{"id":"https://openalex.org/W3131497595","doi":"https://doi.org/10.37421/2155-9929.2021.12.447","title":"COVID-19 Spreading Across World Correlates with 677T Allele of the Methylenetetrahydrofolate Reductase (MTHFR) Gene Prevalence","display_name":"COVID-19 Spreading Across World Correlates with 677T Allele of the Methylenetetrahydrofolate Reductase (MTHFR) Gene Prevalence","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3131497595","doi":"https://doi.org/10.37421/2155-9929.2021.12.447","mag":"3131497595"},"language":"en","primary_location":{"id":"mag:3131497595","doi":"https://doi.org/10.37421/2155-9929.2021.12.447","is_oa":true,"landing_page_url":"https://www.hilarispublisher.com/open-access/covid19-spreading-across-world-correlates-with-677t-allele-of-the-methylenetetrahydrofolate-reductase-mthfr-gene-prevale.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764805115","display_name":"Journal of Molecular Biomarkers & Diagnosis","issn_l":"2155-9929","issn":["2155-9929"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Molecular Biomarkers & Diagnosis","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.hilarispublisher.com/open-access/covid19-spreading-across-world-correlates-with-677t-allele-of-the-methylenetetrahydrofolate-reductase-mthfr-gene-prevale.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055742848","display_name":"Giovanni Ponti","orcid":"https://orcid.org/0000-0002-1971-7306","observed_orcids":["https://orcid.org/0000-0002-1971-7306"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giovanni Ponti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1971-7306","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025473720","display_name":"Lorenza Pastorino","orcid":"https://orcid.org/0000-0002-2575-8331","observed_orcids":["https://orcid.org/0000-0002-2575-8331"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lorenza Pastorino","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2575-8331","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113934208","display_name":"Gabriella Oliva","orcid":"https://orcid.org/0009-0002-0682-7343","observed_orcids":["https://orcid.org/0009-0002-0682-7343"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriella Oliva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002929955","display_name":"Tomris \u00d6zben","orcid":"https://orcid.org/0000-0002-1413-4523","observed_orcids":["https://orcid.org/0000-0002-1413-4523"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomris \u00d6zben","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1413-4523","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008816459","display_name":"Marco Manfredini","orcid":"https://orcid.org/0000-0003-3601-655X","observed_orcids":["https://orcid.org/0000-0003-3601-655X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marco Manfredini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037970786","display_name":"Shaniko Kaleci","orcid":"https://orcid.org/0000-0002-1166-2961","observed_orcids":["https://orcid.org/0000-0002-1166-2961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaniko Kaleci","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1166-2961","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036037643","display_name":"Nicoletta Lelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicoletta Lelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062561144","display_name":"Raffaele Iannella","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raffaele Iannella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5069189039","display_name":"Aldo Tomasi","orcid":"https://orcid.org/0000-0002-1356-3430","observed_orcids":["https://orcid.org/0000-0002-1356-3430"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aldo Tomasi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1356-3430","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"1","first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.7773000001907349,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.7773000001907349,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.06759999692440033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.02370000071823597,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mthfr-c677t-polymorphism","display_name":"MTHFR C677T polymorphism","score":0.9290000200271606},{"id":"https://openalex.org/keywords/methylenetetrahydrofolate-reductase","display_name":"methylenetetrahydrofolate reductase","score":0.9829999804496765},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.8479999899864197},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8240000009536743},{"id":"https://openalex.org/keywords/covid-19-incidence","display_name":"COVID-19 incidence","score":0.8849999904632568},{"id":"https://openalex.org/keywords/covid-19-mortality","display_name":"COVID-19 mortality","score":0.9990000128746033},{"id":"https://openalex.org/keywords/latino-population","display_name":"Latino population","score":0.8050000071525574},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.6840000152587891},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.9559561610221863},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.7016968727111816},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6890063285827637},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.523868978023529},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.512925386428833},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.4697466492652893},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41848060488700867},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3860202431678772},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35167235136032104},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3260473906993866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2625184655189514},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10716202855110168},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.10110285878181458},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3131497595","doi":"https://doi.org/10.37421/2155-9929.2021.12.447","is_oa":true,"landing_page_url":"https://www.hilarispublisher.com/open-access/covid19-spreading-across-world-correlates-with-677t-allele-of-the-methylenetetrahydrofolate-reductase-mthfr-gene-prevale.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764805115","display_name":"Journal of Molecular Biomarkers & Diagnosis","issn_l":"2155-9929","issn":["2155-9929"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Molecular Biomarkers & Diagnosis","raw_type":null}],"best_oa_location":{"id":"mag:3131497595","doi":"https://doi.org/10.37421/2155-9929.2021.12.447","is_oa":true,"landing_page_url":"https://www.hilarispublisher.com/open-access/covid19-spreading-across-world-correlates-with-677t-allele-of-the-methylenetetrahydrofolate-reductase-mthfr-gene-prevale.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764805115","display_name":"Journal of Molecular Biomarkers & Diagnosis","issn_l":"2155-9929","issn":["2155-9929"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Molecular Biomarkers & Diagnosis","raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3164067306","https://openalex.org/W3081953044","https://openalex.org/W4401439348","https://openalex.org/W7130324051","https://openalex.org/W4408110661","https://openalex.org/W4361190753","https://openalex.org/W4389552386","https://openalex.org/W7161181384","https://openalex.org/W4417465557","https://openalex.org/W4389340988"],"abstract_inverted_index":{"Homocysteine":[0],"assessment":[2],"has":[3],"been":[4],"proposed":[5],"as":[6],"a":[7,45,97],"potential":[8],"predictive":[9],"biomarker":[10],"for":[11,76,81,88],"the":[12,26,30,49,68,72,116],"severity":[14,120],"of":[15,20,32,52,63,111,121],"COVID-19":[16,37,57,77,122],"infection.":[17,124],"The":[18,61],"purpose":[19],"this":[21,82],"review":[22],"was":[23,79],"to":[24],"analyze":[25],"correlation":[28,100],"between":[29,101],"prevalence":[31,51,62],"MTHFR":[33,53,64,112],"677T":[34,54,65,102],"allele":[35,55,66,103],"and":[36,39,56,59,71,74,105,118],"incidence":[38,58,73,117],"mortality":[40,75],"worldwide.":[42],"There":[43],"is":[44],"clear":[46],"trend":[47],"towards":[48],"worldwide":[50],"mortality.":[60],"in":[67],"Latino":[69],"population":[70],"higher":[80],"ethnic":[83],"group":[84],"than":[85],"that":[86],"reported":[87],"most":[89],"other":[90],"populations":[91],"globally.":[93],"Statistical":[94],"analysis":[95],"showed":[96],"relatively":[98],"strong":[99],"death":[106],"from":[107],"coronavirus.":[108],"Genetic":[109],"polymorphism":[110],"C677T":[113],"may":[114],"modulate":[115],"pandemic":[123]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-03-01T00:00:00"}