{"id":"https://openalex.org/W3131902604","doi":"https://doi.org/10.3389/fncel.2021.638854","title":"Indoleamine-2,3-Dioxygenase 1 Deficiency Suppresses Seizures in Epilepsy","display_name":"Indoleamine-2,3-Dioxygenase 1 Deficiency Suppresses Seizures in Epilepsy","publication_year":2021,"publication_date":"2021-02-18","ids":{"openalex":"https://openalex.org/W3131902604","doi":"https://doi.org/10.3389/fncel.2021.638854","mag":"3131902604","pmid":"https://pubmed.ncbi.nlm.nih.gov/33679331","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7935521"},"language":"en","primary_location":{"id":"doi:10.3389/fncel.2021.638854","doi":"https://doi.org/10.3389/fncel.2021.638854","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2021.638854","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncel.2021.638854/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3131902604"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fncel.2021.638854/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073928508","display_name":"Ning Deng","orcid":"https://orcid.org/0000-0002-8317-4342","observed_orcids":["https://orcid.org/0000-0002-8317-4342"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Deng","raw_affiliation_strings":["Southern Medical University","School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073928508","display_name":"Ning Deng","orcid":"https://orcid.org/0000-0002-8317-4342","observed_orcids":["https://orcid.org/0000-0002-8317-4342"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Deng","raw_affiliation_strings":["Southern Medical University","School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059271961","display_name":"Jiao Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiao Hu","raw_affiliation_strings":["Southern Medical University","Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China","School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059271961","display_name":"Jiao Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiao Hu","raw_affiliation_strings":["Southern Medical University","Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China","School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102832596","display_name":"Yifan Xiong","orcid":"https://orcid.org/0000-0002-0544-049X","observed_orcids":["https://orcid.org/0000-0002-0544-049X","https://orcid.org/0009-0005-5020-5471"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Hong","raw_affiliation_strings":["Southern Medical University","School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136190765","display_name":"Yu Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Hong","raw_affiliation_strings":["Southern Medical University","Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China","School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069680645","display_name":"\u4e01\u8dc3\u6587","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuewen Ding","raw_affiliation_strings":["Southern Medical University","Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China","School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055464445","display_name":"Yuewen Ding","orcid":"https://orcid.org/0000-0001-5559-7033","observed_orcids":["https://orcid.org/0000-0001-5559-7033","https://orcid.org/0000-0002-1122-7943"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuewen Ding","raw_affiliation_strings":["Southern Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102832596","display_name":"Yifan Xiong","orcid":"https://orcid.org/0000-0002-0544-049X","observed_orcids":["https://orcid.org/0000-0002-0544-049X","https://orcid.org/0009-0005-5020-5471"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifan Xiong","raw_affiliation_strings":["Southern Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102832596","display_name":"Yifan Xiong","orcid":"https://orcid.org/0000-0002-0544-049X","observed_orcids":["https://orcid.org/0000-0002-0544-049X","https://orcid.org/0009-0005-5020-5471"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifan Xiong","raw_affiliation_strings":["Southern Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101809759","display_name":"Zhiyong Wu","orcid":"https://orcid.org/0000-0001-7414-817X","observed_orcids":["https://orcid.org/0000-0001-7414-817X"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyong Wu","raw_affiliation_strings":["Southern Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101809759","display_name":"Zhiyong Wu","orcid":"https://orcid.org/0000-0001-7414-817X","observed_orcids":["https://orcid.org/0000-0001-7414-817X"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyong Wu","raw_affiliation_strings":["Southern Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007035358","display_name":"Wei Xie","orcid":"https://orcid.org/0000-0002-3218-7231","observed_orcids":["https://orcid.org/0000-0002-3218-7231"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Xie","raw_affiliation_strings":["Southern Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007035358","display_name":"Wei Xie","orcid":"https://orcid.org/0000-0002-3218-7231","observed_orcids":["https://orcid.org/0000-0002-3218-7231"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Xie","raw_affiliation_strings":["Southern Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Medical University","institution_ids":["https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069680645"],"corresponding_institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.7259,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.84926061,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"15","issue":null,"first_page":"638854","last_page":"638854"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0502999983727932,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ido1","display_name":"IDO1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.8190000057220459},{"id":"https://openalex.org/keywords/seizures","display_name":"seizures","score":0.6039999723434448},{"id":"https://openalex.org/keywords/kynurenine-pathway","display_name":"kynurenine pathway","score":0.8259999752044678},{"id":"https://openalex.org/keywords/tryptophan-metabolism","display_name":"tryptophan metabolism","score":0.9679999947547913},{"id":"https://openalex.org/keywords/kynurenic-acid","display_name":"kynurenic acid","score":0.8180000185966492},{"id":"https://openalex.org/keywords/quinolinic-acid","display_name":"quinolinic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.824999988079071},{"id":"https://openalex.org/keywords/glial-activation","display_name":"glial activation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9279999732971191},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.8980000019073486},{"id":"https://openalex.org/keywords/lithium-pilocarpine-induced-epilepsy","display_name":"lithium-pilocarpine-induced epilepsy","score":0.8059999942779541},{"id":"https://openalex.org/keywords/neuronal-damage","display_name":"neuronal injury","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C2776710720","wikidata":"https://www.wikidata.org/wiki/Q80417","display_name":"Kynurenine pathway","level":5,"score":0.8305071592330933},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.8126059174537659},{"id":"https://openalex.org/C2777503454","wikidata":"https://www.wikidata.org/wiki/Q415768","display_name":"Kynurenine","level":4,"score":0.7681825160980225},{"id":"https://openalex.org/C2777896816","wikidata":"https://www.wikidata.org/wiki/Q411945","display_name":"Quinolinic acid","level":4,"score":0.7168620824813843},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46789491176605225},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45396339893341064},{"id":"https://openalex.org/C83478079","wikidata":"https://www.wikidata.org/wiki/Q908221","display_name":"Indoleamine 2,3-dioxygenase","level":4,"score":0.4537038207054138},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44604671001434326},{"id":"https://openalex.org/C2777204577","wikidata":"https://www.wikidata.org/wiki/Q411461","display_name":"Pilocarpine","level":3,"score":0.44549915194511414},{"id":"https://openalex.org/C2776841986","wikidata":"https://www.wikidata.org/wiki/Q642217","display_name":"Kynurenic acid","level":4,"score":0.43877556920051575},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35314297676086426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34633100032806396},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1503148376941681},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.1364119052886963},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08048579096794128},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.07145088911056519},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.057198017835617065},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fncel.2021.638854","doi":"https://doi.org/10.3389/fncel.2021.638854","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2021.638854","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncel.2021.638854/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-104472/v1","doi":"https://doi.org/10.21203/rs.3.rs-104472/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-104472/v1","pdf_url":"https://www.researchsquare.com/article/rs-104472/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:33679331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33679331","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7935521","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7935521/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Neurosci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c5cd29209ef1441d9049cea84eade513","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c5cd29209ef1441d9049cea84eade513","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular Neuroscience, Vol 15 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fncel.2021.638854","doi":"https://doi.org/10.3389/fncel.2021.638854","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fncel.2021.638854","pdf_url":"https://www.frontiersin.org/articles/10.3389/fncel.2021.638854/pdf","source":{"id":"https://openalex.org/S36653316","display_name":"Frontiers in Cellular Neuroscience","issn_l":"1662-5102","issn":["1662-5102"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7968969158","display_name":null,"funder_award_id":"81873158","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3131902604.pdf","grobid_xml":"https://content.openalex.org/works/W3131902604.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W114145985","https://openalex.org/W136203605","https://openalex.org/W192631905","https://openalex.org/W1156921483","https://openalex.org/W1176648364","https://openalex.org/W1547937746","https://openalex.org/W1572350532","https://openalex.org/W1776233564","https://openalex.org/W1870728755","https://openalex.org/W1920696238","https://openalex.org/W1964595024","https://openalex.org/W1975440733","https://openalex.org/W1978915379","https://openalex.org/W1988691690","https://openalex.org/W1989507216","https://openalex.org/W1994455271","https://openalex.org/W1996177596","https://openalex.org/W2015725097","https://openalex.org/W2022766686","https://openalex.org/W2022981588","https://openalex.org/W2030080816","https://openalex.org/W2031616221","https://openalex.org/W2042731928","https://openalex.org/W2055523179","https://openalex.org/W2057522312","https://openalex.org/W2059952417","https://openalex.org/W2062502442","https://openalex.org/W2064113082","https://openalex.org/W2070960343","https://openalex.org/W2077548349","https://openalex.org/W2091016720","https://openalex.org/W2103946141","https://openalex.org/W2111068498","https://openalex.org/W2113172296","https://openalex.org/W2122817080","https://openalex.org/W2139298313","https://openalex.org/W2153227444","https://openalex.org/W2157059809","https://openalex.org/W2223880435","https://openalex.org/W2299985741","https://openalex.org/W2322232345","https://openalex.org/W2556540841","https://openalex.org/W2586586215","https://openalex.org/W2592509339","https://openalex.org/W2606409681","https://openalex.org/W2613437841","https://openalex.org/W2621333085","https://openalex.org/W2768365173","https://openalex.org/W2782229361","https://openalex.org/W2790927186","https://openalex.org/W2804288927","https://openalex.org/W2804347261","https://openalex.org/W2885917397","https://openalex.org/W2901441114","https://openalex.org/W2912181843","https://openalex.org/W2912830893","https://openalex.org/W2937748466","https://openalex.org/W2954314772","https://openalex.org/W2981988056","https://openalex.org/W2983871227","https://openalex.org/W2999806763","https://openalex.org/W3048139974","https://openalex.org/W3124566059"],"related_works":["https://openalex.org/W2120420582","https://openalex.org/W7128926061","https://openalex.org/W2912830893","https://openalex.org/W4414297703","https://openalex.org/W2365762311","https://openalex.org/W7159660173","https://openalex.org/W7098095912","https://openalex.org/W2042454390","https://openalex.org/W4390653524"],"abstract_inverted_index":{"Background:":[0],"Indoleamine-2,3-dioxygenase":[1],"1":[2],"(IDO1)":[3],"is":[4,41],"the":[5,11,28,35,142,147,152,165,189,193,208,212,218,227,254,303,333,339],"initial":[6],"and":[7,64,71,84,93,97,103,113,126,133,158,171,180,188,195,211,220,230,252,257,283,287,297,315,319,337],"rate-limiting":[8],"enzyme":[9,173,290,322],"in":[10,27,39,56,99,146,192,201,217,224,241,244,277,332],"metabolism":[12,22],"of":[13,30,37,82,91,95,149,154,167,214,259,306,335],"tryptophan":[14],"(TRP)":[15],"to":[16,79,86,123,341],"kynurenine":[17],"(KYN).":[18],"IDO1-dependent":[19,304],"neurotoxic":[20,307],"KYN":[21,98],"plays":[23],"a":[24,57,343],"crucial":[25],"role":[26],"pathogenesis":[29,334],"many":[31],"neurodegenerative":[32],"disorders.":[33],"However,":[34],"function":[36],"IDO1":[38,51,72,92,150,186,206,238,247,265,293,328],"epilepsy":[40,55,63,102,336,347],"still":[42],"unclear.":[43],"Objective:":[44],"In":[45,183],"this":[46,184],"study,":[47,185],"we":[48],"investigated":[49],"whether":[50],"deficiency":[52,248,266],"could":[53],"affect":[54],"lithium-pilocarpine-induced":[58,138],"model.":[59],"Methods:":[60],"Patients":[61],"with":[62,101,137,203],"controls":[65],"were":[66,77,106,129,175,199,222],"enrolled.":[67],"Male":[68],"C57BL/6":[69],"mice":[70,76,105,136,225,273],"knockout":[73],"(KO,":[74],"IDO1\u2212/\u2212)":[75],"subjected":[78],"intraperitoneal":[80],"injection":[81],"lithium":[83],"pilocarpine":[85],"induce":[87],"epilepsy.":[88,139,204],"The":[89],"levels":[90,166,187,213],"concentrations":[94,153],"TRP":[96],"patients":[100,202],"epileptic":[104,124,245,272],"evaluated":[107],"by":[108,177,301],"enzyme-linked":[109],"immunosorbent":[110],"assay":[111],"(ELISA)":[112],"liquid":[114],"chromatography-mass":[115],"spectrometry":[116],"(LC-MS),":[117],"respectively.":[118],"Then,":[119],"behavioral":[120],"phenotypes":[121],"related":[122],"seizures":[125,262,296],"neuronal":[127,268,299],"damage":[128,300],"compared":[130],"between":[131],"KO":[132],"wild-type":[134],"(WT)":[135],"To":[140],"explore":[141],"underlying":[143],"pathways":[144],"involved":[145,331],"effects":[148],"deficiency,":[151],"kynurenic":[155],"acid":[156,160],"(KYNA)":[157],"quinolinic":[159],"(QUIN),":[161],"glial":[162,280,312],"cell":[163,281,313],"activation,":[164],"major":[168],"pro-inflammatory":[169,215,284,316],"cytokines,":[170],"antioxidant":[172,289,321],"activity":[174],"measured":[176],"LC-MS,":[178],"immunohistochemistry,":[179],"ELISA.":[181],"Results:":[182],"KYN/TRP":[190,209],"ratio":[191],"sera":[194,219],"cerebrospinal":[196],"fluid":[197],"(CSF)":[198],"increased":[200,223],"Also,":[205],"levels,":[207,286],"ratio,":[210],"cytokines":[216,285],"hippocampi":[221],"during":[226],"acute":[228],"phase":[229,232],"chronic":[231],"after":[233],"status":[234],"epilepticus":[235],"(SE).":[236],"Furthermore,":[237],"was":[239],"localized":[240],"microglial":[242],"cells":[243],"mice.":[246],"delayed":[249],"SE":[250],"onset":[251],"attenuated":[253],"frequency,":[255],"duration,":[256],"severity":[258],"spontaneous":[260],"recurrent":[261],"(SRSs).":[263],"Moreover,":[264],"improved":[267,320],"survival.":[269],"Additionally,":[270],"IDO1\u2212/\u2212":[271],"showed":[274],"progressive":[275],"declines":[276],"QUIN":[278],"production,":[279],"activation":[282,314],"enhanced":[288],"activity.":[291,323],"Conclusions:":[292],"deletion":[294],"suppressed":[295],"alleviated":[298],"reducing":[302],"production":[305,318],"metabolites,":[308],"which":[309],"finally":[310],"inhibited":[311],"cytokine":[317],"Our":[324],"study":[325],"demonstrates":[326],"that":[327],"may":[329],"be":[330,342],"has":[338],"potential":[340],"therapeutic":[344],"target":[345],"for":[346],"treatment.":[348]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2021-03-01T00:00:00"}
