{"id":"https://openalex.org/W3131745210","doi":"https://doi.org/10.1016/j.actbio.2021.02.026","title":"External cues to drive B cell function towards immunotherapy","display_name":"External cues to drive B cell function towards immunotherapy","publication_year":2021,"publication_date":"2021-02-23","ids":{"openalex":"https://openalex.org/W3131745210","doi":"https://doi.org/10.1016/j.actbio.2021.02.026","mag":"3131745210","pmid":"https://pubmed.ncbi.nlm.nih.gov/33636402"},"language":"en","primary_location":{"id":"doi:10.1016/j.actbio.2021.02.026","doi":"https://doi.org/10.1016/j.actbio.2021.02.026","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.actbio.2021.02.026","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1742706121001215/pdf","source":{"id":"https://openalex.org/S173145877","display_name":"Acta Biomaterialia","issn_l":"1742-7061","issn":["1742-7061","1878-7568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biomaterialia","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S1742706121001215/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020753790","display_name":"Diana Stoycheva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Diana Stoycheva","raw_affiliation_strings":["Laboratory of Applied Mechanobiology, Department for Health Sciences and Technology, ETH Z\u00fcrich, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Applied Mechanobiology, Department for Health Sciences and Technology, ETH Z\u00fcrich, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053329564","display_name":"Hasan \u015eim\u015fek","orcid":"https://orcid.org/0000-0001-5062-1014","observed_orcids":["https://orcid.org/0000-0001-5062-1014"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hasan Simsek","raw_affiliation_strings":["Institute for Biology, Experimental Biophysics/Mechanobiology, Humboldt University of Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biology, Experimental Biophysics/Mechanobiology, Humboldt University of Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042171970","display_name":"Willi Weber","orcid":"https://orcid.org/0000-0003-4110-6744","observed_orcids":["https://orcid.org/0000-0003-4110-6744"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Willi Weber","raw_affiliation_strings":["Institute for Biology, Experimental Biophysics/Mechanobiology, Humboldt University of Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biology, Experimental Biophysics/Mechanobiology, Humboldt University of Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074953707","display_name":"Anja Erika Hauser","orcid":"https://orcid.org/0000-0002-7725-9526","observed_orcids":["https://orcid.org/0000-0002-7725-9526"]},"institutions":[{"id":"https://openalex.org/I4210095248","display_name":"German Rheumatism Research Centre","ror":"https://ror.org/00shv0x82","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210095248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anja E. Hauser","raw_affiliation_strings":["Immunodynamics, Deutsches Rheuma-Forschungszentrum Berlin, A Leibniz Institute, Berlin, Germany; Department of Rheumatology and Clinical Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Department of Rheumatology and Clinical Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Immunodynamics, Deutsches Rheuma-Forschungszentrum Berlin, A Leibniz Institute, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunodynamics, Deutsches Rheuma-Forschungszentrum Berlin, A Leibniz Institute, Berlin, Germany; Department of Rheumatology and Clinical Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I4210095248","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Immunodynamics, Deutsches Rheuma-Forschungszentrum Berlin, A Leibniz Institute, Berlin, Germany","institution_ids":["https://openalex.org/I4210095248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053304878","display_name":"Enrico Klotzsch","orcid":"https://orcid.org/0000-0002-7577-9042","observed_orcids":["https://orcid.org/0000-0002-7577-9042"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["CH","DE"],"is_corresponding":true,"raw_author_name":"Enrico Klotzsch","raw_affiliation_strings":["Laboratory of Applied Mechanobiology, Department for Health Sciences and Technology, ETH Z\u00fcrich, Z\u00fcrich, Switzerland; Institute for Biology, Experimental Biophysics/Mechanobiology, Humboldt University of Berlin, Berlin, Germany. Electronic address: enrico.klotzsch@hu-berlin.de","Institute for Biology, Experimental Biophysics/Mechanobiology, Humboldt University of Berlin, Berlin, Germany","Laboratory of Applied Mechanobiology, Department for Health Sciences and Technology, ETH Z\u00fcrich, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Applied Mechanobiology, Department for Health Sciences and Technology, ETH Z\u00fcrich, Z\u00fcrich, Switzerland; Institute for Biology, Experimental Biophysics/Mechanobiology, Humboldt University of Berlin, Berlin, Germany. Electronic address: enrico.klotzsch@hu-berlin.de","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I39343248"]},{"raw_affiliation_string":"Institute for Biology, Experimental Biophysics/Mechanobiology, Humboldt University of Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]},{"raw_affiliation_string":"Laboratory of Applied Mechanobiology, Department for Health Sciences and Technology, ETH Z\u00fcrich, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5053304878"],"corresponding_institution_ids":["https://openalex.org/I35440088","https://openalex.org/I39343248"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.4465,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.41056911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"133","issue":null,"first_page":"222","last_page":"230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.586899995803833,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.586899995803833,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.36329999566078186,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/b-cell-activation","display_name":"B cell activation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/mechanobiology","display_name":"mechanobiology","score":0.8429999947547913},{"id":"https://openalex.org/keywords/substrate-stiffness","display_name":"substrate stiffness","score":0.7540000081062317},{"id":"https://openalex.org/keywords/surface-topology","display_name":"surface topology","score":0.968999981880188},{"id":"https://openalex.org/keywords/biochemical-signaling","display_name":"biochemical signaling","score":0.753000020980835},{"id":"https://openalex.org/keywords/antibody-production","display_name":"antibody production","score":0.6349999904632568},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.625},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.9509999752044678},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6050000190734863},{"id":"https://openalex.org/keywords/t-cell-regulation","display_name":"T cell regulation","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.6018508672714233},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5926092863082886},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5487934350967407},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2770940065383911},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2219492495059967},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.20096978545188904},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17825984954833984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1643671989440918}],"mesh":[{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003463","descriptor_name":"Cues","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.actbio.2021.02.026","doi":"https://doi.org/10.1016/j.actbio.2021.02.026","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.actbio.2021.02.026","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1742706121001215/pdf","source":{"id":"https://openalex.org/S173145877","display_name":"Acta Biomaterialia","issn_l":"1742-7061","issn":["1742-7061","1878-7568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biomaterialia","raw_type":"journal-article"},{"id":"pmid:33636402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33636402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta biomaterialia","raw_type":"Journal Article"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/471643","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/471643","pdf_url":"https://www.research-collection.ethz.ch/bitstream/20.500.11850/471643/2/1-s2.0-S1742706121001215-main.pdf","source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Biomaterialia, 133","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.3929/ethz-b-000471643","doi":"https://doi.org/10.3929/ethz-b-000471643","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000471643","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1016/j.actbio.2021.02.026","doi":"https://doi.org/10.1016/j.actbio.2021.02.026","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.actbio.2021.02.026","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1742706121001215/pdf","source":{"id":"https://openalex.org/S173145877","display_name":"Acta Biomaterialia","issn_l":"1742-7061","issn":["1742-7061","1878-7568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biomaterialia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1215258082","display_name":null,"funder_award_id":"SFB1444","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5344153752","display_name":null,"funder_award_id":"95664","funder_id":"https://openalex.org/F4320320338","funder_display_name":"Human Frontier Science Program"},{"id":"https://openalex.org/G551823739","display_name":null,"funder_award_id":"TRR130","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8601258261","display_name":null,"funder_award_id":"RGY0065/2017","funder_id":"https://openalex.org/F4320320338","funder_display_name":"Human Frontier Science Program"}],"funders":[{"id":"https://openalex.org/F4320320338","display_name":"Human Frontier Science Program","ror":"https://ror.org/02ebx7v45"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320882","display_name":"Volkswagen Foundation","ror":"https://ror.org/03bsmfz84"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3131745210.pdf","grobid_xml":"https://content.openalex.org/works/W3131745210.grobid-xml"},"referenced_works_count":170,"referenced_works":["https://openalex.org/W31480411","https://openalex.org/W773735717","https://openalex.org/W1205874559","https://openalex.org/W1266777110","https://openalex.org/W1503420941","https://openalex.org/W1522802573","https://openalex.org/W1526389706","https://openalex.org/W1530235393","https://openalex.org/W1541663213","https://openalex.org/W1550723234","https://openalex.org/W1555009403","https://openalex.org/W1559708380","https://openalex.org/W1585132230","https://openalex.org/W1611185316","https://openalex.org/W1616773517","https://openalex.org/W1666706706","https://openalex.org/W1711965101","https://openalex.org/W1748415986","https://openalex.org/W1842275027","https://openalex.org/W1895813995","https://openalex.org/W1934077925","https://openalex.org/W1975630733","https://openalex.org/W1976302032","https://openalex.org/W1976750616","https://openalex.org/W1980313076","https://openalex.org/W1982022868","https://openalex.org/W1984378774","https://openalex.org/W1986766821","https://openalex.org/W1988165411","https://openalex.org/W1988376910","https://openalex.org/W1988928788","https://openalex.org/W1991701295","https://openalex.org/W2003694098","https://openalex.org/W2007229947","https://openalex.org/W2009501393","https://openalex.org/W2011830638","https://openalex.org/W2018244125","https://openalex.org/W2018521012","https://openalex.org/W2019206924","https://openalex.org/W2020206181","https://openalex.org/W2027498023","https://openalex.org/W2027681787","https://openalex.org/W2030707267","https://openalex.org/W2040861204","https://openalex.org/W2040876247","https://openalex.org/W2051341672","https://openalex.org/W2052186210","https://openalex.org/W2055861239","https://openalex.org/W2058720855","https://openalex.org/W2058755496","https://openalex.org/W2060467993","https://openalex.org/W2060566320","https://openalex.org/W2062087600","https://openalex.org/W2065743975","https://openalex.org/W2065906324","https://openalex.org/W2070638961","https://openalex.org/W2071793654","https://openalex.org/W2072717004","https://openalex.org/W2072953299","https://openalex.org/W2074051660","https://openalex.org/W2074227330","https://openalex.org/W2077297620","https://openalex.org/W2079574749","https://openalex.org/W2084284769","https://openalex.org/W2086244192","https://openalex.org/W2086450075","https://openalex.org/W2089205238","https://openalex.org/W2094364673","https://openalex.org/W2099052265","https://openalex.org/W2099900951","https://openalex.org/W2100303404","https://openalex.org/W2103392694","https://openalex.org/W2103883318","https://openalex.org/W2106829507","https://openalex.org/W2107082479","https://openalex.org/W2107894271","https://openalex.org/W2115263908","https://openalex.org/W2121686754","https://openalex.org/W2121889667","https://openalex.org/W2122507029","https://openalex.org/W2123232632","https://openalex.org/W2126873850","https://openalex.org/W2128666074","https://openalex.org/W2132983016","https://openalex.org/W2134077324","https://openalex.org/W2135360970","https://openalex.org/W2140821709","https://openalex.org/W2141111992","https://openalex.org/W2141812411","https://openalex.org/W2144254347","https://openalex.org/W2144653977","https://openalex.org/W2146819767","https://openalex.org/W2146853551","https://openalex.org/W2152777246","https://openalex.org/W2153283302","https://openalex.org/W2154132418","https://openalex.org/W2154594040","https://openalex.org/W2158860780","https://openalex.org/W2162338315","https://openalex.org/W2165006836","https://openalex.org/W2166855444","https://openalex.org/W2168572010","https://openalex.org/W2170837110","https://openalex.org/W2171338526","https://openalex.org/W2200842302","https://openalex.org/W2205980957","https://openalex.org/W2230487266","https://openalex.org/W2267378807","https://openalex.org/W2268921967","https://openalex.org/W2305782972","https://openalex.org/W2339442385","https://openalex.org/W2341408485","https://openalex.org/W2341757884","https://openalex.org/W2468970696","https://openalex.org/W2520500352","https://openalex.org/W2522847451","https://openalex.org/W2530292134","https://openalex.org/W2536452417","https://openalex.org/W2545065327","https://openalex.org/W2553172239","https://openalex.org/W2560099569","https://openalex.org/W2562989187","https://openalex.org/W2619094261","https://openalex.org/W2622883680","https://openalex.org/W2731449818","https://openalex.org/W2734233338","https://openalex.org/W2739276243","https://openalex.org/W2739884871","https://openalex.org/W2745062575","https://openalex.org/W2752883195","https://openalex.org/W2761733520","https://openalex.org/W2761980878","https://openalex.org/W2770244745","https://openalex.org/W2778441553","https://openalex.org/W2789922392","https://openalex.org/W2790138041","https://openalex.org/W2791011024","https://openalex.org/W2797218281","https://openalex.org/W2803840621","https://openalex.org/W2806609121","https://openalex.org/W2831967782","https://openalex.org/W2876750881","https://openalex.org/W2884258243","https://openalex.org/W2886736637","https://openalex.org/W2889787113","https://openalex.org/W2910414574","https://openalex.org/W2924359684","https://openalex.org/W2938678047","https://openalex.org/W2945057866","https://openalex.org/W2945986261","https://openalex.org/W2947462908","https://openalex.org/W2958883192","https://openalex.org/W2977152238","https://openalex.org/W2980909677","https://openalex.org/W2990039983","https://openalex.org/W2990506666","https://openalex.org/W2991714929","https://openalex.org/W2998795792","https://openalex.org/W2998859344","https://openalex.org/W3000282923","https://openalex.org/W3000311037","https://openalex.org/W3000982459","https://openalex.org/W3029644242","https://openalex.org/W3029779858","https://openalex.org/W3045496294","https://openalex.org/W3045884835","https://openalex.org/W3082547749","https://openalex.org/W3111523834","https://openalex.org/W3113309731","https://openalex.org/W3115096716"],"related_works":["https://openalex.org/W7131796766","https://openalex.org/W4283446443","https://openalex.org/W3175507335","https://openalex.org/W4403261636","https://openalex.org/W2778441553","https://openalex.org/W3203068591","https://openalex.org/W4288443093","https://openalex.org/W4291017570","https://openalex.org/W2891030524","https://openalex.org/W4233509639"],"abstract_inverted_index":{"Immunotherapy":[0],"stands":[1],"out":[2],"as":[3,85,112,206,238,253,287,310],"a":[4,150,239],"powerful":[5],"and":[6,16,29,39,75,89,92,95,99,146,171,211,227,292,306,317],"promising":[7,240],"therapeutic":[8],"strategy":[9],"in":[10,52,66,107,140,159,242,267,311],"the":[11,47,67,108,141,164,169,186,194,200,243,268,280,312],"treatment":[12,142],"of":[13,49,63,118,143,174,196,202,245,260,282,314],"cancer,":[14],"infections,":[15,145],"autoimmune":[17,147,318],"diseases.":[18,41,148,319],"Adoptive":[19],"immune":[20,68,109],"therapies":[21],"are":[22,236],"usually":[23],"centered":[24],"on":[25,103,155,295],"modified":[26],"T":[27,35,113],"cells":[28,36,51,65,87,105,120,134,176,235,248],"their":[30,44,124,228,307],"specific":[31],"expansion":[32],"towards":[33],"antigen-specific":[34,73],"against":[37,79,270],"cancer":[38],"other":[40,104],"However,":[42],"despite":[43],"unmatched":[45],"features,":[46],"potential":[48],"B":[50,64,119,133,156,175,190,215,223,234,247,296,302],"immunotherapy":[53],"is":[54,70],"just":[55],"beginning":[56],"to":[57,71,127],"be":[58,178,265],"explored.":[59],"The":[60],"main":[61,187],"role":[62,139],"response":[69,110],"secrete":[72,90],"antibodies":[74],"provide":[76],"long-term":[77],"protection":[78],"foreign":[80],"pathogens.":[81],"They":[82],"further":[83,219,300],"function":[84],"antigen-presenting":[86],"(APCs)":[88],"pro-":[91],"anti-inflammatory":[93],"cytokines":[94],"thus":[96],"exert":[97],"positive":[98],"negative":[100],"regulatory":[101],"stimuli":[102],"involved":[106],"such":[111,205,252,286],"cells.":[114],"Therefore,":[115],"while":[116],"hyperactivation":[117],"can":[121,135,264],"cause":[122],"autoimmunity,":[123],"dysfunctions":[125],"lead":[126],"severe":[128],"immunodeficiencies.":[129],"Only":[130],"suitably":[131],"activated":[132],"play":[136],"an":[137],"active":[138],"cancers,":[144],"As":[149],"result,":[151],"studies":[152],"have":[153],"focused":[154],"cell-targeted":[157,224,303],"immunotherapies":[158],"recent":[160],"years.":[161],"For":[162],"this,":[163],"development,":[165],"functions,":[166],"interactions":[167],"with":[168],"microenvironment,":[170],"clinical":[172,229,308],"importance":[173,281],"should":[177],"well":[179],"understood.":[180],"In":[181,275],"this":[182,276],"review,":[183],"we":[184,198,278],"summarize":[185,301],"events":[188],"during":[189],"cell":[191,216,297],"activation.":[192],"From":[193],"viewpoint":[195],"mechanobiology":[197],"discuss":[199,279],"translation":[201],"external":[203,283],"cues":[204,285],"surface":[207,288],"topology,":[208,289],"substrate":[209,290],"stiffness,":[210,291],"biochemical":[212,293],"signaling":[213,294],"into":[214,221],"functions.":[217],"We":[218,299],"dive":[220],"current":[222],"therapy":[225,304],"strategies":[226,305],"applications.":[230],"STATEMENT":[231],"OF":[232],"SIGNIFICANCE:":[233],"proving":[237],"tool":[241],"field":[244],"immunotherapy.":[246],"exhibit":[249],"various":[250],"functions":[251],"antibody":[254],"production,":[255],"antigen":[256],"presentation":[257],"or":[258,272],"secretion":[259],"immune-regulatory":[261],"factors":[262],"which":[263],"utilized":[266],"fight":[269],"oncological":[271],"immunological":[273],"disorders.":[274],"review":[277],"mechanobiological":[284],"function.":[298],"applications,":[309],"context":[313],"anti-tumor":[315],"responses":[316]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-03-01T00:00:00"}
