{"id":"https://openalex.org/W3132931799","doi":"https://doi.org/10.15252/embr.202051349","title":"CA10 regulates neurexin heparan sulfate addition via a direct binding in the secretory pathway","display_name":"CA10 regulates neurexin heparan sulfate addition via a direct binding in the secretory pathway","publication_year":2021,"publication_date":"2021-02-15","ids":{"openalex":"https://openalex.org/W3132931799","doi":"https://doi.org/10.15252/embr.202051349","mag":"3132931799","pmid":"https://pubmed.ncbi.nlm.nih.gov/33586859","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8024894"},"language":"en","primary_location":{"id":"doi:10.15252/embr.202051349","doi":"https://doi.org/10.15252/embr.202051349","is_oa":true,"landing_page_url":"https://doi.org/10.15252/embr.202051349","pdf_url":"https://link.springer.com/content/pdf/10.15252/embr.202051349.pdf","source":{"id":"https://openalex.org/S57252141","display_name":"EMBO Reports","issn_l":"1469-221X","issn":["1469-221X","1469-3178"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.15252/embr.202051349.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061996148","display_name":"Laia Montoliu\u2010Gaya","orcid":"https://orcid.org/0000-0001-7684-6318","observed_orcids":["https://orcid.org/0000-0001-7684-6318"]},"institutions":[{"id":"https://openalex.org/I4405272501","display_name":"Wallenberg Centre for Molecular and Translational Medicine","ror":"https://ror.org/048rhnt15","country_code":"SE","type":"facility","lineage":["https://openalex.org/I4405272501"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Laia Montoliu-Gaya","raw_affiliation_strings":["Department of Laboratory Medicine, Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-7684-6318","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I4405272501","https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030685094","display_name":"Daniel Tietze","orcid":"https://orcid.org/0000-0002-9251-1902","observed_orcids":["https://orcid.org/0000-0002-9251-1902"]},"institutions":[{"id":"https://openalex.org/I4405272501","display_name":"Wallenberg Centre for Molecular and Translational Medicine","ror":"https://ror.org/048rhnt15","country_code":"SE","type":"facility","lineage":["https://openalex.org/I4405272501"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Daniel Tietze","raw_affiliation_strings":["Department of Chemistry and Molecular Biology, Faculty of Science, University of Gothenburg, Gothenburg, Sweden","Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-9251-1902","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Molecular Biology, Faculty of Science, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I4405272501","https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052177924","display_name":"Debora Kaminski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I4405272501","display_name":"Wallenberg Centre for Molecular and Translational Medicine","ror":"https://ror.org/048rhnt15","country_code":"SE","type":"facility","lineage":["https://openalex.org/I4405272501"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Debora Kaminski","raw_affiliation_strings":["Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden","Department of Laboratory Medicine, Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden","institution_ids":["https://openalex.org/I2801112325"]},{"raw_affiliation_string":"Department of Laboratory Medicine, Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I4405272501","https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048392322","display_name":"Ekaterina E. Mirgorodskaya","orcid":"https://orcid.org/0000-0002-4519-6567","observed_orcids":["https://orcid.org/0000-0002-4519-6567"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ekaterina Mirgorodskaya","raw_affiliation_strings":["Proteomics Core Facility, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics Core Facility, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031928710","display_name":"Alesia A. Tietze","orcid":"https://orcid.org/0000-0002-9281-548X","observed_orcids":["https://orcid.org/0000-0002-9281-548X"]},"institutions":[{"id":"https://openalex.org/I4405272501","display_name":"Wallenberg Centre for Molecular and Translational Medicine","ror":"https://ror.org/048rhnt15","country_code":"SE","type":"facility","lineage":["https://openalex.org/I4405272501"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Alesia A Tietze","raw_affiliation_strings":["Department of Chemistry and Molecular Biology, Faculty of Science, University of Gothenburg, Gothenburg, Sweden","Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Molecular Biology, Faculty of Science, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I4405272501","https://openalex.org/I881427289"]}]},{"author_position":"last","author":{"id":null,"display_name":"Fredrik H Sterky","orcid":"https://orcid.org/0000-0001-8881-0523","observed_orcids":["https://orcid.org/0000-0001-8881-0523"]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I4405272501","display_name":"Wallenberg Centre for Molecular and Translational Medicine","ror":"https://ror.org/048rhnt15","country_code":"SE","type":"facility","lineage":["https://openalex.org/I4405272501"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Fredrik H Sterky","raw_affiliation_strings":["Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden","Department of Laboratory Medicine, Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-8881-0523","affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden","institution_ids":["https://openalex.org/I2801112325"]},{"raw_affiliation_string":"Department of Laboratory Medicine, Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I4405272501","https://openalex.org/I881427289"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801112325","https://openalex.org/I4405272501","https://openalex.org/I881427289"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":0.4905,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.53310392,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"22","issue":"4","first_page":"e51349","last_page":"e51349"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.3562000095844269,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.3562000095844269,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.35179999470710754,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.23559999465942383,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurexin","display_name":"neurexin","score":0.9369999766349792},{"id":"https://openalex.org/keywords/heparan-sulfate","display_name":"heparan sulfate","score":0.9850000143051147},{"id":"https://openalex.org/keywords/xylosyltransferase","display_name":"xylosyltransferase","score":0.7680000066757202},{"id":"https://openalex.org/keywords/golgi-apparatus","display_name":"Golgi apparatus","score":0.7360000014305115},{"id":"https://openalex.org/keywords/secretory-pathway","display_name":"secretory pathway","score":0.875},{"id":"https://openalex.org/keywords/site-specific-glycosylation","display_name":"site-specific glycosylation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/synaptogenesis","display_name":"synaptogenesis","score":0.8870000243186951},{"id":"https://openalex.org/keywords/ligand-binding","display_name":"ligand binding","score":0.8629999756813049},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C2778041096","wikidata":"https://www.wikidata.org/wiki/Q424668","display_name":"Heparan sulfate","level":3,"score":0.6480716466903687},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5250104069709778},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5193363428115845},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.44001099467277527},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3818136751651764},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25208616256713867},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.07575741410255432}],"mesh":[{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006497","descriptor_name":"Heparan Sulfate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019006","descriptor_name":"Neural Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055571","descriptor_name":"Secretory Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.15252/embr.202051349","doi":"https://doi.org/10.15252/embr.202051349","is_oa":true,"landing_page_url":"https://doi.org/10.15252/embr.202051349","pdf_url":"https://link.springer.com/content/pdf/10.15252/embr.202051349.pdf","source":{"id":"https://openalex.org/S57252141","display_name":"EMBO Reports","issn_l":"1469-221X","issn":["1469-221X","1469-3178"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Reports","raw_type":"journal-article"},{"id":"pmid:33586859","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33586859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8024894","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8024894/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.15252/embr.202051349","doi":"https://doi.org/10.15252/embr.202051349","is_oa":true,"landing_page_url":"https://doi.org/10.15252/embr.202051349","pdf_url":"https://link.springer.com/content/pdf/10.15252/embr.202051349.pdf","source":{"id":"https://openalex.org/S57252141","display_name":"EMBO Reports","issn_l":"1469-221X","issn":["1469-221X","1469-3178"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Reports","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1107926153","display_name":null,"funder_award_id":"JS2016-0026","funder_id":"https://openalex.org/F4320310766","funder_display_name":"Jeanssons Stiftelser"},{"id":"https://openalex.org/G3423618974","display_name":"Building a Synapse: Role of CA-related Proteins","funder_award_id":"2017-03331","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G4701725501","display_name":null,"funder_award_id":"UDP2017-0038","funder_id":"https://openalex.org/F4320315060","funder_display_name":"Wenner-Gren Stiftelserna"}],"funders":[{"id":"https://openalex.org/F4320310766","display_name":"Jeanssons Stiftelser","ror":"https://ror.org/00r6p8t42"},{"id":"https://openalex.org/F4320315060","display_name":"Wenner-Gren Stiftelserna","ror":"https://ror.org/033b0v780"},{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320323421","display_name":"G\u00f6teborgs Universitet","ror":"https://ror.org/01tm6cn81"},{"id":"https://openalex.org/F4320336501","display_name":"Wallenberg Centre for Molecular and Translational Medicine","ror":"https://ror.org/048rhnt15"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3132931799.pdf","grobid_xml":"https://content.openalex.org/works/W3132931799.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1481943575","https://openalex.org/W1513458886","https://openalex.org/W1526474070","https://openalex.org/W1555338988","https://openalex.org/W1561162876","https://openalex.org/W1598256573","https://openalex.org/W1619466689","https://openalex.org/W1919311176","https://openalex.org/W1963514652","https://openalex.org/W1974521107","https://openalex.org/W1975473978","https://openalex.org/W1977520891","https://openalex.org/W1978646107","https://openalex.org/W1980345050","https://openalex.org/W1986938020","https://openalex.org/W1987512281","https://openalex.org/W1993933334","https://openalex.org/W2014678714","https://openalex.org/W2025174538","https://openalex.org/W2037199116","https://openalex.org/W2052130011","https://openalex.org/W2057569198","https://openalex.org/W2060384627","https://openalex.org/W2070534813","https://openalex.org/W2072147769","https://openalex.org/W2074938877","https://openalex.org/W2077686670","https://openalex.org/W2079115556","https://openalex.org/W2080324921","https://openalex.org/W2084113994","https://openalex.org/W2086619421","https://openalex.org/W2089324914","https://openalex.org/W2096372770","https://openalex.org/W2106826824","https://openalex.org/W2107784203","https://openalex.org/W2122490040","https://openalex.org/W2152821878","https://openalex.org/W2154450864","https://openalex.org/W2154626303","https://openalex.org/W2154792548","https://openalex.org/W2156014566","https://openalex.org/W2162687166","https://openalex.org/W2169707043","https://openalex.org/W2195449819","https://openalex.org/W2584304204","https://openalex.org/W2584407619","https://openalex.org/W2622842747","https://openalex.org/W2637381607","https://openalex.org/W2765792294","https://openalex.org/W2771190354","https://openalex.org/W2792837771","https://openalex.org/W2801087917","https://openalex.org/W2885963228","https://openalex.org/W2898460257","https://openalex.org/W2903168567","https://openalex.org/W2910837881","https://openalex.org/W2918763848","https://openalex.org/W2936600357","https://openalex.org/W3003788831","https://openalex.org/W4229710144","https://openalex.org/W4235774781"],"related_works":["https://openalex.org/W2892270490","https://openalex.org/W3210870796","https://openalex.org/W2584407619","https://openalex.org/W6904798154","https://openalex.org/W2885963228","https://openalex.org/W3044867082","https://openalex.org/W4411978114","https://openalex.org/W7202257901","https://openalex.org/W3080337107","https://openalex.org/W3163905649"],"abstract_inverted_index":{"Neurexins":[0],"are":[1],"presynaptic":[2],"adhesion":[3],"molecules":[4,35],"that":[5,42,59,116,131,141,146],"shape":[6],"the":[7,66,113,118,126,139,160],"molecular":[8],"composition":[9],"of":[10,13,33,121,125,138,162],"synapses.":[11],"Diversification":[12],"neurexins":[14,165],"in":[15,65,82,112,152],"numerous":[16],"isoforms":[17],"is":[18,51,53,73,84,106],"believed":[19],"to":[20,63,86,101,171],"confer":[21],"synapse-specific":[22],"properties":[23],"by":[24,98,108],"engaging":[25],"with":[26],"distinct":[27],"ligands.":[28],"For":[29],"example,":[30],"a":[31,37,61,109,157,168],"subset":[32],"neurexin":[34,64,78],"carry":[36],"heparan":[38],"sulfate":[39],"(HS)":[40],"glycosaminoglycan":[41],"controls":[43],"ligand":[44,62,92],"binding,":[45],"but":[46],"how":[47],"this":[48],"post-translational":[49],"modification":[50],"controlled":[52],"not":[54],"known.":[55],"Here,":[56],"we":[57],"observe":[58],"CA10,":[60],"secretory":[67,114],"pathway,":[68],"regulates":[69],"neurexin-HS":[70],"formation.":[71],"CA10":[72,80,132,147],"exclusively":[74],"found":[75],"on":[76,135,164],"non-HS":[77],"and":[79,90,94,166],"expressed":[81],"neurons":[83],"sufficient":[85],"suppress":[87],"HS":[88,122,163],"addition":[89],"attenuate":[91],"binding":[93],"synapse":[95],"formation":[96],"induced":[97],"ligands":[99],"known":[100],"recruit":[102],"HS.":[103],"This":[104],"effect":[105],"mediated":[107],"direct":[110],"interaction":[111],"pathway":[115],"blocks":[117,149],"primary":[119],"step":[120],"biosynthesis:":[123],"xylosylation":[124],"serine":[127,140],"residue.":[128],"NMR":[129],"reveals":[130],"engages":[133],"residues":[134],"either":[136],"side":[137],"can":[142],"be":[143],"HS-modified,":[144],"suggesting":[145],"sterically":[148],"xylosyltransferase":[150],"access":[151],"Golgi.":[153],"These":[154],"results":[155],"suggest":[156],"mechanism":[158,170],"for":[159],"regulation":[161],"exemplify":[167],"new":[169],"regulate":[172],"site-specific":[173],"glycosylations.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-01T00:00:00"}