{"id":"https://openalex.org/W3131255899","doi":"https://doi.org/10.1021/jacs.0c12358","title":"Assembly Pathway Selection with DNA Reaction Circuits for Programming Multiple Cell\u2013Cell Interactions","display_name":"Assembly Pathway Selection with DNA Reaction Circuits for Programming Multiple Cell\u2013Cell Interactions","publication_year":2021,"publication_date":"2021-02-25","ids":{"openalex":"https://openalex.org/W3131255899","doi":"https://doi.org/10.1021/jacs.0c12358","mag":"3131255899","pmid":"https://pubmed.ncbi.nlm.nih.gov/33631070"},"language":"en","primary_location":{"id":"doi:10.1021/jacs.0c12358","doi":"https://doi.org/10.1021/jacs.0c12358","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.0c12358","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085554978","display_name":"Mingshu Xiao","orcid":"https://orcid.org/0000-0003-0673-1544","observed_orcids":["https://orcid.org/0000-0003-0673-1544"]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingshu Xiao","raw_affiliation_strings":["Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, P. R. China"],"raw_orcid":"https://orcid.org/0000-0003-0673-1544","affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, P. R. China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026511955","display_name":"Wei Lai","orcid":"https://orcid.org/0000-0003-1428-0667","observed_orcids":["https://orcid.org/0000-0003-1428-0667"]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Lai","raw_affiliation_strings":["Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, P. R. China"],"raw_orcid":"https://orcid.org/0000-0003-1428-0667","affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, P. R. China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024989448","display_name":"Huizhen Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huizhen Yu","raw_affiliation_strings":["Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, P. R. China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025605043","display_name":"Zijing Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zijing Yu","raw_affiliation_strings":["Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, P. R. China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100361042","display_name":"Li Li","orcid":"https://orcid.org/0000-0001-8494-4997","observed_orcids":["https://orcid.org/0000-0001-8494-4997"]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Li","raw_affiliation_strings":["Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, P. R. China"],"raw_orcid":"https://orcid.org/0000-0001-8494-4997","affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, P. R. China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006228310","display_name":"Chunhai Fan","orcid":"https://orcid.org/0000-0002-7171-7338","observed_orcids":["https://orcid.org/0000-0002-7171-7338"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunhai Fan","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, and Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China"],"raw_orcid":"https://orcid.org/0000-0002-7171-7338","affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, and Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072600496","display_name":"Hao Pei","orcid":"https://orcid.org/0000-0002-6885-6708","observed_orcids":["https://orcid.org/0000-0002-6885-6708"]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hao Pei","raw_affiliation_strings":["Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, P. R. China"],"raw_orcid":"https://orcid.org/0000-0002-6885-6708","affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, P. R. China","institution_ids":["https://openalex.org/I66867065"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072600496"],"corresponding_institution_ids":["https://openalex.org/I66867065"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":4.4147,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.96866463,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"143","issue":"9","first_page":"3448","last_page":"3454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12029","display_name":"DNA and Biological Computing","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2614","display_name":"Theoretical Computer Science"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-cell-interactions","display_name":"cell-cell interactions","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cell-surface-engineering","display_name":"cell surface engineering","score":0.8259999752044678},{"id":"https://openalex.org/keywords/allosteric-activation","display_name":"allosteric activation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/molecular-self-assembly","display_name":"molecular self-assembly","score":0.7820000052452087},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.7519999742507935},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.7699999809265137},{"id":"https://openalex.org/keywords/adaptive-immunotherapy","display_name":"adaptive immunotherapy","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cellular-immunotherapy","display_name":"cellular immunotherapy","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.804313063621521},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.639337420463562},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6224194169044495},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.44414281845092773},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3778686225414276},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3759145140647888},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17417943477630615},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13739269971847534}],"mesh":[{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055029","descriptor_name":"Inverted Repeat Sequences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060846","descriptor_name":"Cell Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jacs.0c12358","doi":"https://doi.org/10.1021/jacs.0c12358","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.0c12358","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:33631070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33631070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2024201145","display_name":null,"funder_award_id":"19QA1403000","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G2269877577","display_name":null,"funder_award_id":"2020TQ0097","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G5457344112","display_name":null,"funder_award_id":"2018YFE0113200","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G891897180","display_name":null,"funder_award_id":"21722502","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1971405375","https://openalex.org/W1971698884","https://openalex.org/W1979731533","https://openalex.org/W1981241659","https://openalex.org/W1982769493","https://openalex.org/W1985483015","https://openalex.org/W1989941661","https://openalex.org/W2011742128","https://openalex.org/W2029435311","https://openalex.org/W2065833295","https://openalex.org/W2070815453","https://openalex.org/W2075915309","https://openalex.org/W2089031748","https://openalex.org/W2102699655","https://openalex.org/W2144577119","https://openalex.org/W2148226248","https://openalex.org/W2167192225","https://openalex.org/W2256857837","https://openalex.org/W2321813557","https://openalex.org/W2323616931","https://openalex.org/W2344118110","https://openalex.org/W2529653490","https://openalex.org/W2760464869","https://openalex.org/W2791073686","https://openalex.org/W2806766210","https://openalex.org/W2807947319","https://openalex.org/W2808592836","https://openalex.org/W2905340820","https://openalex.org/W2906143348","https://openalex.org/W2947878607","https://openalex.org/W2970604796","https://openalex.org/W2979086681","https://openalex.org/W2980670178","https://openalex.org/W3016695264","https://openalex.org/W3037289547","https://openalex.org/W3038532033","https://openalex.org/W4230362313"],"related_works":["https://openalex.org/W4409147943","https://openalex.org/W4396665815","https://openalex.org/W4319333586","https://openalex.org/W4229048216","https://openalex.org/W4409954929","https://openalex.org/W4200162769","https://openalex.org/W4383682759","https://openalex.org/W4411451605","https://openalex.org/W3139040162","https://openalex.org/W2282857151"],"abstract_inverted_index":{"The":[0,48],"manipulation":[1],"of":[2,8,44,56,66,99,109,113,121,144,157],"cell-cell":[3,46,146],"interactions":[4,147],"promotes":[5,154],"the":[6,41,54,64,79,97,106,111,141,155],"study":[7],"multicellular":[9,19,100],"behavior,":[10],"but":[11],"it":[12],"remains":[13],"a":[14,32,57],"great":[15],"challenge":[16],"for":[17,40,88,140],"programming":[18,67],"assembly":[20],"in":[21,148],"complex":[22,149],"reaction":[23,34,85,150],"pathways":[24,73,151],"with":[25,82,102],"multiple":[26,45,145],"cell":[27,80,94,158],"types.":[28],"Here":[29],"we":[30],"report":[31],"DNA":[33,49,59,84],"circuit-based":[35],"approach":[36],"to":[37,118],"cell-surface":[38],"engineering":[39],"programmable":[42,90,142],"regulation":[43],"interactions.":[47],"circuits":[50,86],"are":[51],"designed":[52],"on":[53,93],"basis":[55],"stem-loop-integrated":[58],"hairpin":[60],"motif,":[61],"which":[62,124],"has":[63],"capability":[65,112],"diverse":[68],"molecular":[69],"self-assembly":[70,101],"and":[71,96,152],"disassembly":[72],"by":[74],"sequential":[75],"allosteric":[76],"activation.":[77],"Modifying":[78],"surface":[81],"such":[83],"allows":[87],"performing":[89],"chemical":[91],"functions":[92],"membranes":[95],"control":[98,108,143],"selectivity.":[103],"We":[104,132],"demonstrate":[105],"selective":[107],"targeting":[110],"natural":[114],"killer":[115],"(NK)":[116],"cells":[117],"two":[119],"types":[120],"tumor":[122],"cells,":[123],"show":[125],"selectively":[126],"enhanced":[127],"cell-specific":[128],"adaptive":[129],"immunotherapy":[130],"efficacy.":[131],"hope":[133],"that":[134],"our":[135],"method":[136],"provides":[137],"new":[138],"ideas":[139],"potentially":[153],"development":[156],"immunotherapy.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-01T00:00:00"}
