{"id":"https://openalex.org/W3130861925","doi":"https://doi.org/10.1182/bloodadvances.2021005271","title":"Alimam S, Villiers W, Dillon R, et al. Patients with triple-negative, JAK2 V617F- and CALR -mutated essential thrombocythemia share a unique gene expression signature. Blood Adv. 2021;5(4):1059-1068.","display_name":"Alimam S, Villiers W, Dillon R, et al. Patients with triple-negative, JAK2 V617F- and CALR -mutated essential thrombocythemia share a unique gene expression signature. Blood Adv. 2021;5(4):1059-1068.","publication_year":2021,"publication_date":"2021-02-18","ids":{"openalex":"https://openalex.org/W3130861925","doi":"https://doi.org/10.1182/bloodadvances.2021005271","mag":"3130861925","pmid":"https://pubmed.ncbi.nlm.nih.gov/33599741","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7903233"},"language":"en","primary_location":{"id":"doi:10.1182/bloodadvances.2021005271","doi":"https://doi.org/10.1182/bloodadvances.2021005271","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2021005271","pdf_url":"https://ashpublications.org/bloodadvances/article-pdf/5/12/2575/1810333/advancesadv2021005271.pdf","source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ashpublications.org/bloodadvances/article-pdf/5/12/2575/1810333/advancesadv2021005271.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009622798","display_name":"Samah Alimam","orcid":"https://orcid.org/0000-0003-4784-7324","observed_orcids":["https://orcid.org/0000-0003-4784-7324","https://orcid.org/0009-0005-6894-5080"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Samah Alimam","raw_affiliation_strings":["Department of Haematology, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom;","Department of Medical and Molecular Genetics, King\u2019s College London, London, United Kingdom;"],"raw_orcid":"https://orcid.org/0000-0003-4784-7324","affiliations":[{"raw_affiliation_string":"Department of Haematology, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom;","institution_ids":["https://openalex.org/I200166805"]},{"raw_affiliation_string":"Department of Medical and Molecular Genetics, King\u2019s College London, London, United Kingdom;","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013992463","display_name":"William Villiers","orcid":"https://orcid.org/0000-0003-3669-5791","observed_orcids":["https://orcid.org/0000-0003-3669-5791"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"William Villiers","raw_affiliation_strings":["Department of Medical and Molecular Genetics, King\u2019s College London, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Molecular Genetics, King\u2019s College London, London, United Kingdom;","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000220772","display_name":"Richard James Dillon","orcid":"https://orcid.org/0000-0001-9333-5296","observed_orcids":["https://orcid.org/0000-0001-9333-5296"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Dillon","raw_affiliation_strings":["Department of Haematology, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom;","Department of Medical and Molecular Genetics, King\u2019s College London, London, United Kingdom;"],"raw_orcid":"https://orcid.org/0000-0001-9333-5296","affiliations":[{"raw_affiliation_string":"Department of Haematology, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom;","institution_ids":["https://openalex.org/I200166805"]},{"raw_affiliation_string":"Department of Medical and Molecular Genetics, King\u2019s College London, London, United Kingdom;","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035107707","display_name":"Michael A. Simpson","orcid":"https://orcid.org/0000-0002-8539-8753","observed_orcids":["https://orcid.org/0000-0002-8539-8753"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Simpson","raw_affiliation_strings":["Department of Medical and Molecular Genetics, King\u2019s College London, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Molecular Genetics, King\u2019s College London, London, United Kingdom;","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032572078","display_name":"Manohursingh Runglall","orcid":"https://orcid.org/0000-0002-0549-9029","observed_orcids":["https://orcid.org/0000-0002-0549-9029"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]},{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Manohursingh Runglall","raw_affiliation_strings":["NIHR Comprehensive Biomedical Research Centre at Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust in partnership with King\u2019s College London and King\u2019s College Hospital, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIHR Comprehensive Biomedical Research Centre at Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust in partnership with King\u2019s College London and King\u2019s College Hospital, London, United Kingdom;","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753","https://openalex.org/I200166805","https://openalex.org/I4210153400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083467513","display_name":"Alexander Smith","orcid":"https://orcid.org/0000-0001-6924-2014","observed_orcids":["https://orcid.org/0000-0001-6924-2014"]},"institutions":[{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexander Smith","raw_affiliation_strings":["Department of Haematology, King\u2019s College NHS Trust, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, King\u2019s College NHS Trust, London, United Kingdom;","institution_ids":["https://openalex.org/I4210153400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090549418","display_name":"Prodromos Chatzikyriakou","orcid":"https://orcid.org/0000-0002-0048-4100","observed_orcids":["https://orcid.org/0000-0002-0048-4100"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Prodromos Chatzikyriakou","raw_affiliation_strings":["Genetics and Molecular Medicine Research Division, King\u2019s College London, London, United Kingdom;"],"raw_orcid":"https://orcid.org/0000-0002-0048-4100","affiliations":[{"raw_affiliation_string":"Genetics and Molecular Medicine Research Division, King\u2019s College London, London, United Kingdom;","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051662657","display_name":"Paul Lavender","orcid":"https://orcid.org/0000-0001-8710-0263","observed_orcids":["https://orcid.org/0000-0001-8710-0263"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210141571","display_name":"Asthma UK","ror":"https://ror.org/03z7xev21","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801572420","https://openalex.org/I4210141571"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Lavender","raw_affiliation_strings":["School of Immunology & Microbial Sciences, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King\u2019s College London, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Immunology & Microbial Sciences, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King\u2019s College London, London, United Kingdom;","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I4210141571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043335755","display_name":"Anju Kanda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anju Kanda","raw_affiliation_strings":["Department of Medical and Molecular Genetics, King\u2019s College London, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Molecular Genetics, King\u2019s College London, London, United Kingdom;","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075911816","display_name":"Ken Mills","orcid":"https://orcid.org/0000-0002-6362-4481","observed_orcids":["https://orcid.org/0000-0002-6362-4481"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ken Mills","raw_affiliation_strings":["Centre for Cancer Research and Cell Biology, Queen\u2019s University, Belfast, United Kingdom;"],"raw_orcid":"https://orcid.org/0000-0002-6362-4481","affiliations":[{"raw_affiliation_string":"Centre for Cancer Research and Cell Biology, Queen\u2019s University, Belfast, United Kingdom;","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064267997","display_name":"Beatr\u00edz Bellosillo","orcid":"https://orcid.org/0000-0002-5335-2726","observed_orcids":["https://orcid.org/0000-0002-5335-2726"]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Beatriz Bellosillo Paricio","raw_affiliation_strings":["Laboratori de Diagn\u00f2stic Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain; and"],"raw_orcid":"https://orcid.org/0000-0002-5335-2726","affiliations":[{"raw_affiliation_string":"Laboratori de Diagn\u00f2stic Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain; and","institution_ids":["https://openalex.org/I4210130874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046268410","display_name":"James Kaufman-Cook","orcid":"https://orcid.org/0009-0005-1162-8316","observed_orcids":["https://orcid.org/0009-0005-1162-8316"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Kaufman-Cook","raw_affiliation_strings":["Department of Medical and Molecular Genetics, King\u2019s College London, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Molecular Genetics, King\u2019s College London, London, United Kingdom;","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075232035","display_name":"Sophie Ord","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sophie Ord","raw_affiliation_strings":["Department of Medical and Molecular Genetics, King\u2019s College London, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Molecular Genetics, King\u2019s College London, London, United Kingdom;","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048532379","display_name":"Shahram Y. Kordasti","orcid":"https://orcid.org/0000-0002-0347-4207","observed_orcids":["https://orcid.org/0000-0002-0347-4207"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shahram Kordasti","raw_affiliation_strings":["Department of Haematology, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom;","Systems Cancer Immunology, Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King\u2019s College London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-0347-4207","affiliations":[{"raw_affiliation_string":"Department of Haematology, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom;","institution_ids":["https://openalex.org/I200166805"]},{"raw_affiliation_string":"Systems Cancer Immunology, Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King\u2019s College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028061272","display_name":"Deepti H. Radia","orcid":"https://orcid.org/0000-0002-3578-0102","observed_orcids":["https://orcid.org/0000-0002-3578-0102"]},"institutions":[{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Deepti Radia","raw_affiliation_strings":["Department of Haematology, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom;","institution_ids":["https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083751425","display_name":"Claire Woodley","orcid":"https://orcid.org/0009-0006-2469-9735","observed_orcids":["https://orcid.org/0009-0006-2469-9735"]},"institutions":[{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claire Woodley","raw_affiliation_strings":["Department of Haematology, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom;","institution_ids":["https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yvonne Francis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yvonne Francis","raw_affiliation_strings":["Department of Haematology, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom;","institution_ids":["https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112225731","display_name":"Ghulam Jeelani Mufti","orcid":"https://orcid.org/0009-0004-7335-9230","observed_orcids":["https://orcid.org/0009-0004-7335-9230"]},"institutions":[{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ghulam Mufti","raw_affiliation_strings":["Department of Haematology, King\u2019s College NHS Trust, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, King\u2019s College NHS Trust, London, United Kingdom;","institution_ids":["https://openalex.org/I4210153400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017537622","display_name":"Donal P. McLornan","orcid":"https://orcid.org/0000-0003-1224-091X","observed_orcids":["https://orcid.org/0000-0003-1224-091X"]},"institutions":[{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Donal P. McLornan","raw_affiliation_strings":["Department of Haematology, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom;","institution_ids":["https://openalex.org/I200166805"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046827092","display_name":"Claire N. Harrison","orcid":"https://orcid.org/0000-0002-3212-920X","observed_orcids":["https://orcid.org/0000-0002-3212-920X"]},"institutions":[{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Claire N. Harrison","raw_affiliation_strings":["Department of Haematology, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom;","institution_ids":["https://openalex.org/I200166805"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5009622798","https://openalex.org/A5013992463","https://openalex.org/A5017537622","https://openalex.org/A5046827092"],"corresponding_institution_ids":["https://openalex.org/I183935753","https://openalex.org/I200166805"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":{"value":3800,"currency":"USD","value_usd":3800},"fwci":3.7239,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.94300366,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"5","issue":"12","first_page":"1059","last_page":"1068"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/essential-thrombocythemia","display_name":"essential thrombocythemia","score":0.996999979019165},{"id":"https://openalex.org/keywords/jak2-v617f-mutation","display_name":"JAK2 V617F mutation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/calr-mutation","display_name":"CALR mutation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mpl-mutation","display_name":"MPL mutation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.8130000233650208},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.9480000138282776},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/promoter-hypomethylation","display_name":"promoter hypomethylation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.753000020980835},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9779999852180481},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.7739999890327454},{"id":"https://openalex.org/keywords/transcriptional-dysregulation","display_name":"transcriptional dysregulation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/c-ebpbeta","display_name":"C/EBP\u03b2","score":0.7929999828338623},{"id":"https://openalex.org/keywords/itga2b","display_name":"ITGA2B","score":0.8640000224113464},{"id":"https://openalex.org/keywords/integrin-beta3","display_name":"CD61","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7239480018615723},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6250803470611572},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5895273685455322},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.5850914120674133},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5387374758720398},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5356881618499756},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5121417045593262},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5079625248908997},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.48984000086784363},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4470507800579071},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42080575227737427},{"id":"https://openalex.org/C2781057849","wikidata":"https://www.wikidata.org/wiki/Q1368780","display_name":"Essential thrombocythemia","level":3,"score":0.4168826639652252},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2178519070148468},{"id":"https://openalex.org/C2778837598","wikidata":"https://www.wikidata.org/wiki/Q948318","display_name":"Polycythemia vera","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013920","descriptor_name":"Thrombocythemia, Essential","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D037282","descriptor_name":"Calreticulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053628","descriptor_name":"Receptors, Thrombopoietin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1182/bloodadvances.2021005271","doi":"https://doi.org/10.1182/bloodadvances.2021005271","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2021005271","pdf_url":"https://ashpublications.org/bloodadvances/article-pdf/5/12/2575/1810333/advancesadv2021005271.pdf","source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},{"id":"doi:10.1182/bloodadvances.2020003172","doi":"https://doi.org/10.1182/bloodadvances.2020003172","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2020003172","pdf_url":"https://ashpublications.org/bloodadvances/article-pdf/5/4/1059/1800642/advancesadv2020003172.pdf","source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},{"id":"pmid:33599741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33599741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood advances","raw_type":"Journal Article"},{"id":"pmid:34137812","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34137812","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood advances","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7903233","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7903233/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Adv","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8267109","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8267109/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Adv","raw_type":"Text"},{"id":"pmh:oai:pure.qub.ac.uk/portal:openaire/92765c90-b4d8-4543-abaf-cf4d2f5fcfeb","doi":null,"is_oa":true,"landing_page_url":"https://pure.qub.ac.uk/en/publications/92765c90-b4d8-4543-abaf-cf4d2f5fcfeb","pdf_url":"https://pureadmin.qub.ac.uk/ws/files/231732480/patients.pdf","source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alimam, S, Villiers, W, Dillon, R, Simpson, M, Runglall, M, Smith, A, Chatzikyriakou, P, Lavender, P, Kanda, A, Mills, K, Bellosillo Paricio, B, Kaufman-Cook, J, Ord, S, Kordasti, S, Radia, D, Woodley, C, Francis, Y, Mufti, G, McLornan, D P & Harrison, C N 2021, 'Patients with triple-negative, JAK2V617F- and CALR-mutated essential thrombocythemia share a unique gene expression signature', Blood Advances, vol. 5, no. 4, pp. 1059-1068. https://doi.org/10.1182/bloodadvances.2020003172","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.univpm.it:11566/290415","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11566/290415","pdf_url":null,"source":{"id":"https://openalex.org/S4306402571","display_name":"Universit\u00e0 Politecnica delle Marche (Universit\u00e0 Politecnica delle Marche)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122534668","host_organization_name":"Marche Polytechnic University","host_organization_lineage":["https://openalex.org/I122534668"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1182/bloodadvances.2021005271","doi":"https://doi.org/10.1182/bloodadvances.2021005271","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2021005271","pdf_url":"https://ashpublications.org/bloodadvances/article-pdf/5/12/2575/1810333/advancesadv2021005271.pdf","source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G8229882807","display_name":null,"funder_award_id":"15-194","funder_id":"https://openalex.org/F4320320631","funder_display_name":"CHILDREN with CANCER UK"}],"funders":[{"id":"https://openalex.org/F4320320631","display_name":"CHILDREN with CANCER UK","ror":"https://ror.org/04bac6g30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3130861925.pdf","grobid_xml":"https://content.openalex.org/works/W3130861925.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1534551308","https://openalex.org/W1884746267","https://openalex.org/W1992609545","https://openalex.org/W2000604849","https://openalex.org/W2020874635","https://openalex.org/W2022610928","https://openalex.org/W2036862498","https://openalex.org/W2043001779","https://openalex.org/W2055986128","https://openalex.org/W2079681891","https://openalex.org/W2088633231","https://openalex.org/W2099269314","https://openalex.org/W2108771181","https://openalex.org/W2111372406","https://openalex.org/W2112242000","https://openalex.org/W2146512944","https://openalex.org/W2169046713","https://openalex.org/W2176681260","https://openalex.org/W2177570048","https://openalex.org/W2191516082","https://openalex.org/W2198107883","https://openalex.org/W2527628624","https://openalex.org/W2550120426","https://openalex.org/W2557353343","https://openalex.org/W2585581352","https://openalex.org/W2732761160","https://openalex.org/W2735075411","https://openalex.org/W2762250529","https://openalex.org/W2773899764","https://openalex.org/W2887200576","https://openalex.org/W2921486313","https://openalex.org/W2943979348","https://openalex.org/W2965373265","https://openalex.org/W4231870220","https://openalex.org/W7098958697","https://openalex.org/W7213177213"],"related_works":["https://openalex.org/W2991273843","https://openalex.org/W3096827862","https://openalex.org/W4321500314","https://openalex.org/W7124172907","https://openalex.org/W6991393857","https://openalex.org/W3024094777","https://openalex.org/W2187320767","https://openalex.org/W2611275719","https://openalex.org/W3096819035","https://openalex.org/W7145124012"],"abstract_inverted_index":{"Approximately":[0],"10%":[1],"to":[2,24,42,201],"15%":[3],"of":[4,55,74,90,120,139,156,163,169,181,193,225,256],"patients":[5,37,76,118,177,205],"with":[6,44,88,149,178,206,246],"essential":[7],"thrombocythemia":[8],"(ET)":[9],"lack":[10],"the":[11,40,61,129,214,238],"common":[12],"driver":[13,46,208],"mutations,":[14],"so-called":[15],"\"triple-negative\"":[16],"(TN)":[17],"disease.":[18],"We":[19],"undertook":[20],"a":[21,153],"systematic":[22],"approach":[23],"investigate":[25],"for":[26,126],"somatic":[27],"mutations":[28,47,79],"and":[29,38,48,64,98,116,134,137,146,186,196,223,233,243],"delineate":[30],"gene":[31,160,194],"expression":[32,195],"signatures":[33],"in":[34,128,176,203,221],"46":[35,75],"TN":[36,190],"compared":[39],"results":[41],"those":[43,202],"known":[45,207],"healthy":[49,114],"volunteers.":[50],"Deep,":[51],"error-corrected,":[52],"next-generation":[53],"sequencing":[54,66],"peripheral":[56,107],"blood":[57,108],"mononuclear":[58,109],"cells":[59],"using":[60,106],"HaloPlexHS":[62],"platform":[63],"whole-exome":[65],"was":[67],"performed.":[68],"Using":[69],"this":[70],"platform,":[71],"10":[72,91],"(22%)":[73],"had":[77],"detectable":[78],"(MPL,":[80],"n":[81,85],"=":[82,86],"6;":[83],"JAK2V617F,":[84],"4)":[87],"3":[89],"cases":[92],"harboring":[93],"germline":[94],"MPL":[95],"mutations.":[96,209],"RNA-sequencing":[97],"DNA":[99,150,197],"methylation":[100,151,198],"analysis":[101,112],"were":[102,173,199],"also":[103],"performed":[104],"by":[105,230],"cells.":[110],"Pathway":[111],"comparing":[113],"volunteers":[115],"ET":[117,179,204,216],"(regardless":[119],"mutational":[121],"status)":[122],"identified":[123],"significant":[124],"enrichment":[125,168],"genes":[127],"tumor":[130,240],"necrosis":[131,241],"factor,":[132,242],"NF\u03baB,":[133],"MAPK":[135],"pathways":[136,245],"upregulation":[138],"platelet":[140],"proliferative":[141],"drivers":[142],"such":[143],"as":[144],"ITGA2B":[145],"ITGB3.":[147],"Correlation":[148],"showed":[152],"consistent":[154],"pattern":[155],"hypomethylation":[157],"at":[158,219],"upregulated":[159,175],"promoters.":[161],"Interrogation":[162],"these":[164],"promoter":[165],"regions":[166],"highlighted":[167],"transcriptional":[170,231],"regulators,":[171],"which":[172],"significantly":[174],"regardless":[180,224],"mutation":[182,226],"status,":[183],"including":[184],"CEBP\u03b2":[185],"NF\u03baB.":[187],"For":[188],"\"true\"":[189],"ET,":[191],"patterns":[192],"similar":[200],"These":[210,250],"observations":[211],"suggest":[212],"that":[213,259],"resultant":[215,247],"phenotype":[217],"may,":[218],"least":[220],"part":[222],"type,":[227],"be":[228],"driven":[229],"misregulation":[232],"may":[234],"propagate":[235],"downstream":[236],"via":[237],"MAPK,":[239],"NF\u03baB":[244],"JAK-STAT":[248],"activation.":[249],"findings":[251],"identify":[252],"potential":[253],"novel":[254],"mechanisms":[255],"disease":[257],"initiation":[258],"require":[260],"further":[261],"evaluation.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":15}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-01T00:00:00"}