{"id":"https://openalex.org/W3131230591","doi":"https://doi.org/10.1002/dvdy.322","title":"Delineating the roles of Grhl2 in craniofacial development through tissue\u2010specific conditional deletion and epistasis approaches in mouse","display_name":"Delineating the roles of Grhl2 in craniofacial development through tissue\u2010specific conditional deletion and epistasis approaches in mouse","publication_year":2021,"publication_date":"2021-02-26","ids":{"openalex":"https://openalex.org/W3131230591","doi":"https://doi.org/10.1002/dvdy.322","mag":"3131230591","pmid":"https://pubmed.ncbi.nlm.nih.gov/33638290"},"language":"en","primary_location":{"id":"doi:10.1002/dvdy.322","doi":"https://doi.org/10.1002/dvdy.322","is_oa":false,"landing_page_url":"https://doi.org/10.1002/dvdy.322","pdf_url":null,"source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006498675","display_name":"Michael E. de Vries","orcid":"https://orcid.org/0009-0007-4755-8000","observed_orcids":["https://orcid.org/0009-0007-4755-8000"]},"institutions":[{"id":"https://openalex.org/I196829312","display_name":"La Trobe University","ror":"https://ror.org/01rxfrp27","country_code":"AU","type":"education","lineage":["https://openalex.org/I196829312"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael de Vries","raw_affiliation_strings":["Department of Medicine, Monash University Central Clinical School, Prahran, Victoria, Australia","Department of Physiology, Anatomy and Microbiology, La Trobe University, Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Monash University Central Clinical School, Prahran, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Department of Physiology, Anatomy and Microbiology, La Trobe University, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I196829312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020242690","display_name":"Harley G. Owens","orcid":"https://orcid.org/0000-0002-9285-5000","observed_orcids":["https://orcid.org/0000-0002-9285-5000"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Harley G. Owens","raw_affiliation_strings":["Department of Medicine, Monash University Central Clinical School, Prahran, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Monash University Central Clinical School, Prahran, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054325335","display_name":"Marina R. Carpinelli","orcid":"https://orcid.org/0000-0001-5115-7831","observed_orcids":["https://orcid.org/0000-0001-5115-7831"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Marina R. Carpinelli","raw_affiliation_strings":["Department of Medicine, Monash University Central Clinical School, Prahran, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Monash University Central Clinical School, Prahran, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028115948","display_name":"Darren D. Partridge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Darren Partridge","raw_affiliation_strings":["Department of Medicine, Monash University Central Clinical School, Prahran, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Monash University Central Clinical School, Prahran, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049270608","display_name":"Ariena J. Kersbergen","orcid":"https://orcid.org/0009-0000-5306-0830","observed_orcids":["https://orcid.org/0009-0000-5306-0830"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ariena Kersbergen","raw_affiliation_strings":["ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia","Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kate D. Sutherland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kate D. Sutherland","raw_affiliation_strings":["ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia","Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006103273","display_name":"Alana Auden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Alana Auden","raw_affiliation_strings":["Department of Medicine, Monash University Central Clinical School, Prahran, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Monash University Central Clinical School, Prahran, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023840219","display_name":"Peter John Anderson","orcid":"https://orcid.org/0000-0002-3730-4652","observed_orcids":["https://orcid.org/0000-0002-3730-4652"]},"institutions":[{"id":"https://openalex.org/I2801308011","display_name":"Women's and Children's Hospital","ror":"https://ror.org/03kwrfk72","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801308011"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["AU","CN"],"is_corresponding":false,"raw_author_name":"Peter J. Anderson","raw_affiliation_strings":["Australian Craniofacial Unit, Women and Children's Hospital, Adelaide, South Australia, Australia","Faculty of Health Sciences, University of Adelaide, South Australia, Australia","Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Craniofacial Unit, Women and Children's Hospital, Adelaide, South Australia, Australia","institution_ids":["https://openalex.org/I2801308011"]},{"raw_affiliation_string":"Faculty of Health Sciences, University of Adelaide, South Australia, Australia","institution_ids":["https://openalex.org/I5681781"]},{"raw_affiliation_string":"Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059629859","display_name":"Stephen M. Jane","orcid":"https://orcid.org/0000-0002-1045-0481","observed_orcids":["https://orcid.org/0000-0002-1045-0481"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Stephen M. Jane","raw_affiliation_strings":["Department of Medicine, Monash University Central Clinical School, Prahran, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Monash University Central Clinical School, Prahran, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007926869","display_name":"Sebastian Dworkin","orcid":"https://orcid.org/0000-0001-5828-9992","observed_orcids":["https://orcid.org/0000-0001-5828-9992"]},"institutions":[{"id":"https://openalex.org/I196829312","display_name":"La Trobe University","ror":"https://ror.org/01rxfrp27","country_code":"AU","type":"education","lineage":["https://openalex.org/I196829312"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Sebastian Dworkin","raw_affiliation_strings":["Department of Physiology, Anatomy and Microbiology, La Trobe University, Melbourne, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0001-5828-9992","affiliations":[{"raw_affiliation_string":"Department of Physiology, Anatomy and Microbiology, La Trobe University, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I196829312"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5007926869"],"corresponding_institution_ids":["https://openalex.org/I196829312"],"apc_list":{"value":3660,"currency":"USD","value_usd":3660},"apc_paid":null,"fwci":0.4918,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.57900755,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"250","issue":"8","first_page":"1191","last_page":"1209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11374","display_name":"Cleft Lip and Palate Research","score":0.7157999873161316,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11374","display_name":"Cleft Lip and Palate Research","score":0.7157999873161316,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":0.1737000048160553,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.07270000129938126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/grhl2","display_name":"GRHL2","score":0.996999979019165},{"id":"https://openalex.org/keywords/craniofacial-development","display_name":"craniofacial development","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pharyngeal-epithelium","display_name":"pharyngeal epithelium","score":0.8870000243186951},{"id":"https://openalex.org/keywords/micrognathia","display_name":"micrognathia","score":0.9509999752044678},{"id":"https://openalex.org/keywords/endoderm","display_name":"endoderm","score":0.6520000100135803},{"id":"https://openalex.org/keywords/lung-development","display_name":"lung development","score":0.9639999866485596},{"id":"https://openalex.org/keywords/neural-crest","display_name":"neural crest","score":0.9769999980926514},{"id":"https://openalex.org/keywords/neural-tube-closure","display_name":"neural tube closure","score":0.7419999837875366},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.7580000162124634},{"id":"https://openalex.org/keywords/conditional-gene-deletion","display_name":"conditional gene deletion","score":0.5419999957084656},{"id":"https://openalex.org/keywords/epistasis","display_name":"epistasis","score":0.6919999718666077},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9042713046073914},{"id":"https://openalex.org/C126749454","wikidata":"https://www.wikidata.org/wiki/Q1348455","display_name":"Neural crest","level":3,"score":0.7596437335014343},{"id":"https://openalex.org/C2781245598","wikidata":"https://www.wikidata.org/wiki/Q5182134","display_name":"Craniofacial","level":2,"score":0.7483012676239014},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.6007347106933594},{"id":"https://openalex.org/C2777164004","wikidata":"https://www.wikidata.org/wiki/Q331858","display_name":"Endoderm","level":4,"score":0.5693584084510803},{"id":"https://openalex.org/C2780594696","wikidata":"https://www.wikidata.org/wiki/Q1127402","display_name":"Neural tube","level":3,"score":0.5149679780006409},{"id":"https://openalex.org/C68838962","wikidata":"https://www.wikidata.org/wiki/Q852654","display_name":"Haploinsufficiency","level":4,"score":0.49151524901390076},{"id":"https://openalex.org/C63101894","wikidata":"https://www.wikidata.org/wiki/Q604095","display_name":"Fate mapping","level":4,"score":0.46694934368133545},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4663825035095215},{"id":"https://openalex.org/C2779329299","wikidata":"https://www.wikidata.org/wiki/Q272474","display_name":"Ectoderm","level":4,"score":0.4642397165298462},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4504184126853943},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.4376389980316162},{"id":"https://openalex.org/C170774537","wikidata":"https://www.wikidata.org/wiki/Q2533722","display_name":"Foregut","level":2,"score":0.41951000690460205},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.3715883791446686},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.36769479513168335},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3599466383457184},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.3227771520614624},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2122352123260498}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009432","descriptor_name":"Neural Crest","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054259","descriptor_name":"Neural Tube","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/dvdy.322","doi":"https://doi.org/10.1002/dvdy.322","is_oa":false,"landing_page_url":"https://doi.org/10.1002/dvdy.322","pdf_url":null,"source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},{"id":"pmid:33638290","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33638290","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental dynamics : an official publication of the American Association of Anatomists","raw_type":"Journal Article"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/132460","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2440/132460","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dx.doi.org/10.1002/dvdy.322","raw_type":"Journal article"},{"id":"pmh:oai:figshare.com:article/28057829","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/journal_contribution/Delineating_the_roles_of_Grhl2_in_craniofacial_development_through_tissue-specific_conditional_deletion_and_epistasis_approaches_in_mouse/28057829","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/298325","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11343/298325","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1315320405","display_name":"Unravelling the holistic genetic control of vertebrate development.","funder_award_id":"DE140100500","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"},{"id":"https://openalex.org/G3714523810","display_name":"Identifying the critical pathways which regulate vertebrate craniofacial development","funder_award_id":"1063837","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1967164347","https://openalex.org/W1968042323","https://openalex.org/W1974707615","https://openalex.org/W1978554173","https://openalex.org/W1982782277","https://openalex.org/W1986072053","https://openalex.org/W1992948990","https://openalex.org/W2001237524","https://openalex.org/W2005642262","https://openalex.org/W2007116888","https://openalex.org/W2009306129","https://openalex.org/W2015786217","https://openalex.org/W2016041603","https://openalex.org/W2031721857","https://openalex.org/W2071716668","https://openalex.org/W2076320536","https://openalex.org/W2076824513","https://openalex.org/W2084691474","https://openalex.org/W2086943246","https://openalex.org/W2093831365","https://openalex.org/W2097947376","https://openalex.org/W2101478474","https://openalex.org/W2102395429","https://openalex.org/W2103597610","https://openalex.org/W2112260444","https://openalex.org/W2113717933","https://openalex.org/W2124770588","https://openalex.org/W2127592180","https://openalex.org/W2131975188","https://openalex.org/W2145060259","https://openalex.org/W2146046550","https://openalex.org/W2154864587","https://openalex.org/W2161282017","https://openalex.org/W2167279371","https://openalex.org/W2310568793","https://openalex.org/W2501196182","https://openalex.org/W2538393649","https://openalex.org/W2557659623","https://openalex.org/W2563698118","https://openalex.org/W2735397139","https://openalex.org/W2763799170","https://openalex.org/W2891665053","https://openalex.org/W2931693188","https://openalex.org/W2990649335","https://openalex.org/W3003412149","https://openalex.org/W3019920359"],"related_works":["https://openalex.org/W2990649335","https://openalex.org/W2622622997","https://openalex.org/W2735397139","https://openalex.org/W2097947376","https://openalex.org/W2771926526","https://openalex.org/W2538393649","https://openalex.org/W3003412149","https://openalex.org/W1968042323","https://openalex.org/W7094112522","https://openalex.org/W4382047992"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"The":[2],"highly":[3,51],"conserved":[4],"Grainyhead\u2010like":[5,30],"(Grhl)":[6],"family":[7,28],"of":[8,17,27,95,112,128,133,147,154,168,174,190,194,220,222,226,249,266],"transcription":[9],"factors":[10],"play":[11],"critical":[12,61],"roles":[13,63,94],"in":[14,97,114,143,156,160,192,206,244,261],"the":[15,18,105,115,119,131,134,144,149,180,195,245,250,262,267],"development":[16],"neural":[19,46,196],"tube":[20,47],"and":[21,41,44,53,68,151,164,183,209,229,247,264],"craniofacial":[22,106,207,251],"skeleton.":[23,107],"In":[24],"particular,":[25],"deletion":[26,77,127,189],"member":[29],"2":[31],"(Grhl2)":[32],"leads":[33,122,137],"to":[34,64,123,138,202],"mid\u2010gestational":[35],"embryonic":[36,98],"lethality,":[37],"maxillary":[38],"clefting,":[39,171],"abdominoschisis,":[40],"both":[42,148,227],"cranial":[43],"caudal":[45],"closure":[48],"defects.":[49],"These":[50],"pleiotropic":[52],"systemic":[54],"defects":[55,163,205],"suggest":[56],"that":[57,110],"Grhl2":[58,96,113,129,155,191,228,243,260],"plays":[59],"numerous":[60],"developmental":[62],"ensure":[65],"correct":[66],"morphogenesis":[67],"patterning.":[69],"Results":[70],"Here,":[71],"using":[72],"four":[73],"separate":[74],"Cre\u2010lox":[75],"conditional":[76],"models,":[78],"as":[79,81,179,253,255],"well":[80,254],"one":[82],"genetic":[83],"epistasis":[84,212],"approach":[85,213],"(Grhl2+/\u2212;Edn1+/\u2212":[86],"double":[87],"heterozygous":[88],"mice)":[89],"we":[90],"have":[91],"investigated":[92],"tissue\u2010specific":[93],"development,":[99,208],"with":[100],"a":[101,165,223,237],"particular":[102],"focus":[103],"on":[104],"We":[108],"find":[109],"loss":[111,221],"pharyngeal":[116],"epithelium":[117],"(using":[118],"ShhCre":[120],"driver)":[121],"low\u2010penetrance":[124],"micrognathia,":[125],"whereas":[126],"within":[130],"ectoderm":[132],"pharynx":[135],"(NestinCre)":[136],"small,":[139],"albeit":[140],"significant,":[141],"differences":[142],"proximal\u2010distal":[145],"elongation":[146],"maxilla":[150],"mandible.":[152],"Loss":[153],"endoderm":[157],"(Sox17\u20102aiCre)":[158],"resulted":[159],"noticeable":[161],"lung":[162],"single":[166,224],"instance":[167],"secondary":[169],"palatal":[170],"although":[172],"formation":[173,248,263],"other":[175],"endoderm\u2010derived":[176],"organs":[177],"such":[178],"stomach,":[181],"bladder":[182],"intestines":[184],"was":[185],"not":[186,200,215],"affected.":[187],"Lastly,":[188],"cells":[193],"crest":[197],"(Wnt1Cre)":[198],"did":[199,214],"lead":[201],"any":[203,217],"discernible":[204],"similarly,":[210],"our":[211,234],"detect":[216],"phenotypic":[218],"consequences":[219],"allele":[225],"Edn1.":[230],"Conclusion":[231],"Taken":[232],"together,":[233],"study":[235],"identifies":[236],"pharyngeal\u2010epithelium":[238],"intrinsic,":[239],"non\u2010cell\u2010autonomous":[240],"role":[241,258],"for":[242,259],"patterning":[246],"skeleton,":[252],"an":[256],"endoderm\u2010specific":[257],"establishment":[265],"mammalian":[268],"lung.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-01T00:00:00"}