{"id":"https://openalex.org/W3132722263","doi":"https://doi.org/10.1016/j.jchromb.2021.122574","title":"Simple determination of valproic acid serum concentrations using BioSPME followed by gas chromatography-mass spectrometric analysis","display_name":"Simple determination of valproic acid serum concentrations using BioSPME followed by gas chromatography-mass spectrometric analysis","publication_year":2021,"publication_date":"2021-02-15","ids":{"openalex":"https://openalex.org/W3132722263","doi":"https://doi.org/10.1016/j.jchromb.2021.122574","mag":"3132722263","pmid":"https://pubmed.ncbi.nlm.nih.gov/33621796"},"language":"en","primary_location":{"id":"doi:10.1016/j.jchromb.2021.122574","doi":"https://doi.org/10.1016/j.jchromb.2021.122574","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jchromb.2021.122574","pdf_url":null,"source":{"id":"https://openalex.org/S103248676","display_name":"Journal of Chromatography B","issn_l":"1570-0232","issn":["1570-0232","1873-376X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography B","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038081337","display_name":"Vitoria Daniela Schaefer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145689991","display_name":"Universidade Feevale","ror":"https://ror.org/05gefd119","country_code":"BR","type":"education","lineage":["https://openalex.org/I145689991"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vitoria Daniela Schaefer","raw_affiliation_strings":["Analytical Toxicology Laboratory, Universidade Feevale, Novo Hamburgo, RS, Brazil; Graduate Program on Toxicology and Analytical Toxicology, Universidade Feevale, Novo Hamburgo, RS, Brazil","Analytical Toxicology Laboratory, Universidade Feevale, Novo Hamburgo, RS, Brazil","Graduate Program on Toxicology and Analytical Toxicology, Universidade Feevale, Novo Hamburgo, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Toxicology Laboratory, Universidade Feevale, Novo Hamburgo, RS, Brazil; Graduate Program on Toxicology and Analytical Toxicology, Universidade Feevale, Novo Hamburgo, RS, Brazil","institution_ids":["https://openalex.org/I145689991"]},{"raw_affiliation_string":"Analytical Toxicology Laboratory, Universidade Feevale, Novo Hamburgo, RS, Brazil","institution_ids":["https://openalex.org/I145689991"]},{"raw_affiliation_string":"Graduate Program on Toxicology and Analytical Toxicology, Universidade Feevale, Novo Hamburgo, RS, Brazil","institution_ids":["https://openalex.org/I145689991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009315161","display_name":"Lilian de Lima Feltraco Lizot","orcid":"https://orcid.org/0000-0003-3165-1407","observed_orcids":["https://orcid.org/0000-0003-3165-1407"]},"institutions":[{"id":"https://openalex.org/I145689991","display_name":"Universidade Feevale","ror":"https://ror.org/05gefd119","country_code":"BR","type":"education","lineage":["https://openalex.org/I145689991"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lilian de Lima Feltraco Lizot","raw_affiliation_strings":["Analytical Toxicology Laboratory, Universidade Feevale, Novo Hamburgo, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Toxicology Laboratory, Universidade Feevale, Novo Hamburgo, RS, Brazil","institution_ids":["https://openalex.org/I145689991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033140181","display_name":"Roberta Zilles Hahn","orcid":"https://orcid.org/0000-0002-0403-0683","observed_orcids":["https://orcid.org/0000-0002-0403-0683"]},"institutions":[{"id":"https://openalex.org/I145689991","display_name":"Universidade Feevale","ror":"https://ror.org/05gefd119","country_code":"BR","type":"education","lineage":["https://openalex.org/I145689991"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Roberta Zilles Hahn","raw_affiliation_strings":["Analytical Toxicology Laboratory, Universidade Feevale, Novo Hamburgo, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Toxicology Laboratory, Universidade Feevale, Novo Hamburgo, RS, Brazil","institution_ids":["https://openalex.org/I145689991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037937738","display_name":"Anelise Schneider","orcid":"https://orcid.org/0000-0001-6836-612X","observed_orcids":["https://orcid.org/0000-0001-6836-612X"]},"institutions":[{"id":"https://openalex.org/I145689991","display_name":"Universidade Feevale","ror":"https://ror.org/05gefd119","country_code":"BR","type":"education","lineage":["https://openalex.org/I145689991"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Anelise Schneider","raw_affiliation_strings":["Analytical Toxicology Laboratory, Universidade Feevale, Novo Hamburgo, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Toxicology Laboratory, Universidade Feevale, Novo Hamburgo, RS, Brazil","institution_ids":["https://openalex.org/I145689991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058840924","display_name":"Marina Venzon Antunes","orcid":"https://orcid.org/0000-0001-9157-9510","observed_orcids":["https://orcid.org/0000-0001-9157-9510"]},"institutions":[{"id":"https://openalex.org/I145689991","display_name":"Universidade Feevale","ror":"https://ror.org/05gefd119","country_code":"BR","type":"education","lineage":["https://openalex.org/I145689991"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marina Venzon Antunes","raw_affiliation_strings":["Analytical Toxicology Laboratory, Universidade Feevale, Novo Hamburgo, RS, Brazil; Graduate Program on Toxicology and Analytical Toxicology, Universidade Feevale, Novo Hamburgo, RS, Brazil","Analytical Toxicology Laboratory, Universidade Feevale, Novo Hamburgo, RS, Brazil","Graduate Program on Toxicology and Analytical Toxicology, Universidade Feevale, Novo Hamburgo, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Toxicology Laboratory, Universidade Feevale, Novo Hamburgo, RS, Brazil; Graduate Program on Toxicology and Analytical Toxicology, Universidade Feevale, Novo Hamburgo, RS, Brazil","institution_ids":["https://openalex.org/I145689991"]},{"raw_affiliation_string":"Analytical Toxicology Laboratory, Universidade Feevale, Novo Hamburgo, RS, Brazil","institution_ids":["https://openalex.org/I145689991"]},{"raw_affiliation_string":"Graduate Program on Toxicology and Analytical Toxicology, Universidade Feevale, Novo Hamburgo, RS, Brazil","institution_ids":["https://openalex.org/I145689991"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074110261","display_name":"Rafael Linden","orcid":"https://orcid.org/0000-0002-6966-5073","observed_orcids":["https://orcid.org/0000-0002-6966-5073"]},"institutions":[{"id":"https://openalex.org/I145689991","display_name":"Universidade Feevale","ror":"https://ror.org/05gefd119","country_code":"BR","type":"education","lineage":["https://openalex.org/I145689991"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Rafael Linden","raw_affiliation_strings":["Analytical Toxicology Laboratory, Universidade Feevale, Novo Hamburgo, RS, Brazil; Graduate Program on Toxicology and Analytical Toxicology, Universidade Feevale, Novo Hamburgo, RS, Brazil. Electronic address: rafael.linden@feevale.br","Analytical Toxicology Laboratory, Universidade Feevale, Novo Hamburgo, RS, Brazil","Graduate Program on Toxicology and Analytical Toxicology, Universidade Feevale, Novo Hamburgo, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Toxicology Laboratory, Universidade Feevale, Novo Hamburgo, RS, Brazil; Graduate Program on Toxicology and Analytical Toxicology, Universidade Feevale, Novo Hamburgo, RS, Brazil. Electronic address: rafael.linden@feevale.br","institution_ids":["https://openalex.org/I145689991"]},{"raw_affiliation_string":"Analytical Toxicology Laboratory, Universidade Feevale, Novo Hamburgo, RS, Brazil","institution_ids":["https://openalex.org/I145689991"]},{"raw_affiliation_string":"Graduate Program on Toxicology and Analytical Toxicology, Universidade Feevale, Novo Hamburgo, RS, Brazil","institution_ids":["https://openalex.org/I145689991"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074110261"],"corresponding_institution_ids":["https://openalex.org/I145689991"],"apc_list":{"value":3200,"currency":"USD","value_usd":3200},"apc_paid":null,"fwci":1.1319,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.70505293,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"1167","issue":null,"first_page":"122574","last_page":"122574"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":1.0},{"id":"https://openalex.org/keywords/solid-phase-microextraction","display_name":"solid-phase microextraction","score":0.9169999957084656},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.9729999899864197},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.7910000085830688},{"id":"https://openalex.org/keywords/bioanalytical-method-validation","display_name":"bioanalytical method validation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/sample-preparation","display_name":"sample preparation","score":0.6029999852180481},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.36399999260902405},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.765999972820282},{"id":"https://openalex.org/keywords/liquid-liquid-extraction-comparison","display_name":"liquid-liquid extraction comparison","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.9068276882171631},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8793631196022034},{"id":"https://openalex.org/C137535248","wikidata":"https://www.wikidata.org/wiki/Q4914691","display_name":"Bioanalysis","level":2,"score":0.7657555341720581},{"id":"https://openalex.org/C2778576202","wikidata":"https://www.wikidata.org/wiki/Q2540164","display_name":"Sample preparation","level":2,"score":0.6322094202041626},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.6295880079269409},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.5592235326766968},{"id":"https://openalex.org/C205345274","wikidata":"https://www.wikidata.org/wiki/Q873009","display_name":"Gas chromatography\u2013mass spectrometry","level":3,"score":0.5540148019790649},{"id":"https://openalex.org/C123460561","wikidata":"https://www.wikidata.org/wiki/Q677065","display_name":"Gas chromatography","level":2,"score":0.522519588470459},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.422049343585968},{"id":"https://openalex.org/C2777172819","wikidata":"https://www.wikidata.org/wiki/Q240642","display_name":"Valproic Acid","level":3,"score":0.41113996505737305},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.3450770378112793},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.18027713894844055},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.12820905447006226},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.06986063718795776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052617","descriptor_name":"Solid Phase Microextraction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jchromb.2021.122574","doi":"https://doi.org/10.1016/j.jchromb.2021.122574","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jchromb.2021.122574","pdf_url":null,"source":{"id":"https://openalex.org/S103248676","display_name":"Journal of Chromatography B","issn_l":"1570-0232","issn":["1570-0232","1873-376X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography B","raw_type":"journal-article"},{"id":"pmid:33621796","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33621796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chromatography. B, Analytical technologies in the biomedical and life sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320323809","display_name":"Minist\u00e9rio da Educa\u00e7\u00e3o","ror":"https://ror.org/04d0xx942"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1971966881","https://openalex.org/W2024201770","https://openalex.org/W2042178630","https://openalex.org/W2093643650","https://openalex.org/W2753966476","https://openalex.org/W2789643018","https://openalex.org/W2945114164","https://openalex.org/W4251353928"],"related_works":["https://openalex.org/W4292265679","https://openalex.org/W7202224453","https://openalex.org/W1982744512","https://openalex.org/W1977125443","https://openalex.org/W2093643650","https://openalex.org/W1972131316","https://openalex.org/W2145443436","https://openalex.org/W1835096230","https://openalex.org/W2883389053","https://openalex.org/W2095608230"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-01T00:00:00"}