{"id":"https://openalex.org/W3131348992","doi":"https://doi.org/10.2147/ijn.s291956","title":"A Comprehensive Review on Factors Influences Biogenesis, Functions, Therapeutic and Clinical Implications of Exosomes","display_name":"A Comprehensive Review on Factors Influences Biogenesis, Functions, Therapeutic and Clinical Implications of Exosomes","publication_year":2021,"publication_date":"2021-02-01","ids":{"openalex":"https://openalex.org/W3131348992","doi":"https://doi.org/10.2147/ijn.s291956","mag":"3131348992","pmid":"https://pubmed.ncbi.nlm.nih.gov/33628021","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7898217"},"language":"en","primary_location":{"id":"doi:10.2147/ijn.s291956","doi":"https://doi.org/10.2147/ijn.s291956","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s291956","pdf_url":"https://www.dovepress.com/getfile.php?fileID=66716","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=66716","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051210077","display_name":"Sangiliyandi Gurunathan","orcid":"https://orcid.org/0000-0001-9924-8433","observed_orcids":["https://orcid.org/0000-0001-9924-8433"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sangiliyandi Gurunathan","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, 05029, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, 05029, Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025835928","display_name":"Min-Hee Kang","orcid":"https://orcid.org/0000-0003-4402-7064","observed_orcids":["https://orcid.org/0000-0003-4402-7064"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Min-Hee Kang","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, 05029, Korea"],"raw_orcid":"https://orcid.org/0000-0003-4402-7064","affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, 05029, Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001188270","display_name":"Jin\u2010Hoi Kim","orcid":"https://orcid.org/0000-0003-1232-5307","observed_orcids":["https://orcid.org/0000-0003-1232-5307"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jin-Hoi Kim","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, 05029, Korea"],"raw_orcid":"https://orcid.org/0000-0003-1232-5307","affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, 05029, Korea","institution_ids":["https://openalex.org/I24062138"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001188270","https://openalex.org/A5025835928","https://openalex.org/A5051210077"],"corresponding_institution_ids":["https://openalex.org/I24062138"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":5.9903,"has_fulltext":true,"cited_by_count":400,"citation_normalized_percentile":{"value":0.9838,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"Volume 16","issue":null,"first_page":"1281","last_page":"1312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":1.0},{"id":"https://openalex.org/keywords/exosome-biogenesis","display_name":"exosome biogenesis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.8019999861717224},{"id":"https://openalex.org/keywords/multivesicular-bodies","display_name":"multivesicular bodies","score":0.7429999709129333},{"id":"https://openalex.org/keywords/exosome-cargo","display_name":"exosome cargo","score":0.6930000185966492},{"id":"https://openalex.org/keywords/exosome-biomarkers","display_name":"exosomal biomarkers","score":0.5580000281333923},{"id":"https://openalex.org/keywords/exosome-therapy","display_name":"exosome therapy","score":0.7039999961853027},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.7749999761581421},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.8519999980926514},{"id":"https://openalex.org/keywords/infectious-diseases","display_name":"infectious diseases","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cellular-homeostasis","display_name":"cellular homeostasis","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.9653204679489136},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.7411618828773499},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.7067010402679443},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5982024073600769},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4757549464702606},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44393235445022583},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.43196603655815125},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2904302477836609},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.20047509670257568},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.061248600482940674},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003141","descriptor_name":"Communicable Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.2147/ijn.s291956","doi":"https://doi.org/10.2147/ijn.s291956","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s291956","pdf_url":"https://www.dovepress.com/getfile.php?fileID=66716","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},{"id":"pmid:33628021","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33628021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of nanomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7898217","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7898217/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Nanomedicine","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:29779ccaafaa4c77a4dec788ea309a49","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/29779ccaafaa4c77a4dec788ea309a49","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol Volume 16, Pp 1281-1312 (2021)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/62215","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/a-comprehensive-review-on-factors-influences-biogenesis-functions-ther-peer-reviewed-article-IJN","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Review"}],"best_oa_location":{"id":"doi:10.2147/ijn.s291956","doi":"https://doi.org/10.2147/ijn.s291956","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s291956","pdf_url":"https://www.dovepress.com/getfile.php?fileID=66716","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.766700029373169,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3795675594","display_name":null,"funder_award_id":"2015R1A5A1009701","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G5849395992","display_name":null,"funder_award_id":"2015R1A5A1009701","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321372","display_name":"Konkuk University","ror":"https://ror.org/025h1m602"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3131348992.pdf","grobid_xml":"https://content.openalex.org/works/W3131348992.grobid-xml"},"referenced_works_count":325,"referenced_works":["https://openalex.org/W117576088","https://openalex.org/W1500925570","https://openalex.org/W1523693806","https://openalex.org/W1524901724","https://openalex.org/W1535490554","https://openalex.org/W1542448731","https://openalex.org/W1574663134","https://openalex.org/W1589968217","https://openalex.org/W1594933778","https://openalex.org/W1601681275","https://openalex.org/W1721689174","https://openalex.org/W1732767904","https://openalex.org/W1762620449","https://openalex.org/W1769060942","https://openalex.org/W1771659011","https://openalex.org/W1787140000","https://openalex.org/W1792460785","https://openalex.org/W1824585857","https://openalex.org/W1857453373","https://openalex.org/W1874379912","https://openalex.org/W1879553156","https://openalex.org/W1889489351","https://openalex.org/W1950118853","https://openalex.org/W1965600613","https://openalex.org/W1965913620","https://openalex.org/W1966257269","https://openalex.org/W1966360086","https://openalex.org/W1966606134","https://openalex.org/W1967828169","https://openalex.org/W1969123951","https://openalex.org/W1970413727","https://openalex.org/W1970870994","https://openalex.org/W1972811031","https://openalex.org/W1976196055","https://openalex.org/W1977613047","https://openalex.org/W1977880576","https://openalex.org/W1978172515","https://openalex.org/W1979751563","https://openalex.org/W1981420342","https://openalex.org/W1982606786","https://openalex.org/W1983562093","https://openalex.org/W1984109999","https://openalex.org/W1986049860","https://openalex.org/W1986321004","https://openalex.org/W1986820887","https://openalex.org/W1987604193","https://openalex.org/W1989603382","https://openalex.org/W1991586131","https://openalex.org/W1991760073","https://openalex.org/W1993140699","https://openalex.org/W1994668150","https://openalex.org/W2001558817","https://openalex.org/W2002498072","https://openalex.org/W2003343932","https://openalex.org/W2004180343","https://openalex.org/W2005154332","https://openalex.org/W2006645013","https://openalex.org/W2009927945","https://openalex.org/W2012420380","https://openalex.org/W2013728504","https://openalex.org/W2015601897","https://openalex.org/W2015781356","https://openalex.org/W2016008005","https://openalex.org/W2017092296","https://openalex.org/W2017418049","https://openalex.org/W2019917125","https://openalex.org/W2020438602","https://openalex.org/W2020992406","https://openalex.org/W2024745748","https://openalex.org/W2028248159","https://openalex.org/W2028863688","https://openalex.org/W2032360452","https://openalex.org/W2032735323","https://openalex.org/W2033295839","https://openalex.org/W2033612573","https://openalex.org/W2034005055","https://openalex.org/W2035861820","https://openalex.org/W2035871823","https://openalex.org/W2038236600","https://openalex.org/W2038744035","https://openalex.org/W2039313867","https://openalex.org/W2043082218","https://openalex.org/W2043456995","https://openalex.org/W2047288034","https://openalex.org/W2050532025","https://openalex.org/W2051688548","https://openalex.org/W2055313665","https://openalex.org/W2055424631","https://openalex.org/W2055791162","https://openalex.org/W2056048178","https://openalex.org/W2057851530","https://openalex.org/W2058180357","https://openalex.org/W2060387475","https://openalex.org/W2064360173","https://openalex.org/W2065891529","https://openalex.org/W2066214537","https://openalex.org/W2066234893","https://openalex.org/W2067471975","https://openalex.org/W2067495493","https://openalex.org/W2069437848","https://openalex.org/W2070528611","https://openalex.org/W2072063027","https://openalex.org/W2074892413","https://openalex.org/W2076315676","https://openalex.org/W2076478428","https://openalex.org/W2080879611","https://openalex.org/W2081124475","https://openalex.org/W2081338631","https://openalex.org/W2082604867","https://openalex.org/W2085554170","https://openalex.org/W2086078586","https://openalex.org/W2087999409","https://openalex.org/W2090175640","https://openalex.org/W2091250479","https://openalex.org/W2091618419","https://openalex.org/W2091868933","https://openalex.org/W2092349886","https://openalex.org/W2101371464","https://openalex.org/W2104583004","https://openalex.org/W2106583271","https://openalex.org/W2107008239","https://openalex.org/W2107373516","https://openalex.org/W2108057472","https://openalex.org/W2108086395","https://openalex.org/W2109057110","https://openalex.org/W2109070574","https://openalex.org/W2111560326","https://openalex.org/W2114021667","https://openalex.org/W2114287704","https://openalex.org/W2116437342","https://openalex.org/W2117695104","https://openalex.org/W2119764013","https://openalex.org/W2120174162","https://openalex.org/W2121354606","https://openalex.org/W2121882633","https://openalex.org/W2122211980","https://openalex.org/W2122635106","https://openalex.org/W2122756910","https://openalex.org/W2124124073","https://openalex.org/W2126210405","https://openalex.org/W2128891846","https://openalex.org/W2130105071","https://openalex.org/W2131195752","https://openalex.org/W2131409719","https://openalex.org/W2134921841","https://openalex.org/W2135550231","https://openalex.org/W2137900362","https://openalex.org/W2138134048","https://openalex.org/W2140267261","https://openalex.org/W2140690761","https://openalex.org/W2140910902","https://openalex.org/W2141003137","https://openalex.org/W2143580680","https://openalex.org/W2143729276","https://openalex.org/W2146304525","https://openalex.org/W2148050305","https://openalex.org/W2149806687","https://openalex.org/W2150554886","https://openalex.org/W2155366992","https://openalex.org/W2155846302","https://openalex.org/W2156281143","https://openalex.org/W2159114297","https://openalex.org/W2159507231","https://openalex.org/W2164093285","https://openalex.org/W2166155213","https://openalex.org/W2166595775","https://openalex.org/W2166846320","https://openalex.org/W2167591654","https://openalex.org/W2167806590","https://openalex.org/W2168120562","https://openalex.org/W2170852633","https://openalex.org/W2171261585","https://openalex.org/W2176562642","https://openalex.org/W2176918495","https://openalex.org/W2177788064","https://openalex.org/W2204776416","https://openalex.org/W2261862398","https://openalex.org/W2264564420","https://openalex.org/W2274685036","https://openalex.org/W2286288823","https://openalex.org/W2290775492","https://openalex.org/W2290891464","https://openalex.org/W2296538017","https://openalex.org/W2312836697","https://openalex.org/W2318433546","https://openalex.org/W2339285831","https://openalex.org/W2342859699","https://openalex.org/W2344418141","https://openalex.org/W2345920029","https://openalex.org/W2403293254","https://openalex.org/W2416973816","https://openalex.org/W2419842412","https://openalex.org/W2464086075","https://openalex.org/W2468961436","https://openalex.org/W2478736220","https://openalex.org/W2487947432","https://openalex.org/W2495898729","https://openalex.org/W2512006014","https://openalex.org/W2514206815","https://openalex.org/W2516370793","https://openalex.org/W2520451013","https://openalex.org/W2521810033","https://openalex.org/W2572178740","https://openalex.org/W2574456047","https://openalex.org/W2577298849","https://openalex.org/W2579136823","https://openalex.org/W2583736683","https://openalex.org/W2587850954","https://openalex.org/W2590858549","https://openalex.org/W2596133050","https://openalex.org/W2597896859","https://openalex.org/W2600094664","https://openalex.org/W2604697223","https://openalex.org/W2608067780","https://openalex.org/W2615498501","https://openalex.org/W2701107559","https://openalex.org/W2727532420","https://openalex.org/W2730287977","https://openalex.org/W2737594104","https://openalex.org/W2738491178","https://openalex.org/W2749972535","https://openalex.org/W2760437786","https://openalex.org/W2760727189","https://openalex.org/W2761235857","https://openalex.org/W2763644153","https://openalex.org/W2765214133","https://openalex.org/W2765904302","https://openalex.org/W2778758901","https://openalex.org/W2781375248","https://openalex.org/W2782521517","https://openalex.org/W2782964521","https://openalex.org/W2783944216","https://openalex.org/W2790210772","https://openalex.org/W2794799998","https://openalex.org/W2797486656","https://openalex.org/W2798033749","https://openalex.org/W2799422921","https://openalex.org/W2800062219","https://openalex.org/W2801941054","https://openalex.org/W2802398269","https://openalex.org/W2802507063","https://openalex.org/W2802988001","https://openalex.org/W2804840825","https://openalex.org/W2807549207","https://openalex.org/W2809795782","https://openalex.org/W2810847500","https://openalex.org/W2885609324","https://openalex.org/W2885826538","https://openalex.org/W2887249435","https://openalex.org/W2888790211","https://openalex.org/W2888911479","https://openalex.org/W2899041727","https://openalex.org/W2900136447","https://openalex.org/W2905083981","https://openalex.org/W2908128192","https://openalex.org/W2914611579","https://openalex.org/W2919131764","https://openalex.org/W2922144466","https://openalex.org/W2924230267","https://openalex.org/W2926623862","https://openalex.org/W2931418311","https://openalex.org/W2935163132","https://openalex.org/W2938250883","https://openalex.org/W2946632930","https://openalex.org/W2951686954","https://openalex.org/W2956636943","https://openalex.org/W2957328132","https://openalex.org/W2970433432","https://openalex.org/W2970563580","https://openalex.org/W2980637827","https://openalex.org/W2984737583","https://openalex.org/W2987239393","https://openalex.org/W2989727052","https://openalex.org/W2994053658","https://openalex.org/W2994663967","https://openalex.org/W2994760533","https://openalex.org/W2997006728","https://openalex.org/W2998276142","https://openalex.org/W3001964675","https://openalex.org/W3003526790","https://openalex.org/W3004900301","https://openalex.org/W3005104290","https://openalex.org/W3005877290","https://openalex.org/W3008463588","https://openalex.org/W3009818378","https://openalex.org/W3011394045","https://openalex.org/W3011825821","https://openalex.org/W3016109319","https://openalex.org/W3016191697","https://openalex.org/W3016382208","https://openalex.org/W3018583818","https://openalex.org/W3020234278","https://openalex.org/W3021627727","https://openalex.org/W3021857102","https://openalex.org/W3024449297","https://openalex.org/W3025139414","https://openalex.org/W3025532240","https://openalex.org/W3025860373","https://openalex.org/W3029492181","https://openalex.org/W3030279988","https://openalex.org/W3031194419","https://openalex.org/W3031718314","https://openalex.org/W3033034878","https://openalex.org/W3033472639","https://openalex.org/W3035172626","https://openalex.org/W3035271767","https://openalex.org/W3035695839","https://openalex.org/W3036321430","https://openalex.org/W3036471888","https://openalex.org/W3036677284","https://openalex.org/W3036894103","https://openalex.org/W3037665121","https://openalex.org/W3038068092","https://openalex.org/W3039053813","https://openalex.org/W3040443028","https://openalex.org/W3040510093","https://openalex.org/W3040661594","https://openalex.org/W3040778371","https://openalex.org/W3042815763","https://openalex.org/W3043477355","https://openalex.org/W3048102154","https://openalex.org/W3096049191","https://openalex.org/W4243182520","https://openalex.org/W4249579699","https://openalex.org/W4292416640"],"related_works":["https://openalex.org/W2925372744","https://openalex.org/W4414290813","https://openalex.org/W2931418311","https://openalex.org/W2968654457","https://openalex.org/W3040618315","https://openalex.org/W3154091431","https://openalex.org/W2757504354","https://openalex.org/W4315649572","https://openalex.org/W3117686231","https://openalex.org/W2139623099"],"abstract_inverted_index":{"Exosomes":[0],"are":[1],"nanoscale-sized":[2],"membrane":[3],"vesicles":[4],"secreted":[5],"by":[6],"almost":[7],"all":[8],"cell":[9,77],"types":[10],"into":[11],"the":[12,64,100,119,124,131,152,174,190],"extracellular":[13],"environment":[14],"upon":[15],"fusion":[16],"of":[17,24,43,66,73,78,112,121,154,176],"multivesicular":[18],"bodies":[19],"and":[20,32,80,107,138,151,159,167,181,184,192,198],"plasma":[21],"membrane.":[22],"Biogenesis":[23],"exosomes":[25,35,44,74,122,149,155,177],"is":[26,95],"a":[27,87],"protein":[28],"quality":[29],"control":[30],"mechanism,":[31],"once":[33],"released,":[34],"transmit":[36],"signals":[37],"to":[38,52,99,105],"other":[39],"cells.":[40],"The":[41,70],"applications":[42],"have":[45],"increased":[46],"immensely":[47],"in":[48,83,123,148,156,195],"biomedical":[49,125],"fields":[50],"owing":[51],"their":[53,76,81,136,182],"cell-specific":[54],"cargos":[55],"that":[56],"facilitate":[57],"intercellular":[58,157],"communications":[59],"with":[60],"neighboring":[61],"cells":[62],"through":[63],"transfer":[65],"biologically":[67],"active":[68],"compounds.":[69],"diverse":[71],"constituents":[72],"reflect":[75],"origin":[79],"detection":[82],"biological":[84],"fluids":[85],"represents":[86],"diagnostic":[88,179],"marker":[89],"for":[90,102],"various":[91],"diseases.":[92,169],"Exosome":[93],"research":[94],"expanding":[96],"rapidly":[97],"due":[98],"potential":[101],"clinical":[103,185],"application":[104],"therapeutics":[106],"diagnosis.":[108],"However,":[109],"several":[110],"aspects":[111],"exosome":[113,196],"biology":[114],"remain":[115],"elusive.":[116],"To":[117],"discover":[118],"use":[120],"applications,":[126],"we":[127,144,172,188],"must":[128],"better":[129],"understand":[130],"basic":[132],"molecular":[133],"mechanisms":[134],"underlying":[135],"biogenesis":[137,150],"function.":[139],"In":[140,170],"this":[141],"comprehensive":[142],"review,":[143],"describe":[145],"factors":[146],"involved":[147],"role":[153,175],"signaling":[158],"cell-cell":[160],"communications,":[161],"immune":[162],"responses,":[163],"cellular":[164],"homeostasis,":[165],"autophagy,":[166],"infectious":[168],"addition,":[171],"discuss":[173,199],"as":[178],"markers,":[180],"therapeutic":[183],"implications.":[186],"Furthermore,":[187],"addressed":[189],"challenges":[191],"outstanding":[193],"developments":[194],"research,":[197],"future":[200],"perspectives.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":58},{"year":2025,"cited_by_count":107},{"year":2024,"cited_by_count":98},{"year":2023,"cited_by_count":59},{"year":2022,"cited_by_count":50},{"year":2021,"cited_by_count":28}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-01T00:00:00"}
