{"id":"https://openalex.org/W3131044740","doi":"https://doi.org/10.1016/j.preteyeres.2021.100952","title":"Implications of genetic variation in the complement system in age-related macular degeneration","display_name":"Implications of genetic variation in the complement system in age-related macular degeneration","publication_year":2021,"publication_date":"2021-02-21","ids":{"openalex":"https://openalex.org/W3131044740","doi":"https://doi.org/10.1016/j.preteyeres.2021.100952","mag":"3131044740","pmid":"https://pubmed.ncbi.nlm.nih.gov/33610747"},"language":"en","primary_location":{"id":"doi:10.1016/j.preteyeres.2021.100952","doi":"https://doi.org/10.1016/j.preteyeres.2021.100952","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.preteyeres.2021.100952","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1350946221000136/pdf","source":{"id":"https://openalex.org/S138587161","display_name":"Progress in Retinal and Eye Research","issn_l":"1350-9462","issn":["1350-9462","1873-1635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in Retinal and Eye Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S1350946221000136/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025137286","display_name":"Sarah de Jong","orcid":"https://orcid.org/0000-0002-3705-3371","observed_orcids":["https://orcid.org/0000-0002-3705-3371"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4405261313","display_name":"Donders Institute for Brain, Cognition and Behaviour","ror":"https://ror.org/053sba816","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sarah de Jong","raw_affiliation_strings":["Department of Ophthalmology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-3705-3371","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949","https://openalex.org/I4405261313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051622125","display_name":"Giuliana Gagliardi","orcid":"https://orcid.org/0000-0001-8118-0629","observed_orcids":["https://orcid.org/0000-0001-8118-0629"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4405261313","display_name":"Donders Institute for Brain, Cognition and Behaviour","ror":"https://ror.org/053sba816","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Giuliana Gagliardi","raw_affiliation_strings":["Department of Ophthalmology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-8118-0629","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949","https://openalex.org/I4405261313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009322829","display_name":"Alejandro Garanto","orcid":"https://orcid.org/0000-0001-5721-1560","observed_orcids":["https://orcid.org/0000-0001-5721-1560"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4210109357","display_name":"Radboud Institute for Molecular Life Sciences","ror":"https://ror.org/01yb10j39","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4210109357"]},{"id":"https://openalex.org/I4210114047","display_name":"Amalia Kinderziekenhuis","ror":"https://ror.org/024pk8k39","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802934949","https://openalex.org/I4210114047"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Alejandro Garanto","raw_affiliation_strings":["Department of Human Genetics, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands; Department of Pediatrics, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands; Amalia Children's Hospital, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","Amalia Children's Hospital, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","Department of Human Genetics, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","Department of Pediatrics, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands; Department of Pediatrics, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands; Amalia Children's Hospital, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4210109357","https://openalex.org/I4210114047"]},{"raw_affiliation_string":"Amalia Children's Hospital, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949","https://openalex.org/I4210114047"]},{"raw_affiliation_string":"Department of Human Genetics, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Department of Pediatrics, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4210109357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069880565","display_name":"Anita de Breuk","orcid":"https://orcid.org/0000-0001-7072-1928","observed_orcids":["https://orcid.org/0000-0001-7072-1928"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4405261313","display_name":"Donders Institute for Brain, Cognition and Behaviour","ror":"https://ror.org/053sba816","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anita de Breuk","raw_affiliation_strings":["Department of Ophthalmology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949","https://openalex.org/I4405261313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001073711","display_name":"Yara T. E. Lechanteur","orcid":"https://orcid.org/0000-0003-0951-4625","observed_orcids":["https://orcid.org/0000-0003-0951-4625"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4405261313","display_name":"Donders Institute for Brain, Cognition and Behaviour","ror":"https://ror.org/053sba816","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Yara T.E. Lechanteur","raw_affiliation_strings":["Department of Ophthalmology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949","https://openalex.org/I4405261313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067327923","display_name":"Suresh K. Katti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suresh Katti","raw_affiliation_strings":["Gemini Therapeutics Inc., Cambridge, MA, 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gemini Therapeutics Inc., Cambridge, MA, 02139, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113662717","display_name":"Lambert P. van den Heuvel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4210109357","display_name":"Radboud Institute for Molecular Life Sciences","ror":"https://ror.org/01yb10j39","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4210109357"]},{"id":"https://openalex.org/I4210114047","display_name":"Amalia Kinderziekenhuis","ror":"https://ror.org/024pk8k39","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802934949","https://openalex.org/I4210114047"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Lambert P. van den Heuvel","raw_affiliation_strings":["Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands; Amalia Children's Hospital, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands; Department of Laboratory Medicine, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","Amalia Children's Hospital, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","Department of Laboratory Medicine, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands; Amalia Children's Hospital, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands; Department of Laboratory Medicine, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4210109357","https://openalex.org/I4210114047"]},{"raw_affiliation_string":"Amalia Children's Hospital, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949","https://openalex.org/I4210114047"]},{"raw_affiliation_string":"Department of Laboratory Medicine, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4210109357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046000826","display_name":"Elena B. Volokhina","orcid":"https://orcid.org/0000-0002-4294-8460","observed_orcids":["https://orcid.org/0000-0002-4294-8460"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4210109357","display_name":"Radboud Institute for Molecular Life Sciences","ror":"https://ror.org/01yb10j39","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4210109357"]},{"id":"https://openalex.org/I4210114047","display_name":"Amalia Kinderziekenhuis","ror":"https://ror.org/024pk8k39","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802934949","https://openalex.org/I4210114047"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Elena B. Volokhina","raw_affiliation_strings":["Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands; Amalia Children's Hospital, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands; Department of Laboratory Medicine, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","Amalia Children's Hospital, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","Department of Laboratory Medicine, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-4294-8460","affiliations":[{"raw_affiliation_string":"Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands; Amalia Children's Hospital, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands; Department of Laboratory Medicine, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4210109357","https://openalex.org/I4210114047"]},{"raw_affiliation_string":"Amalia Children's Hospital, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949","https://openalex.org/I4210114047"]},{"raw_affiliation_string":"Department of Laboratory Medicine, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4210109357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049656883","display_name":"Anneke I. den Hollander","orcid":"https://orcid.org/0000-0003-0634-5408","observed_orcids":["https://orcid.org/0000-0003-0634-5408"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4405261313","display_name":"Donders Institute for Brain, Cognition and Behaviour","ror":"https://ror.org/053sba816","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Anneke I. den Hollander","raw_affiliation_strings":["Department of Ophthalmology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands; Department of Human Genetics, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands. Electronic address: anneke.denhollander@radboudumc.nl","Department of Human Genetics, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","Department of Ophthalmology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands; Department of Human Genetics, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands. Electronic address: anneke.denhollander@radboudumc.nl","institution_ids":["https://openalex.org/I2802934949","https://openalex.org/I4405261313"]},{"raw_affiliation_string":"Department of Human Genetics, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Department of Ophthalmology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525, GA, Nijmegen, the Netherlands","institution_ids":["https://openalex.org/I2802934949","https://openalex.org/I4405261313"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5049656883"],"corresponding_institution_ids":["https://openalex.org/I2802934949","https://openalex.org/I4405261313"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":2.1091,"has_fulltext":true,"cited_by_count":71,"citation_normalized_percentile":{"value":0.90536585,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"84","issue":null,"first_page":"100952","last_page":"100952"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.02979999966919422,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":1.0},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.9990000128746033},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/genetic-variation","display_name":"genetic variation","score":0.7059999704360962},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.6399999856948853},{"id":"https://openalex.org/keywords/complement-inhibitors","display_name":"complement inhibitors","score":0.9480000138282776},{"id":"https://openalex.org/keywords/amd-pathogenesis","display_name":"AMD pathogenesis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.8479999899864197},{"id":"https://openalex.org/keywords/genome-editing","display_name":"genome editing","score":0.972000002861023},{"id":"https://openalex.org/keywords/disease-models","display_name":"disease models","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.8709790706634521},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6468448042869568},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.6439430713653564},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.6070500016212463},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48059651255607605},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.4640122652053833},{"id":"https://openalex.org/C189446657","wikidata":"https://www.wikidata.org/wiki/Q4736500","display_name":"Alternative complement pathway","level":4,"score":0.4455646276473999},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4262261986732483},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4258258044719696},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38497403264045715},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3349764347076416},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3297312259674072},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22492939233779907},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16632041335105896},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.1655532717704773},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09588778018951416},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.06805047392845154},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.preteyeres.2021.100952","doi":"https://doi.org/10.1016/j.preteyeres.2021.100952","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.preteyeres.2021.100952","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1350946221000136/pdf","source":{"id":"https://openalex.org/S138587161","display_name":"Progress in Retinal and Eye Research","issn_l":"1350-9462","issn":["1350-9462","1873-1635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in Retinal and Eye Research","raw_type":"journal-article"},{"id":"pmid:33610747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33610747","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in retinal and eye research","raw_type":"Journal Article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/237835","doi":null,"is_oa":false,"landing_page_url":"https://repository.ubn.ru.nl/handle/2066/237835","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Progress in Retinal and Eye Research, 84","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/237835","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/237835","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Progress in Retinal and Eye Research, 84","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.preteyeres.2021.100952","doi":"https://doi.org/10.1016/j.preteyeres.2021.100952","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.preteyeres.2021.100952","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1350946221000136/pdf","source":{"id":"https://openalex.org/S138587161","display_name":"Progress in Retinal and Eye Research","issn_l":"1350-9462","issn":["1350-9462","1873-1635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in Retinal and Eye Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2096490213","display_name":null,"funder_award_id":"2019-17","funder_id":"https://openalex.org/F4320316304","funder_display_name":"Stichting Steunfonds Uitzicht"},{"id":"https://openalex.org/G4222382880","display_name":null,"funder_award_id":"PPA-0517-0717-RAD","funder_id":"https://openalex.org/F4320306340","funder_display_name":"Foundation Fighting Blindness"},{"id":"https://openalex.org/G7426559030","display_name":null,"funder_award_id":"PPA-0517-0717-RAD","funder_id":"https://openalex.org/F4320316304","funder_display_name":"Stichting Steunfonds Uitzicht"},{"id":"https://openalex.org/G8559680832","display_name":null,"funder_award_id":"PPA-0517-0717-RAD","funder_id":"https://openalex.org/F4320326394","funder_display_name":"Stichting Blindenhulp"}],"funders":[{"id":"https://openalex.org/F4320306340","display_name":"Foundation Fighting Blindness","ror":"https://ror.org/011728q79"},{"id":"https://openalex.org/F4320316304","display_name":"Stichting Steunfonds Uitzicht","ror":"https://ror.org/05r1tfa82"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320325760","display_name":"Oogfonds","ror":"https://ror.org/00x6ysg61"},{"id":"https://openalex.org/F4320326325","display_name":"Algemene Nederlandse Vereniging ter voorkoming van Blindheid","ror":"https://ror.org/0210ag428"},{"id":"https://openalex.org/F4320326341","display_name":"Landelijke Stichting voor Blinden en Slechtzienden","ror":"https://ror.org/03apwp296"},{"id":"https://openalex.org/F4320326393","display_name":"Stichting Blinden-Penning","ror":"https://ror.org/0236wrw52"},{"id":"https://openalex.org/F4320326394","display_name":"Stichting Blindenhulp","ror":"https://ror.org/01kczb637"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3131044740.pdf","grobid_xml":"https://content.openalex.org/works/W3131044740.grobid-xml"},"referenced_works_count":273,"referenced_works":["https://openalex.org/W62535517","https://openalex.org/W77072218","https://openalex.org/W154709760","https://openalex.org/W196970741","https://openalex.org/W385732249","https://openalex.org/W1122985724","https://openalex.org/W1486365785","https://openalex.org/W1491374817","https://openalex.org/W1499593166","https://openalex.org/W1509391708","https://openalex.org/W1519481032","https://openalex.org/W1547275353","https://openalex.org/W1590398299","https://openalex.org/W1609980169","https://openalex.org/W1670632949","https://openalex.org/W1707478454","https://openalex.org/W1710437513","https://openalex.org/W1760485743","https://openalex.org/W1853339213","https://openalex.org/W1871202872","https://openalex.org/W1883306593","https://openalex.org/W1901360874","https://openalex.org/W1923089788","https://openalex.org/W1928260253","https://openalex.org/W1930918755","https://openalex.org/W1937446661","https://openalex.org/W1965404473","https://openalex.org/W1965972308","https://openalex.org/W1966355819","https://openalex.org/W1966736212","https://openalex.org/W1967076712","https://openalex.org/W1969854304","https://openalex.org/W1970232820","https://openalex.org/W1975188427","https://openalex.org/W1977327764","https://openalex.org/W1979551570","https://openalex.org/W1980344266","https://openalex.org/W1980530607","https://openalex.org/W1985960971","https://openalex.org/W1990057691","https://openalex.org/W1994797655","https://openalex.org/W1997288094","https://openalex.org/W1997746165","https://openalex.org/W1997761753","https://openalex.org/W1999967353","https://openalex.org/W2000399151","https://openalex.org/W2001661375","https://openalex.org/W2005447579","https://openalex.org/W2005969028","https://openalex.org/W2009256817","https://openalex.org/W2013520568","https://openalex.org/W2016520383","https://openalex.org/W2016996903","https://openalex.org/W2022967445","https://openalex.org/W2024064075","https://openalex.org/W2024991121","https://openalex.org/W2027707278","https://openalex.org/W2028283509","https://openalex.org/W2031564141","https://openalex.org/W2034206896","https://openalex.org/W2034970911","https://openalex.org/W2035137261","https://openalex.org/W2045534957","https://openalex.org/W2046894045","https://openalex.org/W2047393488","https://openalex.org/W2051369374","https://openalex.org/W2056044165","https://openalex.org/W2058278883","https://openalex.org/W2059491558","https://openalex.org/W2060767100","https://openalex.org/W2061626915","https://openalex.org/W2062097745","https://openalex.org/W2062910860","https://openalex.org/W2064847480","https://openalex.org/W2065391400","https://openalex.org/W2065627672","https://openalex.org/W2071958051","https://openalex.org/W2073579251","https://openalex.org/W2074240120","https://openalex.org/W2074330772","https://openalex.org/W2074549590","https://openalex.org/W2080778821","https://openalex.org/W2081737697","https://openalex.org/W2082704740","https://openalex.org/W2086188106","https://openalex.org/W2087858817","https://openalex.org/W2088551743","https://openalex.org/W2088874869","https://openalex.org/W2092180774","https://openalex.org/W2093870205","https://openalex.org/W2095444125","https://openalex.org/W2097013149","https://openalex.org/W2097480181","https://openalex.org/W2103735661","https://openalex.org/W2103941977","https://openalex.org/W2104426232","https://openalex.org/W2105479207","https://openalex.org/W2106901733","https://openalex.org/W2107356267","https://openalex.org/W2112564853","https://openalex.org/W2113784410","https://openalex.org/W2115585762","https://openalex.org/W2117386992","https://openalex.org/W2118822739","https://openalex.org/W2121723196","https://openalex.org/W2121855384","https://openalex.org/W2122236495","https://openalex.org/W2124330580","https://openalex.org/W2125236492","https://openalex.org/W2127358429","https://openalex.org/W2127439967","https://openalex.org/W2131150338","https://openalex.org/W2131852221","https://openalex.org/W2132060134","https://openalex.org/W2132851481","https://openalex.org/W2134267237","https://openalex.org/W2136501493","https://openalex.org/W2140644434","https://openalex.org/W2140653050","https://openalex.org/W2141596893","https://openalex.org/W2141959946","https://openalex.org/W2142236101","https://openalex.org/W2143340044","https://openalex.org/W2148522103","https://openalex.org/W2155641466","https://openalex.org/W2160226180","https://openalex.org/W2160429819","https://openalex.org/W2162838839","https://openalex.org/W2163083170","https://openalex.org/W2163193571","https://openalex.org/W2165795903","https://openalex.org/W2165915271","https://openalex.org/W2165955856","https://openalex.org/W2166164651","https://openalex.org/W2168558228","https://openalex.org/W2170961664","https://openalex.org/W2171679548","https://openalex.org/W2229741299","https://openalex.org/W2233221674","https://openalex.org/W2276666579","https://openalex.org/W2284817282","https://openalex.org/W2287827881","https://openalex.org/W2296040915","https://openalex.org/W2318395464","https://openalex.org/W2327817460","https://openalex.org/W2347191528","https://openalex.org/W2399087400","https://openalex.org/W2400013325","https://openalex.org/W2405994756","https://openalex.org/W2415123795","https://openalex.org/W2415663312","https://openalex.org/W2468521850","https://openalex.org/W2498129978","https://openalex.org/W2523518278","https://openalex.org/W2523592271","https://openalex.org/W2548952825","https://openalex.org/W2559556008","https://openalex.org/W2560154882","https://openalex.org/W2560241007","https://openalex.org/W2565787913","https://openalex.org/W2566643825","https://openalex.org/W2582581571","https://openalex.org/W2582626148","https://openalex.org/W2583232897","https://openalex.org/W2589572904","https://openalex.org/W2592132756","https://openalex.org/W2605167569","https://openalex.org/W2610579933","https://openalex.org/W2616726006","https://openalex.org/W2617717655","https://openalex.org/W2622238715","https://openalex.org/W2624919575","https://openalex.org/W2750719761","https://openalex.org/W2753515397","https://openalex.org/W2754409727","https://openalex.org/W2758028768","https://openalex.org/W2766505847","https://openalex.org/W2781073743","https://openalex.org/W2781905533","https://openalex.org/W2782225202","https://openalex.org/W2783987221","https://openalex.org/W2784443155","https://openalex.org/W2784771549","https://openalex.org/W2785786028","https://openalex.org/W2787453495","https://openalex.org/W2789250565","https://openalex.org/W2789344364","https://openalex.org/W2792779193","https://openalex.org/W2795523207","https://openalex.org/W2799563784","https://openalex.org/W2802822211","https://openalex.org/W2803389404","https://openalex.org/W2805000756","https://openalex.org/W2805666330","https://openalex.org/W2806653131","https://openalex.org/W2808052176","https://openalex.org/W2808064981","https://openalex.org/W2809531722","https://openalex.org/W2885464284","https://openalex.org/W2890787322","https://openalex.org/W2891507872","https://openalex.org/W2896599515","https://openalex.org/W2897831960","https://openalex.org/W2900065218","https://openalex.org/W2902240538","https://openalex.org/W2905434803","https://openalex.org/W2905889206","https://openalex.org/W2907722125","https://openalex.org/W2908602993","https://openalex.org/W2911804184","https://openalex.org/W2913359783","https://openalex.org/W2914762802","https://openalex.org/W2937641092","https://openalex.org/W2949742218","https://openalex.org/W2949872302","https://openalex.org/W2955642130","https://openalex.org/W2959393635","https://openalex.org/W2962379471","https://openalex.org/W2969993267","https://openalex.org/W2970568117","https://openalex.org/W2975961891","https://openalex.org/W2981346196","https://openalex.org/W2984009413","https://openalex.org/W2984258847","https://openalex.org/W2987816919","https://openalex.org/W2990432234","https://openalex.org/W2991356149","https://openalex.org/W2995122020","https://openalex.org/W2995306986","https://openalex.org/W2997339811","https://openalex.org/W2998671326","https://openalex.org/W3003285681","https://openalex.org/W3003389941","https://openalex.org/W3004643344","https://openalex.org/W3004885588","https://openalex.org/W3006514131","https://openalex.org/W3007934773","https://openalex.org/W3008861510","https://openalex.org/W3009405648","https://openalex.org/W3010752005","https://openalex.org/W3012786050","https://openalex.org/W3014331824","https://openalex.org/W3024871561","https://openalex.org/W3033767525","https://openalex.org/W3034151544","https://openalex.org/W3037639207","https://openalex.org/W3039418548","https://openalex.org/W3045210430","https://openalex.org/W3045567013","https://openalex.org/W3077433246","https://openalex.org/W3080226930","https://openalex.org/W3080354946","https://openalex.org/W3081661825","https://openalex.org/W3082449889","https://openalex.org/W3087102910","https://openalex.org/W3092175833","https://openalex.org/W3093275616","https://openalex.org/W3094159919","https://openalex.org/W3106096596","https://openalex.org/W3112700691","https://openalex.org/W3115647236","https://openalex.org/W3117753461","https://openalex.org/W3145351529","https://openalex.org/W4211020962","https://openalex.org/W4240259803","https://openalex.org/W6607990297","https://openalex.org/W6627139435","https://openalex.org/W6675598620","https://openalex.org/W6678999628","https://openalex.org/W6732740577","https://openalex.org/W6736194429","https://openalex.org/W6781282697","https://openalex.org/W6784320728"],"related_works":["https://openalex.org/W3135244093","https://openalex.org/W1576158588","https://openalex.org/W3190512093","https://openalex.org/W2067554653","https://openalex.org/W1991883753","https://openalex.org/W2117957387","https://openalex.org/W2560241007","https://openalex.org/W3173766535","https://openalex.org/W2263018236","https://openalex.org/W2034970911"],"abstract_inverted_index":{"Age-related":[0],"macular":[1],"degeneration":[2],"(AMD)":[3],"is":[4,20,103],"the":[5,12,15,24,32,43,64,89,110,114,172,187,198,226],"main":[6,33],"cause":[7],"of":[8,31,67,91,107,113,182,190,203,228],"vision":[9],"loss":[10],"among":[11],"elderly":[13],"in":[14,58,63,79,117,142,145,171,193,218,225,233],"Western":[16],"world.":[17],"While":[18],"AMD":[19,47,68,92,118,163,194],"a":[21,105],"multifactorial":[22],"disease,":[23],"complement":[25,44,56,71,115,140,191],"system":[26,45,116],"was":[27,48],"identified":[28],"as":[29],"one":[30],"pathways":[34],"contributing":[35],"to":[36,97,122,138,161,185],"disease":[37,133,164],"risk.":[38],"The":[39],"strong":[40],"link":[41],"between":[42],"and":[46,53,62,75,120,132,144,147,155,166,201,206,222],"demonstrated":[49],"by":[50,54],"genetic":[51],"associations,":[52],"elevated":[55],"activation":[57,141,192],"local":[59],"eye":[60],"tissue":[61],"systemic":[65],"circulation":[66],"patients.":[69],"Several":[70],"inhibitors":[72],"have":[73,135],"been":[74,136],"are":[76],"being":[77],"explored":[78],"clinical":[80,126],"trials,":[81],"but":[82],"thus":[83],"far":[84],"with":[85,208],"limited":[86],"success,":[87],"leaving":[88],"majority":[90],"patients":[93],"without":[94],"treatment":[95],"options":[96],"date.":[98],"This":[99],"indicates":[100],"that":[101],"there":[102],"still":[104],"gap":[106],"knowledge":[108,220],"regarding":[109],"functional":[111],"implications":[112],"pathogenesis":[119],"how":[121,212],"bring":[123],"these":[124],"towards":[125],"translation.":[127],"Many":[128],"different":[129],"experimental":[130],"set-ups":[131],"models":[134],"used":[137],"study":[139,162],"vivo":[143],"vitro,":[146],"recently":[148],"emerging":[149],"patient-derived":[150],"induced":[151],"pluripotent":[152],"stem":[153],"cells":[154],"genome-editing":[156],"techniques":[157],"open":[158],"new":[159,168],"opportunities":[160],"mechanisms":[165],"test":[167],"therapeutic":[169,231],"strategies":[170,232],"future.":[173],"In":[174],"this":[175],"review":[176],"we":[177],"provide":[178],"an":[179,209],"extensive":[180],"overview":[181],"methods":[183],"employed":[184],"understand":[186],"molecular":[188],"processes":[189],"pathogenesis.":[195],"We":[196],"discuss":[197],"findings,":[199],"advantages":[200],"challenges":[202],"each":[204],"approach":[205],"conclude":[207],"outlook":[210],"on":[211],"recent,":[213],"exciting":[214],"developments":[215],"can":[216,223],"fill":[217],"current":[219],"gaps":[221],"aid":[224],"development":[227],"effective":[229],"complement-targeting":[230],"AMD.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-01T00:00:00"}
