{"id":"https://openalex.org/W3132778321","doi":"https://doi.org/10.1056/nejmc2030164","title":"Five-Year Outcomes for Refractory B-Cell Lymphomas with CAR T-Cell Therapy","display_name":"Five-Year Outcomes for Refractory B-Cell Lymphomas with CAR T-Cell Therapy","publication_year":2021,"publication_date":"2021-02-17","ids":{"openalex":"https://openalex.org/W3132778321","doi":"https://doi.org/10.1056/nejmc2030164","mag":"3132778321","pmid":"https://pubmed.ncbi.nlm.nih.gov/33596362"},"language":"en","primary_location":{"id":"doi:10.1056/nejmc2030164","doi":"https://doi.org/10.1056/nejmc2030164","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmc2030164","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMc2030164?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMc2030164?articleTools=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015896987","display_name":"Elise A. Chong","orcid":"https://orcid.org/0000-0001-8895-1625","observed_orcids":["https://orcid.org/0000-0001-8895-1625"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elise A. Chong","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, PA","University of Pennsylvania, Philadelphia, PA elise.chong@pennmedicine.upenn.edu"],"raw_orcid":"https://orcid.org/0000-0001-8895-1625","affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA elise.chong@pennmedicine.upenn.edu","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088355904","display_name":"Marco Ruella","orcid":"https://orcid.org/0000-0003-4301-5811","observed_orcids":["https://orcid.org/0000-0003-4301-5811"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marco Ruella","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, PA","University of Pennsylvania, Philadelphia, PA elise.chong@pennmedicine.upenn.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA elise.chong@pennmedicine.upenn.edu","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080630441","display_name":"Stephen J. Schuster","orcid":"https://orcid.org/0000-0002-3376-8978","observed_orcids":["https://orcid.org/0000-0002-3376-8978"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Schuster","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, PA","University of Pennsylvania, Philadelphia, PA elise.chong@pennmedicine.upenn.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA elise.chong@pennmedicine.upenn.edu","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":21.6385,"has_fulltext":true,"cited_by_count":341,"citation_normalized_percentile":{"value":0.99777503,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"384","issue":"7","first_page":"673","last_page":"674"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.8840000033378601},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/follicular-lymphoma","display_name":"follicular lymphoma","score":1.0},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9639999866485596},{"id":"https://openalex.org/keywords/long-term-outcomes","display_name":"long-term outcomes","score":0.8270000219345093},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.7532682418823242},{"id":"https://openalex.org/C2777058707","wikidata":"https://www.wikidata.org/wiki/Q123251","display_name":"Follicular lymphoma","level":3,"score":0.7496417760848999},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.689039409160614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5694418549537659},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5505915284156799},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5080718994140625},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4683648347854614},{"id":"https://openalex.org/C2911194787","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"CAR T-cell therapy","level":5,"score":0.43569260835647583},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43535733222961426},{"id":"https://openalex.org/C2777257650","wikidata":"https://www.wikidata.org/wiki/Q4833719","display_name":"B-cell lymphoma","level":3,"score":0.42042088508605957},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41876283288002014},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2496708333492279},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.174017071723938},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.10649293661117554},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.10632142424583435},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.0769573450088501},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.06262916326522827},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.049953460693359375},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018941","descriptor_name":"Antigens, CD19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejmc2030164","doi":"https://doi.org/10.1056/nejmc2030164","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmc2030164","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMc2030164?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:33596362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33596362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Letter"}],"best_oa_location":{"id":"doi:10.1056/nejmc2030164","doi":"https://doi.org/10.1056/nejmc2030164","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmc2030164","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMc2030164?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1472606672","display_name":"Resistance To Targeted Immunotherapies:CART19 as a Paradigm","funder_award_id":"K99CA212302","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1527440055","display_name":"Resistance To Targeted Immunotherapies:CART19 as a Paradigm","funder_award_id":"R00CA212302","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6079785670","display_name":null,"funder_award_id":"NRF-2018M3A9H4056537","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G6598968374","display_name":null,"funder_award_id":"2018M3A9H4056537","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321202","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3132778321.pdf","grobid_xml":"https://content.openalex.org/works/W3132778321.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W2773804840","https://openalex.org/W2775369717","https://openalex.org/W2903062212","https://openalex.org/W2903225254","https://openalex.org/W3014583893"],"related_works":["https://openalex.org/W2775369717","https://openalex.org/W7165775590","https://openalex.org/W4401876457","https://openalex.org/W4401876077","https://openalex.org/W4281809825","https://openalex.org/W7221018785","https://openalex.org/W7125930958","https://openalex.org/W2946786528","https://openalex.org/W3029165453","https://openalex.org/W3199232787"],"abstract_inverted_index":{"Long-Term":[0],"Follow-up":[1],"of":[2],"CAR":[3],"T-Cell\u2013Treated":[4],"Lymphoma":[5],"Progression-free":[6],"survival":[7],"at":[8],"5":[9],"years":[10],"was":[11],"31%":[12],"in":[13,22],"patients":[14,23],"with":[15,24],"diffuse":[16],"large":[17],"B-cell":[18],"lymphoma":[19],"and":[20],"43%":[21],"follicular":[25],"lymphoma.":[26],"A":[27],"total":[28],"...":[29]},"counts_by_year":[{"year":2026,"cited_by_count":40},{"year":2025,"cited_by_count":61},{"year":2024,"cited_by_count":73},{"year":2023,"cited_by_count":58},{"year":2022,"cited_by_count":78},{"year":2021,"cited_by_count":31}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-01T00:00:00"}