{"id":"https://openalex.org/W3132396655","doi":"https://doi.org/10.1007/s00520-021-06100-4","title":"Persistence, compliance, discontinuation rates and switch rates in denosumab and bisphosphonate treatment of bone metastases in cancer patients: reasons of switch, osteonecrosis of the jaw (ONJ) and other critical points","display_name":"Persistence, compliance, discontinuation rates and switch rates in denosumab and bisphosphonate treatment of bone metastases in cancer patients: reasons of switch, osteonecrosis of the jaw (ONJ) and other critical points","publication_year":2021,"publication_date":"2021-02-25","ids":{"openalex":"https://openalex.org/W3132396655","doi":"https://doi.org/10.1007/s00520-021-06100-4","mag":"3132396655","pmid":"https://pubmed.ncbi.nlm.nih.gov/33634351"},"language":"en","primary_location":{"id":"doi:10.1007/s00520-021-06100-4","doi":"https://doi.org/10.1007/s00520-021-06100-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00520-021-06100-4","pdf_url":null,"source":{"id":"https://openalex.org/S50055314","display_name":"Supportive Care in Cancer","issn_l":"0941-4355","issn":["0941-4355","1433-7339"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Supportive Care in Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066059934","display_name":"Maura Rossi","orcid":"https://orcid.org/0000-0001-9445-0376","observed_orcids":["https://orcid.org/0000-0001-9445-0376"]},"institutions":[{"id":"https://openalex.org/I4210157726","display_name":"Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo","ror":"https://ror.org/04yxyzj48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210157726"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maura Rossi","raw_affiliation_strings":["Oncology Unit and Centro Documentazione Osteonecrosi, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Unit and Centro Documentazione Osteonecrosi, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy","institution_ids":["https://openalex.org/I4210157726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066634989","display_name":"Alessio Gambino","orcid":"https://orcid.org/0000-0002-0130-0799","observed_orcids":["https://orcid.org/0000-0002-0130-0799"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessio Gambino","raw_affiliation_strings":["Department of Surgical Sciences, Oral Medicine Section, CIR-Dental School, University of Turin, Via Nizza 230, 10126, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Sciences, Oral Medicine Section, CIR-Dental School, University of Turin, Via Nizza 230, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007572798","display_name":"Marco Cabras","orcid":"https://orcid.org/0000-0002-8240-5874","observed_orcids":["https://orcid.org/0000-0002-8240-5874"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Marco Cabras","raw_affiliation_strings":["Department of Surgical Sciences, Oral Medicine Section, CIR-Dental School, University of Turin, Via Nizza 230, 10126, Turin, Italy. cabrasmarco300@gmail.com","Department of Surgical Sciences, Oral Medicine Section, CIR-Dental School, University of Turin, Via Nizza 230, 10126, Turin, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8240-5874","affiliations":[{"raw_affiliation_string":"Department of Surgical Sciences, Oral Medicine Section, CIR-Dental School, University of Turin, Via Nizza 230, 10126, Turin, Italy. cabrasmarco300@gmail.com","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Department of Surgical Sciences, Oral Medicine Section, CIR-Dental School, University of Turin, Via Nizza 230, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083865449","display_name":"Manuela Alessio","orcid":"https://orcid.org/0000-0002-9118-9237","observed_orcids":["https://orcid.org/0000-0002-9118-9237"]},"institutions":[{"id":"https://openalex.org/I4210157726","display_name":"Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo","ror":"https://ror.org/04yxyzj48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210157726"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Manuela Alessio","raw_affiliation_strings":["Study Coordinator S.C. I.R.F.I., Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Study Coordinator S.C. I.R.F.I., Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy","institution_ids":["https://openalex.org/I4210157726"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025486771","display_name":"Vittorio Fusco","orcid":"https://orcid.org/0000-0003-0263-9820","observed_orcids":["https://orcid.org/0000-0003-0263-9820"]},"institutions":[{"id":"https://openalex.org/I4210157726","display_name":"Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo","ror":"https://ror.org/04yxyzj48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210157726"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vittorio Fusco","raw_affiliation_strings":["Oncology Unit and Centro Documentazione Osteonecrosi, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Unit and Centro Documentazione Osteonecrosi, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy","institution_ids":["https://openalex.org/I4210157726"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007572798"],"corresponding_institution_ids":["https://openalex.org/I55143463"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":null,"fwci":0.6002,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.66227262,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"29","issue":"8","first_page":"4185","last_page":"4186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":1.0},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/medication-persistence","display_name":"treatment persistence","score":0.8709999918937683},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.949999988079071},{"id":"https://openalex.org/keywords/treatment-switching","display_name":"treatment switching","score":0.6980000138282776},{"id":"https://openalex.org/keywords/osteonecrosis-of-the-jaw","display_name":"osteonecrosis of the jaw","score":0.9570000171661377},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.4189999997615814},{"id":"https://openalex.org/keywords/cancer-patients","display_name":"cancer patients","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9417750835418701},{"id":"https://openalex.org/C2776286101","wikidata":"https://www.wikidata.org/wiki/Q408283","display_name":"Denosumab","level":3,"score":0.9179854393005371},{"id":"https://openalex.org/C2777556957","wikidata":"https://www.wikidata.org/wiki/Q2377991","display_name":"Osteonecrosis of the jaw","level":4,"score":0.9143021106719971},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.7044931650161743},{"id":"https://openalex.org/C2777251235","wikidata":"https://www.wikidata.org/wiki/Q412205","display_name":"Bisphosphonate","level":3,"score":0.6338056325912476},{"id":"https://openalex.org/C2991975920","wikidata":"https://www.wikidata.org/wiki/Q621261","display_name":"Pain medicine","level":3,"score":0.5322202444076538},{"id":"https://openalex.org/C2780037786","wikidata":"https://www.wikidata.org/wiki/Q3357479","display_name":"Osteoradionecrosis","level":3,"score":0.4699319303035736},{"id":"https://openalex.org/C2911223091","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone Density Conservation Agents","level":4,"score":0.444139301776886},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3580608069896698},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.3505907356739044},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3392125964164734},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2614476680755615},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.2218494713306427},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2062574028968811},{"id":"https://openalex.org/C2779329777","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone density","level":3,"score":0.12050369381904602},{"id":"https://openalex.org/C2779526319","wikidata":"https://www.wikidata.org/wiki/Q615057","display_name":"Anesthesiology","level":2,"score":0.07243379950523376}],"mesh":[{"descriptor_ui":"D000069448","descriptor_name":"Denosumab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010020","descriptor_name":"Osteonecrosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D059266","descriptor_name":"Bisphosphonate-Associated Osteonecrosis of the Jaw","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D059266","descriptor_name":"Bisphosphonate-Associated Osteonecrosis of the Jaw","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00520-021-06100-4","doi":"https://doi.org/10.1007/s00520-021-06100-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00520-021-06100-4","pdf_url":null,"source":{"id":"https://openalex.org/S50055314","display_name":"Supportive Care in Cancer","issn_l":"0941-4355","issn":["0941-4355","1433-7339"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Supportive Care in Cancer","raw_type":"journal-article"},{"id":"pmid:33634351","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33634351","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer","raw_type":"Letter"},{"id":"pmh:oai:iris.unito.it:2318/1867149","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/1867149","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.979200005531311,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W2112950162","https://openalex.org/W2136646477","https://openalex.org/W2296523290","https://openalex.org/W2734610622","https://openalex.org/W2757279747","https://openalex.org/W2790124499","https://openalex.org/W2965080360","https://openalex.org/W3007352892","https://openalex.org/W3100646092","https://openalex.org/W3116396047"],"related_works":["https://openalex.org/W3007352892","https://openalex.org/W2734610622","https://openalex.org/W2766054814","https://openalex.org/W2767665648","https://openalex.org/W4411622572","https://openalex.org/W2214924201","https://openalex.org/W2965080360","https://openalex.org/W2610193221","https://openalex.org/W2343946811","https://openalex.org/W1993014421"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-01T00:00:00"}