{"id":"https://openalex.org/W3131505336","doi":"https://doi.org/10.1172/jci.insight.140443","title":"Versatile workflow for cell type\u2013resolved transcriptional and epigenetic profiles from cryopreserved human lung","display_name":"Versatile workflow for cell type\u2013resolved transcriptional and epigenetic profiles from cryopreserved human lung","publication_year":2021,"publication_date":"2021-02-27","ids":{"openalex":"https://openalex.org/W3131505336","doi":"https://doi.org/10.1172/jci.insight.140443","mag":"3131505336","pmid":"https://pubmed.ncbi.nlm.nih.gov/33630765","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8026197"},"language":"en","primary_location":{"id":"doi:10.1172/jci.insight.140443","doi":"https://doi.org/10.1172/jci.insight.140443","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.140443","pdf_url":"http://insight.jci.org/articles/view/140443/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://insight.jci.org/articles/view/140443/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024163264","display_name":"Maria Llamazares Prada","orcid":"https://orcid.org/0000-0001-6559-9374","observed_orcids":["https://orcid.org/0000-0001-6559-9374"]},"institutions":[{"id":"https://openalex.org/I4210157022","display_name":"BioMed X","ror":"https://ror.org/05drfac92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157022"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maria Llamazares-Prada","raw_affiliation_strings":["BioMed X Institute, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMed X Institute, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210157022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047787641","display_name":"Elisa Espinet","orcid":"https://orcid.org/0000-0002-0690-9878","observed_orcids":["https://orcid.org/0000-0002-0690-9878"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210151150","display_name":"Heidelberg Institute for Stem Cell Technology and Experimental Medicine","ror":"https://ror.org/049yqqs33","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210151150"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elisa Espinet","raw_affiliation_strings":["Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany","Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0690-9878","affiliations":[{"raw_affiliation_string":"Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany","institution_ids":["https://openalex.org/I4210151150"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057802355","display_name":"Vedrana Mijo\u0161ek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157022","display_name":"BioMed X","ror":"https://ror.org/05drfac92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157022"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vedrana Mijo\u0161ek","raw_affiliation_strings":["BioMed X Institute, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMed X Institute, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210157022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085624993","display_name":"Uwe Schwartz","orcid":"https://orcid.org/0000-0002-7628-2687","observed_orcids":["https://orcid.org/0000-0002-7628-2687"]},"institutions":[{"id":"https://openalex.org/I4210157022","display_name":"BioMed X","ror":"https://ror.org/05drfac92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157022"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Uwe Schwartz","raw_affiliation_strings":["BioMed X Institute, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7628-2687","affiliations":[{"raw_affiliation_string":"BioMed X Institute, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210157022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002758394","display_name":"Pavlo Lutsik","orcid":"https://orcid.org/0000-0001-9383-8555","observed_orcids":["https://orcid.org/0000-0001-9383-8555"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Pavlo Lutsik","raw_affiliation_strings":["Division of Cancer Epigenomics, DKFZ, Member of the German Center for Lung Research (DZL), Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9383-8555","affiliations":[{"raw_affiliation_string":"Division of Cancer Epigenomics, DKFZ, Member of the German Center for Lung Research (DZL), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4210129183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000608020","display_name":"Raluca Tamas","orcid":"https://orcid.org/0009-0002-4814-1964","observed_orcids":["https://orcid.org/0009-0002-4814-1964"]},"institutions":[{"id":"https://openalex.org/I4210157022","display_name":"BioMed X","ror":"https://ror.org/05drfac92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157022"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Raluca Tamas","raw_affiliation_strings":["BioMed X Institute, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMed X Institute, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210157022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110678101","display_name":"Mandy Richter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157022","display_name":"BioMed X","ror":"https://ror.org/05drfac92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157022"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mandy Richter","raw_affiliation_strings":["BioMed X Institute, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMed X Institute, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210157022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034183021","display_name":"Annika Behrendt","orcid":"https://orcid.org/0009-0007-8330-1632","observed_orcids":["https://orcid.org/0009-0007-8330-1632"]},"institutions":[{"id":"https://openalex.org/I4210157022","display_name":"BioMed X","ror":"https://ror.org/05drfac92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157022"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Annika Behrendt","raw_affiliation_strings":["BioMed X Institute, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMed X Institute, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210157022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103005436","display_name":"Stephanie T. Pohl","orcid":"https://orcid.org/0000-0003-3531-6155","observed_orcids":["https://orcid.org/0000-0003-3531-6155"]},"institutions":[{"id":"https://openalex.org/I4210157022","display_name":"BioMed X","ror":"https://ror.org/05drfac92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157022"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephanie T. Pohl","raw_affiliation_strings":["BioMed X Institute, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMed X Institute, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210157022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060606035","display_name":"Naja P. Benz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157022","display_name":"BioMed X","ror":"https://ror.org/05drfac92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157022"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Naja P. Benz","raw_affiliation_strings":["BioMed X Institute, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMed X Institute, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210157022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085505239","display_name":"Thomas Muley","orcid":"https://orcid.org/0000-0002-8141-0604","observed_orcids":["https://orcid.org/0000-0002-8141-0604"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Muley","raw_affiliation_strings":["Translational Lung Research Center, Member of the DZL, Heidelberg, Germany","Translational Research Unit, Thoraxklinik, University Hospital Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Lung Research Center, Member of the DZL, Heidelberg, Germany","institution_ids":[]},{"raw_affiliation_string":"Translational Research Unit, Thoraxklinik, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109226131","display_name":"Arne Warth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Arne Warth","raw_affiliation_strings":["Translational Research Unit, Thoraxklinik, University Hospital Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Research Unit, Thoraxklinik, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064807273","display_name":"Claus Peter Heu\u00dfel","orcid":"https://orcid.org/0000-0001-5809-5733","observed_orcids":["https://orcid.org/0000-0001-5809-5733"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claus Peter Heu\u00dfel","raw_affiliation_strings":["Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik, University of Heidelberg, Heidelberg, Germany","Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany","Translational Lung Research Center, Member of the DZL, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5809-5733","affiliations":[{"raw_affiliation_string":"Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Translational Lung Research Center, Member of the DZL, Heidelberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053291675","display_name":"Hauke Winter","orcid":"https://orcid.org/0009-0007-5242-6942","observed_orcids":["https://orcid.org/0009-0007-5242-6942"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hauke Winter","raw_affiliation_strings":["Department of Surgery, Thoraxklinik, University Hospital Heidelberg, Heidelberg, Germany","Translational Lung Research Center, Member of the DZL, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Thoraxklinik, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Translational Lung Research Center, Member of the DZL, Heidelberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086979139","display_name":"Jonathan J. M. Landry","orcid":"https://orcid.org/0000-0003-2262-9099","observed_orcids":["https://orcid.org/0000-0003-2262-9099"]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jonathan J. M. Landry","raw_affiliation_strings":["Genomics Core Facility, EMBL, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2262-9099","affiliations":[{"raw_affiliation_string":"Genomics Core Facility, EMBL, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210138560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024585720","display_name":"Felix J.F. Herth","orcid":"https://orcid.org/0000-0002-7638-2506","observed_orcids":["https://orcid.org/0000-0002-7638-2506"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Felix J.F. Herth","raw_affiliation_strings":["Department of Pneumology and Critical Care Medicine and Translational Research Unit, Thoraxklinik, University Hospital Heidelberg, Heidelberg, Germany","Translational Research Unit, Thoraxklinik, University Hospital Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pneumology and Critical Care Medicine and Translational Research Unit, Thoraxklinik, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Translational Research Unit, Thoraxklinik, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110850092","display_name":"Tinne C. J. Mertens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tinne C.J. Mertens","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058022497","display_name":"Harry Karmouty\u2010Quintana","orcid":"https://orcid.org/0000-0003-4753-9823","observed_orcids":["https://orcid.org/0000-0003-4753-9823"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry Karmouty-Quintana","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, USA"],"raw_orcid":"https://orcid.org/0000-0003-4753-9823","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063526989","display_name":"Ina Koch","orcid":"https://orcid.org/0000-0002-8766-017X","observed_orcids":["https://orcid.org/0000-0002-8766-017X"]},"institutions":[{"id":"https://openalex.org/I4210125421","display_name":"Asklepios Fachkliniken M\u00fcnchen-Gauting","ror":"https://ror.org/02v4fpg03","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125421"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ina Koch","raw_affiliation_strings":["Asklepios Biobank for Lung Diseases, Department of Thoracic Surgery, Asklepios Fachkliniken M\u00fcnchen-Gauting, DZL, Gauting, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asklepios Biobank for Lung Diseases, Department of Thoracic Surgery, Asklepios Fachkliniken M\u00fcnchen-Gauting, DZL, Gauting, Germany","institution_ids":["https://openalex.org/I4210125421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048071608","display_name":"Vladim\u0131\u0301r Bene\u0161","orcid":"https://orcid.org/0000-0002-0352-2547","observed_orcids":["https://orcid.org/0000-0002-0352-2547"]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vladimir Benes","raw_affiliation_strings":["Genomics Core Facility, EMBL, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0352-2547","affiliations":[{"raw_affiliation_string":"Genomics Core Facility, EMBL, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210138560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071136927","display_name":"Jan O. Korbel","orcid":"https://orcid.org/0000-0002-2798-3794","observed_orcids":["https://orcid.org/0000-0002-2798-3794","https://orcid.org/0000-0002-5371-5320","https://orcid.org/0009-0003-2781-6229"]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan O. Korbel","raw_affiliation_strings":["Genome Biology Unit, EMBL, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Biology Unit, EMBL, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210138560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048456384","display_name":"Sebastian M. Waszak","orcid":"https://orcid.org/0000-0003-3042-9521","observed_orcids":["https://orcid.org/0000-0003-3042-9521"]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian M. Waszak","raw_affiliation_strings":["Genome Biology Unit, EMBL, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Biology Unit, EMBL, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210138560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081577791","display_name":"Andreas Trumpp","orcid":"https://orcid.org/0000-0002-6212-3466","observed_orcids":["https://orcid.org/0000-0002-6212-3466"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210151150","display_name":"Heidelberg Institute for Stem Cell Technology and Experimental Medicine","ror":"https://ror.org/049yqqs33","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210151150"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Trumpp","raw_affiliation_strings":["Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany","Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6212-3466","affiliations":[{"raw_affiliation_string":"Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany","institution_ids":["https://openalex.org/I4210151150"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David M. Wyatt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David M. Wyatt","raw_affiliation_strings":["Biotherapeutics Discovery and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotherapeutics Discovery and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043823442","display_name":"Heiko F. Stahl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heiko F. Stahl","raw_affiliation_strings":["Immunology and Respiratory Disease Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology and Respiratory Disease Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020136143","display_name":"Christoph Plass","orcid":"https://orcid.org/0000-0003-2554-3952","observed_orcids":["https://orcid.org/0000-0003-2554-3952"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Plass","raw_affiliation_strings":["Division of Cancer Epigenomics, DKFZ, Member of the German Center for Lung Research (DZL), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Epigenomics, DKFZ, Member of the German Center for Lung Research (DZL), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4210129183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073388259","display_name":"Renata Zofia Jurkowska","orcid":"https://orcid.org/0000-0002-4507-2222","observed_orcids":["https://orcid.org/0000-0002-4507-2222"]},"institutions":[{"id":"https://openalex.org/I4210157022","display_name":"BioMed X","ror":"https://ror.org/05drfac92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210157022"]},{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["DE","GB"],"is_corresponding":true,"raw_author_name":"Renata Z. Jurkowska","raw_affiliation_strings":["BioMed X Institute, Heidelberg, Germany","School of Biosciences, Cardiff University, Cardiff, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-4507-2222","affiliations":[{"raw_affiliation_string":"BioMed X Institute, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210157022"]},{"raw_affiliation_string":"School of Biosciences, Cardiff University, Cardiff, United Kingdom","institution_ids":["https://openalex.org/I79510175"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5073388259"],"corresponding_institution_ids":["https://openalex.org/I4210157022","https://openalex.org/I79510175"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":{"value":4100,"currency":"USD","value_usd":4100},"fwci":0.4706,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.52947945,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cryopreservation","display_name":"cryopreservation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/human-lung-tissue","display_name":"human lung tissue","score":0.7919999957084656},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5460000038146973},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.8109999895095825},{"id":"https://openalex.org/keywords/basal-cells","display_name":"basal cells","score":0.7110000252723694},{"id":"https://openalex.org/keywords/airway-epithelium","display_name":"airway epithelium","score":0.6840000152587891},{"id":"https://openalex.org/keywords/tissue-viability","display_name":"tissue viability","score":0.6159999966621399},{"id":"https://openalex.org/keywords/biobanking","display_name":"biobanking","score":0.671999990940094},{"id":"https://openalex.org/keywords/chronic-lung-disease","display_name":"chronic lung disease","score":0.828000009059906},{"id":"https://openalex.org/keywords/lung-microenvironment","display_name":"lung microenvironment","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7465612888336182},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.6876103281974792},{"id":"https://openalex.org/C179933525","wikidata":"https://www.wikidata.org/wiki/Q1144664","display_name":"Cryopreservation","level":3,"score":0.591503381729126},{"id":"https://openalex.org/C2779744229","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Human lung","level":3,"score":0.5431023240089417},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4847709536552429},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47165289521217346},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4461635947227478},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3814324140548706},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3492441773414612},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3402406871318817},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3376186490058899},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25757139921188354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21891453862190247},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21246570348739624},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18040809035301208},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.10733148455619812},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.08648592233657837}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015925","descriptor_name":"Cryopreservation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1172/jci.insight.140443","doi":"https://doi.org/10.1172/jci.insight.140443","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.140443","pdf_url":"http://insight.jci.org/articles/view/140443/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},{"id":"doi:10.1101/2020.04.01.018861","doi":"https://doi.org/10.1101/2020.04.01.018861","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.04.01.018861","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/04/03/2020.04.01.018861.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:8026197","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8026197","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"Text"},{"id":"pmid:33630765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33630765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI insight","raw_type":"Journal Article"},{"id":"pmh:oai:diposit.ub.edu:2445/220236","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2445/220236","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Articles publicats en revistes (Patologia i Terap\u00e8utica Experimental)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:138584","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/138584/3/140443.2-20210313140804-covered-e0fd13ba177f913fd3156f593ead4cfd.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/138584/3/140443.2-20210313140804-covered-e0fd13ba177f913fd3156f593ead4cfd.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:4b9ddf2689b3451391994aacacc3f941","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4b9ddf2689b3451391994aacacc3f941","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JCI Insight, Vol 6, Iss 6 (2021)","raw_type":"article"},{"id":"pmh:oai:epub.uni-regensburg.de:56692","doi":null,"is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/56692/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.duo.uio.no:10852/90949","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/90949","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2379-3708","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1172/jci.insight.140443","doi":"https://doi.org/10.1172/jci.insight.140443","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.140443","pdf_url":"http://insight.jci.org/articles/view/140443/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306257","display_name":"Boehringer Ingelheim","ror":"https://ror.org/05kffp613"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320310693","display_name":"Deutsches Krebsforschungszentrum","ror":"https://ror.org/04cdgtt98"},{"id":"https://openalex.org/F4320320881","display_name":"Universit\u00e4t Heidelberg","ror":"https://ror.org/038t36y30"},{"id":"https://openalex.org/F4320326487","display_name":"Deutsches Zentrum f\u00fcr Lungenforschung","ror":"https://ror.org/03dx11k66"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3131505336.pdf","grobid_xml":"https://content.openalex.org/works/W3131505336.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W1567281461","https://openalex.org/W1755170314","https://openalex.org/W1952691959","https://openalex.org/W1987180785","https://openalex.org/W2008067936","https://openalex.org/W2016469998","https://openalex.org/W2017952636","https://openalex.org/W2022293686","https://openalex.org/W2036759594","https://openalex.org/W2037743556","https://openalex.org/W2049429726","https://openalex.org/W2072076251","https://openalex.org/W2088245621","https://openalex.org/W2100808624","https://openalex.org/W2110065044","https://openalex.org/W2112250552","https://openalex.org/W2115892399","https://openalex.org/W2125806967","https://openalex.org/W2138207763","https://openalex.org/W2146147565","https://openalex.org/W2146512944","https://openalex.org/W2169456326","https://openalex.org/W2171352366","https://openalex.org/W2179438025","https://openalex.org/W2223794222","https://openalex.org/W2236822143","https://openalex.org/W2260223112","https://openalex.org/W2301339423","https://openalex.org/W2308074142","https://openalex.org/W2320745690","https://openalex.org/W2324917897","https://openalex.org/W2336820982","https://openalex.org/W2372280949","https://openalex.org/W2468543693","https://openalex.org/W2507247487","https://openalex.org/W2507892764","https://openalex.org/W2532808087","https://openalex.org/W2551651776","https://openalex.org/W2551658846","https://openalex.org/W2557741846","https://openalex.org/W2560076216","https://openalex.org/W2563025099","https://openalex.org/W2606799292","https://openalex.org/W2612519453","https://openalex.org/W2613295242","https://openalex.org/W2744794223","https://openalex.org/W2750114219","https://openalex.org/W2766959028","https://openalex.org/W2768700270","https://openalex.org/W2776525882","https://openalex.org/W2794635382","https://openalex.org/W2799444748","https://openalex.org/W2801527818","https://openalex.org/W2808837841","https://openalex.org/W2865352686","https://openalex.org/W2872432516","https://openalex.org/W2883837134","https://openalex.org/W2885499809","https://openalex.org/W2887886950","https://openalex.org/W2895817676","https://openalex.org/W2898122624","https://openalex.org/W2904211489","https://openalex.org/W2904478560","https://openalex.org/W2940024093","https://openalex.org/W2943439515","https://openalex.org/W2948402706","https://openalex.org/W2950862527","https://openalex.org/W2950891712","https://openalex.org/W2951169655","https://openalex.org/W2951506174","https://openalex.org/W2951858660","https://openalex.org/W2952221403","https://openalex.org/W2964240868","https://openalex.org/W2971496408","https://openalex.org/W2983549323","https://openalex.org/W2984504343","https://openalex.org/W2993993303","https://openalex.org/W2994559322","https://openalex.org/W2999417355","https://openalex.org/W3000676906","https://openalex.org/W3021543659","https://openalex.org/W3022968840","https://openalex.org/W3030739213","https://openalex.org/W3037780309","https://openalex.org/W3041062936","https://openalex.org/W3095310253","https://openalex.org/W3101697142","https://openalex.org/W3163788854"],"related_works":["https://openalex.org/W3217443318","https://openalex.org/W3017056542","https://openalex.org/W4293458133","https://openalex.org/W2984504343","https://openalex.org/W1755170314","https://openalex.org/W7171531077","https://openalex.org/W4234594631","https://openalex.org/W2952221403","https://openalex.org/W4396501685","https://openalex.org/W4416634956"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"complexity":[2],"of":[3,29,89,124,192,198,211],"the":[4,22,27,153,190],"lung":[5,31,91,130,200],"microenvironment":[6],"together":[7],"with":[8,93,108],"changes":[9],"in":[10,36],"cellular":[11,159],"composition":[12],"during":[13],"disease":[14],"progression":[15],"make":[16],"it":[17],"exceptionally":[18],"hard":[19],"to":[20,26,58,64,135,155,226,246],"understand":[21],"molecular":[23],"mechanisms":[24],"leading":[25],"development":[28],"chronic":[30],"diseases.":[32],"Although":[33],"recent":[34],"advances":[35],"cell":[37,73,95,103,126],"type":[38],"resolved":[39],"and":[40,66,105,132,138,143,171,181,241],"single-cell":[41,114,207,222],"sequencing":[42,169,209],"approaches":[43],"hold":[44],"great":[45],"promise":[46],"for":[47,122,195,234],"studying":[48],"complex":[49],"diseases,":[50],"their":[51],"implementation":[52],"greatly":[53],"relies":[54],"on":[55],"local":[56],"access":[57,245],"fresh":[59],"tissue,":[60,140],"as":[61],"traditional":[62],"methods":[63],"process":[65],"store":[67],"tissue":[68,92,236],"do":[69],"not":[70,162],"allow":[71],"viable":[72],"isolation.":[74],"To":[75],"overcome":[76],"these":[77],"hurdles,":[78],"we":[79,175,204],"developed":[80],"a":[81],"novel,":[82],"versatile":[83],"workflow":[84,194,231],"that":[85,118,158,177,219],"allows":[86],"long-term":[87],"storage":[88],"human":[90,199,216,247],"high":[94],"viability,":[96],"permits":[97],"thorough":[98],"sample":[99],"quality":[100],"check":[101],"before":[102],"isolation,":[104],"is":[106,120,133,161,232],"compatible":[107],"next":[109],"generation":[110],"sequencing-based":[111],"profiling,":[112],"including":[113,141],"approaches.":[115,223],"We":[116],"demonstrate":[117],"cryopreservation":[119,220,230],"suitable":[121],"isolation":[123],"multiple":[125],"types":[127],"from":[128,149,214],"different":[129],"locations":[131],"applicable":[134],"both":[136],"healthy":[137],"diseased":[139],"COPD":[142],"tumor":[144],"samples.":[145],"Basal":[146],"cells":[147,212],"isolated":[148,213],"cryopreserved":[150,215],"airways":[151],"retain":[152],"ability":[154],"differentiate,":[156],"indicating":[157],"identity":[160],"altered":[163],"by":[164,238],"cryopreservation.":[165],"Importantly,":[166],"using":[167],"RNA":[168,208],"(RNA-seq)":[170],"Illumina":[172],"EPIC":[173],"Array,":[174],"show":[176],"genome-wide":[178],"gene":[179],"expression":[180],"DNA":[182],"methylation":[183],"signatures":[184],"are":[185],"preserved":[186],"upon":[187],"cryopreservation,":[188],"emphasizing":[189],"suitability":[191],"our":[193,229],"-omics":[196],"profiling":[197],"cells.":[201],"In":[202],"addition,":[203],"obtained":[205],"high-quality":[206],"data":[210],"lung,":[217],"demonstrating":[218],"empowers":[221],"Overall,":[224],"thanks":[225],"its":[227],"simplicity,":[228],"well-suited":[233],"prospective":[235],"collection":[237],"academic":[239],"collaborators":[240],"biobanks,":[242],"opening":[243],"worldwide":[244],"tissue.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2021-03-01T00:00:00"}
