{"id":"https://openalex.org/W3130055403","doi":"https://doi.org/10.21203/rs.3.rs-248965/v1","title":"Detection of the new SARS-CoV-2 variant B.1.526 with the Spike E484K mutation in South America","display_name":"Detection of the new SARS-CoV-2 variant B.1.526 with the Spike E484K mutation in South America","publication_year":2021,"publication_date":"2021-02-17","ids":{"openalex":"https://openalex.org/W3130055403","doi":"https://doi.org/10.21203/rs.3.rs-248965/v1","mag":"3130055403"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-248965/v1","doi":"https://doi.org/10.21203/rs.3.rs-248965/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-248965/v1","pdf_url":"https://www.researchsquare.com/article/rs-248965/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-248965/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045535619","display_name":"Juan Carlos Fern\u00e1ndez\u2010Cadena","orcid":"https://orcid.org/0000-0002-0398-8371","observed_orcids":["https://orcid.org/0000-0002-0398-8371"]},"institutions":[{"id":"https://openalex.org/I3132284232","display_name":"Universidad Esp\u00edritu Santo","ror":"https://ror.org/00b210x50","country_code":"EC","type":"education","lineage":["https://openalex.org/I3132284232"]}],"countries":["EC"],"is_corresponding":false,"raw_author_name":"Juan Fern\u00e1ndez Cadena","raw_affiliation_strings":["Omics Sciences Laboratory, Faculty of Medical Sciences, Universidad Esp\u00edritu Santo"],"raw_orcid":"https://orcid.org/0000-0002-0398-8371","affiliations":[{"raw_affiliation_string":"Omics Sciences Laboratory, Faculty of Medical Sciences, Universidad Esp\u00edritu Santo","institution_ids":["https://openalex.org/I3132284232"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mindy Mu\u00f1oz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3132284232","display_name":"Universidad Esp\u00edritu Santo","ror":"https://ror.org/00b210x50","country_code":"EC","type":"education","lineage":["https://openalex.org/I3132284232"]}],"countries":["EC"],"is_corresponding":false,"raw_author_name":"Mindy Mu\u00f1oz","raw_affiliation_strings":["Omics Sciences Laboratory, Faculty of Medical Sciences, Universidad Esp\u00edritu Santo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Omics Sciences Laboratory, Faculty of Medical Sciences, Universidad Esp\u00edritu Santo","institution_ids":["https://openalex.org/I3132284232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005013487","display_name":"Gabriel Morey-Le\u00f3n G","orcid":"https://orcid.org/0000-0003-1824-8285","observed_orcids":["https://orcid.org/0000-0003-1824-8285"]},"institutions":[{"id":"https://openalex.org/I2405095","display_name":"University of Guayaquil","ror":"https://ror.org/047kyg834","country_code":"EC","type":"education","lineage":["https://openalex.org/I2405095"]},{"id":"https://openalex.org/I4210090927","display_name":"Universidad Estatal de Milagro","ror":"https://ror.org/00gd7ns03","country_code":"EC","type":"education","lineage":["https://openalex.org/I4210090927"]}],"countries":["EC"],"is_corresponding":false,"raw_author_name":"Gabriel Morey Le\u00f3n","raw_affiliation_strings":["Faculty of Medical Sciences, Universidad de Guayaquil"],"raw_orcid":"https://orcid.org/0000-0003-1824-8285","affiliations":[{"raw_affiliation_string":"Faculty of Medical Sciences, Universidad de Guayaquil","institution_ids":["https://openalex.org/I2405095","https://openalex.org/I4210090927"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008777896","display_name":"Rub\u00e9n Armas-Gonz\u00e1lez","orcid":"https://orcid.org/0000-0001-9892-3572","observed_orcids":["https://orcid.org/0000-0001-9892-3572"]},"institutions":[{"id":"https://openalex.org/I2135383","display_name":"Escuela Superior Politecnica del Litoral","ror":"https://ror.org/04qenc566","country_code":"EC","type":"education","lineage":["https://openalex.org/I2135383"]}],"countries":["EC"],"is_corresponding":false,"raw_author_name":"Rub\u00e9n Armas-Gonz\u00e1lez","raw_affiliation_strings":["Faculty of Sciences, Escuela Superior Polit\u00e9cnica del Litoral"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Sciences, Escuela Superior Polit\u00e9cnica del Litoral","institution_ids":["https://openalex.org/I2135383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045862007","display_name":"Darlyn Jos\u00e9 Amaya-M\u00e1rquez","orcid":"https://orcid.org/0000-0003-4961-0283","observed_orcids":["https://orcid.org/0000-0003-4961-0283"]},"institutions":[{"id":"https://openalex.org/I2135383","display_name":"Escuela Superior Politecnica del Litoral","ror":"https://ror.org/04qenc566","country_code":"EC","type":"education","lineage":["https://openalex.org/I2135383"]}],"countries":["EC"],"is_corresponding":false,"raw_author_name":"Darlyn Amaya M\u00e1rquez","raw_affiliation_strings":["Faculty of Sciences, Escuela Superior Polit\u00e9cnica del Litoral"],"raw_orcid":"https://orcid.org/0000-0003-4961-0283","affiliations":[{"raw_affiliation_string":"Faculty of Sciences, Escuela Superior Polit\u00e9cnica del Litoral","institution_ids":["https://openalex.org/I2135383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060848389","display_name":"Katheryn Sacheri-Viteri","orcid":"https://orcid.org/0000-0002-2650-7438","observed_orcids":["https://orcid.org/0000-0002-2650-7438"]},"institutions":[{"id":"https://openalex.org/I3132284232","display_name":"Universidad Esp\u00edritu Santo","ror":"https://ror.org/00b210x50","country_code":"EC","type":"education","lineage":["https://openalex.org/I3132284232"]}],"countries":["EC"],"is_corresponding":false,"raw_author_name":"Katheryn Sacheri Viteri","raw_affiliation_strings":["Omics Sciences Laboratory, Faculty of Medical Sciences, Universidad Esp\u00edritu Santo"],"raw_orcid":"https://orcid.org/0000-0002-2650-7438","affiliations":[{"raw_affiliation_string":"Omics Sciences Laboratory, Faculty of Medical Sciences, Universidad Esp\u00edritu Santo","institution_ids":["https://openalex.org/I3132284232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062426175","display_name":"Pa\u00fal C\u00e1rdenas","orcid":"https://orcid.org/0000-0001-9626-4489","observed_orcids":["https://orcid.org/0000-0001-9626-4489"]},"institutions":[{"id":"https://openalex.org/I69094615","display_name":"Universidad San Francisco de Quito","ror":"https://ror.org/01r2c3v86","country_code":"EC","type":"education","lineage":["https://openalex.org/I69094615"]}],"countries":["EC"],"is_corresponding":false,"raw_author_name":"Pa\u00fal C\u00e1rdenas & USFQ-COVID Consortium","raw_affiliation_strings":["Instituto de Microbiolog\u00eda, Universidad San Francisco de Quito"],"raw_orcid":"https://orcid.org/0000-0001-9626-4489","affiliations":[{"raw_affiliation_string":"Instituto de Microbiolog\u00eda, Universidad San Francisco de Quito","institution_ids":["https://openalex.org/I69094615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081509779","display_name":"Fernando Valiente\u2010Echeverr\u00eda","orcid":"https://orcid.org/0000-0001-9156-2516","observed_orcids":["https://orcid.org/0000-0001-9156-2516"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Fernando Valiente-Echeverr\u00eda","raw_affiliation_strings":["Universidad de Chile"],"raw_orcid":"https://orcid.org/0000-0001-9156-2516","affiliations":[{"raw_affiliation_string":"Universidad de Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024545818","display_name":"Ricardo Soto\u2010Rifo","orcid":"https://orcid.org/0000-0003-0945-2970","observed_orcids":["https://orcid.org/0000-0003-0945-2970"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Ricardo Soto Rifo","raw_affiliation_strings":["Molecular and Cellular Virology Laboratory, Virology Program, Institute of Biomedical Sciences, HIV/AIDS Workgroup, Universidad de Chile"],"raw_orcid":"https://orcid.org/0000-0003-0945-2970","affiliations":[{"raw_affiliation_string":"Molecular and Cellular Virology Laboratory, Virology Program, Institute of Biomedical Sciences, HIV/AIDS Workgroup, Universidad de Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015622256","display_name":"Derly Andrade-Molina","orcid":"https://orcid.org/0000-0002-2651-5884","observed_orcids":["https://orcid.org/0000-0002-2651-5884"]},"institutions":[{"id":"https://openalex.org/I3132284232","display_name":"Universidad Esp\u00edritu Santo","ror":"https://ror.org/00b210x50","country_code":"EC","type":"education","lineage":["https://openalex.org/I3132284232"]}],"countries":["EC"],"is_corresponding":true,"raw_author_name":"Derly Andrade Molina","raw_affiliation_strings":["Omics Sciences Laboratory, Faculty of Medical Sciences, Universidad Esp\u00edritu Santo"],"raw_orcid":"https://orcid.org/0000-0002-2651-5884","affiliations":[{"raw_affiliation_string":"Omics Sciences Laboratory, Faculty of Medical Sciences, Universidad Esp\u00edritu Santo","institution_ids":["https://openalex.org/I3132284232"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5015622256"],"corresponding_institution_ids":["https://openalex.org/I3132284232"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9380000233650208},{"id":"https://openalex.org/keywords/e484k-mutation","display_name":"E484K mutation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/spike-protein","display_name":"spike protein","score":0.6050000190734863},{"id":"https://openalex.org/keywords/variants-of-concern","display_name":"variants of concern","score":0.7799999713897705},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.7269999980926514},{"id":"https://openalex.org/keywords/viral-mutations","display_name":"viral mutations","score":0.5809999704360962},{"id":"https://openalex.org/keywords/travel-associated-transmission","display_name":"travel-associated transmission","score":0.5559999942779541},{"id":"https://openalex.org/keywords/contact-tracing","display_name":"contact tracing","score":0.574999988079071},{"id":"https://openalex.org/keywords/south-america","display_name":"South America","score":0.7110000252723694},{"id":"https://openalex.org/keywords/equator","display_name":"equator","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C2781390188","wikidata":"https://www.wikidata.org/wiki/Q25203449","display_name":"Spike (software development)","level":2,"score":0.9139517545700073},{"id":"https://openalex.org/C2909509916","wikidata":"https://www.wikidata.org/wiki/Q22329850","display_name":"Spike Protein","level":5,"score":0.7713844776153564},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6568583846092224},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.6256158947944641},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5551460385322571},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.42193835973739624},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3724904954433441},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34327077865600586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3386540412902832},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2604137063026428},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19622144103050232},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09679204225540161},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.08605048060417175},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C115903868","wikidata":"https://www.wikidata.org/wiki/Q80993","display_name":"Software engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-248965/v1","doi":"https://doi.org/10.21203/rs.3.rs-248965/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-248965/v1","pdf_url":"https://www.researchsquare.com/article/rs-248965/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-248965/v1","doi":"https://doi.org/10.21203/rs.3.rs-248965/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-248965/v1","pdf_url":"https://www.researchsquare.com/article/rs-248965/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320317367","display_name":"Universidad de Especialidades Esp\u00edritu Santo","ror":"https://ror.org/00b210x50"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3130055403.pdf","grobid_xml":"https://content.openalex.org/works/W3130055403.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W2031611770","https://openalex.org/W2127774996","https://openalex.org/W3034548712","https://openalex.org/W3039901154","https://openalex.org/W3112516998","https://openalex.org/W3121659230","https://openalex.org/W3126729284","https://openalex.org/W3127401064","https://openalex.org/W3128186941","https://openalex.org/W3129829341","https://openalex.org/W3134446480","https://openalex.org/W3135383916","https://openalex.org/W3136588845","https://openalex.org/W3189449818","https://openalex.org/W6790338584"],"related_works":["https://openalex.org/W3200572542","https://openalex.org/W3197379990","https://openalex.org/W3165272552","https://openalex.org/W3133951695","https://openalex.org/W3155526284","https://openalex.org/W3171347866","https://openalex.org/W4283333060","https://openalex.org/W3161894206","https://openalex.org/W3185488876","https://openalex.org/W3201358697"],"abstract_inverted_index":{"Abstract":[0],"Here,":[1],"we":[2],"report":[3],"two":[4],"sequences":[5,42],"of":[6,61,79,83],"the":[7,20,29,50,76,86],"new":[8,81],"SARS-CoV-2":[9],"variant":[10,18,82],"recently":[11],"detected":[12],"and":[13,25,38,58],"designed":[14],"as":[15],"B.1.526.":[16],"This":[17],"carries":[19],"immune":[21],"escape-associated":[22],"mutation":[23,88],"E484K":[24,87],"additional":[26],"mutations":[27],"in":[28,89],"S,":[30],"N,":[31],"NSP2,":[32],"NSP3,":[33],"NSP4,":[34],"NSP6,":[35],"NSP8,":[36],"NSP12":[37],"NSP13":[39],"genes.":[40],"Viral":[41],"were":[43],"obtained":[44],"from":[45,49,59],"an":[46,73],"individual":[47],"traveling":[48],"US":[51],"to":[52],"Equator":[53],"with":[54,85],"a":[55,80],"negative":[56],"RT-PCR":[57],"one":[60],"his":[62],"closest":[63],"contacts":[64],"that":[65],"became":[66],"infected.":[67],"These":[68],"cases":[69],"should":[70],"be":[71],"considered":[72],"alert":[74],"for":[75],"potential":[77],"circulation":[78],"concern":[84],"South":[90],"America":[91]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-03-01T00:00:00"}