{"id":"https://openalex.org/W3131198922","doi":"https://doi.org/10.1016/j.ygeno.2021.02.012","title":"Upregulation of hsa-miR-196a-5p is associated with MIR196A2 methylation and affects the malignant biological behaviors of glioma","display_name":"Upregulation of hsa-miR-196a-5p is associated with MIR196A2 methylation and affects the malignant biological behaviors of glioma","publication_year":2021,"publication_date":"2021-02-23","ids":{"openalex":"https://openalex.org/W3131198922","doi":"https://doi.org/10.1016/j.ygeno.2021.02.012","mag":"3131198922","pmid":"https://pubmed.ncbi.nlm.nih.gov/33636314"},"language":"en","primary_location":{"id":"doi:10.1016/j.ygeno.2021.02.012","doi":"https://doi.org/10.1016/j.ygeno.2021.02.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ygeno.2021.02.012","pdf_url":null,"source":{"id":"https://openalex.org/S146035217","display_name":"Genomics","issn_l":"0888-7543","issn":["0888-7543","1089-8646"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.ygeno.2021.02.012","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063631303","display_name":"Shanqiang Qu","orcid":"https://orcid.org/0000-0002-2709-0101","observed_orcids":["https://orcid.org/0000-0002-2709-0101"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanqiang Qu","raw_affiliation_strings":["Department of Neurosurgery, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090636475","display_name":"Ouwen Qiu","orcid":"https://orcid.org/0000-0002-6777-2764","observed_orcids":["https://orcid.org/0000-0002-6777-2764"]},"institutions":[{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ouwen Qiu","raw_affiliation_strings":["Department of Neurosurgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China","institution_ids":["https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075348524","display_name":"Jing Ze Huang","orcid":"https://orcid.org/0000-0001-7593-0980","observed_orcids":["https://orcid.org/0000-0001-7593-0980"]},"institutions":[{"id":"https://openalex.org/I4210096354","display_name":"The Seventh Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/00rfd5b88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210096354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Huang","raw_affiliation_strings":["Department of Stomatology, the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stomatology, the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China","institution_ids":["https://openalex.org/I4210096354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009865679","display_name":"Jin Liu","orcid":"https://orcid.org/0000-0002-1335-9720","observed_orcids":["https://orcid.org/0000-0002-1335-9720"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210125219","display_name":"Lishui City People's Hospital","ror":"https://ror.org/028yz2737","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125219"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Liu","raw_affiliation_strings":["Department of Neurosurgery, Lishui People's Hospital (the Sixth Affiliated Hospital of Wenzhou Medical University), Lishui 323000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Lishui People's Hospital (the Sixth Affiliated Hospital of Wenzhou Medical University), Lishui 323000, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210125219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006435389","display_name":"Huafu Wang","orcid":"https://orcid.org/0000-0001-9894-9860","observed_orcids":["https://orcid.org/0000-0001-9894-9860","https://orcid.org/0000-0001-7319-1862"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210125219","display_name":"Lishui City People's Hospital","ror":"https://ror.org/028yz2737","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125219"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huafu Wang","raw_affiliation_strings":["Department of Clinical Pharmacy, Lishui People's Hospital (the Sixth affiliated Hospital of Wenzhou Medical University), Lishui 323000, China. Electronic address: huayuanlu402@126.com","Department of Clinical Pharmacy, Lishui People's Hospital (The Sixth Affiliated Hospital of Wenzhou Medical University) Lishui 323000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Lishui People's Hospital (the Sixth affiliated Hospital of Wenzhou Medical University), Lishui 323000, China. Electronic address: huayuanlu402@126.com","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210125219"]},{"raw_affiliation_string":"Department of Clinical Pharmacy, Lishui People's Hospital (The Sixth Affiliated Hospital of Wenzhou Medical University) Lishui 323000, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210125219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5006435389"],"corresponding_institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210125219"],"apc_list":{"value":2410,"currency":"USD","value_usd":2410},"apc_paid":null,"fwci":1.6336,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.83078919,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"113","issue":"3","first_page":"1001","last_page":"1010"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.05829999968409538,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.01979999989271164,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.9440000057220459},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9369999766349792},{"id":"https://openalex.org/keywords/mirna-overexpression","display_name":"microRNA overexpression","score":0.8050000071525574},{"id":"https://openalex.org/keywords/gene-body-methylation","display_name":"gene body methylation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9200000166893005},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.9950000047683716},{"id":"https://openalex.org/keywords/idh-mutation","display_name":"IDH mutation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/1p-19q-codeletion","display_name":"1p/19q codeletion","score":0.9589999914169312},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.31299999356269836}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7509317994117737},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7325970530509949},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6900275945663452},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5787830352783203},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5782725811004639},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5735475420951843},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.47609198093414307},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.41528207063674927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36345601081848145},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35037797689437866},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3129379153251648},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2532758116722107},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2251175343990326},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13933175802230835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12649649381637573}],"mesh":[{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ygeno.2021.02.012","doi":"https://doi.org/10.1016/j.ygeno.2021.02.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ygeno.2021.02.012","pdf_url":null,"source":{"id":"https://openalex.org/S146035217","display_name":"Genomics","issn_l":"0888-7543","issn":["0888-7543","1089-8646"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics","raw_type":"journal-article"},{"id":"pmid:33636314","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33636314","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ygeno.2021.02.012","doi":"https://doi.org/10.1016/j.ygeno.2021.02.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ygeno.2021.02.012","pdf_url":null,"source":{"id":"https://openalex.org/S146035217","display_name":"Genomics","issn_l":"0888-7543","issn":["0888-7543","1089-8646"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1972169216","https://openalex.org/W2076483508","https://openalex.org/W2102002182","https://openalex.org/W2125600846","https://openalex.org/W2134629862","https://openalex.org/W2148977460","https://openalex.org/W2158217645","https://openalex.org/W2341890933","https://openalex.org/W2402849622","https://openalex.org/W2468164249","https://openalex.org/W2592437555","https://openalex.org/W2623800171","https://openalex.org/W2760867057","https://openalex.org/W2761184186","https://openalex.org/W2767377392","https://openalex.org/W2804658429","https://openalex.org/W2805876954","https://openalex.org/W2887200576","https://openalex.org/W2910969205","https://openalex.org/W2911225106","https://openalex.org/W2911712670","https://openalex.org/W2944727022","https://openalex.org/W2947627971","https://openalex.org/W2965751992","https://openalex.org/W2991696464","https://openalex.org/W2992283979","https://openalex.org/W2993071643","https://openalex.org/W3028304854","https://openalex.org/W3099697837","https://openalex.org/W3139677331","https://openalex.org/W4234865248","https://openalex.org/W6713237453","https://openalex.org/W6770739777","https://openalex.org/W6770872141","https://openalex.org/W6792382022"],"related_works":["https://openalex.org/W2414810065","https://openalex.org/W1992069272","https://openalex.org/W7098138592","https://openalex.org/W4413114429","https://openalex.org/W2405631285","https://openalex.org/W2039979225","https://openalex.org/W2110899581","https://openalex.org/W1992186370","https://openalex.org/W2918148100","https://openalex.org/W1894587178"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-01T00:00:00"}