{"id":"https://openalex.org/W3130119618","doi":"https://doi.org/10.1055/s-0041-1723798","title":"Point-of-Care Diagnostic Assays and Novel Preclinical Technologies for Hemostasis and Thrombosis","display_name":"Point-of-Care Diagnostic Assays and Novel Preclinical Technologies for Hemostasis and Thrombosis","publication_year":2021,"publication_date":"2021-02-26","ids":{"openalex":"https://openalex.org/W3130119618","doi":"https://doi.org/10.1055/s-0041-1723798","mag":"3130119618","pmid":"https://pubmed.ncbi.nlm.nih.gov/33636744"},"language":"en","primary_location":{"id":"doi:10.1055/s-0041-1723798","doi":"https://doi.org/10.1055/s-0041-1723798","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0041-1723798","pdf_url":null,"source":{"id":"https://openalex.org/S96726197","display_name":"Seminars in Thrombosis and Hemostasis","issn_l":"0094-6176","issn":["0094-6176","1098-9064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Thrombosis and Hemostasis","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102894919","display_name":"Christina M. Caruso","orcid":"https://orcid.org/0000-0002-7453-019X","observed_orcids":["https://orcid.org/0000-0002-7453-019X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210146983","display_name":"Children's Healthcare of Atlanta","ror":"https://ror.org/050fhx250","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146983"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Caruso","raw_affiliation_strings":["Department of Pediatrics, Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210146983"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065031384","display_name":"Wilbur Aaron Lam","orcid":"https://orcid.org/0000-0002-0325-7990","observed_orcids":["https://orcid.org/0000-0002-0325-7990"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]},{"id":"https://openalex.org/I4210146983","display_name":"Children's Healthcare of Atlanta","ror":"https://ror.org/050fhx250","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146983"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wilbur A. Lam","raw_affiliation_strings":["Department of Pediatrics, Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia","Wallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine, Georgia Institute of Technology, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210146983"]},{"raw_affiliation_string":"Wallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine, Georgia Institute of Technology, Atlanta, Georgia","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5065031384"],"corresponding_institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298","https://openalex.org/I4210146983"],"apc_list":null,"apc_paid":null,"fwci":0.3736,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.33333333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"47","issue":"02","first_page":"120","last_page":"128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.6284000277519226,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.6284000277519226,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.3188000023365021,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.017500000074505806,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/point-of-care-testing","display_name":"point-of-care testing","score":0.7960000038146973},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/microfluidic-assay","display_name":"microfluidic assay","score":0.8109999895095825},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.6679999828338623},{"id":"https://openalex.org/keywords/coagulation-factors","display_name":"coagulation factors","score":0.9430000185966492},{"id":"https://openalex.org/keywords/bleeding-disorders","display_name":"bleeding disorders","score":0.7639999985694885},{"id":"https://openalex.org/keywords/prothrombotic-disorders","display_name":"prothrombotic disorders","score":0.7549999952316284},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.8368793725967407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6312267780303955},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.5848626494407654},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5108954310417175},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.44643816351890564},{"id":"https://openalex.org/C51915194","wikidata":"https://www.wikidata.org/wiki/Q17075487","display_name":"Point of care","level":2,"score":0.43846607208251953},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.41505491733551025},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.41364091634750366},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38866177201271057},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3601177930831909},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2910759150981903},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2265462577342987},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21987444162368774},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.21821674704551697},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18621209263801575}],"mesh":[{"descriptor_ui":"D000067716","descriptor_name":"Point-of-Care Testing","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D006487","descriptor_name":"Hemostasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0041-1723798","doi":"https://doi.org/10.1055/s-0041-1723798","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0041-1723798","pdf_url":null,"source":{"id":"https://openalex.org/S96726197","display_name":"Seminars in Thrombosis and Hemostasis","issn_l":"0094-6176","issn":["0094-6176","1098-9064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Thrombosis and Hemostasis","raw_type":"journal-article"},{"id":"pmid:33636744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33636744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in thrombosis and hemostasis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1570842275","https://openalex.org/W1936028382","https://openalex.org/W1965380637","https://openalex.org/W1975352530","https://openalex.org/W1979443037","https://openalex.org/W1979594167","https://openalex.org/W1995244172","https://openalex.org/W1996282847","https://openalex.org/W2009204985","https://openalex.org/W2011543194","https://openalex.org/W2019588710","https://openalex.org/W2024195790","https://openalex.org/W2027234515","https://openalex.org/W2034371538","https://openalex.org/W2034921547","https://openalex.org/W2036284239","https://openalex.org/W2041605095","https://openalex.org/W2041777103","https://openalex.org/W2042051737","https://openalex.org/W2056398805","https://openalex.org/W2063878434","https://openalex.org/W2065593094","https://openalex.org/W2088776590","https://openalex.org/W2110172512","https://openalex.org/W2118277673","https://openalex.org/W2120726327","https://openalex.org/W2127202845","https://openalex.org/W2132345790","https://openalex.org/W2132612915","https://openalex.org/W2134766290","https://openalex.org/W2142834161","https://openalex.org/W2152005278","https://openalex.org/W2158415193","https://openalex.org/W2167988448","https://openalex.org/W2196467705","https://openalex.org/W2218416533","https://openalex.org/W2620905845","https://openalex.org/W2653525619","https://openalex.org/W2748517697","https://openalex.org/W2787277009","https://openalex.org/W2969166120"],"related_works":["https://openalex.org/W1936028382","https://openalex.org/W2139739213","https://openalex.org/W4403637369","https://openalex.org/W2142992963","https://openalex.org/W4413640057","https://openalex.org/W7125943465","https://openalex.org/W2022343625","https://openalex.org/W2987171755","https://openalex.org/W2128640810","https://openalex.org/W2618687506"],"abstract_inverted_index":{"Hemostasis":[0],"is":[1],"a":[2,140],"complex":[3],"wound-healing":[4],"process":[5],"involving":[6],"numerous":[7],"mechanical":[8],"and":[9,12,21,37,50,68,105,121,136,145,164],"biochemical":[10],"mechanisms":[11,28],"influenced":[13],"by":[14,124],"many":[15],"factors":[16],"including":[17],"platelets,":[18],"coagulation":[19],"factors,":[20],"endothelial":[22,80],"components.":[23],"Slight":[24],"alterations":[25],"in":[26,65,169],"these":[27,87,161],"can":[29,41],"lead":[30,42],"to":[31,43,77,99,152,159,171],"either":[32],"prothrombotic":[33],"or":[34],"bleeding":[35],"consequences,":[36],"such":[38],"hemostatic":[39],"imbalances":[40],"significant":[44],"clinical":[45,110,166],"consequences":[46],"with":[47],"resultant":[48],"morbidity":[49],"mortality.":[51],"An":[52],"ideal":[53],"hemostasis":[54],"assay":[55],"would":[56],"not":[57,90],"only":[58],"address":[59,114],"all":[60],"the":[61,115,153,172],"unique":[62],"processes":[63],"involved":[64],"clot":[66],"formation":[67],"resolution":[69],"but":[70],"also":[71],"take":[72],"place":[73],"under":[74,139],"flow":[75,91,146],"conditions":[76],"account":[78],"for":[79],"involvement.":[81],"Global":[82],"assays":[83,88,94,113,123],"do":[84],"exist;":[85],"however,":[86],"are":[89],"based.":[92],"Flow-based":[93],"have":[95,137],"been":[96],"limited":[97],"secondary":[98],"their":[100],"large":[101],"blood":[102,131],"volume":[103],"requirements":[104],"low":[106,130],"throughput,":[107],"limiting":[108],"potential":[109,165],"applications.":[111],"Microfluidic-based":[112],"aforementioned":[116],"limitations":[117],"of":[118,142],"both":[119],"global":[120],"flow-based":[122],"utilizing":[125],"standardized":[126],"devices":[127],"that":[128],"require":[129],"volumes,":[132],"offer":[133],"reproducible":[134],"analysis,":[135],"functionality":[138],"range":[141],"shear":[143],"stresses":[144],"conditions.":[147],"While":[148],"still":[149],"largely":[150],"confined":[151],"preclinical":[154],"space,":[155],"here":[156],"we":[157],"aim":[158],"discuss":[160],"novel":[162],"technologies":[163],"implications,":[167],"particularly":[168],"comparison":[170],"current,":[173],"commercially":[174],"available":[175],"point-of-care":[176],"assays.":[177]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-01T00:00:00"}