{"id":"https://openalex.org/W3131801204","doi":"https://doi.org/10.1038/s41467-021-21515-7","title":"Spatially mapped single-cell chromatin accessibility","display_name":"Spatially mapped single-cell chromatin accessibility","publication_year":2021,"publication_date":"2021-02-24","ids":{"openalex":"https://openalex.org/W3131801204","doi":"https://doi.org/10.1038/s41467-021-21515-7","mag":"3131801204","pmid":"https://pubmed.ncbi.nlm.nih.gov/33627658","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7904839"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-021-21515-7","doi":"https://doi.org/10.1038/s41467-021-21515-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-21515-7","pdf_url":"https://www.nature.com/articles/s41467-021-21515-7.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-021-21515-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080898247","display_name":"Casey A. Thornton","orcid":"https://orcid.org/0000-0003-3589-6911","observed_orcids":["https://orcid.org/0000-0003-3589-6911"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Casey A. Thornton","raw_affiliation_strings":["Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA","Molecular and Medical Genetics, Oregon Health & Science University, Portland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Molecular and Medical Genetics, Oregon Health & Science University, Portland, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086348500","display_name":"Ryan M. Mulqueen","orcid":"https://orcid.org/0000-0002-3903-7594","observed_orcids":["https://orcid.org/0000-0002-3903-7594"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan M. Mulqueen","raw_affiliation_strings":["Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA","Molecular and Medical Genetics, Oregon Health & Science University, Portland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Molecular and Medical Genetics, Oregon Health & Science University, Portland, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079469089","display_name":"Kristof A. Torkenczy","orcid":"https://orcid.org/0000-0002-4869-7957","observed_orcids":["https://orcid.org/0000-0002-4869-7957"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristof A. Torkenczy","raw_affiliation_strings":["Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA","Molecular and Medical Genetics, Oregon Health & Science University, Portland, USA"],"raw_orcid":"https://orcid.org/0000-0002-4869-7957","affiliations":[{"raw_affiliation_string":"Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Molecular and Medical Genetics, Oregon Health & Science University, Portland, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060773615","display_name":"Andrew Nishida","orcid":"https://orcid.org/0000-0002-9606-2235","observed_orcids":["https://orcid.org/0000-0002-9606-2235"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Nishida","raw_affiliation_strings":["Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA","Molecular and Medical Genetics, Oregon Health & Science University, Portland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Molecular and Medical Genetics, Oregon Health & Science University, Portland, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068542248","display_name":"Eve G. Lowenstein","orcid":"https://orcid.org/0000-0002-4720-2166","observed_orcids":["https://orcid.org/0000-0002-4720-2166"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eve G. Lowenstein","raw_affiliation_strings":["Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA","Molecular and Medical Genetics, Oregon Health & Science University, Portland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Molecular and Medical Genetics, Oregon Health & Science University, Portland, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062633069","display_name":"Andrew J. Fields","orcid":"https://orcid.org/0000-0002-0853-8054","observed_orcids":["https://orcid.org/0000-0002-0853-8054"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Fields","raw_affiliation_strings":["Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA","Molecular and Medical Genetics, Oregon Health & Science University, Portland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Molecular and Medical Genetics, Oregon Health & Science University, Portland, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034834036","display_name":"Frank J. Steemers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178645029","display_name":"Illumina (United States)","ror":"https://ror.org/05k34t975","country_code":"US","type":"company","lineage":["https://openalex.org/I178645029"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank J. Steemers","raw_affiliation_strings":["Illumina Inc., San Diego, CA, USA","Illumina Inc., San Diego, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illumina Inc., San Diego, CA, USA","institution_ids":["https://openalex.org/I178645029"]},{"raw_affiliation_string":"Illumina Inc., San Diego, USA","institution_ids":["https://openalex.org/I178645029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065908924","display_name":"Wenri H. Zhang","orcid":"https://orcid.org/0000-0001-7622-2054","observed_orcids":["https://orcid.org/0000-0001-7622-2054"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenri Zhang","raw_affiliation_strings":["Anesthesiology and Peri-Operative Medicine, Oregon Health & Science University, Portland, OR, USA","Anesthesiology and Peri-Operative Medicine, Oregon Health & Science University, Portland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology and Peri-Operative Medicine, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Anesthesiology and Peri-Operative Medicine, Oregon Health & Science University, Portland, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Heather L. McConnell","orcid":"https://orcid.org/0000-0002-0505-6316","observed_orcids":["https://orcid.org/0000-0002-0505-6316"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather L. McConnell","raw_affiliation_strings":["Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, OR, USA","Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, USA"],"raw_orcid":"https://orcid.org/0000-0002-0505-6316","affiliations":[{"raw_affiliation_string":"Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109438902","display_name":"Randy L Woltjer","orcid":"https://orcid.org/0000-0003-0755-9846","observed_orcids":["https://orcid.org/0000-0003-0755-9846"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randy L. Woltjer","raw_affiliation_strings":["Department of Pathology, Oregon Health & Science University, Portland, OR, USA","Department of Pathology, Oregon Health & Science University, Portland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Pathology, Oregon Health & Science University, Portland, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031938939","display_name":"Anusha Mishra","orcid":"https://orcid.org/0000-0002-3642-5049","observed_orcids":["https://orcid.org/0000-0002-3642-5049"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anusha Mishra","raw_affiliation_strings":["Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, OR, USA","Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA","Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, USA","Knight Cardiovascular Institute, Oregon Health & Science University, Portland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Knight Cardiovascular Institute, Oregon Health & Science University, Portland, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041505294","display_name":"Kevin M. Wright","orcid":"https://orcid.org/0000-0001-5094-5270","observed_orcids":["https://orcid.org/0000-0001-5094-5270"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2802707198","display_name":"Vollum Institute","ror":"https://ror.org/054hm6j14","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802707198"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin M. Wright","raw_affiliation_strings":["The Vollum Institute, Oregon Health & Science University, Portland, OR, USA","The Vollum Institute, Oregon Health & Science University, Portland, USA"],"raw_orcid":"https://orcid.org/0000-0001-5094-5270","affiliations":[{"raw_affiliation_string":"The Vollum Institute, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2802707198"]},{"raw_affiliation_string":"The Vollum Institute, Oregon Health & Science University, Portland, USA","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2802707198"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042986766","display_name":"Andrew Adey","orcid":"https://orcid.org/0000-0001-7648-8717","observed_orcids":["https://orcid.org/0000-0001-7648-8717"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4390039369","display_name":"OHSU Knight Cancer Institute","ror":"https://ror.org/002shna07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew C. Adey","raw_affiliation_strings":["CEDAR, Oregon Health & Science University, Portland, OR, USA. adey@ohsu.edu","Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA. adey@ohsu.edu","Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA. adey@ohsu.edu","Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA. adey@ohsu.edu","Molecular and Medical Genetics, Oregon Health & Science University, Portland, USA"],"raw_orcid":"https://orcid.org/0000-0001-7648-8717","affiliations":[{"raw_affiliation_string":"CEDAR, Oregon Health & Science University, Portland, OR, USA. adey@ohsu.edu","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA. adey@ohsu.edu","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]},{"raw_affiliation_string":"Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA. adey@ohsu.edu","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA. adey@ohsu.edu","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Molecular and Medical Genetics, Oregon Health & Science University, Portland, USA","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5042986766"],"corresponding_institution_ids":["https://openalex.org/I165690674","https://openalex.org/I4390039369"],"apc_list":{"value":5560,"currency":"USD","value_usd":5560},"apc_paid":{"value":5560,"currency":"USD","value_usd":5560},"fwci":5.0961,"has_fulltext":true,"cited_by_count":85,"citation_normalized_percentile":{"value":0.97439687,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"12","issue":"1","first_page":"1274","last_page":"1274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-cell-chromatin-accessibility","display_name":"single-cell chromatin accessibility","score":0.8659999966621399},{"id":"https://openalex.org/keywords/single-cell-atac-seq","display_name":"single-cell ATAC-seq","score":0.6840000152587891},{"id":"https://openalex.org/keywords/combinatorial-indexing","display_name":"combinatorial indexing","score":0.628000020980835},{"id":"https://openalex.org/keywords/cortical-lamination","display_name":"cortical lamination","score":0.7120000123977661},{"id":"https://openalex.org/keywords/primary-somatosensory-cortex","display_name":"primary somatosensory cortex","score":0.9179999828338623},{"id":"https://openalex.org/keywords/primary-visual-cortex","display_name":"primary visual cortex","score":0.972000002861023},{"id":"https://openalex.org/keywords/ischemic-cerebral-infarction","display_name":"ischemic cerebral infarction","score":0.9300000071525574},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.9670000076293945},{"id":"https://openalex.org/keywords/mouse-brain","display_name":"mouse brain","score":0.3529999852180481},{"id":"https://openalex.org/keywords/human-brain","display_name":"human brain","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7370152473449707},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.5301600098609924},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5157921314239502},{"id":"https://openalex.org/C2779345533","wikidata":"https://www.wikidata.org/wiki/Q75785","display_name":"Visual cortex","level":2,"score":0.49924683570861816},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4582139849662781},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.456811785697937},{"id":"https://openalex.org/C175779824","wikidata":"https://www.wikidata.org/wiki/Q7574078","display_name":"Spatial organization","level":2,"score":0.4400993585586548},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41506555676460266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40519773960113525},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38719603419303894},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13621503114700317},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020244","descriptor_name":"Infarction, Middle Cerebral Artery","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41467-021-21515-7","doi":"https://doi.org/10.1038/s41467-021-21515-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-21515-7","pdf_url":"https://www.nature.com/articles/s41467-021-21515-7.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/815720","doi":"https://doi.org/10.1101/815720","is_oa":true,"landing_page_url":"https://doi.org/10.1101/815720","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:7904839","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7904839","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:33627658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33627658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21515-7","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-021-21515-7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:1ad12e0e2a2a4ba0b41d734d7e7f4e32","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1ad12e0e2a2a4ba0b41d734d7e7f4e32","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-021-21515-7","doi":"https://doi.org/10.1038/s41467-021-21515-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-21515-7","pdf_url":"https://www.nature.com/articles/s41467-021-21515-7.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2216370110","display_name":"Epigenetic tools and resources for cell-type and spatial analysis of individual mammalian non-neuronal cells","funder_award_id":"R01DA047237","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G3831082094","display_name":null,"funder_award_id":"R35GM124704","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G7321252909","display_name":"Defining the epigenetic landscape at single cell resolution","funder_award_id":"R35GM124704","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7626613124","display_name":null,"funder_award_id":"R01DA047237","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320309233","display_name":"Oregon Health and Science University","ror":"https://ror.org/009avj582"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3131801204.pdf","grobid_xml":"https://content.openalex.org/works/W3131801204.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W1492083415","https://openalex.org/W1537642251","https://openalex.org/W1558511675","https://openalex.org/W1631320694","https://openalex.org/W1849400986","https://openalex.org/W1968657935","https://openalex.org/W1979594866","https://openalex.org/W1987289944","https://openalex.org/W1988702707","https://openalex.org/W2007000124","https://openalex.org/W2026863186","https://openalex.org/W2030008105","https://openalex.org/W2033215199","https://openalex.org/W2035025978","https://openalex.org/W2042789810","https://openalex.org/W2058165240","https://openalex.org/W2069977787","https://openalex.org/W2075054405","https://openalex.org/W2079070487","https://openalex.org/W2084942072","https://openalex.org/W2089124259","https://openalex.org/W2103441770","https://openalex.org/W2112505121","https://openalex.org/W2119451273","https://openalex.org/W2123491442","https://openalex.org/W2126537932","https://openalex.org/W2127238312","https://openalex.org/W2142922993","https://openalex.org/W2145016172","https://openalex.org/W2147029479","https://openalex.org/W2159592906","https://openalex.org/W2167141364","https://openalex.org/W2167279371","https://openalex.org/W2171808845","https://openalex.org/W2231058499","https://openalex.org/W2406250479","https://openalex.org/W2523183261","https://openalex.org/W2580989000","https://openalex.org/W2581829163","https://openalex.org/W2582412045","https://openalex.org/W2582946425","https://openalex.org/W2608758393","https://openalex.org/W2615166509","https://openalex.org/W2688688779","https://openalex.org/W2746578491","https://openalex.org/W2747545374","https://openalex.org/W2750049634","https://openalex.org/W2750416916","https://openalex.org/W2750740711","https://openalex.org/W2793136543","https://openalex.org/W2797310920","https://openalex.org/W2806122497","https://openalex.org/W2886347923","https://openalex.org/W2887694579","https://openalex.org/W2887910040","https://openalex.org/W2889236955","https://openalex.org/W2902084853","https://openalex.org/W2902272440","https://openalex.org/W2902652978","https://openalex.org/W2915848182","https://openalex.org/W2916020270","https://openalex.org/W2918223507","https://openalex.org/W2923237341","https://openalex.org/W2923300855","https://openalex.org/W2925146678","https://openalex.org/W2934716754","https://openalex.org/W2949177718","https://openalex.org/W2951499602","https://openalex.org/W2952602120","https://openalex.org/W2972983657","https://openalex.org/W2974304113","https://openalex.org/W2985765936","https://openalex.org/W3046196569","https://openalex.org/W3093858607","https://openalex.org/W3102485225","https://openalex.org/W3135168232","https://openalex.org/W4210838940","https://openalex.org/W4247053599"],"related_works":["https://openalex.org/W4233678118","https://openalex.org/W4210838940","https://openalex.org/W6964463004","https://openalex.org/W4292121951","https://openalex.org/W2887910040","https://openalex.org/W2951499602","https://openalex.org/W4313561175","https://openalex.org/W2891503351","https://openalex.org/W1492083415","https://openalex.org/W4387168665"],"abstract_inverted_index":{"Abstract":[0],"High-throughput":[1],"single-cell":[2,21,46,123],"epigenomic":[3],"assays":[4],"can":[5],"resolve":[6],"cell":[7,67],"type":[8],"heterogeneity":[9],"in":[10,81,92,100,136],"complex":[11],"tissues,":[12],"however,":[13],"spatial":[14,109],"orientation":[15],"is":[16],"lost.":[17],"Here,":[18],"we":[19,107,126],"present":[20],"combinatorial":[22],"indexing":[23],"on":[24],"Microbiopsies":[25],"Assigned":[26],"to":[27,57,76,88],"Positions":[28],"for":[29,32,41],"the":[30,62,93,101,128,137],"Assay":[31],"Transposase":[33],"Accessible":[34],"Chromatin,":[35],"or":[36],"sciMAP-ATAC,":[37],"as":[38],"a":[39,69,82,141],"method":[40],"highly":[42],"scalable,":[43],"spatially":[44,129],"resolved,":[45],"profiling":[47],"of":[48,54,65,78,132,143],"chromatin":[49,121],"states.":[50],"sciMAP-ATAC":[51,87],"produces":[52],"data":[53,114],"equivalent":[55],"quality":[56],"non-spatial":[58,116],"sci-ATAC":[59],"and":[60,99,111,119],"retains":[61],"positional":[63],"information":[64],"each":[66],"within":[68],"214":[70],"micron":[71],"cubic":[72],"region,":[73],"with":[74,115],"up":[75],"hundreds":[77],"tracked":[79],"positions":[80],"single":[83],"experiment.":[84],"We":[85],"apply":[86],"assess":[89],"cortical":[90],"lamination":[91],"adult":[94],"mouse":[95,138],"primary":[96,103],"somatosensory":[97],"cortex":[98],"human":[102],"visual":[104],"cortex,":[105],"where":[106],"produce":[108],"trajectories":[110],"integrate":[112],"our":[113],"single-nucleus":[117],"RNA":[118],"other":[120],"accessibility":[122],"datasets.":[124],"Finally,":[125],"characterize":[127],"progressive":[130],"nature":[131],"cerebral":[133,146],"ischemic":[134],"infarction":[135],"brain":[139],"using":[140],"model":[142],"transient":[144],"middle":[145],"artery":[147],"occlusion.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-01T00:00:00"}
