{"id":"https://openalex.org/W3131184341","doi":"https://doi.org/10.3390/vaccines9020149","title":"An Oncolytic Adenovirus Encoding SA-4-1BBL Adjuvant Fused to HPV-16 E7 Antigen Produces a Specific Antitumor Effect in a Cancer Mouse Model","display_name":"An Oncolytic Adenovirus Encoding SA-4-1BBL Adjuvant Fused to HPV-16 E7 Antigen Produces a Specific Antitumor Effect in a Cancer Mouse Model","publication_year":2021,"publication_date":"2021-02-12","ids":{"openalex":"https://openalex.org/W3131184341","doi":"https://doi.org/10.3390/vaccines9020149","mag":"3131184341","pmid":"https://pubmed.ncbi.nlm.nih.gov/33673295","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7917608"},"language":"en","primary_location":{"id":"doi:10.3390/vaccines9020149","doi":"https://doi.org/10.3390/vaccines9020149","is_oa":true,"landing_page_url":"https://doi.org/10.3390/vaccines9020149","pdf_url":"https://www.mdpi.com/2076-393X/9/2/149/pdf?version=1613799987","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-393X/9/2/149/pdf?version=1613799987","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054146807","display_name":"Alejandra G. Mart\u00ednez-P\u00e9rez","orcid":"https://orcid.org/0000-0001-8535-3910","observed_orcids":["https://orcid.org/0000-0001-8535-3910"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Alejandra G. Martinez-Perez","raw_affiliation_strings":["Department of Histology, School of Medicine, Autonomous University of Nuevo Le\u00f3n, Monterrey, NL 64460, Mexico"],"raw_orcid":"https://orcid.org/0000-0001-8535-3910","affiliations":[{"raw_affiliation_string":"Department of Histology, School of Medicine, Autonomous University of Nuevo Le\u00f3n, Monterrey, NL 64460, Mexico","institution_ids":["https://openalex.org/I169046204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090487181","display_name":"Jos\u00e9 Juan Perez\u2010Trujillo","orcid":"https://orcid.org/0000-0002-6737-6155","observed_orcids":["https://orcid.org/0000-0002-6737-6155","https://orcid.org/0000-0003-2944-8733"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jose J. Perez-Trujillo","raw_affiliation_strings":["Department of Histology, School of Medicine, Autonomous University of Nuevo Le\u00f3n, Monterrey, NL 64460, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology, School of Medicine, Autonomous University of Nuevo Le\u00f3n, Monterrey, NL 64460, Mexico","institution_ids":["https://openalex.org/I169046204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089899799","display_name":"Rodolfo Garza-Morales","orcid":"https://orcid.org/0000-0002-3613-521X","observed_orcids":["https://orcid.org/0000-0002-3613-521X"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodolfo Garza-Morales","raw_affiliation_strings":["Department of Surgery, School of Medicine, University of Louisville, Louisville, KY 40202, USA"],"raw_orcid":"https://orcid.org/0000-0002-3613-521X","affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Medicine, University of Louisville, Louisville, KY 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036142959","display_name":"Norma E. Ramirez-Avila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Norma E. Ramirez-Avila","raw_affiliation_strings":["Department of Histology, School of Medicine, Autonomous University of Nuevo Le\u00f3n, Monterrey, NL 64460, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology, School of Medicine, Autonomous University of Nuevo Le\u00f3n, Monterrey, NL 64460, Mexico","institution_ids":["https://openalex.org/I169046204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070547873","display_name":"Mar\u00eda de Jes\u00fas Loera\u2010Arias","orcid":"https://orcid.org/0000-0001-9561-3624","observed_orcids":["https://orcid.org/0000-0001-9561-3624"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Maria J. Loera-Arias","raw_affiliation_strings":["Department of Histology, School of Medicine, Autonomous University of Nuevo Le\u00f3n, Monterrey, NL 64460, Mexico"],"raw_orcid":"https://orcid.org/0000-0001-9561-3624","affiliations":[{"raw_affiliation_string":"Department of Histology, School of Medicine, Autonomous University of Nuevo Le\u00f3n, Monterrey, NL 64460, Mexico","institution_ids":["https://openalex.org/I169046204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077647701","display_name":"Jorge G. G\u00f3mez-Guti\u00e9rrez","orcid":"https://orcid.org/0000-0003-3610-260X","observed_orcids":["https://orcid.org/0000-0003-3610-260X"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge G. Gomez-Gutierrez","raw_affiliation_strings":["Department of Surgery, School of Medicine, University of Louisville, Louisville, KY 40202, USA"],"raw_orcid":"https://orcid.org/0000-0003-3610-260X","affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Medicine, University of Louisville, Louisville, KY 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053672834","display_name":"Odila Saucedo C\u00e1rdenas","orcid":"https://orcid.org/0000-0003-3922-2615","observed_orcids":["https://orcid.org/0000-0003-3922-2615"]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]},{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Odila Saucedo-Cardenas","raw_affiliation_strings":["Department of Histology, School of Medicine, Autonomous University of Nuevo Le\u00f3n, Monterrey, NL 64460, Mexico","Department of Molecular Genetics, Northeast Biomedical Research Center, Mexican Institute of Social Security (IMSS), Monterrey, NL 64000, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology, School of Medicine, Autonomous University of Nuevo Le\u00f3n, Monterrey, NL 64460, Mexico","institution_ids":["https://openalex.org/I169046204"]},{"raw_affiliation_string":"Department of Molecular Genetics, Northeast Biomedical Research Center, Mexican Institute of Social Security (IMSS), Monterrey, NL 64000, Mexico","institution_ids":["https://openalex.org/I164915025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066325137","display_name":"Aracely Garc\u00eda\u2010Garc\u00eda","orcid":"https://orcid.org/0000-0002-1699-9678","observed_orcids":["https://orcid.org/0000-0002-1699-9678"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Aracely Garcia-Garcia","raw_affiliation_strings":["Department of Histology, School of Medicine, Autonomous University of Nuevo Le\u00f3n, Monterrey, NL 64460, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology, School of Medicine, Autonomous University of Nuevo Le\u00f3n, Monterrey, NL 64460, Mexico","institution_ids":["https://openalex.org/I169046204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030749946","display_name":"Humberto Rodr\u00edguez\u2010Rocha","orcid":"https://orcid.org/0000-0003-0486-7448","observed_orcids":["https://orcid.org/0000-0003-0486-7448"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Humberto Rodriguez-Rocha","raw_affiliation_strings":["Department of Histology, School of Medicine, Autonomous University of Nuevo Le\u00f3n, Monterrey, NL 64460, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology, School of Medicine, Autonomous University of Nuevo Le\u00f3n, Monterrey, NL 64460, Mexico","institution_ids":["https://openalex.org/I169046204"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063717244","display_name":"Roberto Montes\u2010de\u2010Oca\u2010Luna","orcid":"https://orcid.org/0000-0001-8253-680X","observed_orcids":["https://orcid.org/0000-0001-8253-680X"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Roberto Montes-de-Oca-Luna","raw_affiliation_strings":["Department of Histology, School of Medicine, Autonomous University of Nuevo Le\u00f3n, Monterrey, NL 64460, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology, School of Medicine, Autonomous University of Nuevo Le\u00f3n, Monterrey, NL 64460, Mexico","institution_ids":["https://openalex.org/I169046204"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063717244"],"corresponding_institution_ids":["https://openalex.org/I169046204"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":1.8094,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.84860107,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":"2","first_page":"149","last_page":"149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncolytic-adenovirus","display_name":"oncolytic adenovirus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/4-1bbl","display_name":"4-1BBL","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.906000018119812},{"id":"https://openalex.org/keywords/oncolytic-virotherapy","display_name":"oncolytic virotherapy","score":0.8539999723434448},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.6679999828338623},{"id":"https://openalex.org/keywords/signal-peptide","display_name":"signal peptide","score":0.6909999847412109},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-targeting","display_name":"endoplasmic reticulum targeting","score":0.9380000233650208},{"id":"https://openalex.org/keywords/tc-1-cells","display_name":"TC-1 cells","score":0.7860000133514404},{"id":"https://openalex.org/keywords/dna-vaccine-adjuvant","display_name":"DNA vaccine adjuvant","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.9031974673271179},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.6578263640403748},{"id":"https://openalex.org/C2777283488","wikidata":"https://www.wikidata.org/wiki/Q7095181","display_name":"Oncolytic adenovirus","level":4,"score":0.6308357119560242},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.610821008682251},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5610607266426086},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5088067650794983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49828219413757324},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45961424708366394},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4520372152328491},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.44170334935188293},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4392744302749634},{"id":"https://openalex.org/C49744831","wikidata":"https://www.wikidata.org/wiki/Q600121","display_name":"Virotherapy","level":4,"score":0.43718114495277405},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4336678087711334},{"id":"https://openalex.org/C2776662205","wikidata":"https://www.wikidata.org/wiki/Q2459684","display_name":"Tumor antigen","level":4,"score":0.4178789258003235},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3540074825286865},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.34666723012924194},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33967509865760803},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/vaccines9020149","doi":"https://doi.org/10.3390/vaccines9020149","is_oa":true,"landing_page_url":"https://doi.org/10.3390/vaccines9020149","pdf_url":"https://www.mdpi.com/2076-393X/9/2/149/pdf?version=1613799987","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},{"id":"pmid:33673295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33673295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7917608","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7917608/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines (Basel)","raw_type":"Text"},{"id":"pmh:oai:scholarworks.utrgv.edu:som_pub-2746","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.utrgv.edu/som_pub/1742","pdf_url":null,"source":{"id":"https://openalex.org/S4306402611","display_name":"ScholarWorks @ UTRGV (The University of Texas Rio Grande Valley)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802326326","host_organization_name":"The University of Texas Rio Grande Valley","host_organization_lineage":["https://openalex.org/I2802326326"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"School of Medicine Publications and Presentations","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:5228df76507645dc83d96835ce7c306d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5228df76507645dc83d96835ce7c306d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vaccines, Vol 9, Iss 2, p 149 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/vaccines9020149","doi":"https://doi.org/10.3390/vaccines9020149","is_oa":true,"landing_page_url":"https://doi.org/10.3390/vaccines9020149","pdf_url":"https://www.mdpi.com/2076-393X/9/2/149/pdf?version=1613799987","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5182017854","display_name":"Oncolytic Adenovirus Armed with SA-4-1BBL Immune Checkpoint Stimulator for Lung Cancer Immunotherapy","funder_award_id":"R21CA249348","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G977097343","display_name":null,"funder_award_id":"255725","funder_id":"https://openalex.org/F4320321739","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda"}],"funders":[{"id":"https://openalex.org/F4320310177","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478"},{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3131184341.pdf","grobid_xml":"https://content.openalex.org/works/W3131184341.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1949342640","https://openalex.org/W1966977267","https://openalex.org/W1981276113","https://openalex.org/W1982712041","https://openalex.org/W1998346042","https://openalex.org/W2004736524","https://openalex.org/W2007198223","https://openalex.org/W2018893865","https://openalex.org/W2022188012","https://openalex.org/W2023520005","https://openalex.org/W2041494950","https://openalex.org/W2067753983","https://openalex.org/W2091703158","https://openalex.org/W2122669148","https://openalex.org/W2129090621","https://openalex.org/W2136890067","https://openalex.org/W2152617650","https://openalex.org/W2153519961","https://openalex.org/W2165922840","https://openalex.org/W2311940676","https://openalex.org/W2339844244","https://openalex.org/W2472221349","https://openalex.org/W2480418585","https://openalex.org/W2580535063","https://openalex.org/W2608335129","https://openalex.org/W2611749693","https://openalex.org/W2751781206","https://openalex.org/W2791767507","https://openalex.org/W2793142165","https://openalex.org/W2904803926","https://openalex.org/W2909089251","https://openalex.org/W2945080083","https://openalex.org/W3001126043","https://openalex.org/W6652087680"],"related_works":["https://openalex.org/W4362524498","https://openalex.org/W4392619229","https://openalex.org/W2002108471","https://openalex.org/W2279008065","https://openalex.org/W2324715299","https://openalex.org/W4313386736","https://openalex.org/W2909089251","https://openalex.org/W1978454000","https://openalex.org/W2258332793","https://openalex.org/W4282919443"],"abstract_inverted_index":{"Human":[0],"papillomaviruses":[1],"(HPVs)":[2],"are":[3,140],"responsible":[4],"for":[5,71],"about":[6],"25%":[7],"of":[8,32,124,174],"cancer":[9,167],"cases":[10],"worldwide.":[11],"HPV-16":[12],"E7":[13,114,187],"antigen":[14,18],"is":[15,61,69,146,161],"a":[16,157],"tumor-associated":[17],"(TAA)":[19],"commonly":[20],"expressed":[21,107],"in":[22,51,81,95,152,164],"HPV-induced":[23,166],"tumors;":[24],"however,":[25,59],"it":[26,76],"has":[27],"low":[28,62],"immunogenicity.":[29],"The":[30],"interaction":[31],"4-1BBL":[33],"with":[34,132],"its":[35],"receptor":[36],"induces":[37],"pleiotropic":[38],"effects":[39],"on":[40,115],"innate,":[41],"adaptive,":[42],"and":[43,64,87,128,179,188],"regulatory":[44],"immunity":[45],"and,":[46],"if":[47],"fused":[48,112,185],"to":[49,99,113,148,186],"TAAs":[50],"DNA":[52],"vaccines,":[53],"can":[54,77,92,176,181],"improve":[55],"the":[56,108,149,170],"antitumor":[57,65,72,101],"response;":[58],"there":[60],"transfection":[63],"efficiency.":[66],"Oncolytic":[67],"virotherapy":[68],"promising":[70],"gene":[73],"therapy":[74],"as":[75],"be":[78,93,177,182],"selectively":[79,141],"replicated":[80],"tumor":[82,89,126,138],"cells,":[83],"inducing":[84],"cell":[85,90,154],"lysis,":[86],"furthermore,":[88],"debris":[91],"taken":[94],"by":[96],"immune":[97],"cells":[98,127,131,139],"potentiate":[100],"responses.":[102],"In":[103,121],"this":[104,180],"study,":[105],"we":[106],"immunomodulatory":[109],"molecule":[110],"SA-4-1BBL":[111],"an":[116,165],"oncolytic":[117,172],"adenovirus":[118],"(OAd)":[119],"system.":[120],"vitro":[122],"infection":[123],"TC-1":[125],"NIH-3T3":[129],"non-tumor":[130],"SA/E7/4-1BBL":[133],"OAd":[134,175],"demonstrated":[135],"that":[136],"only":[137],"destroyed.":[142],"Moreover,":[143],"protein":[144],"expression":[145],"targeted":[147],"endoplasmic":[150],"reticulum":[151],"both":[153],"lines":[155],"when":[156,184],"signal":[158],"peptide":[159],"(SP)":[160],"added.":[162],"Finally,":[163],"murine":[168],"model,":[169],"therapeutic":[171],"activity":[173],"detected,":[178],"improved":[183],"SP.":[189]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-01T00:00:00"}