{"id":"https://openalex.org/W3132832695","doi":"https://doi.org/10.1021/acsinfecdis.0c00160","title":"Antibiotic Adjuvant Activity Revealed in a Photoaffinity Approach to Determine the Molecular Target of Antipyocyanin Compounds","display_name":"Antibiotic Adjuvant Activity Revealed in a Photoaffinity Approach to Determine the Molecular Target of Antipyocyanin Compounds","publication_year":2021,"publication_date":"2021-02-15","ids":{"openalex":"https://openalex.org/W3132832695","doi":"https://doi.org/10.1021/acsinfecdis.0c00160","mag":"3132832695","pmid":"https://pubmed.ncbi.nlm.nih.gov/33587590","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8325921"},"language":"en","primary_location":{"id":"doi:10.1021/acsinfecdis.0c00160","doi":"https://doi.org/10.1021/acsinfecdis.0c00160","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.0c00160","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8325921","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101893837","display_name":"Zinan Zhang","orcid":"https://orcid.org/0000-0003-3831-2272","observed_orcids":["https://orcid.org/0000-0003-3831-2272"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zinan Zhang","raw_affiliation_strings":["Department of Chemistry, Princeton University, Washington Road, Princeton, New Jersey 08544, United States"],"raw_orcid":"https://orcid.org/0000-0003-3831-2272","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Princeton University, Washington Road, Princeton, New Jersey 08544, United States","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039560706","display_name":"Dominic Ortega","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51504820","display_name":"San Jose State University","ror":"https://ror.org/04qyvz380","country_code":"US","type":"education","lineage":["https://openalex.org/I51504820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dominic Ortega","raw_affiliation_strings":["Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States","institution_ids":["https://openalex.org/I51504820"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anthony Rush","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Rush","raw_affiliation_strings":["Department of Bioengineering, Stanford University, 443 Via Ortega, Stanford, California 94305, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Stanford University, 443 Via Ortega, Stanford, California 94305, United States","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069867979","display_name":"Lauren R. Blankenship","orcid":"https://orcid.org/0000-0002-1714-4399","observed_orcids":["https://orcid.org/0000-0002-1714-4399"]},"institutions":[{"id":"https://openalex.org/I51504820","display_name":"San Jose State University","ror":"https://ror.org/04qyvz380","country_code":"US","type":"education","lineage":["https://openalex.org/I51504820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren R. Blankenship","raw_affiliation_strings":["Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States","institution_ids":["https://openalex.org/I51504820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052857576","display_name":"Zi Jun Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51504820","display_name":"San Jose State University","ror":"https://ror.org/04qyvz380","country_code":"US","type":"education","lineage":["https://openalex.org/I51504820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zi Jun Cheng","raw_affiliation_strings":["Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States","institution_ids":["https://openalex.org/I51504820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015306357","display_name":"Rebecca E. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51504820","display_name":"San Jose State University","ror":"https://ror.org/04qyvz380","country_code":"US","type":"education","lineage":["https://openalex.org/I51504820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca E. Moore","raw_affiliation_strings":["Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States","institution_ids":["https://openalex.org/I51504820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103878595","display_name":"Minh L. N. Tran","orcid":"https://orcid.org/0000-0002-2415-6259","observed_orcids":["https://orcid.org/0000-0002-2415-6259"]},"institutions":[{"id":"https://openalex.org/I51504820","display_name":"San Jose State University","ror":"https://ror.org/04qyvz380","country_code":"US","type":"education","lineage":["https://openalex.org/I51504820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minh L. N. Tran","raw_affiliation_strings":["Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States","institution_ids":["https://openalex.org/I51504820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041794365","display_name":"Lucero G. Sandoval","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51504820","display_name":"San Jose State University","ror":"https://ror.org/04qyvz380","country_code":"US","type":"education","lineage":["https://openalex.org/I51504820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucero G. Sandoval","raw_affiliation_strings":["Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States","institution_ids":["https://openalex.org/I51504820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106329103","display_name":"Kareem Aboulhosn","orcid":"https://orcid.org/0009-0009-4542-4679","observed_orcids":["https://orcid.org/0009-0009-4542-4679"]},"institutions":[{"id":"https://openalex.org/I51504820","display_name":"San Jose State University","ror":"https://ror.org/04qyvz380","country_code":"US","type":"education","lineage":["https://openalex.org/I51504820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kareem Aboulhosn","raw_affiliation_strings":["Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States","institution_ids":["https://openalex.org/I51504820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102835501","display_name":"Seiichiro Watanabe","orcid":"https://orcid.org/0000-0002-6568-1981","observed_orcids":["https://orcid.org/0000-0002-6568-1981"]},"institutions":[{"id":"https://openalex.org/I51504820","display_name":"San Jose State University","ror":"https://ror.org/04qyvz380","country_code":"US","type":"education","lineage":["https://openalex.org/I51504820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seiichiro Watanabe","raw_affiliation_strings":["Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States","institution_ids":["https://openalex.org/I51504820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079417628","display_name":"Kendra S. Cortez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51504820","display_name":"San Jose State University","ror":"https://ror.org/04qyvz380","country_code":"US","type":"education","lineage":["https://openalex.org/I51504820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kendra S. Cortez","raw_affiliation_strings":["Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States","institution_ids":["https://openalex.org/I51504820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049281021","display_name":"David H. Perlman","orcid":"https://orcid.org/0000-0002-8718-3959","observed_orcids":["https://orcid.org/0000-0002-8718-3959"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David H. Perlman","raw_affiliation_strings":["Princeton Proteomics and Mass Spectrometry Center, Princeton University, Washington Road, Princeton, New Jersey 08544, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Princeton Proteomics and Mass Spectrometry Center, Princeton University, Washington Road, Princeton, New Jersey 08544, United States","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037542759","display_name":"Martin F. Semmelhack","orcid":"https://orcid.org/0000-0003-0277-3894","observed_orcids":["https://orcid.org/0000-0003-0277-3894"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin F. Semmelhack","raw_affiliation_strings":["Department of Chemistry, Princeton University, Washington Road, Princeton, New Jersey 08544, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Princeton University, Washington Road, Princeton, New Jersey 08544, United States","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102767798","display_name":"Laura C. Miller","orcid":"https://orcid.org/0000-0003-0937-5362","observed_orcids":["https://orcid.org/0000-0003-0937-5362"]},"institutions":[{"id":"https://openalex.org/I51504820","display_name":"San Jose State University","ror":"https://ror.org/04qyvz380","country_code":"US","type":"education","lineage":["https://openalex.org/I51504820"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Laura C. Miller Conrad","raw_affiliation_strings":["Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States"],"raw_orcid":"https://orcid.org/0000-0003-0937-5362","affiliations":[{"raw_affiliation_string":"Department of Chemistry, San Jos\u00e9 State University, 1 Washington Square, San Jose, California 95192, United States","institution_ids":["https://openalex.org/I51504820"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102767798"],"corresponding_institution_ids":["https://openalex.org/I51504820"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01659019,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"3","first_page":"535","last_page":"543"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9409999847412109},{"id":"https://openalex.org/keywords/pyocyanin","display_name":"pyocyanin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/photoaffinity-labeling","display_name":"photoaffinity labeling","score":0.7889999747276306},{"id":"https://openalex.org/keywords/colistin","display_name":"colistin","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cationic-antimicrobial-peptides","display_name":"cationic antimicrobial peptides","score":0.8690000176429749},{"id":"https://openalex.org/keywords/colistin-resistance","display_name":"colistin resistance","score":0.8190000057220459},{"id":"https://openalex.org/keywords/virulence-factor-inhibition","display_name":"virulence factor inhibition","score":0.8399999737739563},{"id":"https://openalex.org/keywords/molecular-mechanism-of-action","display_name":"molecular mechanisms of action","score":0.6600000262260437},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C2779259085","wikidata":"https://www.wikidata.org/wiki/Q418946","display_name":"Colistin","level":3,"score":0.8069547414779663},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.7903505563735962},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.666751503944397},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.649166464805603},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5395374298095703},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5183942914009094},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.4866796135902405},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3269462287425995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3248554766178131},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.22189787030220032},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18915674090385437},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14340484142303467},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003091","descriptor_name":"Colistin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011710","descriptor_name":"Pyocyanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acsinfecdis.0c00160","doi":"https://doi.org/10.1021/acsinfecdis.0c00160","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.0c00160","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:33587590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33587590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8325921","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8325921","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Infect Dis","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8325921","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8325921","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Infect Dis","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2365927308","display_name":null,"funder_award_id":"DUE-1258366","funder_id":"https://openalex.org/F4320337408","funder_display_name":"Division of Undergraduate Education"},{"id":"https://openalex.org/G2710219200","display_name":null,"funder_award_id":"HRD-1302873","funder_id":"https://openalex.org/F4320337407","funder_display_name":"Division of Human Resource Development"},{"id":"https://openalex.org/G3341918868","display_name":"San Jose State University Undergraduate MBRS RISE Program","funder_award_id":"R25GM071381","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3522989319","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM007753","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6649237432","display_name":"Blocking Cationic Antimicrobial Peptide-Resistance in Pseudomonas aeruginosa","funder_award_id":"SC3GM118199","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320307776","display_name":"Merck","ror":"https://ror.org/02891sr49"},{"id":"https://openalex.org/F4320310280","display_name":"California State University","ror":"https://ror.org/020qm1538"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337407","display_name":"Division of Human Resource Development","ror":"https://ror.org/03mamvh39"},{"id":"https://openalex.org/F4320337408","display_name":"Division of Undergraduate Education","ror":"https://ror.org/02kd4km72"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W53393557","https://openalex.org/W1501432141","https://openalex.org/W1827586750","https://openalex.org/W1936661643","https://openalex.org/W1964466122","https://openalex.org/W1978868837","https://openalex.org/W1979429534","https://openalex.org/W1981593008","https://openalex.org/W1983964848","https://openalex.org/W1984693521","https://openalex.org/W1993109262","https://openalex.org/W2012472444","https://openalex.org/W2013299789","https://openalex.org/W2016341743","https://openalex.org/W2026465178","https://openalex.org/W2027896141","https://openalex.org/W2038252445","https://openalex.org/W2056267543","https://openalex.org/W2057738744","https://openalex.org/W2060816398","https://openalex.org/W2067381924","https://openalex.org/W2068354047","https://openalex.org/W2071689053","https://openalex.org/W2074619179","https://openalex.org/W2081960029","https://openalex.org/W2091513339","https://openalex.org/W2097322935","https://openalex.org/W2103752133","https://openalex.org/W2112920437","https://openalex.org/W2113410040","https://openalex.org/W2118812289","https://openalex.org/W2126918333","https://openalex.org/W2133425351","https://openalex.org/W2133985721","https://openalex.org/W2137081432","https://openalex.org/W2139382674","https://openalex.org/W2145457819","https://openalex.org/W2149623513","https://openalex.org/W2154063145","https://openalex.org/W2159436322","https://openalex.org/W2162802558","https://openalex.org/W2168485847","https://openalex.org/W2179324586","https://openalex.org/W2416085361","https://openalex.org/W2505648140","https://openalex.org/W2511941815","https://openalex.org/W2597311782","https://openalex.org/W2781117671","https://openalex.org/W2864259052","https://openalex.org/W2898380553","https://openalex.org/W2898408013","https://openalex.org/W2899828593","https://openalex.org/W2912318433","https://openalex.org/W2956731794","https://openalex.org/W2969755518","https://openalex.org/W2994834904","https://openalex.org/W3009885589","https://openalex.org/W3014667439","https://openalex.org/W3020760655","https://openalex.org/W3033963356","https://openalex.org/W3046130328","https://openalex.org/W4242318543"],"related_works":["https://openalex.org/W3016562827","https://openalex.org/W4244152114","https://openalex.org/W4307646766","https://openalex.org/W3174505301","https://openalex.org/W4353031810","https://openalex.org/W3033963356","https://openalex.org/W3033559275","https://openalex.org/W7117341577","https://openalex.org/W4282938219","https://openalex.org/W3009235991"],"abstract_inverted_index":{"Infections":[0],"with":[1],"Pseudomonas":[2],"aeruginosa":[3,121],"are":[4,14],"a":[5,78,85],"looming":[6],"threat":[7],"to":[8,16,40,51,96,109,118],"public":[9],"health.":[10],"New":[11],"treatment":[12],"strategies":[13],"needed":[15],"combat":[17,119],"this":[18],"pathogen,":[19],"for":[20],"example,":[21],"by":[22],"blocking":[23],"the":[24,42,55,60,73,92,98],"production":[25],"of":[26,34,46,76,101],"virulence":[27],"factors":[28],"like":[29,105],"pyocyanin.":[30],"A":[31],"photoaffinity":[32],"analogue":[33],"an":[35],"antipyocyanin":[36],"compound":[37],"was":[38],"developed":[39],"interrogate":[41],"inhibitor\u2019s":[43],"molecular":[44],"mechanism":[45],"action.":[47],"While":[48],"we":[49,67],"sought":[50],"develop":[52],"antivirulence":[53],"inhibitors,":[54],"proteomics":[56],"results":[57],"suggested":[58],"that":[59,69],"compounds":[61,71],"had":[62],"antibiotic":[63,87],"adjuvant":[64,88],"activity.":[65],"Unexpectedly,":[66],"found":[68],"these":[70],"amplify":[72],"bactericidal":[74],"activity":[75],"colistin,":[77,106],"well-characterized":[79],"antibiotic,":[80],"suggesting":[81],"they":[82],"may":[83],"represent":[84],"first-in-class":[86],"therapy.":[89],"Analogues":[90],"have":[91],"potential":[93],"not":[94],"only":[95],"widen":[97],"therapeutic":[99],"index":[100],"cationic":[102],"antimicrobial":[103],"peptides":[104],"but":[107],"also":[108],"be":[110],"effective":[111],"against":[112],"colistin-resistant":[113],"strains,":[114],"strengthening":[115],"our":[116],"arsenal":[117],"P.":[120],"infections.":[122]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-01T00:00:00"}