{"id":"https://openalex.org/W3132740243","doi":"https://doi.org/10.1002/mgg3.1618","title":"Vitamin D status and CYP27B 1\u20101260 promoter polymorphism in Tunisian patients with systemic lupus erythematosus","display_name":"Vitamin D status and CYP27B 1\u20101260 promoter polymorphism in Tunisian patients with systemic lupus erythematosus","publication_year":2021,"publication_date":"2021-02-17","ids":{"openalex":"https://openalex.org/W3132740243","doi":"https://doi.org/10.1002/mgg3.1618","mag":"3132740243","pmid":"https://pubmed.ncbi.nlm.nih.gov/33594806","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8104169"},"language":"en","primary_location":{"id":"doi:10.1002/mgg3.1618","doi":"https://doi.org/10.1002/mgg3.1618","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mgg3.1618","pdf_url":null,"source":{"id":"https://openalex.org/S2764373787","display_name":"Molecular Genetics & Genomic Medicine","issn_l":"2324-9269","issn":["2324-9269"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Genetics & Genomic Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/mgg3.1618","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075751443","display_name":"Raouia Fakhfakh","orcid":"https://orcid.org/0000-0001-5379-0622","observed_orcids":["https://orcid.org/0000-0001-5379-0622"]},"institutions":[{"id":"https://openalex.org/I4210165772","display_name":"Hopital Universitaire Habib Bourguiba","ror":"https://ror.org/052g5ww90","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210165772"]}],"countries":["TN"],"is_corresponding":true,"raw_author_name":"Raouia Fakhfakh","raw_affiliation_strings":["Autoimmunity, Cancer and immunogenetics research laboratory, University hospital Habib Bourguiba of Sfax, Sfax, Tunisia"],"raw_orcid":"https://orcid.org/0000-0001-5379-0622","affiliations":[{"raw_affiliation_string":"Autoimmunity, Cancer and immunogenetics research laboratory, University hospital Habib Bourguiba of Sfax, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210165772"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102950407","display_name":"Sawsan Feki","orcid":"https://orcid.org/0000-0002-5382-5968","observed_orcids":["https://orcid.org/0000-0002-5382-5968"]},"institutions":[{"id":"https://openalex.org/I4210165772","display_name":"Hopital Universitaire Habib Bourguiba","ror":"https://ror.org/052g5ww90","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210165772"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Sawsan Feki","raw_affiliation_strings":["Autoimmunity, Cancer and immunogenetics research laboratory, University hospital Habib Bourguiba of Sfax, Sfax, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autoimmunity, Cancer and immunogenetics research laboratory, University hospital Habib Bourguiba of Sfax, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210165772"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103955954","display_name":"A\u00efda Elleuch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165772","display_name":"Hopital Universitaire Habib Bourguiba","ror":"https://ror.org/052g5ww90","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210165772"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Aida Elleuch","raw_affiliation_strings":["Biochemistry Department, Habib Bourguiba University Hospital, Sfax, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, Habib Bourguiba University Hospital, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210165772"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029630904","display_name":"Manel Neifar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165772","display_name":"Hopital Universitaire Habib Bourguiba","ror":"https://ror.org/052g5ww90","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210165772"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Manel Neifar","raw_affiliation_strings":["Biochemistry Department, Habib Bourguiba University Hospital, Sfax, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, Habib Bourguiba University Hospital, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210165772"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071358379","display_name":"Sameh Marzouk","orcid":"https://orcid.org/0000-0002-1494-2360","observed_orcids":["https://orcid.org/0000-0002-1494-2360"]},"institutions":[{"id":"https://openalex.org/I4210110673","display_name":"Hopital Universitaire Hedi Chaker","ror":"https://ror.org/01vqqz948","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210110673"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Sameh Marzouk","raw_affiliation_strings":["Internal Medicine Department, HediChaker University Hospital, Sfax, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine Department, HediChaker University Hospital, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210110673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028561248","display_name":"N\u00e9srine Elloumi","orcid":"https://orcid.org/0000-0001-6154-5854","observed_orcids":["https://orcid.org/0000-0001-6154-5854"]},"institutions":[{"id":"https://openalex.org/I4210165772","display_name":"Hopital Universitaire Habib Bourguiba","ror":"https://ror.org/052g5ww90","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210165772"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Nesrine Elloumi","raw_affiliation_strings":["Autoimmunity, Cancer and immunogenetics research laboratory, University hospital Habib Bourguiba of Sfax, Sfax, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autoimmunity, Cancer and immunogenetics research laboratory, University hospital Habib Bourguiba of Sfax, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210165772"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071894540","display_name":"Hend Hachicha","orcid":"https://orcid.org/0000-0002-5819-2899","observed_orcids":["https://orcid.org/0000-0002-5819-2899"]},"institutions":[{"id":"https://openalex.org/I4210165772","display_name":"Hopital Universitaire Habib Bourguiba","ror":"https://ror.org/052g5ww90","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210165772"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Hend Hachicha","raw_affiliation_strings":["Autoimmunity, Cancer and immunogenetics research laboratory, University hospital Habib Bourguiba of Sfax, Sfax, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autoimmunity, Cancer and immunogenetics research laboratory, University hospital Habib Bourguiba of Sfax, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210165772"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086299895","display_name":"Olfa Abida","orcid":"https://orcid.org/0000-0003-0208-145X","observed_orcids":["https://orcid.org/0000-0003-0208-145X"]},"institutions":[{"id":"https://openalex.org/I4210165772","display_name":"Hopital Universitaire Habib Bourguiba","ror":"https://ror.org/052g5ww90","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210165772"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Olfa Abida","raw_affiliation_strings":["Autoimmunity, Cancer and immunogenetics research laboratory, University hospital Habib Bourguiba of Sfax, Sfax, Tunisia"],"raw_orcid":"https://orcid.org/0000-0003-0208-145X","affiliations":[{"raw_affiliation_string":"Autoimmunity, Cancer and immunogenetics research laboratory, University hospital Habib Bourguiba of Sfax, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210165772"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038045771","display_name":"Zouhir Bahloul","orcid":"https://orcid.org/0000-0002-8481-5981","observed_orcids":["https://orcid.org/0000-0002-8481-5981"]},"institutions":[{"id":"https://openalex.org/I4210110673","display_name":"Hopital Universitaire Hedi Chaker","ror":"https://ror.org/01vqqz948","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210110673"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Zouhir Bahloul","raw_affiliation_strings":["Internal Medicine Department, HediChaker University Hospital, Sfax, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine Department, HediChaker University Hospital, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210110673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031274624","display_name":"Fatma Makni Ayadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165772","display_name":"Hopital Universitaire Habib Bourguiba","ror":"https://ror.org/052g5ww90","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210165772"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Fatma Ayadi","raw_affiliation_strings":["Biochemistry Department, Habib Bourguiba University Hospital, Sfax, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, Habib Bourguiba University Hospital, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210165772"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030553031","display_name":"Hatem Masmoudi","orcid":"https://orcid.org/0000-0002-5161-2846","observed_orcids":["https://orcid.org/0000-0002-5161-2846"]},"institutions":[{"id":"https://openalex.org/I4210165772","display_name":"Hopital Universitaire Habib Bourguiba","ror":"https://ror.org/052g5ww90","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210165772"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Hatem Masmoudi","raw_affiliation_strings":["Autoimmunity, Cancer and immunogenetics research laboratory, University hospital Habib Bourguiba of Sfax, Sfax, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autoimmunity, Cancer and immunogenetics research laboratory, University hospital Habib Bourguiba of Sfax, Sfax, Tunisia","institution_ids":["https://openalex.org/I4210165772"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075751443"],"corresponding_institution_ids":["https://openalex.org/I4210165772"],"apc_list":{"value":2420,"currency":"USD","value_usd":2420},"apc_paid":{"value":2420,"currency":"USD","value_usd":2420},"fwci":1.2017,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.76578739,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"9","issue":"3","first_page":"e1618","last_page":"e1618"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.18690000474452972,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9359999895095825},{"id":"https://openalex.org/keywords/vitamin-d-status","display_name":"vitamin D status","score":0.9739999771118164},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d","display_name":"25-hydroxyvitamin D","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cyp27b1","display_name":"CYP27B1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/vitamin-d-metabolism","display_name":"vitamin D metabolism","score":0.9049999713897705},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8410000205039978},{"id":"https://openalex.org/keywords/vitamin-d-deficiency","display_name":"vitamin D deficiency","score":0.7390000224113464},{"id":"https://openalex.org/keywords/tunisian-patients","display_name":"Tunisian patients","score":0.7620000243186951},{"id":"https://openalex.org/keywords/prednisolone","display_name":"prednisolone","score":0.875},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.659359335899353},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.5514720678329468},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5390043258666992},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5011305809020996},{"id":"https://openalex.org/C2779740938","wikidata":"https://www.wikidata.org/wiki/Q4138762","display_name":"vitamin D deficiency","level":3,"score":0.45635345578193665},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41601911187171936},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40155237913131714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2732833921909332},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11188393831253052},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08669698238372803}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014416","descriptor_name":"Tunisia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014808","descriptor_name":"Vitamin D Deficiency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014808","descriptor_name":"Vitamin D Deficiency","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015090","descriptor_name":"25-Hydroxyvitamin D3 1-alpha-Hydroxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/mgg3.1618","doi":"https://doi.org/10.1002/mgg3.1618","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mgg3.1618","pdf_url":null,"source":{"id":"https://openalex.org/S2764373787","display_name":"Molecular Genetics & Genomic Medicine","issn_l":"2324-9269","issn":["2324-9269"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Genetics & Genomic Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8104169","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8104169/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8104169/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Genet Genomic Med","raw_type":"Text"},{"id":"pmid:33594806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33594806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular genetics & genomic medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c563a97989e24ba69959a234cb385805","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c563a97989e24ba69959a234cb385805","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Genetics & Genomic Medicine, Vol 9, Iss 3, Pp n/a-n/a (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/mgg3.1618","doi":"https://doi.org/10.1002/mgg3.1618","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mgg3.1618","pdf_url":null,"source":{"id":"https://openalex.org/S2764373787","display_name":"Molecular Genetics & Genomic Medicine","issn_l":"2324-9269","issn":["2324-9269"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Genetics & Genomic Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3132740243.pdf","grobid_xml":"https://content.openalex.org/works/W3132740243.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W13274195","https://openalex.org/W201163592","https://openalex.org/W1481716770","https://openalex.org/W1490330304","https://openalex.org/W1599102932","https://openalex.org/W1599146062","https://openalex.org/W1775819922","https://openalex.org/W1795316817","https://openalex.org/W1859178604","https://openalex.org/W1896055237","https://openalex.org/W1911894412","https://openalex.org/W1959636718","https://openalex.org/W1967113804","https://openalex.org/W1977598211","https://openalex.org/W1979432001","https://openalex.org/W1980599797","https://openalex.org/W2003322712","https://openalex.org/W2009547297","https://openalex.org/W2015197986","https://openalex.org/W2036210929","https://openalex.org/W2038012108","https://openalex.org/W2040596947","https://openalex.org/W2042399219","https://openalex.org/W2044812900","https://openalex.org/W2052520185","https://openalex.org/W2053361293","https://openalex.org/W2054849381","https://openalex.org/W2068081568","https://openalex.org/W2069005072","https://openalex.org/W2070527591","https://openalex.org/W2085286594","https://openalex.org/W2092817189","https://openalex.org/W2093076036","https://openalex.org/W2096771654","https://openalex.org/W2103979725","https://openalex.org/W2106647095","https://openalex.org/W2112398552","https://openalex.org/W2121281629","https://openalex.org/W2124037296","https://openalex.org/W2124070987","https://openalex.org/W2135604027","https://openalex.org/W2141268642","https://openalex.org/W2142544310","https://openalex.org/W2144379648","https://openalex.org/W2162748586","https://openalex.org/W2171469662","https://openalex.org/W2316309358","https://openalex.org/W2331047553","https://openalex.org/W2395710398","https://openalex.org/W2401280391","https://openalex.org/W2551560047","https://openalex.org/W2563244602","https://openalex.org/W2737961213","https://openalex.org/W2765658908","https://openalex.org/W2971867263","https://openalex.org/W3017091447","https://openalex.org/W3081282712","https://openalex.org/W3149947358","https://openalex.org/W4292083220","https://openalex.org/W4392135214"],"related_works":["https://openalex.org/W7129012585","https://openalex.org/W2414857752","https://openalex.org/W2563466792","https://openalex.org/W4291498084","https://openalex.org/W2069640635","https://openalex.org/W2773581676","https://openalex.org/W3107876574","https://openalex.org/W2788763760","https://openalex.org/W2941367205","https://openalex.org/W2552895781"],"abstract_inverted_index":{"AIM:":[0],"An":[1],"association":[2,198],"between":[3,42],"serum":[4,69,102],"vitamin":[5,32,65],"D":[6,33,45,66,175,183,189],"(Vit":[7],"D)":[8],"levels":[9,143,190],"and":[10,55,68,88,98,109,125,144,156,217],"systemic":[11],"lupus":[12],"erythematosus":[13],"(SLE)":[14],"has":[15,81],"been":[16,82],"reported":[17],"by":[18,96,106],"several":[19],"studies":[20,211],"that":[21],"suggested":[22],"the":[23,40,48,58,148,167,170,187,200,204,222],"involvement":[24],"of":[25,29,31,52,57,135,150,173,224],"genetically":[26,205],"determined":[27,206],"characteristics":[28,223],"enzymes":[30],"metabolism.":[34],"Our":[35,130],"study":[36,80],"aimed":[37],"to":[38,93,214,221],"evaluate":[39],"relationship":[41],"25":[43],"hydroxyvitamin":[44],"(25[OH]D)":[46],"level,":[47],"most":[49],"representative":[50],"metabolite":[51],"VitD":[53],"status,":[54],"polymorphism":[56,112,152],"cytochrome":[59],"P450,":[60],"CYP27B1":[61],"gene,":[62],"which":[63],"influence":[64],"metabolism,":[67],"levels,":[70],"in":[71,84,153,179,191],"SLE":[72,85,154,193],"Tunisian":[73],"patients.":[74],"MATERIAL":[75],"AND":[76],"METHODS:":[77],"A":[78],"cross-sectional":[79],"conducted":[83],"patients":[86,155,194],"(supplemented":[87],"not":[89],"supplemented":[90],"patients),":[91],"matched":[92],"healthy":[94],"controls":[95,157],"age":[97],"gender.":[99],"The":[100],"25[OH]D":[101,137],"level":[103,138],"was":[104,113,121],"measured":[105],"chemiluminescence":[107],"assay":[108],"CYP27B1-1260":[110,151],"genetic":[111],"carried":[114],"out":[115],"using":[116,123],"PCR-RFLP":[117],"methods.":[118],"Statistical":[119],"analysis":[120,149],"made":[122],"Shesis":[124],"SPSS.20":[126],"Software.":[127],"RESULTS:":[128],").":[129],"results":[131],"showed":[132],"a":[133,159,196],"correlation":[134],"high":[136,171],"with":[139,199,203],"complement":[140],"component":[141],"3":[142],"prednisolone":[145],"drug.":[146],"Moreover,":[147],"revealed":[158],"nonsignificant":[160],"allelic":[161],"or":[162,202],"genotypic":[163],"association.":[164],"CONCLUSION:":[165],"Despite":[166],"sunny":[168],"climate,":[169],"prevalence":[172],"Vit":[174,188],"deficiency":[176],"is":[177],"common":[178],"Tunisia.":[180],"This":[181],"hypovitaminosis":[182],"feature":[184],"may":[185],"affect":[186],"our":[192],"but":[195],"direct":[197],"disease":[201],"features":[207],"remains":[208],"unclear.":[209],"More":[210],"are":[212],"needed":[213],"establish":[215],"thresholds":[216],"susceptibility":[218],"genes":[219],"according":[220],"each":[225],"population.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-03-01T00:00:00"}