{"id":"https://openalex.org/W3131781607","doi":"https://doi.org/10.3390/ijms22041822","title":"Effect of Chronic Western Diets on Non-Alcoholic Fatty Liver of Male Mice Modifying the PPAR-\u03b3 Pathway via miR-27b-5p Regulation","display_name":"Effect of Chronic Western Diets on Non-Alcoholic Fatty Liver of Male Mice Modifying the PPAR-\u03b3 Pathway via miR-27b-5p Regulation","publication_year":2021,"publication_date":"2021-02-12","ids":{"openalex":"https://openalex.org/W3131781607","doi":"https://doi.org/10.3390/ijms22041822","mag":"3131781607","pmid":"https://pubmed.ncbi.nlm.nih.gov/33673073","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7917964"},"language":"en","primary_location":{"id":"doi:10.3390/ijms22041822","doi":"https://doi.org/10.3390/ijms22041822","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22041822","pdf_url":"https://www.mdpi.com/1422-0067/22/4/1822/pdf?version=1613122094","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/22/4/1822/pdf?version=1613122094","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100410012","display_name":"Jian Zhang","orcid":"https://orcid.org/0000-0002-8402-9753","observed_orcids":["https://orcid.org/0000-0002-8402-9753"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Zhang","raw_affiliation_strings":["Pharmaceutical Sciences, Texas A&amp;M Health Science Center, College Station, TX 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Sciences, Texas A&amp;M Health Science Center, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033481259","display_name":"Catherine A. Powell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine A Powell","raw_affiliation_strings":["Pharmaceutical Sciences, Texas A&amp;M Health Science Center, College Station, TX 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Sciences, Texas A&amp;M Health Science Center, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050974728","display_name":"Matthew Kay","orcid":"https://orcid.org/0009-0007-7751-6311","observed_orcids":["https://orcid.org/0009-0007-7751-6311"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew K Kay","raw_affiliation_strings":["Pharmaceutical Sciences, Texas A&amp;M Health Science Center, College Station, TX 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Sciences, Texas A&amp;M Health Science Center, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113821777","display_name":"Ravi Sonkar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Sonkar","raw_affiliation_strings":["Pharmaceutical Sciences, Texas A&amp;M Health Science Center, College Station, TX 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Sciences, Texas A&amp;M Health Science Center, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053863218","display_name":"Sunitha Meruvu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunitha Meruvu","raw_affiliation_strings":["Pharmaceutical Sciences, Texas A&amp;M Health Science Center, College Station, TX 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Sciences, Texas A&amp;M Health Science Center, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080651861","display_name":"Mahua Choudhury","orcid":"https://orcid.org/0000-0002-3654-8743","observed_orcids":["https://orcid.org/0000-0002-3654-8743"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mahua Choudhury","raw_affiliation_strings":["Pharmaceutical Sciences, Texas A&amp;M Health Science Center, College Station, TX 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Sciences, Texas A&amp;M Health Science Center, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080651861"],"corresponding_institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":3.0522,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.92928671,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"22","issue":"4","first_page":"1822","last_page":"1822"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.6898999810218811,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.6898999810218811,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.26460000872612,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.878000020980835},{"id":"https://openalex.org/keywords/western-diet","display_name":"Western diet","score":0.9570000171661377},{"id":"https://openalex.org/keywords/high-fat-high-fructose-diet","display_name":"high-fat high-fructose diet","score":0.9739999771118164},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8109999895095825},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.7310000061988831},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8970000147819519},{"id":"https://openalex.org/keywords/metabolic-dysfunction","display_name":"metabolic dysfunction","score":0.7310000061988831},{"id":"https://openalex.org/keywords/steatosis","display_name":"steatosis","score":0.6859999895095825},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/stearoyl-coa-desaturase-1","display_name":"stearoyl-CoA desaturase 1","score":0.8700000047683716},{"id":"https://openalex.org/keywords/fas","display_name":"Fas","score":0.902999997138977},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.5429999828338623},{"id":"https://openalex.org/keywords/c57bl-6j-mice","display_name":"C57BL/6J mice","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8341966271400452},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8339252471923828},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.8131344318389893},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7950073480606079},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.5350156426429749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44890540838241577},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4466910660266876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33738815784454346},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18542072176933289},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07695546746253967},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07299378514289856},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D066273","descriptor_name":"Diet, Western","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms22041822","doi":"https://doi.org/10.3390/ijms22041822","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22041822","pdf_url":"https://www.mdpi.com/1422-0067/22/4/1822/pdf?version=1613122094","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7917964","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7917964","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:33673073","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33673073","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:caed751a36bf4742ae5dd9c45f1fd8cb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/caed751a36bf4742ae5dd9c45f1fd8cb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 22, Iss 1822, p 1822 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms22041822","doi":"https://doi.org/10.3390/ijms22041822","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22041822","pdf_url":"https://www.mdpi.com/1422-0067/22/4/1822/pdf?version=1613122094","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3131781607.pdf","grobid_xml":"https://content.openalex.org/works/W3131781607.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W118110054","https://openalex.org/W1539647663","https://openalex.org/W1578250568","https://openalex.org/W1791881915","https://openalex.org/W1966064283","https://openalex.org/W1975489439","https://openalex.org/W1977922773","https://openalex.org/W1994261934","https://openalex.org/W1999665022","https://openalex.org/W2002022639","https://openalex.org/W2002349285","https://openalex.org/W2025657436","https://openalex.org/W2034700421","https://openalex.org/W2036975830","https://openalex.org/W2046113619","https://openalex.org/W2048060485","https://openalex.org/W2052478346","https://openalex.org/W2055736494","https://openalex.org/W2059929718","https://openalex.org/W2062618014","https://openalex.org/W2069009920","https://openalex.org/W2073145655","https://openalex.org/W2077342495","https://openalex.org/W2081713502","https://openalex.org/W2088150017","https://openalex.org/W2091296342","https://openalex.org/W2098633597","https://openalex.org/W2104111386","https://openalex.org/W2105359426","https://openalex.org/W2113063440","https://openalex.org/W2113576333","https://openalex.org/W2127552529","https://openalex.org/W2137631404","https://openalex.org/W2144591738","https://openalex.org/W2150957692","https://openalex.org/W2164567049","https://openalex.org/W2184324737","https://openalex.org/W2214515281","https://openalex.org/W2279591026","https://openalex.org/W2286797029","https://openalex.org/W2287075929","https://openalex.org/W2342803240","https://openalex.org/W2463708289","https://openalex.org/W2550668182","https://openalex.org/W2557220603","https://openalex.org/W2558996269","https://openalex.org/W2559970822","https://openalex.org/W2573090827","https://openalex.org/W2617130129","https://openalex.org/W2752675429","https://openalex.org/W2767093292","https://openalex.org/W2767801219","https://openalex.org/W2782982995","https://openalex.org/W2792959572","https://openalex.org/W2803897617","https://openalex.org/W2809691730","https://openalex.org/W2904575550","https://openalex.org/W2904806538","https://openalex.org/W2946142949","https://openalex.org/W2967561146","https://openalex.org/W2975136909","https://openalex.org/W4244189832"],"related_works":["https://openalex.org/W3035431767","https://openalex.org/W2264301996","https://openalex.org/W3165340773","https://openalex.org/W4205904308","https://openalex.org/W3159244062","https://openalex.org/W4414301379","https://openalex.org/W2784920011","https://openalex.org/W2236056553","https://openalex.org/W6986334467","https://openalex.org/W4316369330"],"abstract_inverted_index":{"Western":[0,191],"diets":[1,11],"contribute":[2],"to":[3,56,130,156,169],"metabolic":[4,53],"diseases.":[5],"However,":[6],"the":[7,57,121,131,174,181,199],"effects":[8],"of":[9,113,183],"various":[10],"and":[12,23,36,60,71,79,92,215],"epigenetic":[13],"mechanisms":[14],"are":[15,108],"mostly":[16],"unknown.":[17],"Here,":[18,186],"six":[19],"week-old":[20],"C57BL/6J":[21],"male":[22,62],"female":[24,85],"mice":[25,50,63,86,167],"were":[26,87,142],"fed":[27,171],"with":[28,75],"a":[29,97],"low-fat":[30],"diet":[31,34,39],"(LFD),":[32],"high-fat":[33,37],"(HFD),":[35],"high-fructose":[38],"(HFD-HF)":[40],"for":[41,194],"20":[42,195],"weeks.":[43],"We":[44],"determined":[45],"that":[46,105,189],"HFD-HF":[47,59,122,147,170,175],"or":[48],"HFD":[49,91,132],"experienced":[51],"significant":[52],"dysregulation":[54],"compared":[55,129,155,168],"LFD.":[58,157],"HFD-fed":[61,166],"showed":[64,148,177],"significantly":[65],"increased":[66,143,164],"body":[67],"weight,":[68],"liver":[69,176,202,214],"size,":[70],"fasting":[72],"glucose":[73],"levels":[74],"downregulated":[76],"PPAR\u03b3,":[77,101],"SCD1,":[78],"FAS":[80],"protein":[81],"expression.":[82],"In":[83],"contrast,":[84],"less":[88],"affected":[89],"by":[90,110],"HFD-HF.":[93],"As":[94],"miR-27b":[95],"contains":[96],"seed":[98],"sequence":[99],"in":[100,120,151,161,165,180],"it":[102],"was":[103,163],"discovered":[104],"these":[106],"changes":[107,150],"accompanied":[109],"male-specific":[111],"upregulation":[112],"miR-27b-5p,":[114],"which":[115],"is":[116],"even":[117],"more":[118],"pronounced":[119],"group":[123,133],"(p":[124,134],"<":[125,135],"0.01":[126],"vs.":[127,137],"LFD)":[128],"0.05":[136],"LFD).":[138],"Other":[139],"miR-27":[140],"subtypes":[141],"but":[144,205],"not":[145],"significantly.":[146],"insignificant":[149],"fibrosis":[152,216],"markers":[153],"when":[154],"Interestingly,":[158],"fat":[159],"ballooning":[160],"hepatocytes":[162],"mice,":[172],"however,":[173],"an":[178,209],"increase":[179],"number":[182],"small":[184],"cells.":[185],"we":[187],"concluded":[188],"chronic":[190],"diet-composition":[192],"administered":[193],"weeks":[196],"may":[197,206],"surpass":[198],"non-alcoholic":[200],"fatty":[201,213],"(NAFL)":[203],"stage":[204,211],"be":[207],"at":[208],"intermediate":[210],"between":[212],"via":[217],"miR-27b-5p-induced":[218],"PPAR\u03b3":[219],"downregulation.":[220]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-03-01T00:00:00"}