{"id":"https://openalex.org/W3131469478","doi":"https://doi.org/10.48550/arxiv.2102.09437","title":"hesim: Health Economic Simulation Modeling and Decision Analysis","display_name":"hesim: Health Economic Simulation Modeling and Decision Analysis","publication_year":2021,"publication_date":"2021-02-18","ids":{"openalex":"https://openalex.org/W3131469478","doi":"https://doi.org/10.48550/arxiv.2102.09437","mag":"3131469478"},"language":"en","primary_location":{"id":"pmh:oai:arXiv.org:2102.09437","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/2102.09437","pdf_url":"https://arxiv.org/pdf/2102.09437","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["arxiv","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2102.09437","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023429612","display_name":"Devin Incerti","orcid":"https://orcid.org/0000-0002-4479-8750","observed_orcids":["https://orcid.org/0000-0002-4479-8750"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Incerti, Devin","raw_affiliation_strings":["Genentech","Genentech South San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Genentech South San Francisco","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013727360","display_name":"Jeroen Paul Jansen","orcid":"https://orcid.org/0000-0003-2686-9217","observed_orcids":["https://orcid.org/0000-0003-2686-9217"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jansen, Jeroen P","raw_affiliation_strings":["University of California , San Francisco","University of California , San Francisco San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California , San Francisco","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"University of California , San Francisco San Francisco","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11195","display_name":"Simulation Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/decision-analysis","display_name":"decision analysis","score":0.6330000162124634},{"id":"https://openalex.org/keywords/health-technology-assessment","display_name":"health technology assessment","score":0.847000002861023},{"id":"https://openalex.org/keywords/state-transition-model","display_name":"state transition model","score":0.8339999914169312},{"id":"https://openalex.org/keywords/markov-model","display_name":"Markov model","score":0.781000018119812},{"id":"https://openalex.org/keywords/semi-markov-model","display_name":"semi-Markov model","score":0.9200000166893005},{"id":"https://openalex.org/keywords/partitioned-survival-model","display_name":"partitioned survival model","score":0.9649999737739563},{"id":"https://openalex.org/keywords/probabilistic-sensitivity-analysis","display_name":"probabilistic sensitivity analysis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.843999981880188},{"id":"https://openalex.org/keywords/quality-adjusted-life-years","display_name":"quality-adjusted life years","score":0.9819999933242798},{"id":"https://openalex.org/keywords/r-package","display_name":"R package","score":0.8450000286102295},{"id":"https://openalex.org/keywords/c-simulation","display_name":"C++ simulation","score":0.492000013589859},{"id":"https://openalex.org/keywords/disease-progression-modeling","display_name":"disease progression modeling","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.6914108991622925},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6811319589614868},{"id":"https://openalex.org/C163836022","wikidata":"https://www.wikidata.org/wiki/Q6771326","display_name":"Markov model","level":3,"score":0.6151838302612305},{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.5395909547805786},{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.5356717705726624},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.49802517890930176},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.4834650158882141},{"id":"https://openalex.org/C59594135","wikidata":"https://www.wikidata.org/wiki/Q5249242","display_name":"Decision model","level":2,"score":0.43808501958847046},{"id":"https://openalex.org/C119693030","wikidata":"https://www.wikidata.org/wiki/Q2180497","display_name":"Economic model","level":2,"score":0.43143048882484436},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.3778318464756012},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.18856260180473328},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1513327658176422},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1171298623085022},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.09226512908935547},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:arXiv.org:2102.09437","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/2102.09437","pdf_url":"https://arxiv.org/pdf/2102.09437","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.2102.09437","doi":"https://doi.org/10.48550/arxiv.2102.09437","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2102.09437","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2102.09437","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/2102.09437","pdf_url":"https://arxiv.org/pdf/2102.09437","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3131469478.pdf","grobid_xml":"https://content.openalex.org/works/W3131469478.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W85469694","https://openalex.org/W1495096696","https://openalex.org/W1498906866","https://openalex.org/W1537598136","https://openalex.org/W1803511184","https://openalex.org/W1870480275","https://openalex.org/W1973408090","https://openalex.org/W1982967337","https://openalex.org/W1998187979","https://openalex.org/W2057530821","https://openalex.org/W2057847137","https://openalex.org/W2062638219","https://openalex.org/W2068943402","https://openalex.org/W2111119204","https://openalex.org/W2122664355","https://openalex.org/W2130968748","https://openalex.org/W2140011409","https://openalex.org/W2159953548","https://openalex.org/W2160889655","https://openalex.org/W2164192628","https://openalex.org/W2169880351","https://openalex.org/W2259708582","https://openalex.org/W2308780747","https://openalex.org/W2340113298","https://openalex.org/W2377410957","https://openalex.org/W2485004161","https://openalex.org/W2569472942","https://openalex.org/W2580366914","https://openalex.org/W2586040350","https://openalex.org/W2588156223","https://openalex.org/W2610182341","https://openalex.org/W2619365413","https://openalex.org/W2787359140","https://openalex.org/W2945807945","https://openalex.org/W2955348236","https://openalex.org/W2989448192","https://openalex.org/W3092126818","https://openalex.org/W3093338574","https://openalex.org/W4230096730","https://openalex.org/W4230538848","https://openalex.org/W4380152916"],"related_works":["https://openalex.org/W2905893945","https://openalex.org/W2953486148","https://openalex.org/W4411372220","https://openalex.org/W2588156223","https://openalex.org/W7160450290","https://openalex.org/W2805416476","https://openalex.org/W4380150605","https://openalex.org/W3092126818","https://openalex.org/W2082442981","https://openalex.org/W4410426271"],"abstract_inverted_index":{"Health":[0],"economic":[1,67],"models":[2,68,82,89,94],"simulate":[3],"the":[4],"costs":[5,180],"and":[6,36,64,91,99,101,110,123,158,181],"effects":[7],"of":[8,22,39,66],"health":[9,14],"technologies":[10],"for":[11,119],"use":[12,21,38],"in":[13,69,125,138,148],"technology":[15],"assessment":[16],"(HTA)":[17],"to":[18,115,135,141],"inform":[19],"efficient":[20],"scarce":[23],"resources.":[24],"Models":[25],"have":[26],"historically":[27],"been":[28],"developed":[29],"using":[30,178],"spreadsheet":[31],"software":[32,46],"(e.g.,":[33],"Microsoft":[34],"Excel)":[35],"while":[37],"R":[40,53],"is":[41,47,51,133,146,176],"growing,":[42],"general":[43],"purpose":[44],"modeling":[45],"still":[48],"limited.":[49],"hesim":[50],"an":[52,70],"package":[54],"that":[55],"helps":[56],"fill":[57],"this":[58],"gap":[59],"by":[60],"facilitating":[61],"parameterization,":[62],"simulation,":[63],"analysis":[65,131,171],"integrated":[71],"manner.":[72],"Supported":[73],"model":[74,139,142],"types":[75],"include":[76],"cohort":[77],"discrete":[78],"time":[79,86],"state":[80,87],"transition":[81,88],"(cDTSTMs),":[83],"individual":[84,159],"continuous":[85],"(iCTSTMs),":[90],"partitioned":[92],"survival":[93],"(PSMs),":[95],"encompassing":[96],"Markov":[97],"(time-homogeneous":[98],"time-inhomogeneous)":[100],"semi-Markov":[102],"processes.":[103],"A":[104],"modular":[105],"design":[106],"based":[107],"on":[108],"R6":[109],"S3":[111],"classes":[112],"allows":[113],"users":[114],"combine":[116],"separate":[117],"submodels":[118],"disease":[120],"progression,":[121],"costs,":[122],"utility":[124],"a":[126,173,187],"flexible":[127],"way.":[128],"Probabilistic":[129],"sensitivity":[130],"(PSA)":[132],"used":[134],"propagate":[136],"uncertainty":[137],"parameters":[140],"outputs.":[143],"Simulation":[144],"code":[145],"written":[147],"C++":[149],"so":[150],"complex":[151],"simulations":[152],"such":[153],"as":[154],"those":[155],"combining":[156],"PSA":[157],"simulation":[160],"can":[161],"be":[162],"run":[163],"much":[164],"more":[165],"quickly":[166],"than":[167],"previously":[168],"possible.":[169],"Decision":[170],"within":[172],"cost-effectiveness":[174],"framework":[175],"performed":[177],"simulated":[179],"quality-adjusted":[182],"life":[183],"years":[184],"(QALYs)":[185],"from":[186],"PSA.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-03-01T00:00:00"}