{"id":"https://openalex.org/W3132330262","doi":"https://doi.org/10.36076/ppj/2019.22.495","title":"The Associations Between Cognitive Dysfunction, Stress Biomarkers, and Administered Anesthesia Type in Total Knee Arthroplasties: Prospective, Randomized Trial","display_name":"The Associations Between Cognitive Dysfunction, Stress Biomarkers, and Administered Anesthesia Type in Total Knee Arthroplasties: Prospective, Randomized Trial","publication_year":2019,"publication_date":"2019-09-11","ids":{"openalex":"https://openalex.org/W3132330262","doi":"https://doi.org/10.36076/ppj/2019.22.495","mag":"3132330262","pmid":"https://pubmed.ncbi.nlm.nih.gov/31561651"},"language":"en","primary_location":{"id":"doi:10.36076/ppj/2019.22.495","doi":"https://doi.org/10.36076/ppj/2019.22.495","is_oa":true,"landing_page_url":"https://doi.org/10.36076/ppj/2019.22.495","pdf_url":"https://doi.org/10.36076/ppj/2019.22.495","source":{"id":"https://openalex.org/S193700400","display_name":"Pain Physician","issn_l":"1533-3159","issn":["1533-3159","2150-1149"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316371","host_organization_name":"American Society of Interventional Pain Physicians","host_organization_lineage":["https://openalex.org/P4310316371"],"host_organization_lineage_names":["American Society of Interventional Pain Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain Physician","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.36076/ppj/2019.22.495","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034712232","display_name":"\u0130pek Saadet Edipo\u011flu","orcid":"https://orcid.org/0000-0002-3510-5991","observed_orcids":["https://orcid.org/0000-0002-3510-5991"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ipek Saadet Edipoglu","raw_affiliation_strings":["Department of Physical Medicine and Rehabilitation, Division of Pain Medicine, Faculty of Medicine, Marmara University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, Division of Pain Medicine, Faculty of Medicine, Marmara University, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034712232"],"corresponding_institution_ids":["https://openalex.org/I74897591"],"apc_list":null,"apc_paid":null,"fwci":4.1067,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.94147511,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"5","issue":"22;5","first_page":"495","last_page":"507"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.16200000047683716,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.05620000138878822,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/postoperative-cognitive-dysfunction","display_name":"postoperative cognitive dysfunction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/total-knee-arthroplasty","display_name":"total knee arthroplasty","score":1.0},{"id":"https://openalex.org/keywords/regional-anesthesia","display_name":"regional anesthesia","score":0.8679999709129333},{"id":"https://openalex.org/keywords/spinal-anesthesia","display_name":"spinal anesthesia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/general-anesthesia","display_name":"general anesthesia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/stress-biomarkers","display_name":"stress biomarkers","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.972000002861023},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9760000109672546},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.6340000033378601},{"id":"https://openalex.org/keywords/blood-glucose","display_name":"blood glucose","score":0.9879999756813049},{"id":"https://openalex.org/keywords/neurocognitive-function","display_name":"neurocognitive function","score":0.718999981880188},{"id":"https://openalex.org/keywords/acute-pain","display_name":"acute pain","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9597241878509521},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.711166501045227},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.6228635311126709},{"id":"https://openalex.org/C2780043718","wikidata":"https://www.wikidata.org/wiki/Q956181","display_name":"Postoperative cognitive dysfunction","level":3,"score":0.582845151424408},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5210608839988708},{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.4835221767425537},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4280073940753937},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.41449353098869324},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.30718040466308594},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.2184644639492035},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000768","descriptor_name":"Anesthesia, General","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000775","descriptor_name":"Anesthesia, Spinal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019645","descriptor_name":"Arthroplasty, Replacement, Knee","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.36076/ppj/2019.22.495","doi":"https://doi.org/10.36076/ppj/2019.22.495","is_oa":true,"landing_page_url":"https://doi.org/10.36076/ppj/2019.22.495","pdf_url":"https://doi.org/10.36076/ppj/2019.22.495","source":{"id":"https://openalex.org/S193700400","display_name":"Pain Physician","issn_l":"1533-3159","issn":["1533-3159","2150-1149"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316371","host_organization_name":"American Society of Interventional Pain Physicians","host_organization_lineage":["https://openalex.org/P4310316371"],"host_organization_lineage_names":["American Society of Interventional Pain Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain Physician","raw_type":"journal-article"},{"id":"pmid:31561651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31561651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain physician","raw_type":"Journal Article"},{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/235509","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11424/235509","pdf_url":null,"source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/98935","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11424/98935","pdf_url":null,"source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"mag:2990690468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31561651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.36076/ppj/2019.22.495","doi":"https://doi.org/10.36076/ppj/2019.22.495","is_oa":true,"landing_page_url":"https://doi.org/10.36076/ppj/2019.22.495","pdf_url":"https://doi.org/10.36076/ppj/2019.22.495","source":{"id":"https://openalex.org/S193700400","display_name":"Pain Physician","issn_l":"1533-3159","issn":["1533-3159","2150-1149"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316371","host_organization_name":"American Society of Interventional Pain Physicians","host_organization_lineage":["https://openalex.org/P4310316371"],"host_organization_lineage_names":["American Society of Interventional Pain Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain Physician","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3132330262.pdf","grobid_xml":"https://content.openalex.org/works/W3132330262.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1486549298","https://openalex.org/W1829558629","https://openalex.org/W1841780104","https://openalex.org/W1955203825","https://openalex.org/W1967866642","https://openalex.org/W1973553804","https://openalex.org/W1989326439","https://openalex.org/W1993700955","https://openalex.org/W1994750313","https://openalex.org/W2020140592","https://openalex.org/W2032484678","https://openalex.org/W2054295765","https://openalex.org/W2098872499","https://openalex.org/W2101220931","https://openalex.org/W2121457428","https://openalex.org/W2130656338","https://openalex.org/W2131497227","https://openalex.org/W2132051203","https://openalex.org/W2135067315","https://openalex.org/W2139525114","https://openalex.org/W2150081271","https://openalex.org/W2170085751","https://openalex.org/W2249915085","https://openalex.org/W2262997591","https://openalex.org/W2263406196","https://openalex.org/W2422158602","https://openalex.org/W2515597905","https://openalex.org/W2546857051","https://openalex.org/W2560471272","https://openalex.org/W2562079630","https://openalex.org/W4241910685","https://openalex.org/W4251935439","https://openalex.org/W6940577404"],"related_works":["https://openalex.org/W2792839382","https://openalex.org/W2561872767","https://openalex.org/W2782360385","https://openalex.org/W2702847377","https://openalex.org/W3005345186","https://openalex.org/W4247852221","https://openalex.org/W2349100905","https://openalex.org/W2054295765","https://openalex.org/W2362977311","https://openalex.org/W2507279246"],"abstract_inverted_index":{"BACKGROUND:":[0],"Postoperative":[1],"cognitive":[2],"dysfunction":[3],"(POCD)":[4],"is":[5,38],"a":[6,113],"serious":[7],"complication":[8],"associated":[9,39,77],"with":[10,40,78,214],"total":[11,104,114],"knee":[12],"arthroplasty":[13,323],"(TKA)":[14],"and":[15,29,90,112,127,142,152,172,189,196,252,264,313],"has":[16],"been":[17],"shown":[18],"to":[19,34,99,329],"increase":[20],"the":[21,41,61,119,123,137,140,143,215,219,226,236,253,279,333,337],"length":[22],"of":[23,43,80,105,115,282,336],"hospital":[24],"stay,":[25],"cause":[26],"functional":[27],"impairment,":[28],"morbidity.":[30],"OBJECTIVES:":[31],"We":[32,121,158,285,317],"aimed":[33],"determine":[35],"whether":[36],"POCD":[37,56,74,331],"use":[42],"general":[44,89,126,190,216,227,297],"or":[45],"regional":[46,65,128,185,203,288,306,327,348],"anesthesia":[47,129,186,191,204,217,228,289,298,307,328],"in":[48,60,291,299],"patients":[49,107,117,124,230,300,320],"undergoing":[50,301],"TKA.":[51,302],"Our":[52,70],"hypothesis":[53,72],"was":[54,73,278],"that":[55,63,163,287,319],"would":[57,75],"be":[58,76],"reduced":[59],"group":[62],"received":[64,202,305],"analgesia":[66],"without":[67,187],"any":[68],"sedations.":[69],"secondary":[71],"biomarkers":[79],"surgical":[81],"stress.":[82],"STUDY":[83],"DESIGN:":[84],"Randomized":[85],"controlled":[86],"study":[87],"between":[88,244],"spinal":[91,350],"anesthesia.":[92,351],"SETTING:":[93],"Single-centered,":[94],"university":[95],"hospital,":[96],"from":[97],"January":[98],"October":[100],"2017.":[101],"METHODS:":[102],"A":[103,276],"112":[106],"were":[108,133,156,164,180,241],"assessed":[109],"for":[110,184,235],"eligibility,":[111],"57":[116],"completed":[118],"study.":[120],"divided":[122],"into":[125],"groups.":[130,192],"Blood":[131],"samples":[132],"obtained":[134],"preoperatively":[135],"at":[136,218,248,332],"first":[138],"intraoperative,":[139],"third":[141],"24th":[144],"postoperative":[145,249,266,338],"hour.":[146],"C-reactive":[147],"protein":[148],"(CRP),":[149],"cortisol,":[150,310],"insulin,":[151,195,312],"blood":[153],"glucose":[154,315],"levels":[155],"tested.":[157],"used":[159],"4":[160],"neurocognitive":[161,181,293],"tests":[162,182],"administered":[165],"1":[166],"day":[167,221,250],"before":[168],"operation,":[169],"7":[170,251],"days":[171,174],"30":[173],"after":[175],"operation.":[176],"Main":[177],"outcome":[178],"measures":[179],"scores":[183,246,295],"sedation":[188],"Cortisol,":[193],"glucose,":[194],"CRP":[197],"levels.":[198,316],"RESULTS:":[199],"Patients":[200,303],"who":[201,304,321],"showed":[205,231,308],"significantly":[206,232],"higher":[207,233,311],"Mini-Mental":[208],"State":[209],"Examination":[210],"(MMSE)":[211],"scored":[212],"compared":[213],"seventh":[220],"(P":[222],"=":[223,259,262,270,273],"0.037).":[224],"In":[225],"group,":[229],"variations":[234],"Stroop":[237],"number":[238,281],"difference.":[239],"There":[240],"negative":[242],"correlations":[243],"MMSE":[245],"measured":[247],"1-hour":[254],"intraoperative":[255],"cortisol":[256,267],"measurements":[257,268],"(r":[258,269],"-0.302;":[260],"P":[261,272],"0.022)":[263],"3-hour":[265],"-0.295;":[271],"0.026).":[274],"LIMITATIONS:":[275],"limitation":[277],"small":[280],"patients.":[283],"CONCLUSIONS:":[284],"demonstrate":[286],"results":[290],"better":[292],"test":[294],"than":[296],"lower":[309,314],"recommend":[318],"undergo":[322],"surgeries":[324],"should":[325],"receive":[326],"avoid":[330],"early":[334],"stages":[335],"period.":[339],"KEY":[340],"WORDS:":[341],"Cognitive":[342],"dysfunction,":[343],"stress":[344],"biomarkers,":[345],"acute":[346],"pain,":[347],"anesthesia,":[349]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":5}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-03-01T00:00:00"}