{"id":"https://openalex.org/W3132794635","doi":"https://doi.org/10.1016/j.canlet.2021.02.011","title":"Exosome-mediated delivery of RNA and DNA for gene therapy","display_name":"Exosome-mediated delivery of RNA and DNA for gene therapy","publication_year":2021,"publication_date":"2021-02-18","ids":{"openalex":"https://openalex.org/W3132794635","doi":"https://doi.org/10.1016/j.canlet.2021.02.011","mag":"3132794635","pmid":"https://pubmed.ncbi.nlm.nih.gov/33610731"},"language":"en","primary_location":{"id":"doi:10.1016/j.canlet.2021.02.011","doi":"https://doi.org/10.1016/j.canlet.2021.02.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.canlet.2021.02.011","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8005491","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076591057","display_name":"Radha Munagala","orcid":"https://orcid.org/0000-0001-5177-0011","observed_orcids":["https://orcid.org/0000-0001-5177-0011"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Radha Munagala","raw_affiliation_strings":["3P Biotechnologies, Inc., Louisville, KY, 40202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3P Biotechnologies, Inc., Louisville, KY, 40202, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014387046","display_name":"Farrukh Aqil","orcid":"https://orcid.org/0000-0002-0081-7251","observed_orcids":["https://orcid.org/0000-0002-0081-7251"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farrukh Aqil","raw_affiliation_strings":["James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA; Department of Medicine, University of Louisville, Louisville, KY, 40202, USA","Department of Medicine, University of Louisville, Louisville, KY, 40202, USA","James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA; Department of Medicine, University of Louisville, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Medicine, University of Louisville, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055705882","display_name":"Jeyaprakash Jeyabalan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeyaprakash Jeyabalan","raw_affiliation_strings":["3P Biotechnologies, Inc., Louisville, KY, 40202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3P Biotechnologies, Inc., Louisville, KY, 40202, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000593211","display_name":"Raghuram Kandimalla","orcid":"https://orcid.org/0000-0002-9202-4071","observed_orcids":["https://orcid.org/0000-0002-9202-4071"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raghuram Kandimalla","raw_affiliation_strings":["James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40202, USA","Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40202, USA","James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA"],"raw_orcid":"https://orcid.org/0000-0002-9202-4071","affiliations":[{"raw_affiliation_string":"James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000886015","display_name":"Margaret Wallen","orcid":"https://orcid.org/0000-0002-2812-6858","observed_orcids":["https://orcid.org/0000-0002-2812-6858"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Margaret Wallen","raw_affiliation_strings":["3P Biotechnologies, Inc., Louisville, KY, 40202, USA"],"raw_orcid":"https://orcid.org/0000-0002-2812-6858","affiliations":[{"raw_affiliation_string":"3P Biotechnologies, Inc., Louisville, KY, 40202, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101758641","display_name":"Neha Tyagi","orcid":"https://orcid.org/0000-0002-4504-5689","observed_orcids":["https://orcid.org/0000-0002-4504-5689"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neha Tyagi","raw_affiliation_strings":["James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40202, USA","Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40202, USA","James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA"],"raw_orcid":"https://orcid.org/0000-0002-4504-5689","affiliations":[{"raw_affiliation_string":"James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036430036","display_name":"Sarah A. Wilcher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Wilcher","raw_affiliation_strings":["Research Resources Center, University of Louisville, Louisville, KY, 40202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Resources Center, University of Louisville, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023898826","display_name":"Jun Yan","orcid":"https://orcid.org/0000-0003-2922-422X","observed_orcids":["https://orcid.org/0000-0003-2922-422X"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Yan","raw_affiliation_strings":["James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA; Department of Surgery, University of Louisville, Louisville, KY, 40202, USA","Department of Surgery, University of Louisville, Louisville, KY, 40202, USA","James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA"],"raw_orcid":"https://orcid.org/0000-0003-2922-422X","affiliations":[{"raw_affiliation_string":"James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA; Department of Surgery, University of Louisville, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Surgery, University of Louisville, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103420977","display_name":"David J. Schultz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Schultz","raw_affiliation_strings":["Department of Biology, University of Louisville, Louisville, KY, 40292, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Louisville, Louisville, KY, 40292, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070690955","display_name":"Wendy A. Spencer","orcid":"https://orcid.org/0000-0002-0455-3628","observed_orcids":["https://orcid.org/0000-0002-0455-3628"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wendy Spencer","raw_affiliation_strings":["3P Biotechnologies, Inc., Louisville, KY, 40202, USA"],"raw_orcid":"https://orcid.org/0000-0002-0455-3628","affiliations":[{"raw_affiliation_string":"3P Biotechnologies, Inc., Louisville, KY, 40202, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102925997","display_name":"Ramesh Chand Gupta","orcid":"https://orcid.org/0000-0002-7086-0802","observed_orcids":["https://orcid.org/0000-0002-7086-0802"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ramesh C. Gupta","raw_affiliation_strings":["3P Biotechnologies, Inc., Louisville, KY, 40202, USA; James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40202, USA. Electronic address: rcgupta@louisville.edu","3P Biotechnologies, Inc., Louisville, KY, 40202, USA","Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40202, USA","James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3P Biotechnologies, Inc., Louisville, KY, 40202, USA; James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40202, USA. Electronic address: rcgupta@louisville.edu","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"3P Biotechnologies, Inc., Louisville, KY, 40202, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102925997"],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":{"value":3840,"currency":"USD","value_usd":3840},"apc_paid":null,"fwci":6.0675,"has_fulltext":false,"cited_by_count":142,"citation_normalized_percentile":{"value":0.98057298,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"505","issue":null,"first_page":"58","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.031199999153614044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.828000009059906},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.6200000047683716},{"id":"https://openalex.org/keywords/nucleic-acid-delivery","display_name":"nucleic acid delivery","score":0.7490000128746033},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.6809999942779541},{"id":"https://openalex.org/keywords/plasmid-dna","display_name":"plasmid DNA","score":0.9980000257492065},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.8640000224113464},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9470000267028809},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.972000002861023},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7580000162124634},{"id":"https://openalex.org/keywords/p53-null-cells","display_name":"p53-null cells","score":0.7730000019073486},{"id":"https://openalex.org/keywords/p53-knockout-mice","display_name":"p53 knockout mice","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.7793728113174438},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.7510712146759033},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.6742555499076843},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5855768322944641},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5807626247406006},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49445533752441406},{"id":"https://openalex.org/C195856716","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"Naked DNA","level":4,"score":0.4908328950405121},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4296107292175293},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.4223652780056},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42005911469459534},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3803223669528961},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32532835006713867},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.2968266010284424},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2773965299129486}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D011094","descriptor_name":"Polyethyleneimine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011094","descriptor_name":"Polyethyleneimine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011094","descriptor_name":"Polyethyleneimine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.canlet.2021.02.011","doi":"https://doi.org/10.1016/j.canlet.2021.02.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.canlet.2021.02.011","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},{"id":"pmid:33610731","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33610731","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer letters","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8005491","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8005491","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Lett","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8005491","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8005491","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Lett","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7799999713897705,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7124320677","display_name":null,"funder_award_id":"R44-CA-221487","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W1128084819","https://openalex.org/W1493553959","https://openalex.org/W1965913620","https://openalex.org/W1967393143","https://openalex.org/W1993812884","https://openalex.org/W1996442711","https://openalex.org/W1998004849","https://openalex.org/W2005352301","https://openalex.org/W2007804755","https://openalex.org/W2013722500","https://openalex.org/W2021222670","https://openalex.org/W2024341039","https://openalex.org/W2039551908","https://openalex.org/W2049980461","https://openalex.org/W2055353965","https://openalex.org/W2066234893","https://openalex.org/W2072970273","https://openalex.org/W2075338937","https://openalex.org/W2084688858","https://openalex.org/W2087017620","https://openalex.org/W2087497808","https://openalex.org/W2106425695","https://openalex.org/W2108244474","https://openalex.org/W2114155569","https://openalex.org/W2143463421","https://openalex.org/W2150092048","https://openalex.org/W2159074577","https://openalex.org/W2178935826","https://openalex.org/W2191217108","https://openalex.org/W2193978092","https://openalex.org/W2254907687","https://openalex.org/W2283717297","https://openalex.org/W2319745661","https://openalex.org/W2343116876","https://openalex.org/W2548889483","https://openalex.org/W2558802491","https://openalex.org/W2559991352","https://openalex.org/W2570212616","https://openalex.org/W2582457689","https://openalex.org/W2588236705","https://openalex.org/W2588307382","https://openalex.org/W2591683990","https://openalex.org/W2592465512","https://openalex.org/W2601308787","https://openalex.org/W2606975140","https://openalex.org/W2624616322","https://openalex.org/W2692664495","https://openalex.org/W2739908631","https://openalex.org/W2743804580","https://openalex.org/W2761665567","https://openalex.org/W2766012986","https://openalex.org/W2786615000","https://openalex.org/W2791444181","https://openalex.org/W2804535713","https://openalex.org/W2810528570","https://openalex.org/W2895748470","https://openalex.org/W2901090537","https://openalex.org/W2903362002","https://openalex.org/W2913664923","https://openalex.org/W2914965689","https://openalex.org/W2942446910","https://openalex.org/W2947197516","https://openalex.org/W2955681916","https://openalex.org/W2969339289","https://openalex.org/W2969798557","https://openalex.org/W2970329262","https://openalex.org/W2994053658","https://openalex.org/W2997125990","https://openalex.org/W3010791964","https://openalex.org/W3017576449","https://openalex.org/W3040542537","https://openalex.org/W4205103488","https://openalex.org/W4293052525","https://openalex.org/W6687596309","https://openalex.org/W6780487680"],"related_works":["https://openalex.org/W2794306047","https://openalex.org/W3008588181","https://openalex.org/W4386033707","https://openalex.org/W1970650594","https://openalex.org/W4387637728","https://openalex.org/W4378085118","https://openalex.org/W2111545764","https://openalex.org/W2079987784","https://openalex.org/W612523068","https://openalex.org/W1980654682"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":22},{"year":2025,"cited_by_count":30},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":10}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}