{"id":"https://openalex.org/W3131984635","doi":"https://doi.org/10.1002/jcp.30329","title":"Glucose deprivation\u2010induced endoplasmic reticulum stress response plays a pivotal role in enhancement of TRAIL cytotoxicity","display_name":"Glucose deprivation\u2010induced endoplasmic reticulum stress response plays a pivotal role in enhancement of TRAIL cytotoxicity","publication_year":2021,"publication_date":"2021-02-15","ids":{"openalex":"https://openalex.org/W3131984635","doi":"https://doi.org/10.1002/jcp.30329","mag":"3131984635","pmid":"https://pubmed.ncbi.nlm.nih.gov/33586156"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.30329","doi":"https://doi.org/10.1002/jcp.30329","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.30329","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11572546","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029283092","display_name":"Kalimuthu Kalishwaralal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kalishwaralal Kalimuthu","raw_affiliation_strings":["Department of Surgery, School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA","Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100752174","display_name":"Jin\u2010Hong Kim","orcid":"https://orcid.org/0000-0002-6480-1929","observed_orcids":["https://orcid.org/0000-0002-6480-1929","https://orcid.org/0000-0002-3213-4965"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Hong Kim","raw_affiliation_strings":["Department of Surgery, School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA","Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101447799","display_name":"Yong Seok Park","orcid":"https://orcid.org/0000-0003-2059-8006","observed_orcids":["https://orcid.org/0000-0003-2059-8006"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Seok Park","raw_affiliation_strings":["Department of Biostatistics University of Pittsburgh  Pittsburgh Pennsylvania USA","Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics University of Pittsburgh  Pittsburgh Pennsylvania USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101971446","display_name":"Xu Luo","orcid":"https://orcid.org/0009-0002-3351-6305","observed_orcids":["https://orcid.org/0009-0002-3351-6305"]},"institutions":[{"id":"https://openalex.org/I4390039344","display_name":"Fred and Pamela Buffett Cancer Center","ror":"https://ror.org/03n63wv08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695","https://openalex.org/I4390039344"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xu Luo","raw_affiliation_strings":["Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center University of Nebraska Medical Center  Omaha Nebraska USA","Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center University of Nebraska Medical Center  Omaha Nebraska USA","institution_ids":["https://openalex.org/I4390039344","https://openalex.org/I59130452"]},{"raw_affiliation_string":"Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA","institution_ids":["https://openalex.org/I4390039344","https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100351902","display_name":"Lin Zhang","orcid":"https://orcid.org/0000-0003-0018-3903","observed_orcids":["https://orcid.org/0000-0003-0018-3903"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Zhang","raw_affiliation_strings":["Department of Pharmacology and Chemical Biology, School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA","Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Chemical Biology, School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001974637","display_name":"Ja\u2010Lok Ku","orcid":"https://orcid.org/0000-0002-7090-537X","observed_orcids":["https://orcid.org/0000-0002-7090-537X"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ja\u2010Lok Ku","raw_affiliation_strings":["Department of Biomedical Sciences/Department of Medicine, Laboratory of Cell Biology, Cancer Research Institute, College of Medicine Seoul National University  Seoul Korea","Department of Biomedical Sciences/Department of Medicine, Laboratory of Cell Biology, Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences/Department of Medicine, Laboratory of Cell Biology, Cancer Research Institute, College of Medicine Seoul National University  Seoul Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Biomedical Sciences/Department of Medicine, Laboratory of Cell Biology, Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054409783","display_name":"Haroon Asif Choudry","orcid":"https://orcid.org/0000-0002-9159-9594","observed_orcids":["https://orcid.org/0000-0002-9159-9594"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Haroon A. Choudry","raw_affiliation_strings":["Department of Surgery, School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA","Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040610316","display_name":"Yong Jun Lee","orcid":"https://orcid.org/0000-0001-5914-8489","observed_orcids":["https://orcid.org/0000-0001-5914-8489"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yong J. Lee","raw_affiliation_strings":["Department of Surgery, School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA","Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0001-5914-8489","affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5040610316"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":4700,"currency":"USD","value_usd":4700},"apc_paid":null,"fwci":1.8029,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.82753112,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"236","issue":"9","first_page":"6666","last_page":"6677"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0560000017285347,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-deprivation","display_name":"glucose deprivation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9850000143051147},{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.8690000176429749},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6930000185966492},{"id":"https://openalex.org/keywords/dr5","display_name":"DR5","score":0.7839999794960022},{"id":"https://openalex.org/keywords/bax-oligomerization","display_name":"Bax oligomerization","score":0.8410000205039978},{"id":"https://openalex.org/keywords/bid","display_name":"Bid","score":0.6399999856948853},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8759999871253967},{"id":"https://openalex.org/keywords/metabolic-stress","display_name":"metabolic stress","score":0.7059999704360962},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2777417711","wikidata":"https://www.wikidata.org/wiki/Q270748","display_name":"Puma","level":3,"score":0.8830114603042603},{"id":"https://openalex.org/C2779725641","wikidata":"https://www.wikidata.org/wiki/Q1076228","display_name":"CHOP","level":3,"score":0.8208653926849365},{"id":"https://openalex.org/C2780900454","wikidata":"https://www.wikidata.org/wiki/Q21102119","display_name":"ATF4","level":4,"score":0.783566951751709},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7650493383407593},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.7356278896331787},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5808396935462952},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.5633974075317383},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5309345722198486},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45401161909103394},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4107429087162018},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4065382182598114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3565766215324402},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3431187868118286},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34081679582595825},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1951056718826294},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17320597171783447},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07646393775939941}],"mesh":[{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050998","descriptor_name":"bcl-2 Homologous Antagonist-Killer Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050998","descriptor_name":"bcl-2 Homologous Antagonist-Killer Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050998","descriptor_name":"bcl-2 Homologous Antagonist-Killer Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050998","descriptor_name":"bcl-2 Homologous Antagonist-Killer Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051023","descriptor_name":"BH3 Interacting Domain Death Agonist Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051023","descriptor_name":"BH3 Interacting Domain Death Agonist Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051023","descriptor_name":"BH3 Interacting Domain Death Agonist Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051023","descriptor_name":"BH3 Interacting Domain Death Agonist Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051701","descriptor_name":"Activating Transcription Factor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051701","descriptor_name":"Activating Transcription Factor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051701","descriptor_name":"Activating Transcription Factor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051701","descriptor_name":"Activating Transcription Factor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051742","descriptor_name":"Transcription Factor CHOP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051742","descriptor_name":"Transcription Factor CHOP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051742","descriptor_name":"Transcription Factor CHOP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051742","descriptor_name":"Transcription Factor CHOP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053221","descriptor_name":"TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D053221","descriptor_name":"TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D053221","descriptor_name":"TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D053221","descriptor_name":"TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/jcp.30329","doi":"https://doi.org/10.1002/jcp.30329","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.30329","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:33586156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33586156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11572546","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11572546","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Cell Physiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11572546","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11572546","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Cell Physiol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G108268404","display_name":null,"funder_award_id":"R03CA205267","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1695878324","display_name":null,"funder_award_id":"R03 CA212125","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2269625183","display_name":null,"funder_award_id":"R03 CA205496","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G721876209","display_name":null,"funder_award_id":"R01 GM118437","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G741073515","display_name":null,"funder_award_id":"P30 CA 047904","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7639423629","display_name":null,"funder_award_id":"R03 CA245171","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000010196","display_name":null,"funder_award_id":"P30-CA047904","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000049379","display_name":null,"funder_award_id":"R03 CA212125","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000064928","display_name":null,"funder_award_id":"R03 CA205496","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000304503","display_name":null,"funder_award_id":"R03CA205267","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000333881","display_name":null,"funder_award_id":"R01GM118437","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W33354229","https://openalex.org/W1484817497","https://openalex.org/W1579667184","https://openalex.org/W1582456049","https://openalex.org/W1614077614","https://openalex.org/W1911342746","https://openalex.org/W1913661233","https://openalex.org/W1956944003","https://openalex.org/W1964184380","https://openalex.org/W1967142704","https://openalex.org/W1968713831","https://openalex.org/W1970885190","https://openalex.org/W1971895570","https://openalex.org/W1978480779","https://openalex.org/W1980298403","https://openalex.org/W1994056283","https://openalex.org/W1995638825","https://openalex.org/W1996094227","https://openalex.org/W1999246265","https://openalex.org/W2005084937","https://openalex.org/W2009069232","https://openalex.org/W2009619113","https://openalex.org/W2016127055","https://openalex.org/W2020433001","https://openalex.org/W2024568242","https://openalex.org/W2028526641","https://openalex.org/W2032590374","https://openalex.org/W2033963058","https://openalex.org/W2038821084","https://openalex.org/W2049312704","https://openalex.org/W2051477069","https://openalex.org/W2056217426","https://openalex.org/W2059351462","https://openalex.org/W2059812577","https://openalex.org/W2067256617","https://openalex.org/W2072740835","https://openalex.org/W2077793109","https://openalex.org/W2085569151","https://openalex.org/W2089476060","https://openalex.org/W2092196409","https://openalex.org/W2092508425","https://openalex.org/W2098439946","https://openalex.org/W2102955022","https://openalex.org/W2105186639","https://openalex.org/W2109232632","https://openalex.org/W2113505777","https://openalex.org/W2114369135","https://openalex.org/W2115205812","https://openalex.org/W2126959399","https://openalex.org/W2133644385","https://openalex.org/W2137560761","https://openalex.org/W2138319384","https://openalex.org/W2152793164","https://openalex.org/W2165884308","https://openalex.org/W2166601968","https://openalex.org/W2166731734","https://openalex.org/W2187537492","https://openalex.org/W2297334570","https://openalex.org/W2325836085","https://openalex.org/W2396644216","https://openalex.org/W2490919379","https://openalex.org/W2594788856","https://openalex.org/W2774792076","https://openalex.org/W2794703348","https://openalex.org/W2889402573","https://openalex.org/W2912327601","https://openalex.org/W3001626749","https://openalex.org/W3046665064"],"related_works":["https://openalex.org/W2922191166","https://openalex.org/W2766222389","https://openalex.org/W2148632242","https://openalex.org/W2039420809","https://openalex.org/W2385169084","https://openalex.org/W3031468220","https://openalex.org/W2095713125","https://openalex.org/W2089198803","https://openalex.org/W1967800198","https://openalex.org/W2063229389"],"abstract_inverted_index":{"Abnormalities":[0],"of":[1,12,70,89,106,115,134],"the":[2,54,68,150,154,160,165,191,213,217,222],"tumor":[3,14,41],"vasculature":[4],"result":[5],"in":[6,67,159,172,198],"insufficient":[7],"blood":[8],"supply":[9],"and":[10,26,39,108,119,153,216],"development":[11],"a":[13,64,104],"microenvironment":[15],"that":[16,33,149,205],"is":[17],"characterized":[18],"by":[19,211],"low":[20,23,27,109],"glucose":[21,97,206],"concentrations,":[22],"extracellular":[24],"pH,":[25],"oxygen":[28],"tensions.":[29],"We":[30,73],"previously":[31],"reported":[32],"glucose-deprived":[34],"conditions":[35],"induce":[36],"metabolic":[37,55],"stress":[38,60],"promote":[40],"necrosis":[42],"factor-related":[43],"apoptosis-inducing":[44],"ligand":[45],"(TRAIL)-induced":[46],"cytotoxicity.":[47,72],"In":[48],"this":[49],"study,":[50],"we":[51],"examined":[52],"whether":[53],"stress-associated":[56],"endoplasmic":[57],"reticulum":[58],"(ER)":[59],"response":[61],"pathway":[62],"plays":[63],"pivotal":[65],"role":[66],"enhancement":[69],"TRAIL":[71,90,107],"observed":[74],"no":[75],"significant":[76],"cytotoxicity":[77],"when":[78],"human":[79],"colorectal":[80],"cancer":[81],"SW48":[82],"cells":[83,147],"were":[84],"treated":[85],"with":[86,122],"various":[87],"doses":[88],"(2-100":[91],"ng/ml)":[92],"for":[93,100],"4":[94,126],"h":[95],"or":[96,137,145,178],"(0-25":[98],"mM)":[99],"24":[101],"h.":[102],"However,":[103],"combination":[105],"glucose-induced":[110],"dose-dependent":[111],"apoptosis":[112,135,168,210],"through":[113],"activation":[114],"caspases":[116],"(-8,":[117],"-9,":[118],"-3).":[120],"Studies":[121],"activating":[123],"transcription":[124],"factor":[125],"(ATF4),":[127],"C/EBP-homologous":[128],"protein":[129,181],"(CHOP),":[130],"p53":[131],"upregulated":[132],"modulator":[133],"(PUMA),":[136],"death":[138,175],"receptor":[139],"5":[140],"(DR5)-deficient":[141],"mouse":[142],"embryonic":[143],"fibroblasts":[144],"HCT116":[146,183,188,200],"suggest":[148,204],"ATF4-CHOP-PUMA":[151,214],"axis":[152,156,215],"ATF4-CHOP-DR5":[155,218],"are":[157],"involved":[158],"combined":[161,166,192],"treatment-induced":[162,167,193],"apoptosis.":[163],"Moreover,":[164],"was":[169,196],"completely":[170],"suppressed":[171,197],"BH3":[173],"interacting-domain":[174],"agonist":[176],"(Bid)-":[177],"Bcl-2-associated":[179],"X":[180],"(Bax)-deficient":[182],"cells,":[184],"but":[185],"not":[186],"Bak-deficient":[187],"cells.":[189,201],"Interestingly,":[190],"Bax":[194],"oligomerization":[195],"PUMA-deficient":[199],"These":[202],"results":[203],"deprivation":[207],"enhances":[208],"TRAIL-induced":[209],"integrating":[212],"axis,":[219],"consequently":[220],"amplifying":[221],"Bid-Bax-associated":[223],"mitochondria-dependent":[224],"pathway.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2021-03-01T00:00:00"}
