{"id":"https://openalex.org/W3132569332","doi":"https://doi.org/10.1016/j.ijbiomac.2021.02.072","title":"Disulfiram and 6-Thioguanine synergistically inhibit the enzymatic activities of USP2 and USP21","display_name":"Disulfiram and 6-Thioguanine synergistically inhibit the enzymatic activities of USP2 and USP21","publication_year":2021,"publication_date":"2021-02-11","ids":{"openalex":"https://openalex.org/W3132569332","doi":"https://doi.org/10.1016/j.ijbiomac.2021.02.072","mag":"3132569332","pmid":"https://pubmed.ncbi.nlm.nih.gov/33582217"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijbiomac.2021.02.072","doi":"https://doi.org/10.1016/j.ijbiomac.2021.02.072","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijbiomac.2021.02.072","pdf_url":null,"source":{"id":"https://openalex.org/S83853393","display_name":"International Journal of Biological Macromolecules","issn_l":"0141-8130","issn":["0141-8130","1879-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Macromolecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069405439","display_name":"Hsin-Cheng Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsin-Cheng Lin","raw_affiliation_strings":["Basic Research Division, Medical Research Department, Taipei Veterans General Hospital, Taipei 112, Taiwan; Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","Basic Research Division, Medical Research Department, Taipei Veterans General Hospital, Taipei 112, Taiwan","Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Research Division, Medical Research Department, Taipei Veterans General Hospital, Taipei 112, Taiwan; Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I148366613","https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Basic Research Division, Medical Research Department, Taipei Veterans General Hospital, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ying Kuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ying Kuan","raw_affiliation_strings":["Program in Molecular Medicine, National Yang Ming Chiao Tung University and Acedemia Sinica, Taipei 112, Taiwan; Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","Program in Molecular Medicine, National Yang Ming Chiao Tung University and Acedemia Sinica, Taipei 112, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Molecular Medicine, National Yang Ming Chiao Tung University and Acedemia Sinica, Taipei 112, Taiwan; Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Program in Molecular Medicine, National Yang Ming Chiao Tung University and Acedemia Sinica, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028121758","display_name":"Hsu-Feng Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsu-Feng Chu","raw_affiliation_strings":["Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan; Biomedical Industry Ph.D. Program, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","Biomedical Industry Ph.D. Program, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan; Biomedical Industry Ph.D. Program, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Biomedical Industry Ph.D. Program, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113832041","display_name":"Shu-Chun Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210111603","display_name":"Keelung Chang Gung Memorial Hospital","ror":"https://ror.org/020dg9f27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210111603"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shu-Chun Cheng","raw_affiliation_strings":["Department of Nephrology, Chang Gung Memorial Hospital, Keelung 204, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Chang Gung Memorial Hospital, Keelung 204, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210111603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007688658","display_name":"Heng\u2010Chih Pan","orcid":"https://orcid.org/0000-0001-5782-7138","observed_orcids":["https://orcid.org/0000-0001-5782-7138"]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210111603","display_name":"Keelung Chang Gung Memorial Hospital","ror":"https://ror.org/020dg9f27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210111603"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Heng-Chih Pan","raw_affiliation_strings":["Department of Nephrology, Chang Gung Memorial Hospital, Keelung 204, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Chang Gung Memorial Hospital, Keelung 204, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210111603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074727195","display_name":"Wei\u2010Yi Chen","orcid":"https://orcid.org/0000-0002-0661-6899","observed_orcids":["https://orcid.org/0000-0002-0661-6899"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Yi Chen","raw_affiliation_strings":["Program in Molecular Medicine, National Yang Ming Chiao Tung University and Acedemia Sinica, Taipei 112, Taiwan; Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","Program in Molecular Medicine, National Yang Ming Chiao Tung University and Acedemia Sinica, Taipei 112, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Molecular Medicine, National Yang Ming Chiao Tung University and Acedemia Sinica, Taipei 112, Taiwan; Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Program in Molecular Medicine, National Yang Ming Chiao Tung University and Acedemia Sinica, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001923294","display_name":"Chiao\u2010Yin Sun","orcid":"https://orcid.org/0000-0001-7438-8042","observed_orcids":["https://orcid.org/0000-0001-7438-8042"]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210111603","display_name":"Keelung Chang Gung Memorial Hospital","ror":"https://ror.org/020dg9f27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210111603"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chiao-Yin Sun","raw_affiliation_strings":["Department of Nephrology, Chang Gung Memorial Hospital, Keelung 204, Taiwan. Electronic address: fish3970@gmail.com","Department of Nephrology, Chang Gung Memorial Hospital, Keelung 204, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Chang Gung Memorial Hospital, Keelung 204, Taiwan. Electronic address: fish3970@gmail.com","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210111603"]},{"raw_affiliation_string":"Department of Nephrology, Chang Gung Memorial Hospital, Keelung 204, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210111603"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109457119","display_name":"Ta-Hsien Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Ta-Hsien Lin","raw_affiliation_strings":["Basic Research Division, Medical Research Department, Taipei Veterans General Hospital, Taipei 112, Taiwan; Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan; Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan; Biomedical Industry Ph.D. Program, National Yang Ming Chiao Tung University, Taipei 112, Taiwan. Electronic address: thlin@vghtpe.gov.tw","Basic Research Division, Medical Research Department, Taipei Veterans General Hospital, Taipei 112, Taiwan","Biomedical Industry Ph.D. Program, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Research Division, Medical Research Department, Taipei Veterans General Hospital, Taipei 112, Taiwan; Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan; Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan; Biomedical Industry Ph.D. Program, National Yang Ming Chiao Tung University, Taipei 112, Taiwan. Electronic address: thlin@vghtpe.gov.tw","institution_ids":["https://openalex.org/I148366613","https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Basic Research Division, Medical Research Department, Taipei Veterans General Hospital, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Biomedical Industry Ph.D. Program, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5001923294","https://openalex.org/A5109457119"],"corresponding_institution_ids":["https://openalex.org/I148366613","https://openalex.org/I2803004286","https://openalex.org/I3020100970","https://openalex.org/I4210111603"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.3314,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.799306,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"176","issue":null,"first_page":"490","last_page":"497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disulfiram","display_name":"disulfiram","score":1.0},{"id":"https://openalex.org/keywords/6-thioguanine","display_name":"6-thioguanine","score":0.996999979019165},{"id":"https://openalex.org/keywords/usp2","display_name":"USP2","score":0.9819999933242798},{"id":"https://openalex.org/keywords/usp21","display_name":"USP21","score":1.0},{"id":"https://openalex.org/keywords/ubiquitin-specific-protease","display_name":"ubiquitin-specific protease","score":0.9490000009536743},{"id":"https://openalex.org/keywords/deubiquitinase-inhibition","display_name":"deubiquitinase inhibition","score":0.8939999938011169},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.8830000162124634},{"id":"https://openalex.org/keywords/synergistic-drug-combination","display_name":"synergistic drug combination","score":0.7540000081062317},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.6370000243186951},{"id":"https://openalex.org/keywords/slow-binding-inhibition","display_name":"slow-binding inhibition","score":0.7480000257492065},{"id":"https://openalex.org/keywords/zinc-finger","display_name":"zinc finger","score":0.796999990940094},{"id":"https://openalex.org/keywords/anticancer-drug-targets","display_name":"anticancer drug targets","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C2778523461","wikidata":"https://www.wikidata.org/wiki/Q409665","display_name":"Disulfiram","level":2,"score":0.9362814426422119},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.8503819704055786},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.626227080821991},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5496852397918701},{"id":"https://openalex.org/C2779832904","wikidata":"https://www.wikidata.org/wiki/Q410420","display_name":"Papain","level":3,"score":0.4649219810962677},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.46406468749046326},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43482428789138794},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.42236363887786865},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3310394883155823},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23346459865570068}],"mesh":[{"descriptor_ui":"D004221","descriptor_name":"Disulfiram","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004221","descriptor_name":"Disulfiram","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013866","descriptor_name":"Thioguanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013866","descriptor_name":"Thioguanine","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D043222","descriptor_name":"Ubiquitin Thiolesterase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D043222","descriptor_name":"Ubiquitin Thiolesterase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ijbiomac.2021.02.072","doi":"https://doi.org/10.1016/j.ijbiomac.2021.02.072","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijbiomac.2021.02.072","pdf_url":null,"source":{"id":"https://openalex.org/S83853393","display_name":"International Journal of Biological Macromolecules","issn_l":"0141-8130","issn":["0141-8130","1879-0003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Macromolecules","raw_type":"journal-article"},{"id":"pmid:33582217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33582217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of biological macromolecules","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1583812762","https://openalex.org/W1964341201","https://openalex.org/W1977447872","https://openalex.org/W1998416671","https://openalex.org/W1999816037","https://openalex.org/W2018880588","https://openalex.org/W2034087450","https://openalex.org/W2078727354","https://openalex.org/W2089190709","https://openalex.org/W2092250940","https://openalex.org/W2093307568","https://openalex.org/W2094181164","https://openalex.org/W2109107096","https://openalex.org/W2113902100","https://openalex.org/W2118225942","https://openalex.org/W2130039756","https://openalex.org/W2139364069","https://openalex.org/W2139592339","https://openalex.org/W2143460288","https://openalex.org/W2147536399","https://openalex.org/W2151230162","https://openalex.org/W2162228855","https://openalex.org/W2171832958","https://openalex.org/W2310322011","https://openalex.org/W2519697102","https://openalex.org/W2527599582","https://openalex.org/W2531600818","https://openalex.org/W2552591484","https://openalex.org/W2556607291","https://openalex.org/W2559675363","https://openalex.org/W2765710196","https://openalex.org/W2772508026","https://openalex.org/W2778062090","https://openalex.org/W2793623730","https://openalex.org/W2802028035","https://openalex.org/W2894232300","https://openalex.org/W2902166610","https://openalex.org/W2909489840","https://openalex.org/W2921491299","https://openalex.org/W2923609917","https://openalex.org/W6758186024"],"related_works":["https://openalex.org/W2095950689","https://openalex.org/W2793623730","https://openalex.org/W2750981220","https://openalex.org/W2186858139","https://openalex.org/W2766755551","https://openalex.org/W2335702665","https://openalex.org/W2340842073","https://openalex.org/W115396426","https://openalex.org/W2966972978","https://openalex.org/W2110395715"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-01T00:00:00"}