{"id":"https://openalex.org/W3132494913","doi":"https://doi.org/10.1002/asia.202100060","title":"Improved Stabilities of Labeling Probes for the Selective Modification of Endogenous Proteins in Living Cells and In Vivo","display_name":"Improved Stabilities of Labeling Probes for the Selective Modification of Endogenous Proteins in Living Cells and In Vivo","publication_year":2021,"publication_date":"2021-02-25","ids":{"openalex":"https://openalex.org/W3132494913","doi":"https://doi.org/10.1002/asia.202100060","mag":"3132494913","pmid":"https://pubmed.ncbi.nlm.nih.gov/33629493"},"language":"en","primary_location":{"id":"doi:10.1002/asia.202100060","doi":"https://doi.org/10.1002/asia.202100060","is_oa":false,"landing_page_url":"https://doi.org/10.1002/asia.202100060","pdf_url":null,"source":{"id":"https://openalex.org/S188582317","display_name":"Chemistry - An Asian Journal","issn_l":"1861-471X","issn":["1861-471X","1861-4728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 An Asian Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079893811","display_name":"Kuan\u2010Yu Lin","orcid":"https://orcid.org/0000-0002-2426-5543","observed_orcids":["https://orcid.org/0000-0002-2426-5543"]},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuan\u2010Yu Lin","raw_affiliation_strings":["Department of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan","These authors contributed equally"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"These authors contributed equally","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006077395","display_name":"Chak Hin Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chak Hin Lam","raw_affiliation_strings":["Department of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan","These authors contributed equally"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"These authors contributed equally","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065646348","display_name":"Xin\u2010Hui Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Xin\u2010Hui Lin","raw_affiliation_strings":["Department of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061860623","display_name":"Jung\u2010I Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jung\u2010I Hsu","raw_affiliation_strings":["Department of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061664552","display_name":"Syuan\u2010Yun Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Syuan\u2010Yun Fan","raw_affiliation_strings":["Department of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083018392","display_name":"Nitesh K. Gupta","orcid":"https://orcid.org/0000-0003-3686-1905","observed_orcids":["https://orcid.org/0000-0003-3686-1905"]},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Nitesh K. Gupta","raw_affiliation_strings":["Department of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057977715","display_name":"Yu\u2010Chun Lin","orcid":"https://orcid.org/0000-0002-9629-7560","observed_orcids":["https://orcid.org/0000-0002-9629-7560","https://orcid.org/0000-0001-5616-2621"]},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu\u2010Chun Lin","raw_affiliation_strings":["Department of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034346947","display_name":"Boon Khoon Tee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Boon Khoon Tee","raw_affiliation_strings":["Department of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026440108","display_name":"J M Li","orcid":"https://orcid.org/0000-0003-1868-5602","observed_orcids":["https://orcid.org/0000-0003-1868-5602"]},"institutions":[{"id":"https://openalex.org/I165441096","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I165441096"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jui\u2010Ping Li","raw_affiliation_strings":["Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, 35053 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, 35053 Taiwan","institution_ids":["https://openalex.org/I165441096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035666454","display_name":"Jen\u2010Kun Chen","orcid":"https://orcid.org/0000-0002-3433-5971","observed_orcids":["https://orcid.org/0000-0002-3433-5971"]},"institutions":[{"id":"https://openalex.org/I165441096","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I165441096"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jen\u2010Kun Chen","raw_affiliation_strings":["Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, 35053 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, 35053 Taiwan","institution_ids":["https://openalex.org/I165441096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101939203","display_name":"Kui\u2010Thong Tan","orcid":"https://orcid.org/0000-0002-0091-8546","observed_orcids":["https://orcid.org/0000-0002-0091-8546"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Kui\u2010Thong Tan","raw_affiliation_strings":["Department of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan","Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, 807 Taiwan","Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-0091-8546","affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, 807 Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, 101 Section 2, Kuang Fu Road, Hsinchu, 30013 Taiwan","institution_ids":["https://openalex.org/I25846049"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101939203"],"corresponding_institution_ids":["https://openalex.org/I152743029","https://openalex.org/I25846049"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":0.4801,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.46999487,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"16","issue":"8","first_page":"937","last_page":"948"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/probe-stability","display_name":"probe stability","score":0.7570000290870667},{"id":"https://openalex.org/keywords/selective-labeling","display_name":"selective labeling","score":0.4959999918937683},{"id":"https://openalex.org/keywords/living-cells","display_name":"living cells","score":0.6129999756813049},{"id":"https://openalex.org/keywords/in-vivo-labeling","display_name":"in vivo labeling","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cell-surface-labeling","display_name":"cell surface labeling","score":0.8059999942779541},{"id":"https://openalex.org/keywords/hypoxia-markers","display_name":"hypoxia markers","score":0.8190000057220459},{"id":"https://openalex.org/keywords/fluorophore-conjugation","display_name":"fluorophore conjugation","score":0.6679999828338623},{"id":"https://openalex.org/keywords/enzymatic-hydrolysis-resistance","display_name":"enzymatic hydrolysis resistance","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7798614501953125},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.7380920648574829},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.65753173828125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5681250095367432},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.452757328748703},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.44029322266578674},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42891374230384827},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42369765043258667},{"id":"https://openalex.org/C2908540775","wikidata":"https://www.wikidata.org/wiki/Q4688981","display_name":"Affinity labeling","level":3,"score":0.4171478748321533},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3776094913482666},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.35354283452033997},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.34459054470062256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27853137254714966},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024402","descriptor_name":"Carbonic Anhydrase II","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D024402","descriptor_name":"Carbonic Anhydrase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/asia.202100060","doi":"https://doi.org/10.1002/asia.202100060","is_oa":false,"landing_page_url":"https://doi.org/10.1002/asia.202100060","pdf_url":null,"source":{"id":"https://openalex.org/S188582317","display_name":"Chemistry - An Asian Journal","issn_l":"1861-471X","issn":["1861-471X","1861-4728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 An Asian Journal","raw_type":"journal-article"},{"id":"pmid:33629493","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33629493","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry, an Asian journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7072932468","display_name":null,"funder_award_id":"108QI009E1","funder_id":"https://openalex.org/F4320323092","funder_display_name":"National Tsing Hua University"}],"funders":[{"id":"https://openalex.org/F4320323092","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1897236478","https://openalex.org/W1967261700","https://openalex.org/W1971295798","https://openalex.org/W1973453135","https://openalex.org/W1978513278","https://openalex.org/W1979276629","https://openalex.org/W1981892553","https://openalex.org/W1985283191","https://openalex.org/W1994905834","https://openalex.org/W2005479769","https://openalex.org/W2018319200","https://openalex.org/W2036648499","https://openalex.org/W2039186342","https://openalex.org/W2041806467","https://openalex.org/W2042056420","https://openalex.org/W2044817923","https://openalex.org/W2046236732","https://openalex.org/W2047178318","https://openalex.org/W2055190474","https://openalex.org/W2081242643","https://openalex.org/W2099616027","https://openalex.org/W2114005496","https://openalex.org/W2116184358","https://openalex.org/W2118812289","https://openalex.org/W2120090919","https://openalex.org/W2131508727","https://openalex.org/W2152854510","https://openalex.org/W2155791832","https://openalex.org/W2163471519","https://openalex.org/W2167105905","https://openalex.org/W2171862695","https://openalex.org/W2282355767","https://openalex.org/W2290712119","https://openalex.org/W2325156674","https://openalex.org/W2332180798","https://openalex.org/W2338312947","https://openalex.org/W2526407243","https://openalex.org/W2531611585","https://openalex.org/W2566055968","https://openalex.org/W2575838842","https://openalex.org/W2613304175","https://openalex.org/W2655024765","https://openalex.org/W2742118221","https://openalex.org/W2771015442","https://openalex.org/W2794711348","https://openalex.org/W2806557186","https://openalex.org/W2810774065","https://openalex.org/W2908038781","https://openalex.org/W3087004347","https://openalex.org/W4236171252","https://openalex.org/W4251089733","https://openalex.org/W6607786901"],"related_works":["https://openalex.org/W3087004347","https://openalex.org/W4323347368","https://openalex.org/W4407053347","https://openalex.org/W2908046591","https://openalex.org/W2742700903","https://openalex.org/W1968072301","https://openalex.org/W2046639578","https://openalex.org/W4412162384","https://openalex.org/W4396563773","https://openalex.org/W7135060679"],"abstract_inverted_index":{"To":[0],"date,":[1],"various":[2],"affinity-based":[3],"protein":[4,93,123],"labeling":[5,33,44,60,74,94],"probes":[6,34,61,96],"have":[7],"been":[8],"developed":[9],"and":[10,22,42,53,72,85,114,122,135,141,148],"applied":[11],"in":[12,19,45,54,86,107,132,144],"biological":[13],"research":[14],"to":[15,111],"modify":[16],"endogenous":[17,76,129],"proteins":[18,77],"cell":[20,25,80],"lysates":[21],"on":[23,31,78],"the":[24,28,32,37,79,91,98],"surface.":[26],"However,":[27],"reactive":[29],"groups":[30],"are":[35],"also":[36],"cause":[38],"of":[39,63,75],"probe":[40,127],"instability":[41],"nonselective":[43],"a":[46,64],"more":[47],"complex":[48],"environment,":[49],"e.":[50],"g.,":[51],"intracellular":[52],"vivo.":[55,87],"Here,":[56],"we":[57],"show":[58],"that":[59],"composed":[62],"sterically":[65],"stabilized":[66],"difluorophenyl":[67,99],"pivalate":[68,100],"can":[69,115],"achieve":[70],"efficient":[71],"selective":[73],"surface,":[81],"inside":[82],"living":[83,133],"cells":[84,134],"As":[88],"compared":[89],"with":[90,97,119],"existing":[92],"probes,":[95],"exhibit":[101],"several":[102],"advantages,":[103],"including":[104],"long-term":[105],"stability":[106],"stock":[108],"solutions,":[109],"resistance":[110],"enzymatic":[112],"hydrolysis":[113],"be":[116],"customized":[117],"easily":[118],"diverse":[120],"fluorophores":[121],"ligands.":[124],"With":[125],"this":[126],"design,":[128],"hypoxia":[130],"biomarker":[131],"nude":[136],"mice":[137],"were":[138],"successfully":[139],"labeled":[140],"validated":[142],"by":[143],"vivo,":[145,147],"ex":[146],"immunohistochemistry":[149],"imaging.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2021-03-01T00:00:00"}