u043a\u0430","host_organization_lineage":["https://openalex.org/P4310320811","https://openalex.org/P4383735918"],"host_organization_lineage_names":["\u0412\u0438\u0434\u0430\u0432\u043d\u0438\u0447\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u041b\u044c\u0432\u0456\u0432\u0441\u044c\u043a\u043e\u0433\u043e \u043d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0443 \u0456\u043c\u0435\u043d\u0456 \u0406\u0432\u0430\u043d\u0430 \u0424\u0440\u0430\u043d\u043a\u0430","Lviv University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Visnyk of Lviv University. Biological series","raw_type":"journal-article"},{"id":"pmh:oai:ojs.www1.lnu.edu.ua:article/11078","doi":null,"is_oa":true,"landing_page_url":"https://ojstest.lnu.edu.ua/bulletins/index.php/biology/article/view/11078","pdf_url":"https://ojstest.lnu.edu.ua/bulletins/index.php/biology/article/download/11078/11368","source":{"id":"https://openalex.org/S4210229824","display_name":"Visnyk of Lviv University Biological series","issn_l":"0206-5657","issn":["0206-5657","2075-5236"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320811","host_organization_name":"\u0412\u0438\u0434\u0430\u0432\u043d\u0438\u0447\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u041b\u044c\u0432\u0456\u0432\u0441\u044c\u043a\u043e\u0433\u043e \u043d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0443 \u0456\u043c\u0435\u043d\u0456 \u0406\u0432\u0430\u043d\u0430 \u0424\u0440\u0430\u043d\u043a\u0430","host_organization_lineage":["https://openalex.org/P4310320811","https://openalex.org/P4383735918"],"host_organization_lineage_names":["\u0412\u0438\u0434\u0430\u0432\u043d\u0438\u0447\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u041b\u044c\u0432\u0456\u0432\u0441\u044c\u043a\u043e\u0433\u043e \u043d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0443 \u0456\u043c\u0435\u043d\u0456 \u0406\u0432\u0430\u043d\u0430 \u0424\u0440\u0430\u043d\u043a\u0430","Lviv University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0206-5657","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.30970/vlubs.2020.83.01","doi":"https://doi.org/10.30970/vlubs.2020.83.01","is_oa":true,"landing_page_url":"https://doi.org/10.30970/vlubs.2020.83.01","pdf_url":"http://publications.lnu.edu.ua/bulletins/index.php/biology/article/download/11078/11368","source":{"id":"https://openalex.org/S4210229824","display_name":"Visnyk of Lviv University Biological series","issn_l":"0206-5657","issn":["0206-5657","2075-5236"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320811","host_organization_name":"\u0412\u0438\u0434\u0430\u0432\u043d\u0438\u0447\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u041b\u044c\u0432\u0456\u0432\u0441\u044c\u043a\u043e\u0433\u043e \u043d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0443 \u0456\u043c\u0435\u043d\u0456 \u0406\u0432\u0430\u043d\u0430 \u0424\u0440\u0430\u043d\u043a\u0430","host_organization_lineage":["https://openalex.org/P4310320811","https://openalex.org/P4383735918"],"host_organization_lineage_names":["\u0412\u0438\u0434\u0430\u0432\u043d\u0438\u0447\u0438\u0439 \u0446\u0435\u043d\u0442\u0440 \u041b\u044c\u0432\u0456\u0432\u0441\u044c\u043a\u043e\u0433\u043e \u043d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0443 \u0456\u043c\u0435\u043d\u0456 \u0406\u0432\u0430\u043d\u0430 \u0424\u0440\u0430\u043d\u043a\u0430","Lviv University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Visnyk of Lviv University. Biological series","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3132941844.pdf","grobid_xml":"https://content.openalex.org/works/W3132941844.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W81902193","https://openalex.org/W1548784534","https://openalex.org/W1570269678","https://openalex.org/W1587717751","https://openalex.org/W1604340849","https://openalex.org/W1721634089","https://openalex.org/W1968420972","https://openalex.org/W1973183155","https://openalex.org/W1980884659","https://openalex.org/W1980914901","https://openalex.org/W1981909070","https://openalex.org/W1985726492","https://openalex.org/W2015643243","https://openalex.org/W2020357852","https://openalex.org/W2044157702","https://openalex.org/W2045819100","https://openalex.org/W2050360907","https://openalex.org/W2050370340","https://openalex.org/W2059500112","https://openalex.org/W2060209523","https://openalex.org/W2063042883","https://openalex.org/W2082024945","https://openalex.org/W2082573795","https://openalex.org/W2092695069","https://openalex.org/W2121859722","https://openalex.org/W2132961751","https://openalex.org/W2134923719","https://openalex.org/W2324161651","https://openalex.org/W2549291642","https://openalex.org/W2588981592","https://openalex.org/W2791456875","https://openalex.org/W2806537341","https://openalex.org/W2908583823","https://openalex.org/W2923139412","https://openalex.org/W2928595966","https://openalex.org/W2953351741","https://openalex.org/W2994577528","https://openalex.org/W3003944425","https://openalex.org/W3007050672","https://openalex.org/W3007052876","https://openalex.org/W3015863623","https://openalex.org/W3017293186","https://openalex.org/W3084060684","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2546730454","https://openalex.org/W3193544905","https://openalex.org/W1928894857","https://openalex.org/W1880636970","https://openalex.org/W2071254360","https://openalex.org/W810557107","https://openalex.org/W245650691","https://openalex.org/W2130765810","https://openalex.org/W1560751680","https://openalex.org/W4229526059"],"abstract_inverted_index":{"The":[0,18,60,162,196,211,226,251,342],"article":[1],"reviews":[2],"the":[3,7,24,28,37,44,50,54,71,74,79,101,105,119,125,153,156,170,174,201,223,255,280,287,295,298,312,351,360,366,371,392,416,429,440],"scientific":[4],"papars":[5],"on":[6,169,350],"structure,":[8],"function":[9,130],"and":[10,151,180,191,207,297,420],"biological":[11],"role":[12,77],"of":[13,30,53,62,70,73,81,100,104,115,121,131,155,165,173,204,209,215,219,229,286,294,304,311,320,338,345,353,362,368,373,391,412,428,439],"von":[14,382],"Willebrand":[15,92,276,383],"factor":[16,26,55,93,139,197,374,430],"(vWF).":[17],"vWF":[19,132,166,230,313,354,364,419],"mainly":[20],"was":[21,65],"considered":[22],"as":[23,238,334],"main":[25,318],"in":[27,78,200,324,331,340],"development":[29],"bleeding":[31,390],"disorders":[32],"(von":[33],"Willebrand\u2019s":[34],"disease).":[35],"On":[36,124],"other":[38,126],"hand,":[39,127],"it":[40],"can":[41],"be":[42],"able":[43],"cause":[45,299],"thrombotic":[46,421],"complications":[47,442],"through":[48],"to":[49,56,66,83,137,144,248,292,378,399,415],"functional":[51,426],"ability":[52,427],"stimulate":[57,431],"platelet":[58,116,432],"adhesion.":[59,433],"aim":[61],"this":[63],"work":[64],"conduct":[67],"an":[68,109,335],"analysis":[69],"structure":[72,310],"factor,":[75],"its":[76,146],"process":[80],"hemostasis":[82,106,288],"determine":[84],"a":[85,95,239,243,301,329,386,409],"border":[86],"between":[87,418],"two":[88],"opposing":[89],"processes.":[90],"Von":[91,275],"is":[94,133,143,167,186,198,231,279,300,328,348,385,424],"hemostatic,":[96],"multimeric":[97,240,309],"glycoprotein,":[98],"one":[99],"key":[102],"components":[103,273],"system,":[107],"taking":[108],"active":[110],"part":[111],"at":[112,118],"startup":[113],"mechanisms":[114],"adhesion":[117],"site":[120],"vesselendothelial":[122],"damage.":[123],"another":[128],"important":[129],"co-factor":[134],"activity":[135],"related":[136],"coagulation":[138,394],"VIII":[140],"(FVIII),":[141],"which":[142,220],"stabilize":[145],"activity,":[147,333],"promoting":[148],"thrombin":[149],"activation":[150],"preventing":[152],"cleavage":[154],"molecule":[157,253],"by":[158,188,192,358,446],"blood":[159,393],"plasma":[160],"proteinases.":[161],"human":[163],"gene":[164],"localized":[168],"short":[171],"arm":[172],"12":[175],"chromosome,":[176],"contains":[177],"52":[178],"exons":[179],"covers":[181],"approximately":[182],"180":[183],"kb.":[184],"VWF":[185],"made":[187],"endothelial":[189],"cells":[190,206],"bone":[193],"marrow":[194],"megakaryocytes.":[195],"preserved":[199],"Weibel-Palade":[202],"bodies":[203],"endotolial":[205],"\u03b1-granules":[208],"platelets.":[210],"primary":[212],"pro-polypeptide":[213],"consists":[214],"2813":[216],"amino":[217],"acid,":[218],"2050":[221],"form":[222],"mature":[224],"peptide.":[225],"molecular":[227,244],"weight":[228,245],"220":[232],"kDa.":[233,250],"In":[234,376,434],"bloodstreamv":[235],"WF":[236],"circulates":[237],"protein":[241],"with":[242,403],"from":[246,397],"400":[247],"20,000":[249],"synthesized":[252],"has":[254],"next":[256],"domain":[257],"structure:":[258],"D1-D2-D\u2019-D3-A1-A2-A3-D4-C1-C2-C3-C4-C5-C6-CK.":[259],"Domains":[260],"are":[261,316,437],"responsible":[262],"for":[263],"binding":[264],"various":[265,404],"proteins,":[266],"including":[267],"FVIII,":[268],"fibrin,":[269],"collagen,":[270],"heparin,":[271],"complement":[272],"etcetra.":[274,455],"disease":[277,454],"(vWD)":[278],"most":[281],"common":[282],"autosomal":[283],"inherited":[284],"disorder":[285],"system":[289,395],"(from":[290],"0.6":[291],"2.0%":[293],"population)":[296],"genetic":[302],"deficiency":[303],"quantitative":[305],"and/or":[306,355],"qualitative":[307],"abnormal":[308],"molecule.":[314],"There":[315],"three":[317],"subtypes":[319],"vWD.":[321],"Quite":[322],"often":[323],"such":[325],"patients":[326],"there":[327,436],"decrease":[330],"FVIII":[332,356],"indirect":[336],"consequence":[337],"changes":[339],"vWF.":[341],"basic":[343],"principle":[344],"vWD":[346],"treatment":[347],"based":[349],"normalization":[352],"levels":[357],"increasing":[359],"level":[361],"external":[363],"under":[365],"action":[367],"desmopressin":[369],"or":[370],"introduction":[372],"concentrates.":[375],"contrast":[377],"hereditary":[379],"vWD,":[380],"acquired":[381,389],"syndrome":[384],"relatively":[387],"rare":[388],"(incidence":[396],"0.04":[398],"0.13":[400],"%)":[401],"associated":[402],"underlying":[405],"diseases.":[406],"For":[407],"today":[408],"significant":[410],"amount":[411],"research":[413],"devoted":[414],"relationship":[417],"complications,":[422],"that":[423],"due":[425],"particular,":[435],"reports":[438],"following":[441],"in:":[443],"pneumonia":[444],"caused":[445],"Streptococcus":[447],"pneumoniae;":[448],"COVID-19;":[449],"polycythemia":[450],"vera;":[451],"chronic":[452],"kidney":[453]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2021-03-01T00:00:00"}
