{"id":"https://openalex.org/W3132850554","doi":"https://doi.org/10.1007/s12032-021-01476-z","title":"Bexarotene inhibits cell proliferation by inducing oxidative stress, DNA damage and apoptosis via PPAR\u03b3/ NF-\u03baB signaling pathway in C6 glioma cells","display_name":"Bexarotene inhibits cell proliferation by inducing oxidative stress, DNA damage and apoptosis via PPAR\u03b3/ NF-\u03baB signaling pathway in C6 glioma cells","publication_year":2021,"publication_date":"2021-02-18","ids":{"openalex":"https://openalex.org/W3132850554","doi":"https://doi.org/10.1007/s12032-021-01476-z","mag":"3132850554","pmid":"https://pubmed.ncbi.nlm.nih.gov/33599853"},"language":"en","primary_location":{"id":"doi:10.1007/s12032-021-01476-z","doi":"https://doi.org/10.1007/s12032-021-01476-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12032-021-01476-z","pdf_url":null,"source":{"id":"https://openalex.org/S204953464","display_name":"Medical Oncology","issn_l":"1357-0560","issn":["1357-0560","1559-131X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/20.500.12684/10739","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012841014","display_name":"Ceyhan Hac\u0131o\u011flu","orcid":"https://orcid.org/0000-0002-0993-6118","observed_orcids":["https://orcid.org/0000-0002-0993-6118"]},"institutions":[{"id":"https://openalex.org/I54001450","display_name":"D\u00fczce \u00dcniversitesi","ror":"https://ror.org/04175wc52","country_code":"TR","type":"education","lineage":["https://openalex.org/I54001450"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ceyhan Hacioglu","raw_affiliation_strings":["Department of Medical Biochemistry, Faculty of Medicine, D\u00fczce University, D\u00fczce, Turkey. ceyhanhacioglu@duzce.edu.tr","Department of Medical Biochemistry, Faculty of Medicine, D\u00fczce University, D\u00fczce, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-0993-6118","affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, Faculty of Medicine, D\u00fczce University, D\u00fczce, Turkey. ceyhanhacioglu@duzce.edu.tr","institution_ids":["https://openalex.org/I54001450"]},{"raw_affiliation_string":"Department of Medical Biochemistry, Faculty of Medicine, D\u00fczce University, D\u00fczce, Turkey","institution_ids":["https://openalex.org/I54001450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017896795","display_name":"Fatih Kar","orcid":"https://orcid.org/0000-0001-8356-9806","observed_orcids":["https://orcid.org/0000-0001-8356-9806"]},"institutions":[{"id":"https://openalex.org/I4387156457","display_name":"Kutahya Saglik Bilimleri Universitesi","ror":"https://ror.org/01fxqs415","country_code":"TR","type":"education","lineage":["https://openalex.org/I4387156457"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Fatih Kar","raw_affiliation_strings":["Department of Medical Services and Techniques, Vocational School of Health Services, K\u00fctahya Health Science University, K\u00fctahya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Services and Techniques, Vocational School of Health Services, K\u00fctahya Health Science University, K\u00fctahya, Turkey","institution_ids":["https://openalex.org/I4387156457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059114639","display_name":"Sedat Ka\u00e7ar","orcid":"https://orcid.org/0000-0002-0671-8529","observed_orcids":["https://orcid.org/0000-0002-0671-8529"]},"institutions":[{"id":"https://openalex.org/I51209816","display_name":"Eski\u015fehir Osmangazi University","ror":"https://ror.org/01dzjez04","country_code":"TR","type":"education","lineage":["https://openalex.org/I51209816"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sedat Kacar","raw_affiliation_strings":["Department of Histology and Embryology, Faculty of Medicine, Eski\u015fehir Osmangazi University, Eski\u015fehir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, Eski\u015fehir Osmangazi University, Eski\u015fehir, Turkey","institution_ids":["https://openalex.org/I51209816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089129259","display_name":"Varol \u015eah\u0131nt\u00fcrk","orcid":"https://orcid.org/0000-0003-2317-3644","observed_orcids":["https://orcid.org/0000-0003-2317-3644"]},"institutions":[{"id":"https://openalex.org/I51209816","display_name":"Eski\u015fehir Osmangazi University","ror":"https://ror.org/01dzjez04","country_code":"TR","type":"education","lineage":["https://openalex.org/I51209816"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Varol Sahinturk","raw_affiliation_strings":["Department of Histology and Embryology, Faculty of Medicine, Eski\u015fehir Osmangazi University, Eski\u015fehir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, Eski\u015fehir Osmangazi University, Eski\u015fehir, Turkey","institution_ids":["https://openalex.org/I51209816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017017877","display_name":"G\u00fcng\u00f6r Kanbak","orcid":"https://orcid.org/0000-0001-7984-3649","observed_orcids":["https://orcid.org/0000-0001-7984-3649"]},"institutions":[{"id":"https://openalex.org/I51209816","display_name":"Eski\u015fehir Osmangazi University","ror":"https://ror.org/01dzjez04","country_code":"TR","type":"education","lineage":["https://openalex.org/I51209816"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Gungor Kanbak","raw_affiliation_strings":["Department of Medical Biochemistry, Faculty of Medicine, Eski\u015fehir Osmangazi University, Eski\u015fehir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, Faculty of Medicine, Eski\u015fehir Osmangazi University, Eski\u015fehir, Turkey","institution_ids":["https://openalex.org/I51209816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012841014"],"corresponding_institution_ids":["https://openalex.org/I54001450"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":null,"fwci":2.9011,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.94073719,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"38","issue":"3","first_page":"31","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.6880000233650208,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.6880000233650208,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.22779999673366547,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bexarotene","display_name":"bexarotene","score":1.0},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.828000009059906},{"id":"https://openalex.org/keywords/c6-glioma-cells","display_name":"C6 glioma cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9570000171661377},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.921999990940094},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8730000257492065},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8650000095367432},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.9959999918937683},{"id":"https://openalex.org/keywords/8-hydroxy-2-deoxyguanosine","display_name":"8-hydroxy-2'-deoxyguanosine","score":0.9470000267028809},{"id":"https://openalex.org/keywords/caspase-3-7-activation","display_name":"caspase-3/7 activation","score":0.828000009059906},{"id":"https://openalex.org/keywords/retinoid-x-receptor-agonist","display_name":"retinoid X receptor agonist","score":0.8820000290870667},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C2778820923","wikidata":"https://www.wikidata.org/wiki/Q418192","display_name":"Bexarotene","level":5,"score":0.9400792121887207},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6709681749343872},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5410373210906982},{"id":"https://openalex.org/C128821507","wikidata":"https://www.wikidata.org/wiki/Q3454518","display_name":"Retinoid X receptor","level":5,"score":0.5220427513122559},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47500312328338623},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45936813950538635},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4527748227119446},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.429026335477829},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.4269621968269348},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.42325806617736816},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.42196395993232727},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.4206804633140564},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3811165392398834},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36598098278045654},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3381166458129883},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.3166731894016266},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.29312044382095337},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.29023414850234985},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2807667851448059},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20627737045288086},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.10824140906333923},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08112803101539612},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077610","descriptor_name":"Bexarotene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047488","descriptor_name":"Retinoid X Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047488","descriptor_name":"Retinoid X Receptors","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s12032-021-01476-z","doi":"https://doi.org/10.1007/s12032-021-01476-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12032-021-01476-z","pdf_url":null,"source":{"id":"https://openalex.org/S204953464","display_name":"Medical Oncology","issn_l":"1357-0560","issn":["1357-0560","1559-131X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Oncology","raw_type":"journal-article"},{"id":"pmid:33599853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33599853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical oncology (Northwood, London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:acikerisim.duzce.edu.tr:20.500.12684/10739","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12684/10739","pdf_url":null,"source":{"id":"https://openalex.org/S4377196355","display_name":"DSpace - D\u00fczce (Duzce University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I54001450","host_organization_name":"D\u00fczce \u00dcniversitesi","host_organization_lineage":["https://openalex.org/I54001450"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:acikerisim.duzce.edu.tr:20.500.12684/10739","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12684/10739","pdf_url":null,"source":{"id":"https://openalex.org/S4377196355","display_name":"DSpace - D\u00fczce (Duzce University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I54001450","host_organization_name":"D\u00fczce \u00dcniversitesi","host_organization_lineage":["https://openalex.org/I54001450"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1491886022","https://openalex.org/W1543746024","https://openalex.org/W1607777232","https://openalex.org/W1745634660","https://openalex.org/W1940921800","https://openalex.org/W1964951140","https://openalex.org/W1969524738","https://openalex.org/W1976790158","https://openalex.org/W1988329373","https://openalex.org/W1995594307","https://openalex.org/W2000660706","https://openalex.org/W2012610188","https://openalex.org/W2014844101","https://openalex.org/W2020383780","https://openalex.org/W2034794719","https://openalex.org/W2037750806","https://openalex.org/W2054196426","https://openalex.org/W2063064231","https://openalex.org/W2072822958","https://openalex.org/W2103808669","https://openalex.org/W2104224178","https://openalex.org/W2113328569","https://openalex.org/W2118278569","https://openalex.org/W2122869544","https://openalex.org/W2134807618","https://openalex.org/W2267382607","https://openalex.org/W2298247090","https://openalex.org/W2470316197","https://openalex.org/W2518737276","https://openalex.org/W2552965505","https://openalex.org/W2563804650","https://openalex.org/W2621333085","https://openalex.org/W2750357431","https://openalex.org/W2785091318","https://openalex.org/W2791456985","https://openalex.org/W2800329306","https://openalex.org/W2807900389","https://openalex.org/W2884318249","https://openalex.org/W2884741638","https://openalex.org/W2914084793","https://openalex.org/W2961328380","https://openalex.org/W3042163725"],"related_works":["https://openalex.org/W1491886022","https://openalex.org/W2298247090","https://openalex.org/W3042163725","https://openalex.org/W4415995816","https://openalex.org/W1986712005","https://openalex.org/W1984018547","https://openalex.org/W4283773466","https://openalex.org/W2356816584","https://openalex.org/W3215475946","https://openalex.org/W77403056"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-03-01T00:00:00"}
