{"id":"https://openalex.org/W3130630232","doi":"https://doi.org/10.1093/ecco-jcc/jjab032","title":"Schlafen 11 Is a Novel Target for Mucosal Regeneration in Ulcerative Colitis","display_name":"Schlafen 11 Is a Novel Target for Mucosal Regeneration in Ulcerative Colitis","publication_year":2021,"publication_date":"2021-02-10","ids":{"openalex":"https://openalex.org/W3130630232","doi":"https://doi.org/10.1093/ecco-jcc/jjab032","mag":"3130630232","pmid":"https://pubmed.ncbi.nlm.nih.gov/33596306"},"language":"en","primary_location":{"id":"doi:10.1093/ecco-jcc/jjab032","doi":"https://doi.org/10.1093/ecco-jcc/jjab032","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ecco-jcc/jjab032","pdf_url":null,"source":{"id":"https://openalex.org/S2735960814","display_name":"Journal of Crohn s and Colitis","issn_l":"1873-9946","issn":["1873-9946","1876-4479"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Crohn's and Colitis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.teikyo.jp/en/publications/e3f94db8-6569-4d0c-ab84-c3c9e646147c","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011049221","display_name":"Sho Watanabe","orcid":"https://orcid.org/0000-0002-7489-5121","observed_orcids":["https://orcid.org/0000-0002-7489-5121"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sho Watanabe","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026658791","display_name":"Ryu Nishimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryu Nishimura","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110674","display_name":"Tomoaki Shirasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoaki Shirasaki","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073656029","display_name":"Nobuhiro Katsukura","orcid":"https://orcid.org/0000-0002-3047-0615","observed_orcids":["https://orcid.org/0000-0002-3047-0615"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuhiro Katsukura","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007838416","display_name":"Shuji Hibiya","orcid":"https://orcid.org/0000-0001-8823-7755","observed_orcids":["https://orcid.org/0000-0001-8823-7755"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuji Hibiya","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078761610","display_name":"Susumu Kirimura","orcid":"https://orcid.org/0009-0009-8449-2068","observed_orcids":["https://orcid.org/0009-0009-8449-2068"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Susumu Kirimura","raw_affiliation_strings":["Department of Comprehensive Pathology, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comprehensive Pathology, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011975737","display_name":"Mariko Negi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mariko Negi","raw_affiliation_strings":["Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076002314","display_name":"Ryuichi Okamoto","orcid":"https://orcid.org/0000-0002-7047-571X","observed_orcids":["https://orcid.org/0000-0002-7047-571X"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryuichi Okamoto","raw_affiliation_strings":["Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan","Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-7047-571X","affiliations":[{"raw_affiliation_string":"Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021685695","display_name":"Yuka Matsumoto","orcid":"https://orcid.org/0000-0001-7429-5487","observed_orcids":["https://orcid.org/0000-0001-7429-5487"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuka Matsumoto","raw_affiliation_strings":["Department of Research and Development for Organoids, Juntendo University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research and Development for Organoids, Juntendo University, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100780480","display_name":"Tetsuya Nakamura","orcid":"https://orcid.org/0000-0002-4244-9119","observed_orcids":["https://orcid.org/0000-0002-4244-9119"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuya Nakamura","raw_affiliation_strings":["Department of Research and Development for Organoids, Juntendo University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research and Development for Organoids, Juntendo University, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045376146","display_name":"Mamoru Watanabe","orcid":"https://orcid.org/0000-0002-5475-9544","observed_orcids":["https://orcid.org/0000-0002-5475-9544"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mamoru Watanabe","raw_affiliation_strings":["Advanced Research Institute, Tokyo Medical and Dental University [TMDU], Tokyo, Japan","Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Research Institute, Tokyo Medical and Dental University [TMDU], Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031307021","display_name":"Kiichiro Tsuchiya","orcid":"https://orcid.org/0000-0002-1977-8707","observed_orcids":["https://orcid.org/0000-0002-1977-8707"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kiichiro Tsuchiya","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031307021"],"corresponding_institution_ids":["https://openalex.org/I125602781"],"apc_list":{"value":3641,"currency":"EUR","value_usd":4202},"apc_paid":null,"fwci":2.6427,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.89910817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"15","issue":"9","first_page":"1558","last_page":"1572"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.94145667552948},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.8902506828308105},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5519579648971558},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.4070138931274414},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2529388666152954},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10487103462219238},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/ecco-jcc/jjab032","doi":"https://doi.org/10.1093/ecco-jcc/jjab032","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ecco-jcc/jjab032","pdf_url":null,"source":{"id":"https://openalex.org/S2735960814","display_name":"Journal of Crohn s and Colitis","issn_l":"1873-9946","issn":["1873-9946","1876-4479"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Crohn's and Colitis","raw_type":"journal-article"},{"id":"pmid:33596306","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33596306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Crohn's & colitis","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:00953:0006728416","doi":null,"is_oa":true,"landing_page_url":"https://pure.teikyo.jp/en/publications/e3f94db8-6569-4d0c-ab84-c3c9e646147c","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Crohn's and Colitis","raw_type":"journal article"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:00953:0006728416","doi":null,"is_oa":true,"landing_page_url":"https://pure.teikyo.jp/en/publications/e3f94db8-6569-4d0c-ab84-c3c9e646147c","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Crohn's and Colitis","raw_type":"journal article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1740762755","display_name":"Identification and functional analysis of colonic label-retaining goblet cells for the application to regeneration of the inflamed mucosa.","funder_award_id":"19H03634","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2830149659","display_name":null,"funder_award_id":"17H06654","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G2834523558","display_name":null,"funder_award_id":"19bm0304001h0007","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G325459376","display_name":"Elucidation of IBD pathology for histological remission","funder_award_id":"21H02898","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3833182398","display_name":null,"funder_award_id":"18H02791","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G3958466263","display_name":null,"funder_award_id":"17K19513","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G4254918922","display_name":null,"funder_award_id":"18bm03041h0006","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G4472258212","display_name":"Understanding the intestinal homeostasis from the perspective of ubiquitin modification","funder_award_id":"17H04024","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5795341113","display_name":"The development of the treatment for complete remission  of IBD using human in vivo model","funder_award_id":"20K22867","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8285098590","display_name":null,"funder_award_id":"19H01050","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G8358654815","display_name":"The regulation of the plasticity by long-term inflammation in intestinal stem cells","funder_award_id":"19K17425","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8478621220","display_name":null,"funder_award_id":"17K15930","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G8550752344","display_name":"Comprehensive analysis of protein ubiquitination during a development of infection-induced cancer.","funder_award_id":"17K19675","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8777427250","display_name":null,"funder_award_id":"19K17425","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G889328946","display_name":"The mechanism of malignant potential in digestive cancers based on intestinal metaplasia","funder_award_id":"18H02791","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8998674236","display_name":null,"funder_award_id":"18K19535","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W809574031","https://openalex.org/W1965157206","https://openalex.org/W1988075836","https://openalex.org/W1992031566","https://openalex.org/W1998646075","https://openalex.org/W2073450825","https://openalex.org/W2110052276","https://openalex.org/W2121569640","https://openalex.org/W2127588983","https://openalex.org/W2143149122","https://openalex.org/W2328825521","https://openalex.org/W2531795054","https://openalex.org/W2548791670","https://openalex.org/W2588361345","https://openalex.org/W2780908039","https://openalex.org/W2787281531","https://openalex.org/W2794023413","https://openalex.org/W2907867570","https://openalex.org/W2914004989","https://openalex.org/W2919677611","https://openalex.org/W2936741942","https://openalex.org/W2944930506","https://openalex.org/W2952597279","https://openalex.org/W2966931594","https://openalex.org/W2976362764","https://openalex.org/W2996372803","https://openalex.org/W2996612201","https://openalex.org/W3029680339","https://openalex.org/W3033475562"],"related_works":["https://openalex.org/W3026543979","https://openalex.org/W3028475840","https://openalex.org/W3030991142","https://openalex.org/W2911544841","https://openalex.org/W4406704456","https://openalex.org/W4206973410","https://openalex.org/W2913893332","https://openalex.org/W2792836514","https://openalex.org/W2789919918","https://openalex.org/W2907867570"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIMS:":[2],"Ulcerative":[3],"colitis":[4],"[UC]":[5],"is":[6,24,229],"a":[7,241],"chronic":[8,36],"inflammatory":[9,75,120],"disease":[10],"of":[11,21,31,47,74,100,129,175,180,194,201],"the":[12,19,29,143,191,198],"colon":[13,67],"with":[14,124,140,206],"an":[15],"intractable":[16],"course.":[17],"Although":[18],"goal":[20],"UC":[22,141,166,207],"therapy":[23],"to":[25,43],"achieve":[26],"mucosal":[27,32,48,81,232,245],"healing,":[28],"pathogenesis":[30],"injury":[33,49,82,233],"caused":[34,83],"by":[35,50,71,84,89,98,157,186],"inflammation":[37,86,114],"remains":[38],"unknown.":[39],"We":[40],"therefore":[41],"aim":[42],"elucidate":[44],"molecular":[45],"mechanisms":[46],"establishing":[51],"in":[52,55,62,93,108,118,165,170,204,208,214,234],"vitro":[53,63,109,212],"and":[54,122,127,146,196,213,236],"vivo":[56,94,215],"humanised":[57],"UC-mimicking":[58,216],"models.":[59],"METHODS:":[60],"An":[61,92,107],"model":[64,95,110,133],"using":[65,221],"human":[66,222],"organoids":[68,101,136],"was":[69,87,96,154,162],"established":[70,97,220],"60":[72],"weeks":[73],"stimulation.":[76],"The":[77,173],"key":[78],"gene":[79,144],"for":[80,231,244],"long-term":[85,113,158],"identified":[88],"microarray":[90],"analysis.":[91],"xenotransplantation":[99,195],"into":[102],"mouse":[103],"colonic":[104,223],"mucosa.":[105,172],"RESULTS:":[106],"demonstrated":[111,237],"that":[112,227],"induced":[115,156,185,197],"irrecoverable":[116],"changes":[117,200],"organoids:":[119],"response":[121],"apoptosis":[123,179],"oxidative":[125],"stress":[126],"suppression":[128],"cell":[130],"viability.":[131],"This":[132],"also":[134],"mimicked":[135],"derived":[137],"from":[138],"patients":[139,205],"at":[142],"expression":[145],"phenotype":[147],"levels.":[148],"Microarray":[149],"analysis":[150],"revealed":[151,226],"Schlafen11":[152],"[SLFN11]":[153],"irreversibly":[155],"inflammation.":[159,187],"Consistently,":[160],"SLFN11":[161,176,228],"highly":[163],"expressed":[164],"mucosa":[167],"but":[168],"absent":[169],"normal":[171],"knockdown":[174],"[SLFN11-KD]":[177],"suppressed":[178],"intestinal":[181],"epithelial":[182],"cells":[183],"[IECs]":[184],"Moreover,":[188],"SLFN11-KD":[189],"improved":[190],"take":[192],"rates":[193],"regenerative":[199],"crypts":[202],"observed":[203],"remission.":[209],"CONCLUSIONS:":[210],"In":[211],"models":[217],"were":[218],"uniquely":[219],"organoids.":[224],"They":[225],"significant":[230],"UC,":[235],"its":[238],"potential":[239],"as":[240],"novel":[242],"target":[243],"regeneration.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-01T00:00:00"}