{"id":"https://openalex.org/W3132920459","doi":"https://doi.org/10.1016/j.jbc.2021.100473","title":"Multisite NHERF1 phosphorylation controls GRK6A regulation of hormone-sensitive phosphate transport","display_name":"Multisite NHERF1 phosphorylation controls GRK6A regulation of hormone-sensitive phosphate transport","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3132920459","doi":"https://doi.org/10.1016/j.jbc.2021.100473","mag":"3132920459","pmid":"https://pubmed.ncbi.nlm.nih.gov/33639163","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8042174"},"language":"en","primary_location":{"id":"doi:10.1016/j.jbc.2021.100473","doi":"https://doi.org/10.1016/j.jbc.2021.100473","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2021.100473","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jbc.2021.100473","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050612324","display_name":"Maria Vistrup-Parry","orcid":"https://orcid.org/0000-0003-2176-2541","observed_orcids":["https://orcid.org/0000-0003-2176-2541"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Maria Vistrup-Parry","raw_affiliation_strings":["Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091006499","display_name":"W. Bruce Sneddon","orcid":"https://orcid.org/0000-0002-7852-8951","observed_orcids":["https://orcid.org/0000-0002-7852-8951"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Bruce Sneddon","raw_affiliation_strings":["Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043012005","display_name":"Sofie Bach","orcid":"https://orcid.org/0000-0002-3056-8532","observed_orcids":["https://orcid.org/0000-0002-3056-8532"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Sofie Bach","raw_affiliation_strings":["Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060992391","display_name":"Kristian Str\u00f8mgaard","orcid":"https://orcid.org/0000-0003-2206-4737","observed_orcids":["https://orcid.org/0000-0003-2206-4737"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kristian Str\u00f8mgaard","raw_affiliation_strings":["Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072441929","display_name":"Peter A. Friedman","orcid":"https://orcid.org/0000-0003-1905-1468","observed_orcids":["https://orcid.org/0000-0003-1905-1468"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter A. Friedman","raw_affiliation_strings":["Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0003-1905-1468","affiliations":[{"raw_affiliation_string":"Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038436171","display_name":"Tatyana Mamonova","orcid":"https://orcid.org/0000-0002-6324-0330","observed_orcids":["https://orcid.org/0000-0002-6324-0330"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tatyana Mamonova","raw_affiliation_strings":["Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Electronic address: tbm7@pitt.edu","Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-6324-0330","affiliations":[{"raw_affiliation_string":"Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Electronic address: tbm7@pitt.edu","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038436171"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":1.3409,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.7868572,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"296","issue":null,"first_page":"100473","last_page":"100473"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0406000018119812,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nherf1","display_name":"NHERF1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/npt2a","display_name":"Npt2a","score":0.9409999847412109},{"id":"https://openalex.org/keywords/sodium-dependent-phosphate-cotransporter","display_name":"sodium-dependent phosphate cotransporter","score":0.859000027179718},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.9490000009536743},{"id":"https://openalex.org/keywords/phosphate-transport","display_name":"phosphate transport","score":0.7730000019073486},{"id":"https://openalex.org/keywords/pdz-domain","display_name":"PDZ domain","score":0.6679999828338623},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/protein-kinase-c-alpha","display_name":"protein kinase C alpha","score":0.9039999842643738},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7799999713897705},{"id":"https://openalex.org/keywords/renal-phosphate-reabsorption","display_name":"renal phosphate reabsorption","score":0.7379999756813049},{"id":"https://openalex.org/keywords/fgf23","display_name":"fibroblast growth factor 23","score":0.8859999775886536},{"id":"https://openalex.org/keywords/multisite-phosphorylation","display_name":"multisite phosphorylation","score":0.6539999842643738},{"id":"https://openalex.org/keywords/electrostatic-network","display_name":"electrostatic network","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7774335145950317},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.5742700099945068},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5063585042953491},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.4861757159233093},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47965529561042786},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.42305365204811096},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36752939224243164},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2606831192970276},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.10784569382667542}],"mesh":[{"descriptor_ui":"D000089703","descriptor_name":"Fibroblast Growth Factor-23","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017136","descriptor_name":"Ion Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050613","descriptor_name":"Sodium-Phosphate Cotransporter Proteins, Type IIa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050613","descriptor_name":"Sodium-Phosphate Cotransporter Proteins, Type IIa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054731","descriptor_name":"PDZ Domains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054768","descriptor_name":"G-Protein-Coupled Receptor Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054768","descriptor_name":"G-Protein-Coupled Receptor Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jbc.2021.100473","doi":"https://doi.org/10.1016/j.jbc.2021.100473","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2021.100473","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8042174","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8042174","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:33639163","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33639163","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/417605a8-d5dd-45d6-ba71-32291e9a8232","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/417605a8-d5dd-45d6-ba71-32291e9a8232","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vistrup-Parry, M, Sneddon, W B, Bach, S, Str\u00f8mgaard, K, Friedman, P A & Mamonova, T 2021, 'Multisite NHERF1 phosphorylation controls GRK6A regulation of hormone-sensitive phosphate transport', Journal of Biological Chemistry, vol. 296, 100473. https://doi.org/10.1016/j.jbc.2021.100473","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.jbc.2021.100473","doi":"https://doi.org/10.1016/j.jbc.2021.100473","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2021.100473","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G233633738","display_name":"Hormonal Regulation of NHERF1 in Bone","funder_award_id":"R01DK105811","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4713515546","display_name":"Functional Polarity of PTH Receptor Signaling: Cellular and Molecular Mechanisms","funder_award_id":"R01DK111427","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W608311264","https://openalex.org/W1500417522","https://openalex.org/W1562767954","https://openalex.org/W1607154936","https://openalex.org/W1755064335","https://openalex.org/W1968859295","https://openalex.org/W1974327314","https://openalex.org/W1976499671","https://openalex.org/W1979541437","https://openalex.org/W1979806834","https://openalex.org/W1994996237","https://openalex.org/W1999372562","https://openalex.org/W2000251153","https://openalex.org/W2012181614","https://openalex.org/W2031000099","https://openalex.org/W2033846769","https://openalex.org/W2046138544","https://openalex.org/W2046823912","https://openalex.org/W2058829783","https://openalex.org/W2062528182","https://openalex.org/W2063216482","https://openalex.org/W2068298188","https://openalex.org/W2068318683","https://openalex.org/W2078450213","https://openalex.org/W2082131326","https://openalex.org/W2098863350","https://openalex.org/W2109050249","https://openalex.org/W2129699893","https://openalex.org/W2134235279","https://openalex.org/W2141450570","https://openalex.org/W2150496308","https://openalex.org/W2151040238","https://openalex.org/W2161020525","https://openalex.org/W2163537415","https://openalex.org/W2166384691","https://openalex.org/W2166569849","https://openalex.org/W2170564629","https://openalex.org/W2170802421","https://openalex.org/W2332286919","https://openalex.org/W2509816044","https://openalex.org/W2530153241","https://openalex.org/W2537140536","https://openalex.org/W2605303692","https://openalex.org/W2735227557","https://openalex.org/W2911904736","https://openalex.org/W2924523172","https://openalex.org/W2955076607","https://openalex.org/W2995181107","https://openalex.org/W3004228056","https://openalex.org/W3016428330","https://openalex.org/W3086170770"],"related_works":["https://openalex.org/W3122006574","https://openalex.org/W1974327314","https://openalex.org/W4392649809","https://openalex.org/W2134235279","https://openalex.org/W4406242129","https://openalex.org/W2115162204","https://openalex.org/W1978957526","https://openalex.org/W7098149515","https://openalex.org/W2911904736","https://openalex.org/W2185686689"],"abstract_inverted_index":{"The":[0,11],"type":[1],"II":[2],"sodium-dependent":[3],"phosphate":[4,9,63,255],"cotransporter":[5],"(NPT2A)":[6],"mediates":[7],"renal":[8],"uptake.":[10],"NPT2A":[12,168],"is":[13,105],"regulated":[14],"by":[15,65,192],"parathyroid":[16],"hormone":[17],"(PTH)":[18],"and":[19,44,103,125,148,166,169,228,233,257],"fibroblast":[20],"growth":[21],"factor":[22],"23,":[23],"which":[24,73],"requires":[25],"Na":[26],"+":[27,29],"/H":[28],"exchange":[30],"regulatory":[31,250],"factor-1":[32],"(NHERF1),":[33],"a":[34,79,113,180,249],"multidomain":[35],"PDZ-containing":[36],"phosphoprotein.":[37],"Phosphocycling":[38],"controls":[39],"the":[40,45,50,98,120,137,144,149,162,167,202,206,239,265],"association":[41,99],"between":[42,100,123,146,164,225],"NHERF1":[43,70,90,101,147,165],"NPT2A.":[46,150],"Here,":[47],"we":[48],"characterize":[49],"critical":[51],"involvement":[52],"of":[53,128,152,198,209,221,231,238,259],"G":[54],"protein\u2013coupled":[55],"receptor":[56],"kinase":[57],"6A":[58],"(GRK6A)":[59],"in":[60,74,117,252,262],"mediating":[61],"PTH-sensitive":[62,253],"transport":[64,256],"targeted":[66],"phosphorylation":[67,77,115,258],"coupled":[68],"with":[69,92,131,155,213,267],"conformational":[71],"rearrangement,":[72],"turn":[75],"allows":[76],"at":[78,235],"secondary":[80],"site.":[81],"GRK6A,":[82],"through":[83],"its":[84],"carboxy-terminal":[85],"PDZ":[86],"recognition":[87],"motif,":[88],"binds":[89],"PDZ1":[91],"greater":[93],"affinity":[94,122,204],"than":[95],"PDZ2.":[96,215],"However,":[97],"PDZ2":[102,124,232,247,263],"GRK6A":[104,210,240],"necessary":[106],"for":[107],"PTH":[108,138,171],"action.":[109,172],"Ser":[110,129,153,182,260],"162":[111,130,134,154,159,183,185,200,227,261],",":[112],"PKC\u03b1":[114],"site":[116],"PDZ2,":[118],"regulates":[119],"binding":[121,203],"GRK6A.":[126,268],"Substitution":[127],"alanine":[132],"(S":[133,158],"A)":[135],"blocks":[136],"action":[139],"but":[140],"does":[141],"not":[142],"disrupt":[143],"interaction":[145,163,266],"Replacement":[151],"aspartic":[156],"acid":[157],"D)":[160],"abrogates":[161],"concurrently":[170],"We":[173],"used":[174],"amber":[175],"codon":[176],"suppression":[177],"to":[178,205],"generate":[179],"phosphorylated":[181],"(pSer":[184],")-PDZ2":[186],"variant.":[187],"K":[188],"D":[189],"values":[190],"determined":[191],"fluorescence":[193],"anisotropy":[194],"indicate":[195],"that":[196,246],"incorporation":[197],"pSer":[199,226],"increased":[201],"carboxy":[207],"terminus":[208],"2-fold":[211],"compared":[212],"WT":[214],"Molecular":[216],"dynamics":[217],"simulations":[218],"predict":[219],"formation":[220],"an":[222],"electrostatic":[223],"network":[224],"Asp":[229],"183":[230],"Arg":[234],"position":[236],"\u22121":[237],"PDZ-binding":[241],"motif.":[242],"Our":[243],"results":[244],"suggest":[245],"plays":[248],"role":[251],"NPT2A-mediated":[254],"modulates":[264]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-01T00:00:00"}
