{"id":"https://openalex.org/W3130239779","doi":"https://doi.org/10.1186/s12877-021-02307-6","title":"Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study","display_name":"Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study","publication_year":2021,"publication_date":"2021-06-29","ids":{"openalex":"https://openalex.org/W3130239779","doi":"https://doi.org/10.1186/s12877-021-02307-6","mag":"3130239779","pmid":"https://pubmed.ncbi.nlm.nih.gov/34187381","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8244233"},"language":"en","primary_location":{"id":"doi:10.1186/s12877-021-02307-6","doi":"https://doi.org/10.1186/s12877-021-02307-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12877-021-02307-6","pdf_url":"https://bmcgeriatr.biomedcentral.com/counter/pdf/10.1186/s12877-021-02307-6","source":{"id":"https://openalex.org/S14643628","display_name":"BMC Geriatrics","issn_l":"1471-2318","issn":["1471-2318"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Geriatrics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcgeriatr.biomedcentral.com/counter/pdf/10.1186/s12877-021-02307-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100640350","display_name":"Jing Xiao","orcid":"https://orcid.org/0009-0003-3653-0089","observed_orcids":["https://orcid.org/0009-0003-3653-0089","https://orcid.org/0000-0003-1462-2065"]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Xiao","raw_affiliation_strings":["Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, No.9 Seyuan Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226019"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, No.9 Seyuan Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226019","institution_ids":["https://openalex.org/I199305430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113933818","display_name":"Jingyi Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyi Lv","raw_affiliation_strings":["Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, No.9 Seyuan Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226019"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, No.9 Seyuan Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226019","institution_ids":["https://openalex.org/I199305430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100437623","display_name":"Shiyu Wang","orcid":"https://orcid.org/0000-0001-8851-1697","observed_orcids":["https://orcid.org/0000-0001-8851-1697"]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiyu Wang","raw_affiliation_strings":["Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, No.9 Seyuan Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226019"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, No.9 Seyuan Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226019","institution_ids":["https://openalex.org/I199305430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080186293","display_name":"Yang Zhou","orcid":"https://orcid.org/0000-0003-0453-4598","observed_orcids":["https://orcid.org/0000-0003-0453-4598"]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Zhou","raw_affiliation_strings":["Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, No.9 Seyuan Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226019"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, No.9 Seyuan Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226019","institution_ids":["https://openalex.org/I199305430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069086206","display_name":"Lunwen Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lunwen Chen","raw_affiliation_strings":["Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, No.9 Seyuan Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226019"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, No.9 Seyuan Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226019","institution_ids":["https://openalex.org/I199305430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083875620","display_name":"Juying Lu","orcid":"https://orcid.org/0000-0002-1563-4933","observed_orcids":["https://orcid.org/0000-0002-1563-4933"]},"institutions":[{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juying Lu","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, No.20 Xisi Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, No.20 Xisi Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226001","institution_ids":["https://openalex.org/I4210086801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357468","display_name":"Xiaoyi Zhang","orcid":"https://orcid.org/0000-0002-4988-819X","observed_orcids":["https://orcid.org/0000-0002-4988-819X"]},"institutions":[{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyi Zhang","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, No.20 Xisi Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, No.20 Xisi Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226001","institution_ids":["https://openalex.org/I4210086801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100638600","display_name":"Xiaojian Wang","orcid":"https://orcid.org/0000-0002-5073-389X","observed_orcids":["https://orcid.org/0000-0002-5073-389X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaojian Wang","raw_affiliation_strings":["Department of Chronic Disease and Prevention, Center for Disease Control and Prevention of Haian, Nantong, Jiangsu, P.R. China, 226600"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chronic Disease and Prevention, Center for Disease Control and Prevention of Haian, Nantong, Jiangsu, P.R. China, 226600","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062333976","display_name":"Yunjuan Gu","orcid":"https://orcid.org/0000-0003-1887-9992","observed_orcids":["https://orcid.org/0000-0003-1887-9992","https://orcid.org/0009-0008-8992-4766"]},"institutions":[{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yunjuan Gu","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, No.20 Xisi Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226001. desette@ntu.edu.cn","Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, No.20 Xisi Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, No.20 Xisi Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226001. desette@ntu.edu.cn","institution_ids":["https://openalex.org/I4210086801"]},{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, No.20 Xisi Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226001","institution_ids":["https://openalex.org/I4210086801"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070585182","display_name":"Qingyun Lu","orcid":"https://orcid.org/0000-0001-6734-6530","observed_orcids":["https://orcid.org/0000-0001-6734-6530"]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qingyun Lu","raw_affiliation_strings":["Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, No.9 Seyuan Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226019. qingyun79@126.com","Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, No.9 Seyuan Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226019"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, No.9 Seyuan Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226019. qingyun79@126.com","institution_ids":["https://openalex.org/I199305430"]},{"raw_affiliation_string":"Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, No.9 Seyuan Road, Chongchuan District, Nantong, Jiangsu, P.R. China, 226019","institution_ids":["https://openalex.org/I199305430"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062333976","https://openalex.org/A5070585182"],"corresponding_institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210086801"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":2.6621,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.90113404,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"21","issue":"1","first_page":"391","last_page":"391"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d","display_name":"25-hydroxyvitamin D","score":0.9390000104904175},{"id":"https://openalex.org/keywords/vitamin-d-deficiency","display_name":"vitamin D deficiency","score":0.9449999928474426},{"id":"https://openalex.org/keywords/vitamin-d-insufficiency","display_name":"vitamin D insufficiency","score":0.9589999914169312},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.8799999952316284},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.8769999742507935},{"id":"https://openalex.org/keywords/vitamin-d-synthesis","display_name":"vitamin D synthesis","score":0.578000009059906},{"id":"https://openalex.org/keywords/vitamin-d-metabolism","display_name":"vitamin D metabolism","score":0.9729999899864197},{"id":"https://openalex.org/keywords/dhcr7","display_name":"DHCR7","score":0.7170000076293945},{"id":"https://openalex.org/keywords/cyp2r1","display_name":"CYP2R1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gc","display_name":"GC","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cyp24a1","display_name":"CYP24A1","score":1.0},{"id":"https://openalex.org/keywords/middle-aged-and-older-adults","display_name":"middle-aged and older adults","score":0.7039999961853027},{"id":"https://openalex.org/keywords/rural-population","display_name":"rural population","score":0.5019999742507935},{"id":"https://openalex.org/keywords/causal-inference","display_name":"causal inference","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.9427169561386108},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8856645226478577},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5337333083152771},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4974212944507599},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.4667656123638153},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.46628308296203613},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.4537135362625122},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.4478394687175751},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4434933364391327},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3649422228336334},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3125861585140228},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30206751823425293},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2751501202583313},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18835943937301636},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.11202460527420044},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.08636534214019775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07929116487503052},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014808","descriptor_name":"Vitamin D Deficiency","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D014808","descriptor_name":"Vitamin D Deficiency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014808","descriptor_name":"Vitamin D Deficiency","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12877-021-02307-6","doi":"https://doi.org/10.1186/s12877-021-02307-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12877-021-02307-6","pdf_url":"https://bmcgeriatr.biomedcentral.com/counter/pdf/10.1186/s12877-021-02307-6","source":{"id":"https://openalex.org/S14643628","display_name":"BMC Geriatrics","issn_l":"1471-2318","issn":["1471-2318"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Geriatrics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8244233","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8244233","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Geriatr","raw_type":"Text"},{"id":"pmid:34187381","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34187381","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC geriatrics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:352e53875e604960ba849a77993bd84b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/352e53875e604960ba849a77993bd84b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Geriatrics, Vol 21, Iss 1, Pp 1-12 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12877-021-02307-6","doi":"https://doi.org/10.1186/s12877-021-02307-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12877-021-02307-6","pdf_url":"https://bmcgeriatr.biomedcentral.com/counter/pdf/10.1186/s12877-021-02307-6","source":{"id":"https://openalex.org/S14643628","display_name":"BMC Geriatrics","issn_l":"1471-2318","issn":["1471-2318"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Geriatrics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.75,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1161922696","display_name":null,"funder_award_id":"31000539","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3130239779.pdf","grobid_xml":"https://content.openalex.org/works/W3130239779.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1505358055","https://openalex.org/W1571896605","https://openalex.org/W1965152135","https://openalex.org/W1969505291","https://openalex.org/W1972306678","https://openalex.org/W1972696558","https://openalex.org/W1983243805","https://openalex.org/W1986019281","https://openalex.org/W1992374108","https://openalex.org/W1992700885","https://openalex.org/W2051983101","https://openalex.org/W2053748342","https://openalex.org/W2065690339","https://openalex.org/W2083233093","https://openalex.org/W2097489176","https://openalex.org/W2098256703","https://openalex.org/W2100190891","https://openalex.org/W2103167986","https://openalex.org/W2106036991","https://openalex.org/W2109025585","https://openalex.org/W2113603970","https://openalex.org/W2124070987","https://openalex.org/W2129327282","https://openalex.org/W2132605013","https://openalex.org/W2134293572","https://openalex.org/W2138657112","https://openalex.org/W2139284747","https://openalex.org/W2140694890","https://openalex.org/W2143104968","https://openalex.org/W2146000754","https://openalex.org/W2151096860","https://openalex.org/W2156810420","https://openalex.org/W2157127265","https://openalex.org/W2157276255","https://openalex.org/W2161519087","https://openalex.org/W2162204400","https://openalex.org/W2162258804","https://openalex.org/W2169322651","https://openalex.org/W2265394350","https://openalex.org/W2324387650","https://openalex.org/W2416604133","https://openalex.org/W2420668314","https://openalex.org/W2557384502","https://openalex.org/W2581245397","https://openalex.org/W2604327896","https://openalex.org/W2613517785","https://openalex.org/W2728563753","https://openalex.org/W2761901182","https://openalex.org/W2793955071","https://openalex.org/W2797868822","https://openalex.org/W2801709424","https://openalex.org/W2891611331","https://openalex.org/W2944721806","https://openalex.org/W2966143717","https://openalex.org/W2975227205","https://openalex.org/W2982654900","https://openalex.org/W3014565260"],"related_works":["https://openalex.org/W4255849020","https://openalex.org/W2801709424","https://openalex.org/W6901649176","https://openalex.org/W2156810420","https://openalex.org/W7095132268","https://openalex.org/W2982654900","https://openalex.org/W2525794269","https://openalex.org/W6977005401","https://openalex.org/W4412136270","https://openalex.org/W7164886573"],"abstract_inverted_index":{"BACKGROUND:":[0],"Vitamin":[1],"D":[2,29,49,103,115,138,162,168,174,199,221,252,306],"deficiency":[3,200,223],"has":[4],"been":[5],"associated":[6,263],"with":[7,57,172,197,219,264,275],"type":[8],"2":[9],"diabetes":[10],"(T2D)":[11],"and":[12,16,51,59,68,81,110,112,119,142,190,211,217,234,260,269,283,312,317],"metabolic":[13],"syndrome":[14],"(MS)":[15],"its":[17,52,60],"components.":[18],"However,":[19],"it":[20],"is":[21,30],"unclear":[22],"whether":[23],"a":[24,244,300],"low":[25],"concentration":[26],"of":[27,35,47,78,89,95,134,185,187,191,193,206,208,212,214,229,231,235,237,267,277,303,310],"vitamin":[28,48,167,173,198,220],"the":[31,45,90,132,146,156,255,265],"cause":[32],"or":[33],"consequence":[34],"these":[36],"health":[37],"conditions.":[38],"Thus,":[39],"this":[40],"study":[41],"aimed":[42],"to":[43,130,153,166],"evaluate":[44],"association":[46],"concentrations":[50,139,253,307],"genetic":[53,297],"risk":[54,266],"scores":[55],"(GRSs)":[56],"MS":[58,141,186,207,230],"component":[61],"diseases,":[62],"such":[63],"as":[64,127],"T2D,":[65],"in":[66,97,247,308,315],"middle-aged":[67,80,316],"elderly":[69,82,318],"participants":[70,88,319],"from":[71,86,320],"rural":[72,321],"eastern":[73],"China.":[74,98,322],"METHODS:":[75],"A":[76],"subset":[77],"2393":[79],"individuals":[83,171,196],"were":[84,125,151],"selected":[85],"70,458":[87],"Nantong":[91],"Chronic":[92],"Diseases":[93],"Study":[94],"2017-2018":[96],"We":[99],"used":[100,126,152],"two":[101,113,256],"25-hydroxyvitamin":[102],"(25[OH]D)":[104],"synthesis":[105,257],"single-nucleotide":[106],"polymorphisms":[107],"(SNPs)":[108],"(DHCR7-rs12785878":[109],"CYP2R1-rs10741657)":[111],"25(OH)":[114,137,161,251,305],"metabolism":[116],"SNPs":[117,158,258],"(GC-rs2282679":[118],"CYP24A1-rs6013897)":[120],"for":[121,281,287,299],"creating":[122],"GRSs,":[123],"which":[124],"instrumental":[128],"variables":[129],"assess":[131],"effect":[133],"genetically":[135,159,248],"lowered":[136],"on":[140,145],"T2D":[143,192,213,236,268,282,311],"based":[144],"Wald":[147],"ratio.":[148],"F":[149],"statistics":[150],"validate":[154],"that":[155],"four":[157],"determined":[160],"concentrations.":[163],"RESULTS:":[164],"Compared":[165],"sufficient":[169],"individuals,":[170],"insufficiency":[175],"had":[176,201,224],"an":[177,202,225],"odds":[178],"ratio":[179],"(OR":[180],"[95%":[181],"confidence":[182],"interval":[183],"{CI}])":[184],"1.30":[188],"(1.06-1.61)":[189],"1.32":[194],"(1.08-1.64),":[195],"ORs":[203,226,276],"(95%":[204,227],"CI)":[205,228],"1.50":[209],"(1.24-1.79)":[210],"1.47":[215],"(1.12-1.80),":[216],"those":[218],"severe":[222],"1.52":[232],"(1.29-1.85)":[233],"1.54":[238],"(1.27-1.85).":[239],"Mendelian":[240,293],"randomization":[241,294],"analysis":[242,295],"showed":[243],"25-nmol/L":[245],"decrease":[246],"instrumented":[249],"serum":[250],"using":[254],"(DHCR7":[259],"CYP2R1":[261],"genes)":[262],"abnormal":[270,313],"diastolic":[271],"blood":[272],"pressure":[273],"(DBP)":[274],"1.10":[278],"(95%CI:":[279,285],"1.02-1.45)":[280],"1.14":[284],"1.03-1.43)":[286],"DBP.":[288],"CONCLUSIONS:":[289],"This":[290],"one":[291],"sample":[292],"shows":[296],"evidence":[298],"causal":[301],"role":[302],"lower":[304],"promoting":[309],"DBP":[314]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-01T00:00:00"}