{"id":"https://openalex.org/W3131780971","doi":"https://doi.org/10.1016/j.bioorg.2021.104719","title":"Flavonoids from Pterogyne nitens as Zika virus NS2B-NS3 protease inhibitors","display_name":"Flavonoids from Pterogyne nitens as Zika virus NS2B-NS3 protease inhibitors","publication_year":2021,"publication_date":"2021-02-11","ids":{"openalex":"https://openalex.org/W3131780971","doi":"https://doi.org/10.1016/j.bioorg.2021.104719","mag":"3131780971","pmid":"https://pubmed.ncbi.nlm.nih.gov/33636437","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8227833"},"language":"en","primary_location":{"id":"doi:10.1016/j.bioorg.2021.104719","doi":"https://doi.org/10.1016/j.bioorg.2021.104719","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bioorg.2021.104719","pdf_url":null,"source":{"id":"https://openalex.org/S165482960","display_name":"Bioorganic Chemistry","issn_l":"0045-2068","issn":["0045-2068","1090-2120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8227833","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045336981","display_name":"Caroline Sprengel Lima","orcid":"https://orcid.org/0000-0003-1798-8994","observed_orcids":["https://orcid.org/0000-0003-1798-8994"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Caroline Sprengel Lima","raw_affiliation_strings":["Laboratory of Antibiotics and Chemotherapeutics (LAQ), Institute of Biosciences, Humanities and Exact Sciences, S\u00e3o Paulo State University (Unesp), S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Antibiotics and Chemotherapeutics (LAQ), Institute of Biosciences, Humanities and Exact Sciences, S\u00e3o Paulo State University (Unesp), S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028052016","display_name":"Melina Mottin","orcid":"https://orcid.org/0000-0003-0878-9029","observed_orcids":["https://orcid.org/0000-0003-0878-9029"]},"institutions":[{"id":"https://openalex.org/I68106152","display_name":"Universidade Federal de Goi\u00e1s","ror":"https://ror.org/0039d5757","country_code":"BR","type":"education","lineage":["https://openalex.org/I68106152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Melina Mottin","raw_affiliation_strings":["Laboratory of Molecular Modeling and Drug Design (LabMol), Faculdade de Farm\u00e1cia, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Modeling and Drug Design (LabMol), Faculdade de Farm\u00e1cia, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil","institution_ids":["https://openalex.org/I68106152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007393879","display_name":"Let\u00edcia Ribeiro de Assis","orcid":"https://orcid.org/0000-0001-9869-8934","observed_orcids":["https://orcid.org/0000-0001-9869-8934"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Leticia Ribeiro de Assis","raw_affiliation_strings":["Laboratory of Antibiotics and Chemotherapeutics (LAQ), Institute of Biosciences, Humanities and Exact Sciences, S\u00e3o Paulo State University (Unesp), S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Antibiotics and Chemotherapeutics (LAQ), Institute of Biosciences, Humanities and Exact Sciences, S\u00e3o Paulo State University (Unesp), S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109410850","display_name":"Nathalya Cristina de Moraes Roso Mesquita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405267372","display_name":"Instituto de F\u00edsica de S\u00e3o Carlos","ror":"https://ror.org/02f1crb75","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374","https://openalex.org/I4405267372"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Nathalya Cristina de Moraes Roso Mesquita","raw_affiliation_strings":["Institute of Physics of S\u00e3o Carlos, University of S\u00e3o Paulo, S\u00e3o Carlos, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physics of S\u00e3o Carlos, University of S\u00e3o Paulo, S\u00e3o Carlos, SP, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405267372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065328429","display_name":"Bruna Katiele de Paula Sousa","orcid":"https://orcid.org/0000-0002-3204-5591","observed_orcids":["https://orcid.org/0000-0002-3204-5591"]},"institutions":[{"id":"https://openalex.org/I68106152","display_name":"Universidade Federal de Goi\u00e1s","ror":"https://ror.org/0039d5757","country_code":"BR","type":"education","lineage":["https://openalex.org/I68106152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bruna Katiele de Paula Sousa","raw_affiliation_strings":["Laboratory of Molecular Modeling and Drug Design (LabMol), Faculdade de Farm\u00e1cia, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Modeling and Drug Design (LabMol), Faculdade de Farm\u00e1cia, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil","institution_ids":["https://openalex.org/I68106152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011485145","display_name":"La\u00eds D. Coimbra","orcid":"https://orcid.org/0000-0003-0120-6898","observed_orcids":["https://orcid.org/0000-0003-0120-6898"]},"institutions":[{"id":"https://openalex.org/I4210152696","display_name":"Brazilian Center for Research in Energy and Materials","ror":"https://ror.org/05m235j20","country_code":"BR","type":"other","lineage":["https://openalex.org/I4210151455","https://openalex.org/I4210152696"]},{"id":"https://openalex.org/I4210158387","display_name":"Brazilian Biosciences National Laboratory","ror":"https://ror.org/04kjcjc51","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210151455","https://openalex.org/I4210152696","https://openalex.org/I4210158387"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lais Durco Coimbra","raw_affiliation_strings":["Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP, Brazil","institution_ids":["https://openalex.org/I4210152696","https://openalex.org/I4210158387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025209262","display_name":"Karina Bispo-dos-Santos","orcid":"https://orcid.org/0000-0003-0305-367X","observed_orcids":["https://orcid.org/0000-0003-0305-367X"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Karina Bispo-dos- Santos","raw_affiliation_strings":["Laboratory of Emerging Viruses (LEVE), Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Emerging Viruses (LEVE), Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040232853","display_name":"Kimberley M. Zorn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148032","display_name":"Collaborations Pharmaceuticals (United States)","ror":"https://ror.org/04m718665","country_code":"US","type":"company","lineage":["https://openalex.org/I4210148032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberley M. Zorn","raw_affiliation_strings":["Collaborations Pharmaceuticals, Inc., Raleigh, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborations Pharmaceuticals, Inc., Raleigh, NC, United States","institution_ids":["https://openalex.org/I4210148032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079070373","display_name":"Rafael V. C. Guido","orcid":"https://orcid.org/0000-0002-7187-0818","observed_orcids":["https://orcid.org/0000-0002-7187-0818"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405267372","display_name":"Instituto de F\u00edsica de S\u00e3o Carlos","ror":"https://ror.org/02f1crb75","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374","https://openalex.org/I4405267372"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafael V.C. Guido","raw_affiliation_strings":["Institute of Physics of S\u00e3o Carlos, University of S\u00e3o Paulo, S\u00e3o Carlos, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physics of S\u00e3o Carlos, University of S\u00e3o Paulo, S\u00e3o Carlos, SP, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405267372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073973321","display_name":"Sean Ekins","orcid":"https://orcid.org/0000-0002-5691-5790","observed_orcids":["https://orcid.org/0000-0002-5691-5790"]},"institutions":[{"id":"https://openalex.org/I4210148032","display_name":"Collaborations Pharmaceuticals (United States)","ror":"https://ror.org/04m718665","country_code":"US","type":"company","lineage":["https://openalex.org/I4210148032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Ekins","raw_affiliation_strings":["Collaborations Pharmaceuticals, Inc., Raleigh, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborations Pharmaceuticals, Inc., Raleigh, NC, United States","institution_ids":["https://openalex.org/I4210148032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025627850","display_name":"Rafael Elias Marques","orcid":"https://orcid.org/0000-0002-6949-0947","observed_orcids":["https://orcid.org/0000-0002-6949-0947"]},"institutions":[{"id":"https://openalex.org/I4210152696","display_name":"Brazilian Center for Research in Energy and Materials","ror":"https://ror.org/05m235j20","country_code":"BR","type":"other","lineage":["https://openalex.org/I4210151455","https://openalex.org/I4210152696"]},{"id":"https://openalex.org/I4210158387","display_name":"Brazilian Biosciences National Laboratory","ror":"https://ror.org/04kjcjc51","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210151455","https://openalex.org/I4210152696","https://openalex.org/I4210158387"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafael Elias Marques","raw_affiliation_strings":["Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP, Brazil","institution_ids":["https://openalex.org/I4210152696","https://openalex.org/I4210158387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058259325","display_name":"Jos\u00e9 Luiz Proen\u00e7a\u2010M\u00f3dena","orcid":"https://orcid.org/0000-0002-4996-3153","observed_orcids":["https://orcid.org/0000-0002-4996-3153"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Luiz Proen\u00e7a-Modena","raw_affiliation_strings":["Laboratory of Emerging Viruses (LEVE), Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Emerging Viruses (LEVE), Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038446513","display_name":"Glaucius Oliva","orcid":"https://orcid.org/0000-0003-2719-0302","observed_orcids":["https://orcid.org/0000-0003-2719-0302"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405267372","display_name":"Instituto de F\u00edsica de S\u00e3o Carlos","ror":"https://ror.org/02f1crb75","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374","https://openalex.org/I4405267372"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Glaucius Oliva","raw_affiliation_strings":["Institute of Physics of S\u00e3o Carlos, University of S\u00e3o Paulo, S\u00e3o Carlos, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physics of S\u00e3o Carlos, University of S\u00e3o Paulo, S\u00e3o Carlos, SP, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405267372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071012302","display_name":"Carolina Horta Andrade","orcid":"https://orcid.org/0000-0003-0101-1492","observed_orcids":["https://orcid.org/0000-0003-0101-1492"]},"institutions":[{"id":"https://openalex.org/I68106152","display_name":"Universidade Federal de Goi\u00e1s","ror":"https://ror.org/0039d5757","country_code":"BR","type":"education","lineage":["https://openalex.org/I68106152"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Carolina Horta Andrade","raw_affiliation_strings":["Laboratory of Molecular Modeling and Drug Design (LabMol), Faculdade de Farm\u00e1cia, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil. Electronic address: carolina@ufg.br","Laboratory of Molecular Modeling and Drug Design (LabMol), Faculdade de Farm\u00e1cia, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Modeling and Drug Design (LabMol), Faculdade de Farm\u00e1cia, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil. Electronic address: carolina@ufg.br","institution_ids":["https://openalex.org/I68106152"]},{"raw_affiliation_string":"Laboratory of Molecular Modeling and Drug Design (LabMol), Faculdade de Farm\u00e1cia, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil","institution_ids":["https://openalex.org/I68106152"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048201644","display_name":"Lu\u00eds Oct\u00e1vio Regasini","orcid":"https://orcid.org/0000-0001-8574-0670","observed_orcids":["https://orcid.org/0000-0001-8574-0670"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Luis Octavio Regasini","raw_affiliation_strings":["Laboratory of Antibiotics and Chemotherapeutics (LAQ), Institute of Biosciences, Humanities and Exact Sciences, S\u00e3o Paulo State University (Unesp), S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil. Electronic address: luis.regasini@unesp.br","Laboratory of Antibiotics and Chemotherapeutics (LAQ), Institute of Biosciences, Humanities and Exact Sciences, S\u00e3o Paulo State University (Unesp), S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Antibiotics and Chemotherapeutics (LAQ), Institute of Biosciences, Humanities and Exact Sciences, S\u00e3o Paulo State University (Unesp), S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil. Electronic address: luis.regasini@unesp.br","institution_ids":["https://openalex.org/I879563668"]},{"raw_affiliation_string":"Laboratory of Antibiotics and Chemotherapeutics (LAQ), Institute of Biosciences, Humanities and Exact Sciences, S\u00e3o Paulo State University (Unesp), S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil","institution_ids":["https://openalex.org/I879563668"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5048201644","https://openalex.org/A5071012302"],"corresponding_institution_ids":["https://openalex.org/I68106152","https://openalex.org/I879563668"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":2.5347,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.90920352,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"109","issue":null,"first_page":"104719","last_page":"104719"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.88919997215271,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.88919997215271,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.06319999694824219,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pterogyne-nitens","display_name":"Pterogyne nitens","score":0.9610000252723694},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9760000109672546},{"id":"https://openalex.org/keywords/zika-virus","display_name":"Zika virus","score":0.9739999771118164},{"id":"https://openalex.org/keywords/ns2b-ns3-protease","display_name":"NS2B-NS3 protease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.972000002861023},{"id":"https://openalex.org/keywords/antiviral-drug-candidates","display_name":"antiviral drug candidates","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hit-to-lead","display_name":"hit-to-lead optimization","score":0.9390000104904175},{"id":"https://openalex.org/keywords/vero-cell-toxicity","display_name":"Vero cell toxicity","score":0.75}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7718574404716492},{"id":"https://openalex.org/C132379496","wikidata":"https://www.wikidata.org/wiki/Q83141645","display_name":"NS3","level":4,"score":0.7701576948165894},{"id":"https://openalex.org/C2777053367","wikidata":"https://www.wikidata.org/wiki/Q202864","display_name":"Zika virus","level":3,"score":0.7277451753616333},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.5806195735931396},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.49375662207603455},{"id":"https://openalex.org/C2780568436","wikidata":"https://www.wikidata.org/wiki/Q1165479","display_name":"Flavivirus","level":3,"score":0.4245827794075012},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.33082979917526245},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28798818588256836},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2713966965675354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10389336943626404}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071244","descriptor_name":"Zika Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000085242","descriptor_name":"Viral Proteases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012431","descriptor_name":"Rutin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D043583","descriptor_name":"Nucleoside-Triphosphatase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047309","descriptor_name":"Flavones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.bioorg.2021.104719","doi":"https://doi.org/10.1016/j.bioorg.2021.104719","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bioorg.2021.104719","pdf_url":null,"source":{"id":"https://openalex.org/S165482960","display_name":"Bioorganic Chemistry","issn_l":"0045-2068","issn":["0045-2068","1090-2120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic Chemistry","raw_type":"journal-article"},{"id":"pmid:33636437","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33636437","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8227833","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8227833","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Bioorg Chem","raw_type":"Text"},{"id":"pmh:oai:repositorio.unesp.br:11449/205925","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/205925","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNESP","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8227833","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8227833","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Bioorg Chem","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1061602276","display_name":"MegaPredict for predicting natural product uses and their drug interactions","funder_award_id":"R43AT010585","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G1500372278","display_name":"Centralized assay datasets for modelling support of small drug discovery organizations","funder_award_id":"R43GM122196","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3404953807","display_name":"Centralized assay datasets for modelling support of small drug discovery organizations","funder_award_id":"R44GM122196","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1486127295","https://openalex.org/W1487052430","https://openalex.org/W1969935656","https://openalex.org/W1984217145","https://openalex.org/W1985469117","https://openalex.org/W2012060186","https://openalex.org/W2012559532","https://openalex.org/W2028046413","https://openalex.org/W2029667189","https://openalex.org/W2031200207","https://openalex.org/W2042530028","https://openalex.org/W2048108754","https://openalex.org/W2068092927","https://openalex.org/W2077335256","https://openalex.org/W2086310992","https://openalex.org/W2087541526","https://openalex.org/W2094476648","https://openalex.org/W2095177841","https://openalex.org/W2105668062","https://openalex.org/W2127326379","https://openalex.org/W2130479394","https://openalex.org/W2134967712","https://openalex.org/W2154714625","https://openalex.org/W2164184272","https://openalex.org/W2171660521","https://openalex.org/W2177317049","https://openalex.org/W2288486409","https://openalex.org/W2338618665","https://openalex.org/W2392178457","https://openalex.org/W2411303485","https://openalex.org/W2413143224","https://openalex.org/W2463036497","https://openalex.org/W2472177135","https://openalex.org/W2474204065","https://openalex.org/W2513827930","https://openalex.org/W2528003671","https://openalex.org/W2530700641","https://openalex.org/W2537861668","https://openalex.org/W2551233461","https://openalex.org/W2553288939","https://openalex.org/W2564044205","https://openalex.org/W2586756644","https://openalex.org/W2587514484","https://openalex.org/W2599069475","https://openalex.org/W2609127248","https://openalex.org/W2620295310","https://openalex.org/W2730438503","https://openalex.org/W2734554201","https://openalex.org/W2735493269","https://openalex.org/W2744018363","https://openalex.org/W2751422890","https://openalex.org/W2755103072","https://openalex.org/W2769437274","https://openalex.org/W2792954732","https://openalex.org/W2793758142","https://openalex.org/W2796302035","https://openalex.org/W2801291332","https://openalex.org/W2805281988","https://openalex.org/W2806678503","https://openalex.org/W2809841748","https://openalex.org/W2887039457","https://openalex.org/W2903985069","https://openalex.org/W2907192831","https://openalex.org/W2912020066","https://openalex.org/W2916672662","https://openalex.org/W2917096347","https://openalex.org/W2918140740","https://openalex.org/W2920333868","https://openalex.org/W2927501604","https://openalex.org/W2942551574","https://openalex.org/W2943921080","https://openalex.org/W4226086528","https://openalex.org/W4238926739","https://openalex.org/W4285719527","https://openalex.org/W4313375380","https://openalex.org/W6786578311"],"related_works":["https://openalex.org/W4310378719","https://openalex.org/W4391419763","https://openalex.org/W3094141576","https://openalex.org/W2553288939","https://openalex.org/W4210244972","https://openalex.org/W6958470872","https://openalex.org/W3015829751","https://openalex.org/W3194237429","https://openalex.org/W3130386212","https://openalex.org/W4389725263"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-03-01T00:00:00"}