{"id":"https://openalex.org/W3131874567","doi":"https://doi.org/10.1021/acs.chemrestox.0c00517","title":"DNA Sequence Modulates the Efficiency of NEIL1-Catalyzed Excision of the Aflatoxin B1-Induced Formamidopyrimidine Guanine Adduct","display_name":"DNA Sequence Modulates the Efficiency of NEIL1-Catalyzed Excision of the Aflatoxin B1-Induced Formamidopyrimidine Guanine Adduct","publication_year":2021,"publication_date":"2021-02-17","ids":{"openalex":"https://openalex.org/W3131874567","doi":"https://doi.org/10.1021/acs.chemrestox.0c00517","mag":"3131874567","pmid":"https://pubmed.ncbi.nlm.nih.gov/33595290","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8727046"},"language":"en","primary_location":{"id":"doi:10.1021/acs.chemrestox.0c00517","doi":"https://doi.org/10.1021/acs.chemrestox.0c00517","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.chemrestox.0c00517","pdf_url":null,"source":{"id":"https://openalex.org/S152840809","display_name":"Chemical Research in Toxicology","issn_l":"0893-228X","issn":["0893-228X","1520-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8727046","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048801780","display_name":"Rachana Tomar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachana Tomar","raw_affiliation_strings":["Department of Chemistry and the Vanderbilt-Ingram Cancer Center, Vanderbilt University, VU Station B, Box 351822, Nashville, Tennessee 37235, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and the Vanderbilt-Ingram Cancer Center, Vanderbilt University, VU Station B, Box 351822, Nashville, Tennessee 37235, United States","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058763058","display_name":"Irina G. Minko","orcid":"https://orcid.org/0000-0002-0012-2265","observed_orcids":["https://orcid.org/0000-0002-0012-2265"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irina G. Minko","raw_affiliation_strings":["Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034732208","display_name":"Andrew H. Kellum","orcid":"https://orcid.org/0000-0003-4178-8175","observed_orcids":["https://orcid.org/0000-0003-4178-8175"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew H. Kellum","raw_affiliation_strings":["Department of Chemistry and the Vanderbilt-Ingram Cancer Center, Vanderbilt University, VU Station B, Box 351822, Nashville, Tennessee 37235, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and the Vanderbilt-Ingram Cancer Center, Vanderbilt University, VU Station B, Box 351822, Nashville, Tennessee 37235, United States","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010550612","display_name":"Markus Voehler","orcid":"https://orcid.org/0000-0002-9509-6396","observed_orcids":["https://orcid.org/0000-0002-9509-6396"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Markus W. Voehler","raw_affiliation_strings":["Department of Chemistry and the Vanderbilt-Ingram Cancer Center, Vanderbilt University, VU Station B, Box 351822, Nashville, Tennessee 37235, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and the Vanderbilt-Ingram Cancer Center, Vanderbilt University, VU Station B, Box 351822, Nashville, Tennessee 37235, United States","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058755910","display_name":"Michael P. Stone","orcid":"https://orcid.org/0000-0002-0922-0216","observed_orcids":["https://orcid.org/0000-0002-0922-0216"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael P. Stone","raw_affiliation_strings":["Department of Chemistry and the Vanderbilt-Ingram Cancer Center, Vanderbilt University, VU Station B, Box 351822, Nashville, Tennessee 37235, United States"],"raw_orcid":"https://orcid.org/0000-0002-0922-0216","affiliations":[{"raw_affiliation_string":"Department of Chemistry and the Vanderbilt-Ingram Cancer Center, Vanderbilt University, VU Station B, Box 351822, Nashville, Tennessee 37235, United States","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071858904","display_name":"Amanda K. McCullough","orcid":"https://orcid.org/0000-0002-9500-4973","observed_orcids":["https://orcid.org/0000-0002-9500-4973"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda K. McCullough","raw_affiliation_strings":["Department of Molecular and Medical Genetics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States","Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Genetics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055892592","display_name":"R. Stephen Lloyd","orcid":"https://orcid.org/0000-0001-7273-372X","observed_orcids":["https://orcid.org/0000-0001-7273-372X"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R. Stephen Lloyd","raw_affiliation_strings":["Department of Molecular and Medical Genetics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States","Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States"],"raw_orcid":"https://orcid.org/0000-0001-7273-372X","affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Genetics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055892592","https://openalex.org/A5058755910"],"corresponding_institution_ids":["https://openalex.org/I165690674","https://openalex.org/I200719446","https://openalex.org/I4390039299"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.9368,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.70922288,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"34","issue":"3","first_page":"901","last_page":"911"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7318999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7318999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.11599999666213989,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.094200000166893,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neil1","display_name":"NEIL1","score":0.7080000042915344},{"id":"https://openalex.org/keywords/aflatoxin-b1","display_name":"aflatoxin B1","score":0.8619999885559082},{"id":"https://openalex.org/keywords/dna-glycosylase","display_name":"DNA glycosylase","score":0.8259999752044678},{"id":"https://openalex.org/keywords/base-excision-repair","display_name":"base excision repair","score":0.9710000157356262},{"id":"https://openalex.org/keywords/sequence-context","display_name":"sequence context","score":0.5709999799728394},{"id":"https://openalex.org/keywords/dna-intercalation","display_name":"DNA intercalation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/single-turnover-kinetics","display_name":"single-turnover kinetics","score":0.6809999942779541},{"id":"https://openalex.org/keywords/dna-repair-efficiency","display_name":"DNA repair efficiency","score":0.45899999141693115},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.6729999780654907},{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.8074285984039307},{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.774337649345398},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6050714254379272},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5924609899520874},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5020246505737305},{"id":"https://openalex.org/C40758303","wikidata":"https://www.wikidata.org/wiki/Q212936","display_name":"Aflatoxin","level":2,"score":0.4447953402996063},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.438339501619339},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.43207088112831116},{"id":"https://openalex.org/C2781247443","wikidata":"https://www.wikidata.org/wiki/Q4153410","display_name":"DNA adduct","level":3,"score":0.4261520504951477},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4106147885322571},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36668628454208374},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30997633934020996},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29467323422431946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2070770561695099},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.12021473050117493},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10393741726875305},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.06008651852607727}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016604","descriptor_name":"Aflatoxin B1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016604","descriptor_name":"Aflatoxin B1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045647","descriptor_name":"DNA Glycosylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045647","descriptor_name":"DNA Glycosylases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.chemrestox.0c00517","doi":"https://doi.org/10.1021/acs.chemrestox.0c00517","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.chemrestox.0c00517","pdf_url":null,"source":{"id":"https://openalex.org/S152840809","display_name":"Chemical Research in Toxicology","issn_l":"0893-228X","issn":["0893-228X","1520-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Toxicology","raw_type":"journal-article"},{"id":"pmid:33595290","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33595290","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical research in toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8727046","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8727046","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chem Res Toxicol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8727046","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8727046","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chem Res Toxicol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1138793970","display_name":null,"funder_award_id":"R01 ES\u2010029357","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G1273393782","display_name":null,"funder_award_id":"S10 RR-05805","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1657769858","display_name":"DNA Adduct-Induced Mutagenesis","funder_award_id":"R01CA055678","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1666740208","display_name":"Console upgrades for biological NMR spectrometers","funder_award_id":"S10RR025677","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1694328731","display_name":"DNA Adduct-Induced Mutagenesis","funder_award_id":"5r01es029357-29","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4180785493","display_name":null,"funder_award_id":"DBI-0922862","funder_id":"https://openalex.org/F4320337398","funder_display_name":"Division of Biological Infrastructure"},{"id":"https://openalex.org/G4761482359","display_name":"Novel Targets in Cancer Chemotherapy: Chemical Biology of Guanine Alkylation","funder_award_id":"P01CA160032","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G668380494","display_name":"Role of Base Excision Repair in Limiting Hepatocellular Carcinomas","funder_award_id":"R01ES031086","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7928200420","display_name":"Chemistry and Biology of Carcinogen-DNA Adducts","funder_award_id":"P01ES005355","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000880732","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA068485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337398","display_name":"Division of Biological Infrastructure","ror":"https://ror.org/04qn9mx93"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1524941871","https://openalex.org/W1841479913","https://openalex.org/W1968039715","https://openalex.org/W1976586299","https://openalex.org/W1977868806","https://openalex.org/W1982635841","https://openalex.org/W1986339515","https://openalex.org/W2001362843","https://openalex.org/W2003138624","https://openalex.org/W2008941708","https://openalex.org/W2013499563","https://openalex.org/W2019522510","https://openalex.org/W2023963242","https://openalex.org/W2030519118","https://openalex.org/W2036013317","https://openalex.org/W2039556954","https://openalex.org/W2044183281","https://openalex.org/W2045944051","https://openalex.org/W2050224588","https://openalex.org/W2058134568","https://openalex.org/W2070195393","https://openalex.org/W2070888848","https://openalex.org/W2070982608","https://openalex.org/W2071611099","https://openalex.org/W2076755375","https://openalex.org/W2084505555","https://openalex.org/W2088684212","https://openalex.org/W2097910118","https://openalex.org/W2101364159","https://openalex.org/W2113358853","https://openalex.org/W2126917185","https://openalex.org/W2134689840","https://openalex.org/W2135272393","https://openalex.org/W2136332525","https://openalex.org/W2140356389","https://openalex.org/W2145585883","https://openalex.org/W2151591887","https://openalex.org/W2163392206","https://openalex.org/W2553169723","https://openalex.org/W2589014390","https://openalex.org/W2597577045","https://openalex.org/W2603268057","https://openalex.org/W2604957168","https://openalex.org/W2747173726","https://openalex.org/W2773622363","https://openalex.org/W2899911984","https://openalex.org/W2914174543","https://openalex.org/W2922013500","https://openalex.org/W2943220352","https://openalex.org/W2944522708","https://openalex.org/W2952050708","https://openalex.org/W2983919041","https://openalex.org/W2984640760","https://openalex.org/W3004480399","https://openalex.org/W3009356145","https://openalex.org/W3022071200","https://openalex.org/W3090573334","https://openalex.org/W3101311801","https://openalex.org/W3102124136","https://openalex.org/W3102626064"],"related_works":["https://openalex.org/W3167569277","https://openalex.org/W2899911984","https://openalex.org/W2140356389","https://openalex.org/W1980657599","https://openalex.org/W2912297700","https://openalex.org/W1986339515","https://openalex.org/W4380244620","https://openalex.org/W1524941871","https://openalex.org/W4414010719","https://openalex.org/W2135272393"],"abstract_inverted_index":{"Dietary":[0],"exposure":[1],"to":[2,35,51,92,95,168],"aflatoxins":[3],"is":[4,155,204],"a":[5],"significant":[6],"risk":[7],"factor":[8],"in":[9,32,57,113,143,197,229,257,278],"the":[10,20,36,60,63,69,105,114,117,131,173,180,193,199,213,234,262,271,279,292,295,298],"development":[11],"of":[12,22,38,59,72,116,150,161,182,187,215,281,294,300],"hepatocellular":[13],"carcinomas.":[14],"Following":[15],"bioactivation":[16],"by":[17],"microsomal":[18],"P450s,":[19],"reaction":[21],"aflatoxin":[23],"B":[24,43],"1":[25,27,44,46,65,119,137,164,201,224],"(AFB":[26,45],")":[28],"with":[29,233,261],"guanine":[30],"(Gua)":[31],"DNA":[33,61,73,132,149,194,240],"leads":[34],"formation":[37],"stable,":[39],"imidazole":[40],"ring-opened":[41],"8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxyaflatoxin":[42],"-FapyGua)":[47],"adducts.":[48],"In":[49],"contrast":[50],"most":[52],"base":[53,108,124,264],"modifications":[54],"that":[55,84,103,130,157,178,192,285],"result":[56],"destabilization":[58],"duplex,":[62],"AFB":[64,118,136,163,200,223],"-FapyGua":[66,120,138,165,202,225],"adduct":[67,203],"increases":[68],"thermal":[70,258],"stability":[71,209,242],"via":[74],"5\u2032-interface":[75],"intercalation":[76],"and":[77,107,139,147,171,175,210,249,297],"base-stacking":[78],"interactions.":[79],"Although":[80],"it":[81,154],"was":[82,287],"anticipated":[83,156],"this":[85,220,282],"stabilization":[86,293],"might":[87,206],"make":[88],"these":[89,183],"lesions":[90],"difficult":[91],"repair":[93,110,184,280],"relative":[94],"helix":[96],"distorting":[97],"modifications,":[98],"prior":[99],"studies":[100],"have":[101],"shown":[102],"both":[104,144],"nucleotide":[106,237],"excision":[109,125],"pathways":[111,185],"participate":[112],"removal":[115],"adduct.":[121],"Specifically":[122],"for":[123],"repair,":[126],"we":[127],"previously":[128],"showed":[129],"glycosylase":[133,273],"NEIL1":[134,272],"excises":[135],"catalyzes":[140],"strand":[141],"scission":[142],"synthetic":[145],"oligodeoxynucleotides":[146],"liver":[148],"exposed":[151],"mice.":[152],"Since":[153],"error-prone":[158],"replication":[159],"bypass":[160],"unrepaired":[162],"adducts":[166,226],"contributes":[167],"cellular":[169],"transformation":[170],"carcinogenesis,":[172],"structural":[174,241],"thermodynamic":[176],"parameters":[177],"modulate":[179,207],"efficiencies":[181,214],"are":[186],"considerable":[188],"interest.":[189],"We":[190],"hypothesized":[191],"sequence":[195,231],"context":[196],"which":[198],"formed":[205],"duplex":[208,296],"consequently":[211],"alter":[212],"NEIL1-initiated":[216],"repair.":[217],"To":[218],"address":[219],"hypothesis,":[221],"site-specific":[222],"were":[227,244],"synthesized":[228],"three":[230],"contexts,":[232],"5\u2032":[235],"neighbor":[236],"being":[238],"varied.":[239],"analyses":[243,269],"conducted":[245],"using":[246,270],"UV":[247],"absorbance-":[248],"NMR-based":[250],"melting":[251],"experiments.":[252],"These":[253],"data":[254],"revealed":[255],"differentials":[256],"stabilities":[259],"associated":[260],"5\u2032-neighbor":[263],"pair.":[265],"Single":[266],"turnover":[267],"kinetic":[268],"demonstrated":[274],"corresponding":[275],"sequence-dependent":[276],"differences":[277],"adduct,":[283],"such":[284],"there":[286],"an":[288],"inverse":[289],"correlation":[290],"between":[291],"efficiency":[299],"NEIL1-mediated":[301],"catalysis.":[302]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2021-03-01T00:00:00"}
