{"id":"https://openalex.org/W3131681136","doi":"https://doi.org/10.1001/jamaoncol.2020.7684","title":"Response Rates to Anti\u2013PD-1 Immunotherapy in Microsatellite-Stable Solid Tumors With 10 or More Mutations per Megabase","display_name":"Response Rates to Anti\u2013PD-1 Immunotherapy in Microsatellite-Stable Solid Tumors With 10 or More Mutations per Megabase","publication_year":2021,"publication_date":"2021-02-18","ids":{"openalex":"https://openalex.org/W3131681136","doi":"https://doi.org/10.1001/jamaoncol.2020.7684","mag":"3131681136","pmid":"https://pubmed.ncbi.nlm.nih.gov/33599686","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7893543"},"language":"en","primary_location":{"id":"doi:10.1001/jamaoncol.2020.7684","doi":"https://doi.org/10.1001/jamaoncol.2020.7684","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaoncol.2020.7684","pdf_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2776411/jamaoncology_valero_2021_br_200026_1621005089.7056.pdf","source":{"id":"https://openalex.org/S2756165422","display_name":"JAMA Oncology","issn_l":"2374-2437","issn":["2374-2437","2374-2445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2776411/jamaoncology_valero_2021_br_200026_1621005089.7056.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075803345","display_name":"Cristina Valero","orcid":"https://orcid.org/0000-0003-3397-2888","observed_orcids":["https://orcid.org/0000-0003-3397-2888"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina Valero","raw_affiliation_strings":["Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100620078","display_name":"Mark Andrew Lee","orcid":"https://orcid.org/0000-0002-5285-8266","observed_orcids":["https://orcid.org/0000-0002-5285-8266"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Lee","raw_affiliation_strings":["Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078981086","display_name":"Douglas Robert Hoen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Hoen","raw_affiliation_strings":["Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013778834","display_name":"Ahmet Zehir","orcid":"https://orcid.org/0000-0001-5406-4104","observed_orcids":["https://orcid.org/0000-0001-5406-4104"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmet Zehir","raw_affiliation_strings":["Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York","Marie-Jos\u00e9e and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Marie-Jos\u00e9e and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037092952","display_name":"Michael F. Berger","orcid":"https://orcid.org/0000-0003-3882-5000","observed_orcids":["https://orcid.org/0000-0003-3882-5000"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael F. Berger","raw_affiliation_strings":["Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York","Marie-Jos\u00e9e and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Marie-Jos\u00e9e and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041344703","display_name":"Venkatraman Seshan","orcid":"https://orcid.org/0000-0002-9258-2698","observed_orcids":["https://orcid.org/0000-0002-9258-2698"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Venkatraman E. Seshan","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080223712","display_name":"Timothy An-thy Chan","orcid":"https://orcid.org/0000-0002-9265-0283","observed_orcids":["https://orcid.org/0000-0002-9265-0283"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy A. Chan","raw_affiliation_strings":["Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, Ohio","Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York","Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084443648","display_name":"Luc G.T. Morris","orcid":"https://orcid.org/0000-0002-4417-2280","observed_orcids":["https://orcid.org/0000-0002-4417-2280"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Luc G. T. Morris","raw_affiliation_strings":["Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5084443648"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":14.7409,"has_fulltext":true,"cited_by_count":208,"citation_normalized_percentile":{"value":0.99547092,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"7","issue":"5","first_page":"739","last_page":"739"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.9810000061988831},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.9120000004768372},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.9449999928474426},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8970000147819519},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.6290000081062317},{"id":"https://openalex.org/keywords/microsatellite-stable-tumors","display_name":"microsatellite stable tumors","score":0.7110000252723694},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.7749999761581421},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.6470000147819519},{"id":"https://openalex.org/keywords/response-rate","display_name":"response rate","score":0.4909999966621399},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7319999933242798},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.609000027179718},{"id":"https://openalex.org/keywords/kidney-cancer","display_name":"kidney cancer","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cancer-immunotherapy-outcomes","display_name":"cancer immunotherapy outcomes","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7488896250724792},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6478824019432068},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4987056255340576},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.49747350811958313},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38418087363243103},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.364898681640625},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2809433937072754},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26800310611724854},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19404426217079163},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1565093696117401},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.13134372234344482}],"mesh":[{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1001/jamaoncol.2020.7684","doi":"https://doi.org/10.1001/jamaoncol.2020.7684","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaoncol.2020.7684","pdf_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2776411/jamaoncology_valero_2021_br_200026_1621005089.7056.pdf","source":{"id":"https://openalex.org/S2756165422","display_name":"JAMA Oncology","issn_l":"2374-2437","issn":["2374-2437","2374-2445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7893543","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7893543","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncol","raw_type":"Text"},{"id":"pmid:33599686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33599686","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1001/jamaoncol.2020.7684","doi":"https://doi.org/10.1001/jamaoncol.2020.7684","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaoncol.2020.7684","pdf_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2776411/jamaoncology_valero_2021_br_200026_1621005089.7056.pdf","source":{"id":"https://openalex.org/S2756165422","display_name":"JAMA Oncology","issn_l":"2374-2437","issn":["2374-2437","2374-2445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.75,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1959294861","display_name":"Identifying and targeting neoantigens in aggressive salivary carcinomas","funder_award_id":"R01DE027738","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G3558678528","display_name":"Elucidating genetics of response to immune checkpoint blockade in lung cancer","funder_award_id":"R01CA205426","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G644517898","display_name":"Towards Precision Immuno-Oncology: Unraveling the Genomic Determinants and Mechanisms Underlying Immunotherapy Efficacy and Resistance","funder_award_id":"R35CA232097","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G855853460","display_name":"Functionalizing recurrent FAT1 mutations and deletions in oral cancer","funder_award_id":"K08DE024774","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310212","display_name":"Fundaci\u00f3n Alfonso Mart\u00edn Escudero","ror":"https://ror.org/02897ye82"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3131681136.pdf","grobid_xml":"https://content.openalex.org/works/W3131681136.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W223909586","https://openalex.org/W2019607817","https://openalex.org/W2502134830","https://openalex.org/W2747774814","https://openalex.org/W2764165143","https://openalex.org/W2909679049","https://openalex.org/W3083986479"],"related_works":["https://openalex.org/W4281650266","https://openalex.org/W4378232359","https://openalex.org/W3098118704","https://openalex.org/W4366817622","https://openalex.org/W2747774814","https://openalex.org/W2947394248","https://openalex.org/W3096242747","https://openalex.org/W3088261538","https://openalex.org/W3083986479","https://openalex.org/W4210362744"],"abstract_inverted_index":{"IMPORTANCE:":[0],"In":[1,242],"June":[2],"2020,":[3],"the":[4,11,55,174,185,205,243,275,351,379],"US":[5],"Food":[6],"and":[7,114,161,173,265,397],"Drug":[8],"Administration":[9],"approved":[10],"anti-programmed":[12,118],"cell":[13,119,124],"death":[14,120,125],"1":[15,121,135],"drug":[16],"pembrolizumab":[17],"for":[18,45,252,260,270,307,315,329,363,387],"patients":[19,69,88],"with":[20,28,70,74,96,117,232,249,283,324,332,365,400],"malignant":[21],"solid":[22,71],"tumors":[23,72,194,209,234,293,334,364],"of":[24,41,57,61,68,137,188,207,213,218,221,238,258,268,311,318,337,353,367,382],"any":[25],"histologic":[26],"type":[27,303],"high":[29,46,62,200],"tumor":[30],"mutational":[31],"burden":[32],"(TMB;":[33],"\u226510":[34],"mutations":[35,190,371],"per":[36,191,372],"megabase).":[37],"The":[38,153,344],"predictive":[39,380],"value":[40,381],"this":[42,347],"universal":[43,59,186,384],"cutoff":[44,187],"TMB":[47,63,261,271,277,284,366,410],"is":[48],"not":[49],"well":[50],"understood.":[51],"OBJECTIVE:":[52],"To":[53],"examine":[54],"performance":[56],"a":[58,90,383],"definition":[60],"in":[64,235,335],"an":[65],"independent":[66],"cohort":[67,84,348],"treated":[73,95,116],"immune":[75,97,138,149,359],"checkpoint":[76,98,139,150,360],"inhibitors.":[77,140],"DESIGN,":[78],"SETTING,":[79],"AND":[80,143,342],"PARTICIPANTS:":[81],"This":[82],"retrospective":[83],"study":[85,349],"included":[86],"1678":[87,167],"at":[89],"single":[91],"cancer":[92,112,203,240,287,302,309,339,376,395,408],"referral":[93],"center":[94],"inhibitors":[99],"from":[100,211,305,346],"January":[101],"1,":[102],"2015,":[103],"to":[104,148,163,216,313,392,412],"December":[105],"31,":[106],"2018.":[107],"Patients":[108],"had":[109,227],"16":[110,239,338],"different":[111],"types":[113,396],"were":[115,171,196,295,322],"or":[122,369],"programmed":[123],"ligand-1":[126],"immunotherapy.":[127],"Tumors":[128,223],"underwent":[129],"next-generation":[130],"sequencing.":[131],"EXPOSURES:":[132],"At":[133],"least":[134],"dose":[136],"MAIN":[141],"OUTCOMES":[142],"MEASURES:":[144],"Best":[145],"overall":[146],"response":[147,229,246,327,356],"inhibitor":[151,361],"therapy.":[152],"hypothesis":[154],"tested":[155],"was":[156,177,389],"formulated":[157],"after":[158],"data":[159,345],"collection":[160],"prior":[162],"analysis.":[164],"RESULTS:":[165],"Of":[166],"patients,":[168],"924":[169],"(55%)":[170],"male,":[172],"median":[175],"age":[176],"64":[178],"years":[179],"(interquartile":[180],"range,":[181],"55-71":[182],"years).":[183],"Using":[184,289],"10":[189,264,368],"megabase,":[192,373],"416":[193],"(25%)":[195],"categorized":[197,224,296],"as":[198,225,297],"having":[199],"TMB.":[201],"Across":[202],"types,":[204],"proportion":[206],"TMB-high":[208,226,253,330,388],"ranged":[210,304],"0%":[212],"kidney":[214],"cancers":[215],"53%":[217],"melanomas":[219],"(113":[220],"214).":[222],"higher":[228,250,326,355],"rates":[230,247,280,300,328,357],"compared":[231,331],"TMB-low":[233,333],"only":[236],"11":[237],"types.":[241,340,377],"entire":[244],"cohort,":[245],"increased":[248,282],"cutoffs":[251,321,411],"categorization,":[254],"reaching":[255],"41%":[256],"(169":[257],"416)":[259],"more":[262,272,370],"than":[263,273],"56%":[266],"(90":[267],"161)":[269],"18,":[274],"highest":[276],"decile.":[278],"Response":[279,299],"also":[281],"percentile":[285],"within":[286,301],"type.":[288],"cancer-specific":[290],"cutoffs,":[291],"457":[292],"(27%)":[294],"TMB-high.":[298],"4%":[306],"pancreatic":[308],"(1":[310],"26)":[312],"70%":[314],"melanoma":[316],"(46":[317],"66).":[319],"Cancer-specific":[320],"associated":[323],"numerically":[325],"14":[336],"CONCLUSIONS":[341],"RELEVANCE:":[343],"validate":[350],"finding":[352],"generally":[354],"following":[358],"therapy":[362],"across":[374,394],"multiple":[375],"However,":[378],"numerical":[385],"threshold":[386],"limited,":[390],"owing":[391],"variability":[393],"unclear":[398],"associations":[399],"survival":[401],"outcomes.":[402],"Further":[403],"investigation":[404],"will":[405],"help":[406],"define":[407],"type-specific":[409],"guide":[413],"decision-making.":[414]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":26},{"year":2024,"cited_by_count":36},{"year":2023,"cited_by_count":45},{"year":2022,"cited_by_count":54},{"year":2021,"cited_by_count":27}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-01T00:00:00"}