{"id":"https://openalex.org/W3130644243","doi":"https://doi.org/10.1016/j.ctarc.2021.100340","title":"NVP-BEZ235 or JAKi Treatment leads to decreased survival of examined GBM and BBC cells","display_name":"NVP-BEZ235 or JAKi Treatment leads to decreased survival of examined GBM and BBC cells","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3130644243","doi":"https://doi.org/10.1016/j.ctarc.2021.100340","mag":"3130644243","pmid":"https://pubmed.ncbi.nlm.nih.gov/33636591","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8787714"},"language":"en","primary_location":{"id":"doi:10.1016/j.ctarc.2021.100340","doi":"https://doi.org/10.1016/j.ctarc.2021.100340","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctarc.2021.100340","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2468294221000393/pdf","source":{"id":"https://openalex.org/S4210186504","display_name":"Cancer Treatment and Research Communications","issn_l":"2468-2942","issn":["2468-2942"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment and Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2468294221000393/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020630255","display_name":"Neftal\u00ed V\u00e1zquez","orcid":"https://orcid.org/0000-0002-1836-8116","observed_orcids":["https://orcid.org/0000-0002-1836-8116"]},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neftali Vazquez","raw_affiliation_strings":["Department of Biology, University of Texas- Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Texas- Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, United States","institution_ids":["https://openalex.org/I2802326326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102833328","display_name":"Alma Lopez","orcid":"https://orcid.org/0000-0003-3621-7300","observed_orcids":["https://orcid.org/0000-0003-3621-7300"]},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alma Lopez","raw_affiliation_strings":["Department of Biology, University of Texas- Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Texas- Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, United States","institution_ids":["https://openalex.org/I2802326326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029813763","display_name":"Victoria Cuello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria Cuello","raw_affiliation_strings":["Department of Biology, University of Texas- Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Texas- Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, United States","institution_ids":["https://openalex.org/I2802326326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028342420","display_name":"Michael W. Persans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Persans","raw_affiliation_strings":["Department of Biology, University of Texas- Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Texas- Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, United States","institution_ids":["https://openalex.org/I2802326326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003588775","display_name":"Erin L. Schuenzel","orcid":"https://orcid.org/0009-0003-6717-1437","observed_orcids":["https://orcid.org/0009-0003-6717-1437"]},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin Schuenzel","raw_affiliation_strings":["Department of Biology, University of Texas- Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Texas- Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, United States","institution_ids":["https://openalex.org/I2802326326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090964018","display_name":"Wendy Innis\u2010Whitehouse","orcid":"https://orcid.org/0000-0001-9379-3350","observed_orcids":["https://orcid.org/0000-0001-9379-3350"]},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy Innis-Whitehouse","raw_affiliation_strings":["School of Medicine, University of Texas- Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, University of Texas- Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, United States","institution_ids":["https://openalex.org/I2802326326"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028116124","display_name":"Megan E. Keniry","orcid":"https://orcid.org/0000-0002-4952-3545","observed_orcids":["https://orcid.org/0000-0002-4952-3545"]},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Megan Keniry","raw_affiliation_strings":["Department of Biology, University of Texas- Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, United States. Electronic address: megan.keniry@utrgv.edu","Department of Biology, University of Texas- Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Texas- Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, United States. Electronic address: megan.keniry@utrgv.edu","institution_ids":["https://openalex.org/I2802326326"]},{"raw_affiliation_string":"Department of Biology, University of Texas- Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, United States","institution_ids":["https://openalex.org/I2802326326"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028116124"],"corresponding_institution_ids":["https://openalex.org/I2802326326"],"apc_list":{"value":1650,"currency":"USD","value_usd":1650},"apc_paid":{"value":1650,"currency":"USD","value_usd":1650},"fwci":0.1569,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.36208244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"27","issue":null,"first_page":"100340","last_page":"100340"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nvp-bez235","display_name":"NVP-BEZ235","score":0.9850000143051147},{"id":"https://openalex.org/keywords/jak-inhibitors","display_name":"JAK inhibitors","score":0.7509999871253967},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9190000295639038},{"id":"https://openalex.org/keywords/basal-like-breast-cancer","display_name":"basal-like breast cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.7770000100135803},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7039999961853027},{"id":"https://openalex.org/keywords/mtor-inhibition","display_name":"mTOR inhibition","score":0.699999988079071},{"id":"https://openalex.org/keywords/feedback-mechanisms","display_name":"feedback mechanisms","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.735700249671936},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5157085061073303},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5116598606109619},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4694846272468567},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.40700146555900574},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2203940749168396},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15773054957389832}],"mesh":[{"descriptor_ui":"D000075242","descriptor_name":"Janus Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000075242","descriptor_name":"Janus Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000081082","descriptor_name":"Phosphoinositide-3 Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000081082","descriptor_name":"Phosphoinositide-3 Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.ctarc.2021.100340","doi":"https://doi.org/10.1016/j.ctarc.2021.100340","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctarc.2021.100340","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2468294221000393/pdf","source":{"id":"https://openalex.org/S4210186504","display_name":"Cancer Treatment and Research Communications","issn_l":"2468-2942","issn":["2468-2942"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment and Research Communications","raw_type":"journal-article"},{"id":"pmid:33636591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33636591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer treatment and research communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8787714","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8787714","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Treat Res Commun","raw_type":"Text"},{"id":"pmh:oai:scholarworks.utrgv.edu:bio_fac-1115","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.utrgv.edu/bio_fac/116","pdf_url":null,"source":{"id":"https://openalex.org/S4306402611","display_name":"ScholarWorks @ UTRGV (The University of Texas Rio Grande Valley)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802326326","host_organization_name":"The University of Texas Rio Grande Valley","host_organization_lineage":["https://openalex.org/I2802326326"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:a9ca0027ddce40e5a2adc7149a3b5848","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a9ca0027ddce40e5a2adc7149a3b5848","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Treatment and Research Communications, Vol 27, Iss , Pp 100340- (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ctarc.2021.100340","doi":"https://doi.org/10.1016/j.ctarc.2021.100340","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctarc.2021.100340","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2468294221000393/pdf","source":{"id":"https://openalex.org/S4210186504","display_name":"Cancer Treatment and Research Communications","issn_l":"2468-2942","issn":["2468-2942"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment and Research Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2149066097","display_name":null,"funder_award_id":"#52007568","funder_id":"https://openalex.org/F4320306082","funder_display_name":"Howard Hughes Medical Institute"},{"id":"https://openalex.org/G2488114176","display_name":null,"funder_award_id":"52007568","funder_id":"https://openalex.org/F4320314778","funder_display_name":"University of Texas Rio Grande Valley"},{"id":"https://openalex.org/G3171062250","display_name":null,"funder_award_id":"2016\u201038422\u201025760","funder_id":"https://openalex.org/F4320306114","funder_display_name":"U.S. Department of Agriculture"},{"id":"https://openalex.org/G3483776055","display_name":null,"funder_award_id":"HHMI 52007568","funder_id":"https://openalex.org/F4320306082","funder_display_name":"Howard Hughes Medical Institute"},{"id":"https://openalex.org/G4745240438","display_name":"Investigating the Roles and Regulation of FOXO Transcription Factors in GBM and basal breast cancer","funder_award_id":"SC3GM132053","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7059879352","display_name":null,"funder_award_id":"2015-38422-24061","funder_id":"https://openalex.org/F4320306114","funder_display_name":"U.S. Department of Agriculture"},{"id":"https://openalex.org/G7977298722","display_name":null,"funder_award_id":"52007568","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8975319328","display_name":"Expanding the Network of STEM Scholars through the ADVANCE Women of Color Summer Writing Retreat","funder_award_id":"1463991","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320307381","display_name":"National Sleep Foundation","ror":"https://ror.org/00zc1hf95"},{"id":"https://openalex.org/F4320314778","display_name":"University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332299","display_name":"National Institute of Food and Agriculture","ror":"https://ror.org/05qx3fv49"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3130644243.pdf","grobid_xml":"https://content.openalex.org/works/W3130644243.grobid-xml"},"referenced_works_count":108,"referenced_works":["https://openalex.org/W73498319","https://openalex.org/W1677659983","https://openalex.org/W1921975008","https://openalex.org/W1964184380","https://openalex.org/W1965758447","https://openalex.org/W1967114760","https://openalex.org/W1971006342","https://openalex.org/W1977659356","https://openalex.org/W1982174937","https://openalex.org/W1986896225","https://openalex.org/W1988568845","https://openalex.org/W1999268473","https://openalex.org/W1999463736","https://openalex.org/W2000042618","https://openalex.org/W2001604240","https://openalex.org/W2006964040","https://openalex.org/W2007341636","https://openalex.org/W2007501395","https://openalex.org/W2011717936","https://openalex.org/W2020007184","https://openalex.org/W2020891498","https://openalex.org/W2025616449","https://openalex.org/W2025915231","https://openalex.org/W2035508274","https://openalex.org/W2039986464","https://openalex.org/W2051766943","https://openalex.org/W2057559260","https://openalex.org/W2058426917","https://openalex.org/W2058675403","https://openalex.org/W2059144308","https://openalex.org/W2061423409","https://openalex.org/W2068427129","https://openalex.org/W2072697288","https://openalex.org/W2073759231","https://openalex.org/W2077223675","https://openalex.org/W2088122871","https://openalex.org/W2101197781","https://openalex.org/W2107277218","https://openalex.org/W2109726534","https://openalex.org/W2110681969","https://openalex.org/W2110966639","https://openalex.org/W2111888363","https://openalex.org/W2112547623","https://openalex.org/W2114414564","https://openalex.org/W2116504531","https://openalex.org/W2117082710","https://openalex.org/W2117263216","https://openalex.org/W2121625674","https://openalex.org/W2124556650","https://openalex.org/W2129763580","https://openalex.org/W2134604851","https://openalex.org/W2135721953","https://openalex.org/W2137035181","https://openalex.org/W2144687234","https://openalex.org/W2146414563","https://openalex.org/W2148856565","https://openalex.org/W2153086428","https://openalex.org/W2153283369","https://openalex.org/W2157461143","https://openalex.org/W2158305336","https://openalex.org/W2161770015","https://openalex.org/W2161810908","https://openalex.org/W2164762451","https://openalex.org/W2166476411","https://openalex.org/W2171095731","https://openalex.org/W2171564712","https://openalex.org/W2174136167","https://openalex.org/W2188538530","https://openalex.org/W2192708678","https://openalex.org/W2291373549","https://openalex.org/W2296095373","https://openalex.org/W2329768139","https://openalex.org/W2346949885","https://openalex.org/W2480418441","https://openalex.org/W2534055440","https://openalex.org/W2589625942","https://openalex.org/W2607477467","https://openalex.org/W2618818202","https://openalex.org/W2744377419","https://openalex.org/W2758830389","https://openalex.org/W2769045462","https://openalex.org/W2772747905","https://openalex.org/W2773646177","https://openalex.org/W2779276028","https://openalex.org/W2789893184","https://openalex.org/W2796576424","https://openalex.org/W2801576688","https://openalex.org/W2802308079","https://openalex.org/W2898789672","https://openalex.org/W2900808021","https://openalex.org/W2946769836","https://openalex.org/W2948867777","https://openalex.org/W2954246766","https://openalex.org/W2979559982","https://openalex.org/W2980252599","https://openalex.org/W2991986724","https://openalex.org/W3004670915","https://openalex.org/W3004733773","https://openalex.org/W3004924135","https://openalex.org/W3018805559","https://openalex.org/W3022390467","https://openalex.org/W3029773958","https://openalex.org/W3082585563","https://openalex.org/W3086332450","https://openalex.org/W3089964895","https://openalex.org/W3092014157","https://openalex.org/W4384831627","https://openalex.org/W6769454163"],"related_works":["https://openalex.org/W7047646765","https://openalex.org/W2582039583","https://openalex.org/W1487439618","https://openalex.org/W2979818067","https://openalex.org/W2367511620","https://openalex.org/W3004670915","https://openalex.org/W2125406050","https://openalex.org/W4388107126","https://openalex.org/W2164180823","https://openalex.org/W1581950988"],"abstract_inverted_index":{"Cancer":[0],"cells":[1,114],"almost":[2],"universally":[3],"harbor":[4],"constitutively":[5],"active":[6],"Phosphatidylinositol-3":[7],"Kinase":[8,93],"(PI3K)":[9],"Pathway":[10,24,42,68,80],"activity":[11],"via":[12],"mutation":[13],"of":[14,22,66,128,172],"key":[15],"signaling":[16],"components":[17],"and/or":[18,118],"epigenetic":[19],"mechanisms.":[20],"Scores":[21],"PI3K":[23,41,67,79,84],"inhibitors":[25],"are":[26],"currently":[27],"under":[28],"investigation":[29],"as":[30],"putative":[31],"chemotherapeutics.":[32],"However,":[33],"feedback":[34],"and":[35,85,99,111,121,140,146,178],"stem":[36,60],"cell":[37,104],"mechanisms":[38],"induced":[39,149],"by":[40],"inhibition":[43,69],"can":[44],"lead":[45],"to":[46,72,134],"reduced":[47],"treatment":[48,74,130,136,159,175],"efficacy.":[49,75],"To":[50],"address":[51],"therapeutic":[52],"barriers,":[53],"we":[54],"examined":[55,107],"whether":[56],"JAKi":[57,95],"would":[58],"reduce":[59],"gene":[61,109,152],"expression":[62,139,153],"in":[63,70,88,96,113,156,162,176],"a":[64],"setting":[65],"order":[71],"improve":[73],"We":[76,106],"targeted":[77],"the":[78,91,170],"with":[81,90,116,131],"NVP-BEZ235":[82,117,135],"(dual":[83],"mTOR":[86],"inhibitor)":[87],"combination":[89],"Janus":[92],"inhibitor":[94],"glioblastoma":[97],"(GBM)":[98],"basal-like":[100],"breast":[101],"cancer":[102],"(BBC)":[103],"lines.":[105],"growth,":[108],"expression,":[110],"apoptosis":[112],"treated":[115],"JAKi.":[119],"Growth":[120],"recovery":[122],"assays":[123],"showed":[124],"no":[125],"significant":[126],"impact":[127,171],"dual":[129,147,157],"NVP-BEZ235/JAKi":[132,158,174],"compared":[133],"alone.":[137],"Gene":[138],"flow":[141],"cytometry":[142],"revealed":[143],"that":[144],"single":[145],"treatments":[148],"apoptosis.":[150],"Stem":[151],"was":[154],"retained":[155],"samples.":[160],"Future":[161],"vivo":[163],"studies":[164],"may":[165],"give":[166],"further":[167],"insight":[168],"into":[169],"combined":[173],"GBM":[177],"BBC.":[179]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-01T00:00:00"}